Gene 90976.m00049 (T.vaginalis)

90976.m00049

Species: T.vaginalis
Alias: 90976.m00049, TvagK0486
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
90976.m00049.AA Protein None 362 None Fasta, JSON
90976.m00049.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of 90976.m00049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90976.m00049.AA CK1 19-272 25 7.8e-75 254.92 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-339/339
Sequence Identity: 25% (88 aa)

YVIKGFIGHGSFG-DIYSC-----EDERDH-----STWAIKIELKTNK--KTSLDKEAQILKKIQS--------------------SPYFPVFHDYGESD
. ..  || |.|| .|| .     .|. ..        |.|.| |...  . .| .|.|..|| |                     .|........|| |
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

EYL-WLVLELLGPSLIGARR-ISS-GSVFSASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRP--------------SRKHPLILIDFGLSK-AFL
.|  ..|..||||.|   |.     .  || .|.....| ||  .|  |  | .||||||.||..                .... . .||||...  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DDNG------------EMIPPRD---SPGFVG-TVPYASFNAHKGLELGCCDDLFSWFVVLLKIHAGE--LPWPTVNNKDV-----VLVAKKEANIANFC
|..|            ...|||.     ||.| |. |.| |.|.| |.|  ||| ||| .|.  . |.  |||  .. ..      | ..|.|    . .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

EG------------LPHQYIIMYRLILSMKRDDIPNYSLF
              .| ..  ..  | |.|..|.|.|  .
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 90976.m00049.AA TTBKL 19-276 28 9.3e-63 210.72 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-276
Range on HMM: 1-288/288
Sequence Identity: 28% (82 aa)

YVIKGFIGHGSFGDIYSCEDERDHST-WAIKIELKTNKKTS--LDKEAQILKKIQ--SSPYFPVFHDYGESDEYLWLVLELLGPSLIGARRISSGS-VFS
..|.. || | || .|  .|  |. .  | |.|.... . .  . .|...|.| |  .||.|| .|..|. . | ..|..|.||.|   |. .    .||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

ASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPS-----RKHPLILIDFGLSKAFLDDNG-----------EMIPPRD---SPGFVGTVPYASFNA
..|. |.||  | ..   |  | .|||.||.|. .  .     | . ..|||||... .....|           .| .||.   ...| ||. |.| |.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HKGLELGCCDDLFSWFVVLLKIHAGELPWPTVNNKDVVLVAKKEANIANFCEG------LPHQYIIMYRLILSMKRDDIPNYSLFYQLL
| ..|.| .|||.||. ..   |.| |||  ...|. .  .||. .  ... .      .| .   ... . |..  | |.|. .|...
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 90976.m00049.AA TTBK 19-272 36 5.3e-59 202.33 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

YVIKGFIGHGSFGDIYSCEDERDH-STWAIKIELKTNKKTSLDKEAQILKKIQSSPYFPVFHDYGESDEYLWLVLELLGPSLIGARRISSGSVFSASTAI
  ..  || | || ||. .|   |    |||.|    .|  |  |  .||| |  ..   |   |  |.. ..|..|.| .|   ||  .   || ||..
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLGIEMLRCIEAFHKFGLVHRDIKPGNFLI--RPSRKHPLILIDFGLSKAFLDDNGEMIPPRDSPGFVGTVPYASFNAHKGLELGCCDDLFSWFVVLLKI
|||. .|  ||. |  |  |||||| || .   ||.     ..||||   ..   ||  ||| . || ||| ||| |||.  |.|  ||| | | .|   
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

HAGELPWPTVNNKDVVLVAKKEANIANFCEGLPHQYIIMYRLILSMKRDDIPNYSLF
  | |||  .  || |   |....     . .||.  .    | |..  | |.| |.
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 90976.m00049.AA Worm6 19-272 29 1.4e-58 200.91 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-279/279
Sequence Identity: 29% (81 aa)

YVIKGFIGHGSFGDIYSCEDERDHS--TWAIKIEL--KTNKKTSLDKEAQILKKI--QSSPYFPVFHDYGESDE--YLWLVLELLGPSLIGARRISSGSV
. .  .|| |.||..|..||. | .    |.| |   ...|.  |. |. .||..  . ...|. . |.|  |.  ....|..|.|..|   |. . .  
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRP------SRKHPLILIDFGLSK--AFLDDNGEMIPPR-DSPGFVGTVPYASFNAHKGLELGC
|| .|.....|..|. ||  |..| .|||.||||| |           | . ..|||...  .......|...|| .  ||.|||.||. ..||| |.. 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

CDDLFSWFVVLLKIHAGELPWPTVNNKDVVLVAKKEA--NI-----ANFCEGLPH-QYIIMYRLILSMKRDDIPNYSLF
 ||. ||| ...    |.|||  .. .| | . ||..  ..     . | .. |. ..      |..... | |.|   
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 90976.m00049.AA CK1-A 19-272 32 2.9e-40 139.95 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-261/261
Sequence Identity: 32% (84 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKIQSSPYFPVFHDYGESDEYLWLVLELLGPSLIGARRISSGSVFSASTAIR
| .   || |||||||     .. .  |||.| .  .   |  ||.. . .|  . .|  . ||.  .|  .|..||||||     . .   |.  | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTVLM

LGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSRK-HPLILIDFGLSKAFLDDNGEM-IPPRDSPGFVGTVPYASFNAHKGLELGCCDDLFSWFVVLLKIH
|   |.  ||  |. . .|||||| |||.   |    | ||||||.| . | . .  || |.    .||. ||| ||| |.|    ||. |   |..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

AGELPWP--TVNNK----DVVLVAKKEANIANFCEGLPHQYIIMYRLILSMKRDDIPNYSLF
 |.|||   . ..|    . ..  |  . |.  | | | .. ..   . ... .. |.|   
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 90976.m00049.AA CK1-D 19-272 33 2.6e-38 132.7 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-261/261
Sequence Identity: 33% (89 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKIQSSPYFPVFHDYGESDEYLWLVLELLGPSLIGARRISSGSVFSASTAIR
| |   || |||||||  ..       |||.|    |   |. |... | .|     |  . .|.  .|  .|..||||||       .   ||  | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTVLM

LGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSRKHPLI-LIDFGLSKAFLDDN-GEMIPPRDSPGFVGTVPYASFNAHKGLELGCCDDLFSWFVVLLKIH
|.  |.. ||  |    .|||||| |||.   ..  .. .|||||.| . | .  . || |.     ||  ||| | |.|.|    ||| |   ||.   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

AGELPW-----PTVNNKDVVLVAKK-EANIANFCEGLPHQYIIMYRLILSMKRDDIPNYSLF
 | |||      |  .|   .. || . .|   |.|.|...        ..| || |.|. .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 90976.m00049.AA CK1-Unclassified 123-205 44 4.3e-28 80.03 In-house 113-199 (244) Show / Hide 
Range on Protein: 123-205
Range on HMM: 113-199/244
Sequence Identity: 44% (39 aa)

MLRCIEAFHKFGLVHRDIKPGNFLI--RPSRKHPLILIDFGLSKAFL--DDNGEMIPPRDSPGFVGTVPYASFNAHKGLELGCCDDL
|.  || .|. ...|||||| |||.  .  ..| . .||||||| ..  | .|. || |.  ...||  ||| |||.|.| .  |||
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 90976.m00049.AA Pkinase 19-190 28 1.2e-25 91.73 Pfam 1-179 (293) Show / Hide 
Range on Protein: 19-190
Range on HMM: 1-179/293
Sequence Identity: 28% (54 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDK------EAQILKKIQSSPYFPVFHDYGESDEYLWLVLELLGP-----SLIGARRIS-
|.|.. || ||||  | | .  .  ..|.||  | ..| . |.      |.||.|.. ..|.   ..|. |.. ....|.|...      .|   ..|| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF--DYIST

-SGSVF--SASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSRKHP---LILIDFGLSKAFLDDNGEMIPPRDSPGFVGTVPYAS
 .. .|  |  ....   ..|| .|  |. | .|||.|| |.||  .. |.   . ..||||.| |        . .   .|.|| .|..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase 90976.m00049.AA CK1-Unclassified 19-99 34 2.4e-23 65.79 In-house 1-90 (244) Show / Hide 
Range on Protein: 19-99
Range on HMM: 1-90/244
Sequence Identity: 34% (31 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKIQSSP-------YFPVFHDYGESDE--YLWLVLELLGPSL
| ..  || ||||.|| | .  ..   |||.| |..|   |..||.|..  |          ..|  . .|  ..  |  .|..||||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 90976.m00049.AA CK1 123-205 41 8.3e-23 75.48 In-house 114-199 (271) Show / Hide 
Range on Protein: 123-205
Range on HMM: 114-199/271
Sequence Identity: 41% (36 aa)

MLRCIEAFHKFGLVHRDIKPGNFLI-R-PSRKHPLILIDFGLSKAFLD-DNGEMIPPRDSPGFVGTVPYASFNAHKGLELGCCDDL
|.. || .|. ...|||||| |||. |   ..| . .|||||.| ..| .... || |.  ...||. ||| |.| |.| .  ||.
MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM
Kinase 90976.m00049.AA CK1-Unique 19-222 23 2.2e-22 74.44 In-house 1-232 (337) Show / Hide 
Range on Protein: 19-222
Range on HMM: 1-232/337
Sequence Identity: 23% (54 aa)

YVIKGFIGHGSFGDIYSCEDERDH------STWAIKIELKTNKKT--SLDKEAQILKKIQSSP-------YFPVFHDYGESDEYLWLVLELLGPSLIGAR
. .   || |..|. .   .. .          . | | .  .|.   |  |  ..| |            |.. || . .. . |.|. ..|||.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RISSGSVFSAS------TAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSR---KHPLILIDFGLSKA--FLDDNGEMIPPRDSPGFVGTVPYASFN
.   .. |  .      .||..|   |  ||  |. |  ||..||.|.          | .  .|.| ..   |.. |... .||    | |. .|..  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHKGLELGCCDDLFSWFVVLLKIHAGE--LPW
 |.  |.|  ||. |||  |...  ..  | |
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSW
Kinase 90976.m00049.AA CK1-G 19-272 28 1.3e-20 66.52 In-house 1-266 (266) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-266/266
Sequence Identity: 28% (77 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKIQSSP-YFPVFHDYGESDEYLWLVLELLGPSLIGARRISSGSVFSASTAI
| .   || |.|| ..  .        |||.|    .   |  | .  |   . |   |  . .|    |  .|..||||||     .  .  ||  | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDW-CDRKFSVKTVC

RLGIEMLRCIEAFHKFGLVHRDIKPGNFLI-RPSRK--HPLILIDFGLSKAFLD-DNGEMIPPRDSPGFVGTVPYASFNAHKGLELGCCDDLFSWFVVLL
 . | |.. .|. |.  |. ||.|| |||| ||| |  | . .||||. | . | . .  || |      ||  | | | | | |    ||. .   . .
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

KIHAGELPW-----PTVNNK-DVVLVAKKEANIANFCEG--LPHQYIIMYRLILSMKRDDIPNYSLF
    |.|||     ..   . . .   |.. ||   |..  .|.|.    | . ... .. | |  .
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 90976.m00049.AA CK1 19-99 34 8e-20 65.07 In-house 1-91 (271) Show / Hide 
Range on Protein: 19-99
Range on HMM: 1-91/271
Sequence Identity: 34% (31 aa)

YVIKGFIGHGSFGDIYSCEDERDHST--WAIKIELKTNKKTSLDKEAQILKKIQS------SPYFPVFHDYGES--DEYLWLVLELLGPSL
| .   || ||||||| ...  ..     |||.| ...|   |..||.|.|  |       ....|  . .|     .|  .|..||||||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 90976.m00049.AA S_TKc 19-351 17 7.2e-17 63.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-351
Range on HMM: 1-231/231
Sequence Identity: 17% (62 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKIQSSPYFPVFHDYGESDEYLWLVLELLGP---SLIGARRISSG----SVF
| |   ||.|.||  | | . ...   ||||        .. .| |||||    |.   ..|. .. ..|..|.|...    .|    .   .    ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSRKHPLILIDFGLSKAFLDDNGEMIPPRDSPGFVGTVPYAS---FNAHKGLELGC-CDDLFS
.  .| ..  .... .|  |. | .|||.|| | |.       . ..||||.. .               |.||  | .   .        |.   |  |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------GYGKCKCDWWS

WFVVLLKIHAGELPWPTVNNKDVVLVAKKEANIANFCEGLPHQYIIMYRLILSMKRDDIPNYSLFYQLLGEAMVDTNSSFMDRFDWELSPDEIIRTATTI
  ..|    .|. |.|                          |.  |...|.                                                
CGCILYEMLCGYPPFP--------------------------QMQMMFKKIG------------------------------------------------

SLAMPRGELPEPPSDFPSDLVQRLMKK-----PEVPEEKN--EDTNDTPSY
             |.   |.......|     | . |  .  .| .  |  
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 90976.m00049.AA TyrKc 19-247 15 7e-05 -143.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-247
Range on HMM: 1-280/280
Sequence Identity: 15% (44 aa)

YVIKGFIGHGSFGDIYSCEDERDHSTWAIKIELKTNKKTSLDKEAQILKKI-QSSPYFPVFHDYGESD-------EYLWLVLELLGP-SLIGARRISSGS
 . .  .|.| || .| ..      . |.|   .   .  . .||.|..|.  . |    .. .  ..       | |..|.|.    .|    | . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

VFSASTAIRLGIEMLRCIEAFHKFGLVHRDIKPGNFLIRPSRKHPLILI-DFGLSKAFLDD-----NGEMIPPRDSPGFVGTVPYA-----SFNAHKG--
 .. .. .   .   .  |  |. ...|||.   | |.   .    . | |||||..  ||     ..... .. . |  . .|.      ..   .|  
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

----------------LELGCCDDL------FSWFVVLLKIHAGELPWPTVN---------NKDVVLVAKK---E-----ANIANFCEGL
                . .|            |.. |. .. .|. . .  |          ...  . |.   |      . .. .| .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF