Gene 81660.m00115 (T.vaginalis)

81660.m00115

Species: T.vaginalis
Alias: TvagK0769, 81660.m00115
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
81660.m00115.AA Protein None 523 None Fasta, JSON
81660.m00115.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 81660.m00115.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81660.m00115.AA PLK 24-281 41 3.6e-106 346.72 In-house 1-258 (258) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-258/258
Sequence Identity: 41% (108 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPNGTVLDMLKKN-NPFSEK
|..    |.|||| .|  ...  .  .||| ... ... |. | |...|. ||..|||.|||.|  .|.|...|||.||.|.|.. ....|.   ...| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

QTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGGGGKRGHTTSVDIWATGVCSFLMLTGK
 . .. ||. ..| |||.||.||||||| ||.|..|.| |..||||...|  |.|.|.|.|||| | .|||.  | | ||   ||.|. |.    .|.||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVL-DGNKQGHSYEVDCWSLGCIMYTLLIGK

QPFQGSDKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
 ||. .| | |||.| |  |  ||   .|| |||.... |...|  |||..... ||| 
PPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 81660.m00115.AA S_TKc 24-281 35 4.7e-99 336.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPN--GTVLDMLKKNNP---
|.| .| |.|.|..|| . .      ||||.|.          .....|..|.|. || ||| ...|||| ...|. .|.|..  |...|..||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGGGGKRGHTT-SVDIWATGVC
   |.| ..  ..||...|| |.|.|..|||||| .|.|||.  | |..||||..||       .|.|||| |..|||.      |... ..|.|. |..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

SFLMLTGKQPFQGSDKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELIT-------HPFI
 . ||.|. ||.  . . ..|.|             |. ||||... |||||. |||| |. .       ||..
LYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81660.m00115.AA CAMK 29-281 20 1.6e-97 314.81 In-house 1-425 (425) Show / Hide 
Range on Protein: 29-281
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

KMGSGGFATVYSGEEMPGR------------LPVAIKCISQTRVAD-------------------------PKVRRKLISEVDIHKS-------LHHQNI
. |.|.|..|. ...                  |||| |. ... |                         || |... .|..|.|.       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEFKGVFQD-------------------ENYVYILL---ELCPNG----TVLDMLKKNNP---------------FSEKQTSQICYQLLNALIYLHEHRV
. .  |..|                   ....|. .   |.|..|     ..|..... .               |.|......  |.. |. |.|.| .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLQNLLLDKN-----------------NHMKLADFGLSAQLQS-----------------------DDEKKMTLCGTPSYLS-PEVVGGGG----
.|||||. |.|||.|                 |  |..|||.......                       ...|  | ||||.| . |||. | |    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KRGHTTSVDIWATGVCSFLMLTGKQPFQGS-------------DKKITYKNISHVSYQWPE--------------KSHVSDL--------AKD
       |.... ..|.|. ||  . ||.|. ||.|.             . . ....|    |..|.               ...||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FVDHALQKDPNARPTAKELITHPFI
.. . ||.||. |.|...   ||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 81660.m00115.AA PLK-Unclassified 24-281 43 4.5e-95 322.16 In-house 1-264 (264) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-264/264
Sequence Identity: 43% (115 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPNGTVLDMLKKN-------
| .  ..|.|||| .|   .  .    |.| |        . | |||||  |||||||.||| |  .| |. .||||||.|||||. ...|.        
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

NPFSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGGGGKR-GHTTSVDIWATGVCS
   .|  .  . ||...|| ||| .|.||||||| |..|. |.  |..||||.. |. | ||| | |||| | .||.    ||  ||   ||.|. |.  
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILD--GKHQGHSYEVDCWSFGCIL

FLMLTGKQPFQGSDKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
  .|.|| ||...| | |||.|   .|  || .|.|| |||...| |. .|  |||  ..  ||| 
YTLLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 81660.m00115.AA Pkinase 24-281 30 2.1e-90 311.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLIS--EVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPNG----TVLDMLK--K
|.|. | |||.|..|| . .   .  ||.|.|.    ....... ..   |. |.|.|.| |||.....|.|....|. .|.|..|       |...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NNPF--SEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHM----KLADFGLSAQL-QSDDEKKMTLCGTPSYLSPEVVGGGGKRGHTTSVDI
...|  ||..   ..||.| .| |.|....||||||..|.|.|.|.|     |..||||..|.    ..  .|.|||| |..|||.   | ......||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

WATGVCSFLMLTGKQPFQGS------DKKITYKNISH--VSYQWPEKSHVS-----------------DLAKDFVDHALQKDPNARPTAKELITHPFI
|. |.  . ||.|. ||.|.      |..  ...| .  ....||... .|                 . .|||..  |.|||. ||||...  ||..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 81660.m00115.AA CAMK1 24-281 30 1.6e-88 257.4 In-house 1-276 (276) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-276/276
Sequence Identity: 30% (84 aa)

YTIKDKMGSGGFATVYSGEEMP---GRLPVAIKCIS-QTRVADPKV--RRKLISEVDIHKS---LHHQNIVEFKGVFQDENYVYILLELCPNGTVLDMLK
| .... |.| |..|| ...     .  ..|||||.  . ..  ..  . .|  |..|.|.   ..|.||. |. .....|..|. .||. .|  .|   
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KNNPFSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKN-NHM--K--LADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGG-GGKRGHTTSVDI
..  ..||. . |  |.| |. |.|.. . ||||| .|||.  . ...  |  .|||||| .. .|...  | ||||.|  |||. .     ..  ..|.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKACDM

WATGVCSFLMLTGKQPFQGSD-KKITYKNISHVSYQWPEK--SHVSDL-AKDFVDHALQKDPNARPTAKELITHPFI
|  || .. .|.| .||.... ..  .. |.  .| .|..   ..||  ||||. | | .||. |.|... . ||.|
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 81660.m00115.AA CAMKL 24-281 27 1.7e-85 272.75 In-house 1-297 (297) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-297/297
Sequence Identity: 27% (83 aa)

YTIKDKMGSGGFATVYSGEE-MPGRLPVAIKCISQTRVA-DPKVRRK-----------LISEVDIHKSLH---HQNIVEFKGVFQDENY------VYILL
|.| .  | |.|..|  ..  .  .  |||| |   .   ||.....           .  |. |.|.|.   |.||. .  |......      .|. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPNGT--VLDMLKKN----NPFSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNN--HMKLADFGLSAQLQS----DDEKKMTLCGTPSYL
|.|..|    .|...|.     ...|... ..  |.. |. |.|.|...|||.|. |.|||.|.    |..|||.|.. .     ...| .| ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEVVGGGGKRGHTTSVDIWATGVCSFLMLTGKQPFQGS--------DKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
.||.. |. |. .   ||||. ||  . |..|. || .         ..   |. |    |..|  .|||  ..|.  . ||..|. |||....  ||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 81660.m00115.AA STE 24-281 25 5e-84 285.47 In-house 1-359 (359) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-359/359
Sequence Identity: 25% (93 aa)

YTIKDKMGSGGFATVYSGEEM-PGRLP--------------VAIKCIS---Q-----------TRVADPKVRRKLISEVDIHKSLH--HQNIVEFKGVFQ
... .| |.|.| ||| .  . ....               .||| ..   .           ..  ... . ... |..|.| ..  |.|||.. | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-------NYVYILLELCPNGTVLDMLK------KNNP--------FSEKQTSQICYQLLNA-LIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSA
.|       ....| .|....|.. |..|      |...        |.|.| . ||.|.| . | |||.|..||||.| .| ||      ||.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLQSD----------------DEKKMTLCGTPSYLSPEVVGGGG---KRGHTTSVDIWATGVCSFLMLTGKQPF-QGSDK----KITYKNISH-------
||...                ..|  |..||| . .|||. ..|   . |..|..|||  | .   |.||| |.  ...      |. .....       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----VSYQWPE-----------------KSHVSDLAKDFVDHALQKDPNARPTAKELIT--HPFI
     . . |.                 ....|.  |||... |||||| ||||..|.   ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 81660.m00115.AA PLK1 24-281 35 2e-75 247.33 In-house 1-253 (253) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-253/253
Sequence Identity: 35% (92 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPNGTVLDMLKKNNPFSEKQ
|.    .| ||||  |  ..   .  .| | .... .  .. | |.  |..||..|||..||.|   | |...|||.||||    .... |.  .  |  
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

TSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGGGGKRGHTTSVDIWATGVCSFLMLTGKQ
.    ||....  |||. ..||||||| || |. . ..|. ||||  ... | |.|.|||||| |. |||.    |.||.  ||||. |   ...| |. 
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVL---NKKGHSFEVDIWSIGCIMYILLFGQP

PFQGSDKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
||  .  | ||. | .  |. |.  |.|  |.... . |..||..|||.....   |.
PFETKCLKETYSRIKKNEYRIPS--HISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 81660.m00115.AA SAK 24-281 35 6.4e-71 240.73 In-house 1-254 (254) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-254/254
Sequence Identity: 35% (93 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSLHHQNIVEFKGVFQDENYVYILLELCPNGTVLDMLKKN-NPFSEK
| ... .| ||||.||  . .   . |||| | .  .    . ..   ||.||  | |  |.|    |.|.||||. ||.| || ..  .|.   ||.|.
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

QTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDEKKMTLCGTPSYLSPEVVGGGGKRGHTTSVDIWATGVCSFLMLTGK
   ..  |..  ..||| | ..|||| | |.|| .. |.|.||||| .||.  .|| .|.|||| |.|||..    .  |    |.|. |   . .|.|.
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIA---TRTAHGLQSDVWSLGCMLYTLLIGR

QPFQGSDKKITYKNISHVSYQWPEKSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
 ||.    | |   .    |  |  .|.|  |.| ... |.|.|  | | .  . |||.
PPFDTDAVKNTLNKVMMAEYIMP--AHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 81660.m00115.AA Ciliate-E2 24-281 23 2.8e-70 239.79 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

YTIKDKMGSGGFATVYSGEE-MPGRLP----------------------VAIKCISQTRVADPKVRRKLISEVD----------IHKSLHHQNIVEFKGV
| .  | |.|.|..|| ..    ...                       .|.|....  .   |   ... |..          | ..| | ||.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DENYVYILLELCPNGTVLDMLKKN-----------NPFSEKQTSQICYQLLN---------------ALIYLHEHR-VIHRDLKLQNLLLDKNNHM
||  |.|..|. .|.|  |. .| .|.|           ..|.||. ..| .|.|.               || |||.   .||||.|..|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLADFGLSAQLQSDDEKKM-------------------------------TLCGTPSYLSPEVVGGGG------KRGHTTSVDIWATGVCSFLMLTGKQP
|..||||| ... | ...                                |.|||| |..||...|..      . |.....|||. ||. . ||.|| |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGSDKKITYKNISHVSYQWP-----------EKSHVSDLAKDFVDH----ALQKDPNARPT-AKELITHPFI
|    ..|  ..|.  ...|            .. ..|. .||.        |||||. |.| ..... ||..
F---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 81660.m00115.AA STE20 24-281 30 6.5e-70 238.59 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-288/288
Sequence Identity: 30% (89 aa)

YTIKDKMGSGGFATVYSGEEMPGRLP----VAIKCISQTRVADP-KVRRKLISEVDIHKSLHHQNIVEFKGVFQDE----NYVYILLELCPNGTVLDMLK
|.. .| |.|.. .|| . . |        |||| ..     .. . .. .. |..| | ..|.|||.. | .. .    .  .|. |.|  |...|..|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

KNN---------PFSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQS-----DDEKKMTLCGTPSYLSPEVVGGGG--
...         |..|.| . ||...| .| |||....||||.| .| ||...   ||||||..|||..     .. |. |..||| ...|||. . .  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KRGHTTSVDIWATGVCSFLMLTGKQPFQGSDKKITYKNISHVSYQWP---E--KSHVSDLAKDFVDHALQKDPNARPTAKELITHPFI
. |... .|||. | .   |..|. |.           |   . . |   .  ... |.  .||||. |||||. ||||..| .||||
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 81660.m00115.AA Pkinase_Tyr 24-177 33 1.2e-34 117.93 Pfam 1-166 (270) Show / Hide 
Range on Protein: 24-177
Range on HMM: 1-166/270
Sequence Identity: 33% (57 aa)

YTIKDKMGSGGFATVYSGEEM----PGRLPVAIKCISQTRVADPKV--RRKLISEVDIHKSL-HHQNIVEFKGVFQ-DENY--VYILLELCPNGTVLDML
 |.  | |.| | .|| |.       ...|||.|.. .   |...   |.....|. | |.| ||.||| . ||   ..    .|| .|..|.|  || |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK----NNPFSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSDDE
.|    ..|.. |.  |.|.|  ... ||.... |||||   | |...||..| .||||.  ...||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase 81660.m00115.AA TyrKc 24-281 25 4.8e-23 83.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-281
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

YTIKDKMGSGGFATVYSGEEMPGRLPVAIKCISQTRVADPKVRRKLISEVDIHKSL--HHQNIVEFKGVFQDE-------NYVYILLELCPNGTVLDMLK
 | ..| |.| | .|| |.     ..||.|..          |. ...|  | ..|  ||.||| . ||  ..         ..|..|..|.|  .| |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KNNP-FSEKQTSQICYQLLNALIYLHEHRVIHRDLKLQNLLLDKNNHMKLADFGLSAQLQSD-------DEKKMTL--CGT-PS---YLSPEVVGGGGKR
|. | .. |.  ..|.|  .   |||....|||||   | |...|...| .|||||  . .|       | ....   .|  .     ..||.     . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

G-HTTSVDIWATGVCSFLMLT-GKQPFQG-----SDKKITYKNISHVSYQWPEKS--------HVSDLAKDFVDHALQKDPNARPTAKELITHPFI
|  ||  |.|. ||| . ..| |.||  |      . .  .... .  .  . ..          ... .       . ||. ||| .|.  | ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
POLO_box 81660.m00115.AA POLO_box 349-415 23 1.4e-09 38.96 Pfam 1-74 (74) Show / Hide 
Range on Protein: 349-415
Range on HMM: 1-74/74
Sequence Identity: 23% (18 aa)

YSHRYGLAYMLHNHICGAC-FNDSSRIILSPDGT-FCQYWASPQTPAPEIVEMSTIE-------VSPIRKKLLLIQ
|. .||. | | |.. . . |||...|||.|..  . .| .    |  . . .....        . ..||| ...
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDH-D-PNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box 81660.m00115.AA POLO_box 449-516 22 2e-06 27.68 Pfam 1-74 (74) Show / Hide 
Range on Protein: 449-516
Range on HMM: 1-74/74
Sequence Identity: 22% (17 aa)

ARTRDGVLFRMANRNIQAN-FRDHTKLVIESNSR-NL-FYD--TGRGVQQLTLGDLGDRER-YHEVRKRFVIVK
 ||. |. ... | ..| | | ||||... .|.. .. ..|  . .  |...| ..  ..   ....|.. ..|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK