Gene GL50803_101850 (G.lamblia)

GL50803_101850

Species: G.lamblia
Alias: GL50803_101850, GK031
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_101850.AA Protein None 404 None Fasta, JSON
GL50803_101850.kin_dom Protein Kinase Domain None 342 None Fasta, JSON

Protein domain

Protein domains of GL50803_101850.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_101850.AA CMGC 61-402 18 8.1e-69 224.96 In-house 1-513 (513) Show / Hide 
Range on Protein: 61-402
Range on HMM: 1-513/513
Sequence Identity: 18% (100 aa)

YCAERPLGQGSFGRVVLAKD--------------TVNNAYVAIKIMKAGKLFTHKGR-------------EEAEIMSLLSD--------------EDPP-
|   ...|.|..| |. ..|              . .| .||||..|  . ... ..              | .|.  |..              .... 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ISCKFIESFMQGN-----------------HYCIVMEALGSNLYHLLKSTK--------------------------MQGFPLQTIRVWARKYLTS--FK
|  | ...|.  |                 | ..|.| .. .||...|...                           . |..  || ...  |..   |
IV-KLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

KLQHESIRIIHTDCKPENTLIPFNNTCVE------------------DIRIVDFGSAVRYPEG-----------------------QMFLYIQSRYYRAP
 .     .|||.| |||| ||  |..|                     ..| |||.|  | .                        ..  |...|.||||
YCHSHWGNIIHRDLKPENILI--NHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP

EVLLLQP----------YDYQIDIWSIAAILFEMHTG--------KVLFPAKSS-----------EILCYMMVDILGYPPKEMIMD----------EEQK
|.||  .          |...||.||.. |..|| ||        | ||| .|.               ......|| |. .||            ||. 
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEW

QISNSLKRYFKMRK-----------QEDAELFHLNENAFPHQVVPDSYLLNKSVIEMAEAQKERIFGRPLRELIRNPVMTQYEGHTS-------------
   ..| .|.|. |            |.| ..  . | || .  ..   | .   . .. . ..         ...    .|    .             
PNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK-------AMVF-NW-IY----EEKFKSHKFNHQFK

--ADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
   . ... ..|.|.|.|||..|.|...||.  ..
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_101850.AA DYRK 61-287 39 7.1e-68 231.81 In-house 1-228 (320) Show / Hide 
Range on Protein: 61-287
Range on HMM: 1-228/320
Sequence Identity: 39% (92 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPISCKFI---ESFMQGNHYCIVMEALGSNLYHLLKSTKMQGF-
|    ..|.|||| || ..|. .| .||||| .  | | . . .| .| ..|...||  .  ..   ..|.  || ||| | |  ||| .|| .. ||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNT-CVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFE
.|. .|..|.. ||. |.|. .  .||| | |||| ..  ..  .  .| ..||||.    . ... |||||.||||||.|  ||.|.||.||   || |
SLNLVRKFAQQILTCLKFLHKNE-NIIHCDLKPENIML--KQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAE

MHTGKVLFPAKSSEILCYMMVDILGYPPKEMI
..||..||| ..   . ......||.|||.||
LFTGWPLFPGENEYDQLACIMEVLGMPPKWMI
Kinase GL50803_101850.AA DYRK1 61-287 40 1.5e-56 194.15 In-house 1-227 (321) Show / Hide 
Range on Protein: 61-287
Range on HMM: 1-227/321
Sequence Identity: 40% (92 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPISCKFIE---SFMQGNHYCIVMEALGSNLYHLLKSTKMQGFP
|  . ..|.|||| || | |...  ||||||.|  | |  . . |  .. |.  .|.    . ..    ||  || |.|.| |  ||| ||. |. .|  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMH
|  .| .|.. .|.   .    . ||| | |||| |.   |     |.|.||||. .  .  .. |||||.||.|||||  .|| .||.||.  || |||
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

TGKVLFPAKSSEILCYMMVDILGYPPKEMI
||  ||  ..       .|..|| |||.||
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMI
Kinase GL50803_101850.AA S_TKc 61-402 20 2.5e-53 184.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 61-402
Range on HMM: 1-231/231
Sequence Identity: 20% (73 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPISCKFIESFMQGNHYCIVMEALGS---NLYHLLKSTKMQG--
|   |..|.|.||.| .....  . .|||||.|       . | | .|..     . |  .|....|   .|...||| ..    .|....|. . .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDY-QIDIWSIAAI
  ||  ..| ...  .   . . |.  .||| | |||| |.         | | |||.| ..       .. ...|.|||||   .|..  .|.||.  |
FPFPE-HARFYMYQICCALEYC-HSH-GIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LFEMHTGKVLFPAKSSEILCYMMVDILGYPPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFPHQVVPDSYLLNKSVIEMAEAQKERIFGRPL
|.|| .|. .||    ...  ..                                                                             
LYEMLCGYPPFP-QMQMMFKKIG-----------------------------------------------------------------------------

RELIRNPVMTQYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALN-------SRFL
                    .|. .|..|.|..||..|.|. |||.         ..
-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_101850.AA DYRK2 61-287 36 4.2e-51 164.27 In-house 1-226 (318) Show / Hide 
Range on Protein: 61-287
Range on HMM: 1-226/318
Sequence Identity: 36% (83 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPISC---KFIESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFP
|     .|.|||| || . |  .. .||||.    | | ..  || .|.. ..  |.  .    .  ..|.  || ||. | |. ||| ..|  . ||| 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMH
|| .|  |.. |.. . |. .  .||| | |||| |   .     .| ..||||     ..... |||||.|||||| |  .|.  ||.||   |. |. 
LQLVRRFAHSILQCLRFLHKN--NIIHCDLKPENILL--KQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELY

TGKVLFPAKSSEILCYMMVDILGYPPKEMI
||. |||        ..|  .|| |||...
TGYPLFPGENENDQFACMMEVLGMPPKKFF
Kinase GL50803_101850.AA HIPK 61-267 35 2.1e-39 121.45 In-house 1-207 (329) Show / Hide 
Range on Protein: 61-267
Range on HMM: 1-207/329
Sequence Identity: 35% (74 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPP--ISCKFIESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFPL
|     ||.| || || .     |  |||||.|    .  .|. | .|.. ||.|..      .. | | . || |.| | |  |||  .|  |    ||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

QTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMHT
. ||      ||  .||   .. .|| | |||| ..     |   ....|||||    .     |.|||||||||..|  |.  ..|.||   .. | . 
KHIRPILQQVLTALMKLK--ELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GKVLFPAKS
|  |.|  .
GWPLYPGAD
Kinase GL50803_101850.AA PRP4 61-267 34 4.8e-38 132.71 In-house 1-209 (320) Show / Hide 
Range on Protein: 61-267
Range on HMM: 1-209/320
Sequence Identity: 34% (73 aa)

YCAERPLGQGSFGRVVLAKDTVNNA-YVAIKIMKAGKLFTHKGREEAEIMSLLSDE-----DPPISCKFIESFMQGNHYCIVMEALGSNLYHLLKS-TKM
|    . ||| |. |. ..|. .    |||||.    .    |  | ||.  |.|      |     .  ..|   .| |.| | .  ||  .||   | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAIL
 |. |  .|. |.  .   | |      |.| | || | |.  ...    . ..||||| .  |  .  | .||.|||||...  |||||||.||..  |
VGLHLKAVRSYAQQLFLALKHLKK--CNILHADIKPDNILVNESKNT---LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTL

FEMHTGKVLFPAKS
.|. |||..|| |.
YELYTGKIMFPGKT
Kinase GL50803_101850.AA YAK 61-287 34 9.9e-35 115.15 In-house 1-229 (347) Show / Hide 
Range on Protein: 61-287
Range on HMM: 1-229/347
Sequence Identity: 34% (81 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPISCK-------FIESFMQGNHYCIVMEALGSNLYHLLKSTKM
|  .  |||| || ||  .    |  .|.|. |    .   .. |. |  .| .   |            . .|   || |.| | |  ||| .|| .| 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAIL
 ||  | ||.|    | .   |  |. .||| | |||| .    |    .|.|.||||.  .    .  |||.|.||.||...  .|   || ||   |.
CGFSFQLIRQWTKQILDGMCVL--ENKQIIHCDLKPENIMLCKPNKP--EIKIIDFGSSC-QEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIV

FEMHTGKVLFPAKSSEILCYMMVDILGYPPKEMI
 |   |  .||  |        .|.||||| .||
AELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMI
Kinase GL50803_101850.AA Pkinase 61-287 27 1.1e-30 109.61 Pfam 1-239 (293) Show / Hide 
Range on Protein: 61-287
Range on HMM: 1-239/293
Sequence Identity: 27% (68 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGRE-----EAEIMSLLSDEDPPISCKFIESFMQGNHYCIVMEAL-GS----NLYHLLK-
|. .|..|.||||.| ....  ..  ||.||.|  .    | ..     |..||  |.   | | ......|. ..|...||| . |      |..... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--STKMQGFPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAV---RYPEGQMFLYIQSRYYRAPEVLL-LQPYDYQ
  ....  |. .... ...  |   . . |.  .||| | |||| ||  |... ....| |||.|      . . |  .  ...|.||||..  |.|.. 
WRHGCFY-FSEWECKFYMYQILRGLEYC-HS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSIAAILFEMHTGKVLFPAK----SSEILCYMMVDILGYPPKEMI
.|.||.  ||.|| .|. .|| .    .     .|.. |.| |... .
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDW
Kinase GL50803_101850.AA CLK 61-194 29 1.6e-30 88.14 In-house 1-147 (350) Show / Hide 
Range on Protein: 61-194
Range on HMM: 1-147/350
Sequence Identity: 29% (44 aa)

YCAERPLGQGSFGRVVLAKDTVN-NAYVAIKIMKAGKLFTHKGREEAE-IMSLLSDE-DP---PI--SCKFIESFMQ-GNHYCIVMEALGSNLYHLLKST
|     ||.| ||.||  .|. | ..|||.|| .. . ..   . | . ||  .    ||       . | ...|   ..| |||.| .| ..| ..||.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------MQGFPLQTIRVWARKYLTSFKKLQHESIRIIHTDCKPENTLI
.       ...|...||. |.  ... |.|  ......||| |||| ..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFL--HDMKLTHTDLKPENICF
Kinase GL50803_101850.AA JNK 179-264 41 1.9e-18 65.12 In-house 124-208 (309) Show / Hide 
Range on Protein: 179-264
Range on HMM: 124-208/309
Sequence Identity: 41% (37 aa)

SIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEG-QMFLYIQSRYYRAPEVLLLQP--YDYQIDIWSIAAILFEMHTGKVLFP
|..||| | ||.| ..  |  |.  . | ||| | .  .   |  |.  ||||||||..  .  |   .||||.  |. || ...||||
SMGIIHRDLKPSNIVV--NQDCT--LKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMIRHHVLFP
Kinase GL50803_101850.AA CLK 203-287 38 1e-16 45.95 In-house 185-272 (350) Show / Hide 
Range on Protein: 203-287
Range on HMM: 185-272/350
Sequence Identity: 38% (34 aa)

DIRIVDFGSAV--RYPEGQMFLYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMHTGKVLFPAKSSEILCYMMVDILG-YPPKEMI
.|...|||||   |.        ...| |||||| |  .. .  |.|||. ||||  ||  ||.  ..     ||  |.|   |. ||
HICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMI
Kinase GL50803_101850.AA MAPK 179-310 28 4.2e-16 51.98 In-house 135-285 (328) Show / Hide 
Range on Protein: 179-310
Range on HMM: 135-285/328
Sequence Identity: 28% (44 aa)

SIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEG----------------QMFLYIQSRYYRAPEVLLL---QPYDYQIDIWSIAAILFEMHT-
| ..|| | ||.| |.  |  |  | .| ||| |                      .|  |.  |.|||||..|    . |. ..|.||.  |. || | 
SANVIHRDLKPSNILV--NENC--DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTD

GKVLFPAKSSEILCYMMVDILGYPPKEMIMDEE-QKQISNSLKRY--FKMRKQED
.|.||| |..     .....|| |..|.|   .  .   | ....  ...... .
RKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKP
Kinase GL50803_101850.AA DYRK 366-402 32 4.1e-10 34.27 In-house 285-320 (320) Show / Hide 
Range on Protein: 366-402
Range on HMM: 285-320/320
Sequence Identity: 32% (12 aa)

GHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
.|. .|...|  |. | |..||..|.|  .||.  ..
RHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase GL50803_101850.AA MAPK 61-90 36 1.5e-08 25.43 In-house 1-36 (328) Show / Hide 
Range on Protein: 61-90
Range on HMM: 1-36/328
Sequence Identity: 36% (13 aa)

YCAERPLGQGSFGRVVLAKDTV------NNAYVAIK
|.  .|.|||..| |. |.|.       .. .||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase GL50803_101850.AA MAPK 378-402 44 3.5e-08 24.15 In-house 304-328 (328) Show / Hide 
Range on Protein: 378-402
Range on HMM: 304-328/328
Sequence Identity: 44% (11 aa)

FLSKILVYDPKRRWTIDEALNSRFL
.|.| || ||..|.|..|||.  ..
LLEKMLVFDPDKRITVEEALQHPYF
Kinase GL50803_101850.AA Pkinase 353-402 15 1.2e-07 28.12 Pfam 224-293 (293) Show / Hide 
Range on Protein: 353-402
Range on HMM: 224-293/293
Sequence Identity: 15% (11 aa)

RELIRNPVMTQYEGHTSADY--------------------EEFEEFLSKILVYDPKRRWTIDEALNSRFL
...|..  ..... . . ..                    ||. .|....| .|||.|.|....|.. ..
MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_101850.AA DYRK1 366-402 40 1.9e-07 21.68 In-house 285-321 (321) Show / Hide 
Range on Protein: 366-402
Range on HMM: 285-321/321
Sequence Identity: 40% (15 aa)

GHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
||. .||  |.. . ..| ||||.| |  .||   |.
GHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase GL50803_101850.AA TyrKc 61-299 17 2e-06 -119.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 61-299
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLL--SDEDPPISCKFIESFMQG-------NHYCIVME-ALGSNLYHLLKS
   .. || | ||.|.... .     ||.| .|...      ..||.||. |  .    |   ...   .|.         ..|||| . . .| . |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH---PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TKMQGFPLQTIRVWAR------KYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEG-------QMFLY---IQSR-----YY
.. . .....   ..        || |         ..|| |    | |.  |.     ..| ||| .    ..       ..       ...       
HRPK-LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

RAPEVLLLQPYDYQIDIWSIAAILFEMHT-GKVLFPA------KSSEILCYMMVDILGYPPKE--------------MIMDE--EQ--------KQISNS
 |||..    .  . |.||    ..|. | |.   |       . .|.. | .      .|..              .|| .  .         ..|   
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase GL50803_101850.AA CLK 363-402 30 4e-06 13.75 In-house 311-350 (350) Show / Hide 
Range on Protein: 363-402
Range on HMM: 311-350/350
Sequence Identity: 30% (12 aa)

QYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
||   .. . ... . ..|.| ||| .| | ..||  .| 
QYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase GL50803_101850.AA HIPK 370-402 39 2.7e-05 12.08 In-house 297-329 (329) Show / Hide 
Range on Protein: 370-402
Range on HMM: 297-329/329
Sequence Identity: 39% (13 aa)

ADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
.|..|| . | |... |...| |  ||||..| 
IDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase GL50803_101850.AA PRP4 375-402 46 2.8e-05 15.4 In-house 293-320 (320) Show / Hide 
Range on Protein: 375-402
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FEEFLSKILVYDPKRRWTIDEALNSRFL
|  .| |.|. |||.| |. |||   |.
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase GL50803_101850.AA JNK 61-90 46 4.7e-05 14.85 In-house 1-30 (309) Show / Hide 
Range on Protein: 61-90
Range on HMM: 1-30/309
Sequence Identity: 46% (14 aa)

YCAERPLGQGSFGRVVLAKDTVNNAYVAIK
|   ...|||  | |. | |.| |  ||||
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIK
Kinase GL50803_101850.AA DYRK2 373-402 30 0.000144 10.41 In-house 289-318 (318) Show / Hide 
Range on Protein: 373-402
Range on HMM: 289-318/318
Sequence Identity: 30% (9 aa)

EEFEEFLSKILVYDPKRRWTIDEALNSRFL
| | .|... .. ||. | | ..||.  ..
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase GL50803_101850.AA JNK 379-402 33 0.009579 6.18 In-house 286-309 (309) Show / Hide 
Range on Protein: 379-402
Range on HMM: 286-309/309
Sequence Identity: 33% (8 aa)

LSKILVYDPKRRWTIDEALNSRFL
|.. || .| .|  .|.||.   .
LFRMLVINPDDRISVDDALQHPYI