Gene 81839.m00114 (T.vaginalis)

81839.m00114

Species: T.vaginalis
Alias: 81839.m00114, TvagK0675
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81839.m00114.AA Protein None 179 None Fasta, JSON
81839.m00114.kin_dom Protein Kinase Domain None 176 None Fasta, JSON

Protein domain

Protein domains of 81839.m00114.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 81839.m00114.AA Pkinase 4-179 38 3.4e-68 237.67 Pfam 1-187 (293) Show / Hide 
Range on Protein: 4-179
Range on HMM: 1-187/293
Sequence Identity: 38% (73 aa)

YTIVRKLGQGGFGVVYLVKTPDGKQ-YAMKVIDLSEMSSQMRAKARS--EVEILSKLNHSNIVKYISSWTDNNKLYIVMNYIDGG----NLRQYIS-RQN
|.|.||.|.|.||.||. .  .  . .|.|.|.... .|...  .|   |..|. .||| |||... ...|....|.|| | .||     |  ||| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GEL-LRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFDI---IYLSDFGLAKSL-YTSSQYAYTQCGTPVYSAPEVLLGDP
| . .  ........||...|||.|.. ||||||||||||..|  .|   . ..|||||| . | ... ..| |||| | ||||..|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ
Kinase 81839.m00114.AA NEK 4-175 37 2.7e-67 229.9 In-house 1-196 (286) Show / Hide 
Range on Protein: 4-175
Range on HMM: 1-196/286
Sequence Identity: 37% (73 aa)

YTIVRKLGQGGFGVVYLVKT-PDGKQ-----YAMKVIDLSEMSSQMRAKAR-SEVEILSKLNHSNIVKYISSWTDNN--KLYIVMNYID-GGNLRQY---
|.|..|.||| ||.||.|.   |||.     |..| |....||.. . .|  .|| ||..|.| |||||. |. ...  .|.||| | . ||.| |    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ISRQN--GELLRIDTVCSICWQIAKALEYIHKN-----HIIHRDLKPENILVSNAFD---IIYLSDFGLAKSLYTSSQYAYT-QCGTPVYSAPEVL
| .|   |...  ...  .. |...|| |.|..     .|.|||.|| ||  ..      .. . |||..| | .....||| | ||| | .|||.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC
Kinase 81839.m00114.AA CAMKL 4-179 29 3.3e-59 187.52 In-house 1-211 (297) Show / Hide 
Range on Protein: 4-179
Range on HMM: 1-211/297
Sequence Identity: 29% (62 aa)

YTIVRKLGQGGFGVVYLVKT-PD-GKQYAMKVIDLSEMS--------------SQMRAKARSEVEILSKLN---HSNIVKYISSWTDNNK------LYIV
|.|.. ||.|.||.| | .     |...|.|.|| . ..              ...  . | |..|...||   | ||.|    ... ..      .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MNYIDGGN--LRQYISRQNGEL--LRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFD-IIYLSDFGLAKS---L-YTSSQYAYTQCGTPVY
| |..||.  | .|| .. .    .  .  . . .||  |..|.|...|.|||.||||||...  .  | ..|||..        .. |   |.||.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

SAPEVLLG--DP
 |||...|  .|
MAPEIFQGNNKP
Kinase 81839.m00114.AA Ciliate-E2 4-177 27 4.5e-59 201.43 In-house 1-261 (365) Show / Hide 
Range on Protein: 4-177
Range on HMM: 1-261/365
Sequence Identity: 27% (73 aa)

YTIVRKLGQGGFGVVYLVKT------------------------PDGKQYAMKVIDLSEMSSQMRAKA--R---------SEVEILSKLNHSNIVKYISS
| ...|.|||.||.||..|                          ..|.||||..  ..  .... .   |          | .||..||| ||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WT--DNNKLYIVMNYIDGGNLRQYIS---RQNGELLR------IDTVCSICWQIAK---------------ALEYIHKNH-IIHRDLKPENILVSNAFDI
.   |.|..|.|| |..||.|..||     . .. .       .  .. | .||..               ||||.|... |||||.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

IYLSDFGLAKSLYTSSQ-------------------------------YAYTQCGTPVYSAPEVLLG
| ..||||.| . ...|                                ..|.|||| | |||.| |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNG
Kinase 81839.m00114.AA CAMK 9-177 22 5e-58 185.25 In-house 1-294 (425) Show / Hide 
Range on Protein: 9-177
Range on HMM: 1-294/425
Sequence Identity: 22% (67 aa)

KLGQGGFGVVYLVKTP-DG------------KQYAMKVIDLSEMS--------------------------SQMRAKARSEVEILSK-------LNHSNI
.||.|.||.|.|..   ..            ...|.|.|| . ..                           ..|.. |.|.||..|       |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYISSWTD-------------------NNKLYIVM---NYIDGG----NLRQYISRQNG-------------ELLRIDTVCSICWQIAKALEYIHKNHI
.| .  . |                   ....|.||    |..||     | .|| .. .               .  . .. . .||. |..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENILVSNAFD----------------IIYLSDFGLAKSLYTS-----------------------SQYAYTQCGTPVYSA-PEVLLG
.||||||||||... .|                 | ..|||.|. .  .                        |  .|.|||| | | ||||.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG
Kinase 81839.m00114.AA Ciliate-E2b 4-175 35 5.8e-55 165.52 In-house 1-177 (272) Show / Hide 
Range on Protein: 4-175
Range on HMM: 1-177/272
Sequence Identity: 35% (63 aa)

YTIVRKLGQGGFGVVYLVKT--PDGKQYAMKVIDLSEMSSQ-MRAKARSEVEILSKLNHSNIVKYISSWTDNNKLYIVMNYIDGGNLRQYISRQNGELLR
  .. |||.| || ||||.    . ..||||.|  .. . | |     .| ..| |.|| .|.|.| |  |....| .| .. |. |  .|. ..  || 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

IDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSN-AFDIIYLSDFGLAKSLYTSSQ---YAYTQCGTPVYSAPEVL
   .  .  .| ..||| |.. ||.||.|||||.| .  .  ..| |.|.|| .|....     .| .||| | |||..
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGY--MKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEII
Kinase 81839.m00114.AA Ciliate-E2-Unclassified 4-177 28 8.7e-52 177.91 In-house 1-240 (352) Show / Hide 
Range on Protein: 4-177
Range on HMM: 1-240/352
Sequence Identity: 28% (69 aa)

YTIVRKLGQGGFGVVYLVKTPDGKQY-----AMKVIDLS--EMSSQ----MRAKARSEVE-------------ILSKLNHSNIVKYISSWTDNNKLYIVM
|.|....||||||.||...  . |||     ..|... .   . ..    . .|.  . .             ||. ..| .|||..   .| ...||||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

NYIDGGNLRQYISRQNG---------------ELLRIDTVC-----SICWQIAKALEYIHKNH-IIHRDLKPENILVSNAFD--IIYLSDFGLAKSLYTS
 |..||.|.|||. ...               . .    ..      ...|| ..|||.|... |||||.||||||..|      | ..|||..| . ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------SQYAYTQCGTPVYS----APEVLLG
               .| ..|.|||| |     ||||| |
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG
Kinase 81839.m00114.AA STE 4-178 27 5.7e-51 175.64 In-house 1-237 (359) Show / Hide 
Range on Protein: 4-178
Range on HMM: 1-237/359
Sequence Identity: 27% (67 aa)

YTIVRKLGQGGFGVVYLV---------KTP-------DGKQYAMKVIDLSEMSS---------------QMRAKARSEVEILSKLN--HSNIVKYISSWT
.....|.|.|.||.||.          ||         |. .|.|...|.. ..               . . .   |..|..|.|  | |||||. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-------NKLYIVMNYIDGGNLRQYISRQNGELLRI------------DTVCSICWQIAKA-LEYIHKNHIIHRDLKPENILVSNAFDIIYLSDFGLA
..       ..|.|.| |.||| |.. | .  | . .             . .. || || |. |.|.|..||||||.|| |||.      . |.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KSLY----------------TSSQYAYTQCGTPVYSAPEVLLGD
..|                 |..|  .| .||| . ||||....
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQN
Kinase 81839.m00114.AA ULK 4-177 30 2.5e-50 173.51 In-house 1-221 (324) Show / Hide 
Range on Protein: 4-177
Range on HMM: 1-221/324
Sequence Identity: 30% (68 aa)

YTIVRKLGQGGFG-VVYLV---KTPD-GKQYAMKVID---LSEMSSQ-----MRAKARSEVEILSKLN---HSN--IVKYIS-SWTDN-NKLYIVMNYID
| . ..||.| || .||     || . ....| |.||   ... ...     |  . ..|..|. ||.   | |  |||..  ..|.| | .||.| | .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLRQYISRQ-------NGELLRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAF-----------DIIYLSDFGLAKSLY---TSSQYAYT
||.|.||| ..       ..  |  . . ... ||. .. ..||. |||||.||.|||..| .            .. ..|||.||..     . |  .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QC------GTPVYSAPEVLLG
..      ||| | ||..| |
CVNEKRIKGTPLYMAPQILQG
Kinase 81839.m00114.AA NEK1 4-173 38 1.8e-48 166.27 In-house 1-191 (276) Show / Hide 
Range on Protein: 4-173
Range on HMM: 1-191/276
Sequence Identity: 38% (73 aa)

YTIVRKLGQGGFGVVYLVK-TPDGKQYAMKVIDLSEMSSQMRAKARSEVEILSKLNHSNIVKYISSWTDNNK--LYIVMNYIDGGNLRQYISRQ--NGEL
|.. ...|.| || ..||| . ||..|..| | ...|... | ... || ||.|. | ||||| .|   | .  ||||| | ||| | | | ||   | |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVS-NAFD---------------IIYLSDFGLAKSLYTSSQYAYTQCGTPVYSAPE
   |.  .   || .|| .||.  |.|||.|. ||  .    .               .. | ||| |. |  .  || |  ||| |  ||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE
Kinase 81839.m00114.AA ULK 4-177 29 2.6e-48 166.73 In-house 1-225 (329) Show / Hide 
Range on Protein: 4-177
Range on HMM: 1-225/329
Sequence Identity: 29% (66 aa)

YTIVRKLGQGGFGVVYLVK-TPD----GKQYAMKVIDLSEMSSQMRA--------KARSEVEILSKLN--------HSNIVKYIS-SWTDN-NKLYIVMN
| . ..||.| ||.||  .   .    ....| |.||...|. .             ..|..|. ||.        | ||||..  ..|.| | .||.| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YIDGGNLRQYISRQ--------NGELLRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFD-----------IIYLSDFGLAKSLYTS---SQ
| .||.|.|||...        ..  |  . . ... ||. .. ..||. |||||.||.|||..| .            .. ..|||.||..  .    |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

YAYTQC------GTPVYSAPEVLLG
 ..|.       ||| | ||..| |
MMMTCVNEKRLCGTPLYMAPQILQG
Kinase 81839.m00114.AA S_TKc 4-178 30 7e-33 116.48 SMART 1-220 (231) Show / Hide 
Range on Protein: 4-178
Range on HMM: 1-220/231
Sequence Identity: 30% (73 aa)

YTIVRKLGQGGFGVVYLVKTPD-GKQYAMKVIDLSEMSSQMRAKARSEVEILSKLNHSNIVKYISSWTDNNKLYIVMNYIDG--GNLRQYISRQNGEL--
|.|.||.|.|.||.||...  . |...|.|.|.          ..|.|..||.| .| ||||.. .. | ..||.|| |.||  |.|..|| .....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFDIIYLSDFGLAKSLYTSSQYAYTQCGTPVYSAPEVL---------------------
  .   .......||..||||.|...||||||||||||...    | ..|||||. |       .|.|||| | |||||                     
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLC

---------------------------------------LGD
                                       .  
GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase 81839.m00114.AA Pkinase_Tyr 4-163 30 5.6e-29 98.77 Pfam 1-170 (270) Show / Hide 
Range on Protein: 4-163
Range on HMM: 1-170/270
Sequence Identity: 30% (53 aa)

YTIVRKLGQGGFGVVYLVKTP-----DGKQYAMKVIDLSEMSSQM--RAKARSEVEILSKL-NHSNIVKYISSWT-DNNK--LYIVMNYIDGGNLRQYIS
 |. .|||.| ||.||. .       .. . | |..     ...   |..  .|..|...| .| |||...   | .     .|||| |  .|.|. |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RQ--NGELLRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFDIIYLSDFGLAKSLYTSSQYAYTQ
..  ... | . . ...||||||..|| . ...|||||   |.||.. . ..  .|||||. .|  ..| |..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYY-YRK
Kinase 81839.m00114.AA TyrKc 4-176 20 5.9e-13 -13.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-176
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)

YTIVRKLGQGGFGVVYLVKTPDGKQYAMKVIDLSEMSSQMRAKARSEVEILSKL--NHSNIVKYISSWTDN-------NKLYIVMNYIDGGNLRQYISRQ
 |  .||| | ||.||. .     | | |..  .      |.  ..| .|..||  .| |||. .   |.          |.||| | ..|.|..|. . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NGELLRIDTVCSICWQIAKALEYIHKNHIIHRDLKPENILVSNAFDIIYLSDFGLAKSLYTS-------SQYA---------------------------
 .. |  .. .|.|||||.  ||.|....|||||   |.||.. . ..  |||||.. .|         . |                            
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

---------------YTQCGTPVYS----------------------APEV------------------------------------LL
               .| ...| .                        |.                                     ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF