Gene 83481.m00037 (T.vaginalis)

83481.m00037

Species: T.vaginalis
Alias: 83481.m00037, TvagK0523
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
83481.m00037.AA Protein None 222 None Fasta, JSON
83481.m00037.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of 83481.m00037.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 83481.m00037.AA CAMKL 27-219 35 8.5e-69 218.64 In-house 1-232 (297) Show / Hide 
Range on Protein: 27-219
Range on HMM: 1-232/297
Sequence Identity: 35% (83 aa)

YTITKLIGKGGFAVVVLAVN-DQTHQQVAIKICDRVQIQ-ENNILAY-----------LEAELRLSMRFN---HPNIAKTYEVIYEPDI------ILIVM
|.| | .|||.|..| ||..   | ..||||| |.  |. . ....            .. | .. ...|   |||| | ||||. |.       | .||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYFPNGD--LQSLLT-HG---VKFTTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKL--NPKIIDFGLS-------KEDSSNLYTFCGTPYYV
|| ..|.  |.  .  ||    ...  |  ..   .. ..||.|..|| ||||||||| .||.   | ||||||.|       . .   | ||||.| | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEMITS--HSYNGMKADIWAFGITLHCLATG
|||.. .   .|.| |.|||. |..|  . .|
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCG
Pkinase 83481.m00037.AA Pkinase 27-219 34 3.1e-64 224.5 Pfam 1-208 (293) Show / Hide 
Range on Protein: 27-219
Range on HMM: 1-208/293
Sequence Identity: 34% (73 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLE-AELRLSMRFNHPNIAKTYEVIYEPDIILIVMEYFPNG----DLQSLLT--HG
|.| . ||.|.|..| ....  | ..||.|| ... . ..   . .  .|...  |.||||| ..|.. ...| | .|||| ..|    || ....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VKF--TTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLNP----KIIDFGLS----KEDSSNLYTFCGTPYYVAPEMITSHSYNGMKADIWAF
 .|  . .| ....  .| ||.|.|..|| |||.||||| .|.. ..    ||.||||.       .| ..||||||.|.||| | ...| | |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GITLHCLATG
|..|.....|
GCILYEMLCG
Kinase 83481.m00037.AA CAMK 32-219 21 1e-62 200.65 In-house 1-330 (425) Show / Hide 
Range on Protein: 32-219
Range on HMM: 1-330/425
Sequence Identity: 21% (70 aa)

LIGKGGFAVVVLAVNDQTH------------QQVAIKICDRVQIQENN-------------------------ILAYLEAELRLSMR-------FNHPNI
 .|.|.|..| |... .|             |.||||| |. ......                          .. .. |... ..        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

AKTYEVIYEPDI-------------------ILIVM---EYFPNG----DLQSLLTHG---------------VKFTTQEQIKIAIGVLNGLNYLHQRGI
 | |||.  |.                    . .||   || ..|    || . ..                  .|| .|  ..   .. ...|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

SHRDIKPENIVFDEK-----------------LNPKIIDFGLS--KEDSS------------------------NLYTFCGTPYYVA-PEMITS------
 |||.||||| .|..                  | ||||||..  .....                         ..||||||.|.| ||.. .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------HSYNGMKADIWAFGITLHCLATG
       . | | |.|.|. |. |  . .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCG
Kinase 83481.m00037.AA AMPK 27-216 37 1.7e-59 175.32 In-house 1-193 (254) Show / Hide 
Range on Protein: 27-216
Range on HMM: 1-193/254
Sequence Identity: 37% (72 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLEAELRLSMRFNHPNIAKTYEVI-YEPDIILIVMEYFPNGDLQSLLTHGVKFTTQ
| | | ||.| |  | ... ..| ..||||| ..  |..      .. |...   |.||.| . ||||   |. | .|||| ..|.| .  .   . . .
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLNPKIIDFGLSK--EDSSNLYTFCGTPYYVAPEMITSHSYNGMKADIWAFGITLHCL
|  .    ...|. |.|. .|.||| ||||. .|.. | || |||||.  .|   |.| || | | |||||..  |.| . |||  |. |  .
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAM
Kinase 83481.m00037.AA Ciliate-E2 27-219 25 2.7e-57 195.21 In-house 1-292 (365) Show / Hide 
Range on Protein: 27-219
Range on HMM: 1-292/365
Sequence Identity: 25% (76 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIK-----------------ICDRVQIQENNILAYLEAELRLSMRFN----------------HPNIAKTYEV
| . |.||.|.|..| .. .... .|.|||                     . |...| . ... |... .. |                |||| | ||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IY--EPDIILIVMEYFPNGDLQSLLT------------HGVKFTTQEQIKIAIGVLN---------------GLNYLHQRG-ISHRDIKPENIVFDEKLN
 .    . | .||||.  |||....                .|| .| ..|   .|.               .|.|||... | |||||||||.|     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

PKIIDFGLSKEDSSN----------------------------------LYTFCGTPYYVAPEMITSHSYNG--------MKADIWAFGITLHCLATG
.|||||||||. . .                                   .|.||||.|.|||.. . .|..         |.|||..|..|... .|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG
Kinase 83481.m00037.AA Ciliate-E2-Unclassified 27-219 27 6.5e-56 192.07 In-house 1-266 (352) Show / Hide 
Range on Protein: 27-219
Range on HMM: 1-266/352
Sequence Identity: 27% (74 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQV-----AIKICDRVQIQENNILAYLEAELRLSMRFN-----------------HPNIAKTYEVIYE--PDIILI
|.| | ||.|||..| .......  |.     ..|| .. | | .|    .  |.   .. .                 ||.. . ... ..   . | |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYFPNGDLQSLLTH-----------------GVKFTTQEQI-----KIAIGVLNGLNYLHQRG-ISHRDIKPENIVFDEKL---NPKIIDFGLSK---
||||...|||.  ...                 . .|| |. .     ...  .|.||.|||. . | |||||||||.||..    ..||||||.||   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

ED---------------SSNLYTFCGTPYYV----APEMITSHSYNGM---KADIWAFGITLHCLATG
..               . ...||||||.|     |||.. .. |...   |.|||..|. |... .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase 83481.m00037.AA Ciliate-E2a 27-220 33 7.4e-54 156.93 In-house 1-213 (275) Show / Hide 
Range on Protein: 27-220
Range on HMM: 1-213/275
Sequence Identity: 33% (73 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQ-VAIKICDRVQIQENNILAYLEAELRLSMRFNHPNIAKTYEVIYEPDIILIVMEYFPNGDLQSLLTHGVKFTTQ
| ..|.|||| |..|.||   || .| ...|. .. ..|...  .|.. |. .. . .|||| | |||    . . .||||.  |.| . .    .|.. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKG-KEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

--EQIKIAIGVL-NGLNYLHQRGISHRDIKPENIVFD-------EKLNPKIIDFGLSKED--SSN--LYTFCGTPYYVA------PEMITSHSYNGMKAD
  |  .|    |  ||.|.|||.| |||.||||| |.       .... |||||||..     ..  ... ||||.|||      .| ... .| . | |
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQY-DTKCD

IWAFGITLHCLATGS
.|  |. ...| .|.
MWSCGVIFYILLCGK
Kinase 83481.m00037.AA QIK 27-220 37 2.7e-53 183.4 In-house 1-215 (272) Show / Hide 
Range on Protein: 27-220
Range on HMM: 1-215/272
Sequence Identity: 37% (80 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLEAELRLSMRFNHPNIAKTYEVIYEPDIILIVMEYFPNGDLQSLLTH--------
|.| . |||| |||| || .  | ..||||| |. |. | | |  .. |  .  . .||.| | |.|.   | . ||.|| .||..   |.         
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEEN-LQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

------------GVKFTTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLNPKIIDFGLS--KEDSSNLYTFCGTPYYVAPEMITSHSYNGMKA
            ||  . .|  ..   .. .  |.|.|.| |||.| ||| .|. .| ||.|||.|   .    | |.||.| | ||||    .|.|.|.
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DIWAFGITLHCLATGS
|||  |. |  | .|.
DIWSMGVVLYVLVCGA
Kinase 83481.m00037.AA S_TKc 27-222 28 1.3e-45 158.78 SMART 1-220 (231) Show / Hide 
Range on Protein: 27-222
Range on HMM: 1-220/231
Sequence Identity: 28% (69 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLEAELRLSMRFNHPNIAKTYEVIYEPDIILIVMEYFPN--GDLQSLLTHGVK---
|.| ..||||.|..| ....  |...||||| .            .. |... .. .|||| | |.|... | . .|||| ..  ||| ... .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLNPKIIDFGLSKEDSSNLYTFCGTPYYVAPEMITSHSYNGMKADIWAFGITLHCLAT
   |.  .  ...  ....|.|.|..|| |||.||||| .||  . ||.||||...     .||||||.|.|||..   .|.. |.|.|..|..|  ...
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GSN--------------------------------------E
|                                        .
GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase 83481.m00037.AA TKL 33-219 22 1.7e-45 157.49 In-house 1-285 (364) Show / Hide 
Range on Protein: 33-219
Range on HMM: 1-285/364
Sequence Identity: 22% (65 aa)

IGKGGFAVVVLAVNDQTH--------QQVAIKICDRVQIQENN------------------------ILAYLEAELRLSMRFNHPNIAKTYEVIYEPDI-
||.|||..|  ..  ..         . ||.|.  . . .|..                        .   .| |...  |..|||| . . .  .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ILIVMEYFPNGDLQSLLTHGVKFTTQEQIKIAIGVLNGLNYLHQ--------RGISHRDIKPENIVFDEKLN--------------PK
            . ||||| |.|.| ..|.       .  ...|...  |.||||.        ..| |||.|..||  ||...              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IIDFGLSKEDSSN----------------------LYTFCGTPYYVAPEMITSHSYNG---------------MKADIWAFGITLHCLATG
| |||||.. | .                      ..| ||||.. |||..  . ..                 |.|...||| |  ..|.
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
Kinase 83481.m00037.AA ULK 27-214 27 2.5e-45 156.22 In-house 1-247 (329) Show / Hide 
Range on Protein: 27-214
Range on HMM: 1-247/329
Sequence Identity: 27% (67 aa)

YTITKLIGKGGFAVVVLAVNDQTH----QQVAIKICDRVQIQENNILAY-------LEAELRLSMRFN--------HPNIAKTYEVIYEPDI--ILIVME
| . . .||| |..|  . | .|.    ..||.|. |. .....| ...       |. | ..  . .        |||| | |.. ....   | |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YFPNGDLQSLLT----------HGVKFTTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLN------------PKIIDFGLSKE-DSSN----
| . |||....            . ... || |.. .  |||. .||...| ||||||.||  ...               || |||..|  |..|    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-LYTFC------GTPYYVAPEMITSH----SYNGMKADIWAFGITLH
 ..|.       |||.| ||. . ..     |.  |.||| .|. ..
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY
Kinase 83481.m00037.AA MARK 134-220 47 3e-34 109.47 In-house 113-203 (262) Show / Hide 
Range on Protein: 134-220
Range on HMM: 113-203/262
Sequence Identity: 47% (43 aa)

VLNGLNYLHQRGISHRDIKPENIVFDEKL--NPKIIDFGLSKED--SSNLYTFCGTPYYVAPEMITSHSYNGMKADIWAFGITLHCLATGS
.. ..||.|...| |||||||||  ||.   | ||||||.| .    . | |||||| | |||.. .  |.| |.|||. |. |  . .|.
IVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGY
Kinase 83481.m00037.AA MARK 27-116 31 7.1e-24 75.08 In-house 1-93 (262) Show / Hide 
Range on Protein: 27-116
Range on HMM: 1-93/262
Sequence Identity: 31% (29 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLEAELRLSMRFNHPNIAKTYEVIY--EPDI-ILIVMEYFPNGDLQSLL
| . | ||.|..|.| ||..  |...||||| .. ...... .  .. |... .. .|||| | ..||   ..   | ..||| ..|.| . .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYI
Kinase 83481.m00037.AA Pkinase_Tyr 27-151 26 5.8e-17 58.08 Pfam 1-137 (270) Show / Hide 
Range on Protein: 27-151
Range on HMM: 1-137/270
Sequence Identity: 26% (37 aa)

YTITKLIGKGGFAVVVLAVND----QTHQQVAIKICDRVQIQENN-ILAYLEAELRLSMRF-NHPNIAKTYEVIY---EPDIILIVMEYFPNGDLQSLLT
 |. | .|.| | .|.... .    .|...||.|.. . .  . . ... . .|... . . .|||| . | |..   ||  |.||||| |.||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

H----GVKFTTQEQIKIAIGVLNGLNYLHQRGISHRDI
     . ..|... ..... . .|..||..... |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 83481.m00037.AA TyrKc 27-216 18 3.4e-13 -9.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-216
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YTITKLIGKGGFAVVVLAVNDQTHQQVAIKICDRVQIQENNILAYLEAELRLSMRF--NHPNIAKTYEVIYEP-------DIILIVMEYFPNGDLQSLL-
 |  | .| | | .|.... .   .|||.| .          .. .  |.|. ...  .|||| . | |. ..       . ..||||| |.|||.. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

THGVKFTTQEQIKIAIGVLNGLNYLHQRGISHRDIKPENIVFDEKLNPKIIDFGLSKED-------------------SSN-------------------
 |. |..... ..... . .| .|||.... |||.   |.  .|..  || |||||..                    ...                   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

--------------LYTFCGTPYYV----------------------APEM--------ITSHSYNGMKADIWAF--------GITLHCL
              ..|....||.                        |.          ..  |. || . |..            .|.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK-QCWHEDPEDRPTFSEIHECF
Kinase 83481.m00037.AA Pkinase_Tyr 203-213 45 1.76267 2.25 Pfam 194-204 (270) Show / Hide 
Range on Protein: 203-213
Range on HMM: 194-204/270
Sequence Identity: 45% (5 aa)

KADIWAFGITL
| |.|.||...
KSDVWSFGVLM