Gene GL50803_102542 (G.lamblia)

GL50803_102542

Species: G.lamblia
Alias: GK111, GL50803_102542
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_102542.AA Protein None 805 None Fasta, JSON
GL50803_102542.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of GL50803_102542.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_102542.AA Pkinase 130-300 26 4.4e-31 110.99 Pfam 28-205 (293) Show / Hide 
Range on Protein: 130-300
Range on HMM: 28-205/293
Sequence Identity: 26% (49 aa)

AVKEVLLDGLDKGDLDTIRL--ELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDKTLECLLTEH----KRRKIPV--PIAVILSVLRQVAAALAYLYG
|||.. ... ... . | |.  |.. .. |.|| ... . ..||.| ||.|.. ....|. ..  .     .|. ..  .  .. ....|.. .|.|.. 
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS

LSGIGTRGLVHRDLRPANIFISADGEY---FVIAGLGLCRN--ALRGGSITAI--TRPYMAPEVLL-HNETSPASDVWSLGVIVYEL
       | .|||| |.||.|. .|.    . |.  ||..     ...  | .  |..||||||.. ... .|..|.||.|.|.||.
M------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM
S_TKc GL50803_102542.AA S_TKc 106-361 23 4.6e-23 83.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-361
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

KQLNDVLNESPAGTVYSLKDYL---GLAVKEVLLDGLDKGDLDTIRLELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDK---TLECLLTEHKRRK--
 .. ... .   |.||  ..       |.|..          ..|| |.. |    || . | . | .| |..|.|..  |    .|  .. ...|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRGGSITAITRPYMAPEVLLHNETSP-ASDVWSLGVI
 | |  .. ....|.. ||.|.  . ||     .|||| |.||...       |.  ||.|      .    |. |||||||     .. ..|.||.|.|
FPFPE-HARFYMYQICCALEYCHSH-GI-----IHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VYELTILRRPDFLEGKDPKDVFVDGWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHE-------TLAT
.||.   ..| |    ... .|           .. ..  ....... .||.|||| |. .           
LYEMLC-GYPPFP---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_102542.AA TK 149-359 12 1.9e-21 67.97 In-house 89-486 (486) Show / Hide 
Range on Protein: 149-359
Range on HMM: 89-486/486
Sequence Identity: 12% (52 aa)

LELATLLD---LSHPGVLKHHQVVEDDDF------------IYVVTDRHDKT-----LECLLTEHKRRKIP-----------------------------
.| . ...   . || ... . |. ...             ...|.   ..      |   | ........                             
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

-------------------------------------------VPIAVILSVLRQVAAALAYLYGL--SGIGTRGLVHRDLRPANIFISADGE-------
                                           .. .  |   .|.|....||  .  ..|   ..|||||   |. .. ..        
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI--QNFVHRDLAARNCLVGENNVCKWHFDG

---YFVIAGLG--------LCRNALRGGSITAITRPY-----------------------------MAPEVLLHNE---------TSPASDVWSLGVIVY
      ||  |        |.|   ...  .. . ..                             ||||.|....          ...|||||.|| ..
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

ELTILRRPDFLEGKDPKDVFVD---------------------------GWRPNLSGVTD-------------GFIKSILERIFVLEPERRPTARELHET
|.  . .  . .| .  || .|                             .|   . .|              ..  .. . . ..||.||| ..||| 
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

L
|
L
Kinase GL50803_102542.AA Ciliate-E2 150-300 20 4.7e-21 69.01 In-house 82-289 (365) Show / Hide 
Range on Protein: 150-300
Range on HMM: 82-289/365
Sequence Identity: 20% (45 aa)

ELATLLDLSHPGVLKHHQVVE--DDDFIYVVTDRHDK-TLECLLT--EHKRRKI-----PVPIAVILSVLRQVAA---------------ALAYLYGLSG
|.  |  |.|| ..| . . .  ||. || |..  .  .|. ..    .|| ..     .  .  |. . .|..                || ||     
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----

IGTRG-LVHRDLRPANIFISADGEYFVIAGLGLCRNAL-----------RGGSITAI------------------------TRPYMAPEVLL--------
   ..  .|||. | ||..        |. .||....            ..  .                           | .|||||.|         
--SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

-HNETSPASDVWSLGVIVYEL
 ... . ..|.|||||| ||.
KQKGYDYKCDIWSLGVILYEM
Kinase GL50803_102542.AA TKL 185-359 17 5.1e-21 72.43 In-house 124-364 (364) Show / Hide 
Range on Protein: 185-359
Range on HMM: 124-364/364
Sequence Identity: 17% (45 aa)

TLECLLTEHKRRKIPVPIAVILSVLRQVAAALAYLYGLS---GIGTRGLVHRDLRPANIFISADGE------Y-------FVIAGLGLCRNALRGG----
.|. .|.          . ....  ...| ...||       .  .....|||| ..||..  ...      |         |. .||.|.  . |    
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND

-----------------SITAI-TRPYMAPEVLLHN----------------ETSPASDVWSLGVIVYELTILRRPDF-LEGKDPK---------DVFVD
                 ..| . |  .||||||  .                | |...||.| |.. .|.   .|| . .   ...          . .|
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD

-GWRPNLS------------GVTDGFIKSILERIFVLEPERRPTARELHETL
 | || .               ..  .|.....    .|| ||.. |. ..|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_102542.AA Ciliate-E2-Unclassified 229-300 27 3.3e-16 52.73 In-house 164-263 (352) Show / Hide 
Range on Protein: 229-300
Range on HMM: 164-263/352
Sequence Identity: 27% (27 aa)

GLVHRDLRPANIFISADGE--YFVIAGLGLCRNALRG------------------GSITAITRPYM----APEVLLHNETS----PASDVWSLGVIVYEL
. .|||. | ||... .|.  |  |...|....                       . .. |  ||    |||||  .. .     ..|.|||||| ||.
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
Kinase GL50803_102542.AA AGC 228-300 22 3.7e-16 36.81 In-house 173-298 (395) Show / Hide 
Range on Protein: 228-300
Range on HMM: 173-298/395
Sequence Identity: 22% (29 aa)

RGLVHRD-LRPANIFISADGEYFVIAGLGLCRNALRGGSI----------------------------------------------------TAI---TR
.| .||| | | || . .|  .  ..  |||    ..|..                                                    |     | 
MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTP

PYMAPEVLLHNETSPASDVWS--LGVIVYEL
 |||||.|     ..| | ||  ||.. ||.
EYMAPEIL----YGKACDWWSFGLGCLMYEM
Kinase GL50803_102542.AA CAMK 130-298 15 8.1e-15 43.48 In-house 35-325 (425) Show / Hide 
Range on Protein: 130-298
Range on HMM: 35-325/425
Sequence Identity: 15% (47 aa)

AVKEVLLDGLD--------------------------KGDLDTIRLELATLLDLS-------HPGVLKHHQVVED-------------------DDFIYV
|.| .  . |.                            |.. .| |.. .  |.       || ..| ..| ||                   |...| 
AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYM

VT---DRHDKT------LECLLTEHKRR----------KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGE-----------
|.   .  .        .. .    ...          .  .. .    . ||.. |..|.  .      . ||||| | || .. ...           
VMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH------NIVHRDLKPENILLDDNNDDSDPVEHDEIF

----Y-FVIAGLGLCRNALRGGS--------------------------ITAITRPYMA-PEVLLH--------------NETSPASDVWSLGVIVY
    .   |.  |. .   .| .                              | .||| ||||.                  .|..|.||.||| |
DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_102542.AA CMGC 118-300 15 4.6e-13 38.35 In-house 13-328 (513) Show / Hide 
Range on Protein: 118-300
Range on HMM: 13-328/513
Sequence Identity: 15% (49 aa)

GTVYSLKDYLG-----------------LAVKEVLLDGLDKGDLD----------TIRLELATLLDLS-----------------HPGVLKHHQVVEDDD
|.||. .| .                   |.| . ..  .. .            ..  |.  |  |.                 |. ..| . .. ...
GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKN

-----------------FIYVVTDRHDKTLECLLTEHKR-----RKIPVPIAV------------ILSVL------RQVAAALA--YLYGLSGIGTRG--
                  .| |..  |..|  .. ....     |..| .  .            | . .      .|.  .|.  |.        ..  
SDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH------SHWGN

LVHRDLRPANIFISADGEYF-------------------VIAGLGLCRNALRGGS----------------------IT--AITRPYMAPEVLLHNETS-
 .|||| |.|| |. ..|..                    |.  ||.|      .                      .|    || | |||.||  .   
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

---------PASDVWSLGVIVYEL
         .. |.||.| | .|.
NHNYSMHYTTPIDMWSVGCIFAEM
Kinase GL50803_102542.AA TyrKc 121-359 18 5.7e-13 -12.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 121-359
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YSLKDYLG---------------LAVKEVLLDGLDKGDLDTIRLELATLLDL--SHPGVLKHHQVVEDD-------DFIYVVTD--RHDKTLECLLTEHK
 .|.. ||                ||| .  |      .  .. |.  .  |  .|| ... . |. ..       . ...|.    |   .. |   ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RRKIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRG-------GSITA----ITRP-----YMAPEV
.    .. .  ||   |.|.  .||         ...||||   |. .....    |.  ||.|.   .         ...     ..       ||||.
K----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLHNETSPASDVWSLGVIVYELTILRRPDFLEG----KDPKDVF---VDGWRPNLSGV--------TDGFIKSILERIFVLEPERRPTARELHETL
. ... ...||||| ||  .|.  .  .   .     .....|.    .| |.                 . .| ..    .|| ||| .|.|| .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_102542.AA Fer 273-360 23 8.6e-13 40.0 In-house 184-283 (283) Show / Hide 
Range on Protein: 273-360
Range on HMM: 184-283/283
Sequence Identity: 23% (23 aa)

YMAPEVLLHNETSPASDVWSLGVIVYELTILRRPDFLE-----------GKDPKDVFVDGWRPNLSGVTDGFIKSILE-RIFVLEPERRPTARELHETLA
..|||..   ..||..|||| ||  .|       ....           . . | . ..| .. .   .  .|..|.. .... .|| |||. |....| 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase GL50803_102542.AA UTK 206-300 25 1.3e-12 39.43 In-house 121-233 (296) Show / Hide 
Range on Protein: 206-300
Range on HMM: 121-233/296
Sequence Identity: 25% (30 aa)

LSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADG------EYFVIAGLG---LCRNAL-------RGGSITAITRP-------YMAPEVLLHN
|.  ...|....||       ..|.|||||   |... ...      . ..||..|   ..|..        ...|     ..        ||||.| |.
LCMAWDIARGMQYLH------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-ETSPASDVWSLGVIVYEL
   . .|||||.|| ..|.
TRFTTKSDVWSFGVVCWEI
Kinase GL50803_102542.AA RTKK 265-359 38 1.7e-12 38.34 In-house 176-272 (272) Show / Hide 
Range on Protein: 265-359
Range on HMM: 176-272/272
Sequence Identity: 38% (38 aa)

SITAITRPYMAPEVLLHNETSPASDVWSLGVIVYELTIL-RRPDFLEGKDPKDVFVD---GWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHETL
| .|.  | |.|| | |   ||||||||||.   |      ||   ||..|.|.      | || ..      | |.| |   ..| .|| ||.    |
SKVAVPFPWMSPESLIHRRFSPASDVWSLGMTAWEICSNGQRP--WEGMEPQDIMLAVHRGQRPVIQNNWPPQIQSLLRRVWERDPNKRPSARDYVSKL
Kinase GL50803_102542.AA Pkinase_Tyr 194-300 25 9.2e-08 26.91 Pfam 99-207 (270) Show / Hide 
Range on Protein: 194-300
Range on HMM: 99-207/270
Sequence Identity: 25% (29 aa)

KRR---KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNA-----L-RGGSITAITRPYMAPEVLLHNET
...   | |...  .|.  .|.|....||        ....||||.  |. .. ..    |.  ||.|         | .. . .  . ||||.. ... 
RKHREDKQPLTMKDLLQMCWQIAKGMEYL------ESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF

SPASDVWSLGVIVYEL
. .||||| ||  .|.
TTKSDVWSFGVLMWEI
Kinase GL50803_102542.AA Pkinase_Tyr 345-359 60 0.021521 8.73 Pfam 256-270 (270) Show / Hide 
Range on Protein: 345-359
Range on HMM: 256-270/270
Sequence Identity: 60% (9 aa)

EPERRPTARELHETL
.||.||| .|.|| |
DPEDRPTFSEIHEQL
Kinase GL50803_102542.AA UTK 345-359 26 0.028309 3.59 In-house 282-296 (296) Show / Hide 
Range on Protein: 345-359
Range on HMM: 282-296/296
Sequence Identity: 26% (4 aa)

EPERRPTARELHETL
.|..||....| ...
DPQERPDFEDLVQQM
Kinase GL50803_102542.AA Pkinase 335-359 22 0.270152 5.66 Pfam 267-293 (293) Show / Hide 
Range on Protein: 335-359
Range on HMM: 267-293/293
Sequence Identity: 22% (6 aa)

KSILERIFVLEPERRPTARELHET--L
|....... . |..||||... .   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Ank GL50803_102542.AA Ank 521-544 37 0.001366 17.21 Pfam 1-24 (33) Show / Hide 
Range on Protein: 521-544
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

RGMTALMHAAQQGHIGPVKLLVEK
 |.|.|. |.. ||.  ||.|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_102542.AA Ank 493-520 25 33.194636 1.39 Pfam 6-33 (33) Show / Hide 
Range on Protein: 493-520
Range on HMM: 6-33/33
Sequence Identity: 25% (7 aa)

LIYAAHTNDMETVQMLANEKDCIGQRDE
| .|.. ...| |.|| .   ..  .| 
LHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_102542.AA Ank 552-573 36 7.1e-05 21.84 Pfam 1-22 (33) Show / Hide 
Range on Protein: 552-573
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

NGWTALMHAAHGNHPEVARILI
.|.|.|. |.. .|.||.. |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_102542.AA Ank 583-603 38 0.000562 18.6 Pfam 1-21 (33) Show / Hide 
Range on Protein: 583-603
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NGRTALMIAAQEGHAEAASVL
.|.|.|..|.. ||.| .. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_102542.AA Ank 614-634 47 0.002619 16.19 Pfam 1-21 (33) Show / Hide 
Range on Protein: 614-634
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

QGNTALILAAEAGHEAVVEAL
 |.|.| ||.. ||. ||. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_102542.AA Ank 640-661 31 0.026585 12.56 Pfam 1-22 (33) Show / Hide 
Range on Protein: 640-661
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

RGVTALMRAAKRNDTLAVSALI
 | |.|. |.....|  |. |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_102542.AA Ank 673-691 42 8.694859 3.49 Pfam 4-22 (33) Show / Hide 
Range on Protein: 673-691
Range on HMM: 4-22/33
Sequence Identity: 42% (8 aa)

TALIQAAICGHVAAVRLLM
|.|  |..|||.  |..|.
TPLHLACRCGHTEVVKMLL
Ank GL50803_102542.AA Ank 701-724 37 0.000548 18.64 Pfam 1-24 (33) Show / Hide 
Range on Protein: 701-724
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

CGATALMKAASENHAEVVQLLMER
.| |.|. |.. .|.|||..|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_102542.AA Ank 732-764 21 1.217386 6.57 Pfam 1-33 (33) Show / Hide 
Range on Protein: 732-764
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

HGLPAIVHAAYGGRLEIVKLLFEKEGHLIDKSN
.|  .   |.. |..|.||.| ..   .  . .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD