GL50803_10744

Species: G.lamblia
Alias: GK099, GL50803_10744
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_10744.AA Protein None 1120 None Fasta, JSON
GL50803_10744.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of GL50803_10744.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_10744.AA S_TKc 19-280 18 3e-11 -12.03 SMART 1-231 (231) Show / Hide
Range on Protein: 19-280
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

PELGPVVGSGYLGQVRTLTNSPGHITEEVRLDVLQESEKTSIRRILHLATTLSHPNIIPIESIFETSSVIYASMERPPC---TLETLIKEAKDSKRK--I
 |.. ..|.|  |.|.  ..      ..| . ..    .. .| |  |     ||||. .  .|.. . .|  ||  .    .| ..||. .  ...  .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PSDTVLLAILQIAEAITYLH-------------------------GFATASGDTIKTSKVTYKALQPSNVFVGCNGCRFLISAIGICIEHEQTDTCFYSA
|  ..   . ||..|. |.|                         |.|.                                        . .  | .| |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------TTFCGTPWYMA

PEILIHNRCSA-ASVMWSLGVITYELATGIRPNFRRTTDPRLVFVQDWKPDLILVRDKEIKKIIERLLVVTEEHRITAPELVN-LLRSNKHVAK
||.|     .  .. .||.|.| ||...|  |      .. ..| .          ..| | .|...|..  |.|.|| |. .  .  ..|   
PEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_10744.AA Pkinase 185-272 20 1e-10 38.95 Pfam 176-293 (293) Show / Hide
Range on Protein: 185-272
Range on HMM: 176-293/293
Sequence Identity: 20% (24 aa)

FYSAPEILI-HNRCSAASVMWSLGVITYELATGIRPNFRRT-----TDPRLVFVQDWKPDLILVRD-----------------------KEIKKIIERLL
.| |||..  ..  . .. |||.|.| ||...|  | |.        |.. ..... .|.|   ..                       .| |..|...|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

VVTEEHRITAPELVNL--L
 .  . |.||.....   .
CKDPKKRPTAEQILQHPWF

Kinase GL50803_10744.AA Ciliate-E2 186-270 18 2.8e-08 24.51 In-house 253-361 (365) Show / Hide
Range on Protein: 186-270
Range on HMM: 253-361/365
Sequence Identity: 18% (24 aa)

YSAPEILI---------HNRCSAASVMWSLGVITYELATGIRPNFRRTTDPRLVFVQDWKPDLILVRDKEIK----------------------------
| |||||          ... . .. .|||||| ||. .| .|                   ..   ...|.                            
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK

KIIER----LLVVTEEHRIT-APELVN
 .| .    .|.. .| ||| . .. |
DLIKKFGKRMLQKDPEKRITGWEQILN

Kinase GL50803_10744.AA DRAK 186-219 50 1.5e-07 18.89 In-house 167-200 (259) Show / Hide
Range on Protein: 186-219
Range on HMM: 167-200/259
Sequence Identity: 50% (17 aa)

YSAPEILIHNRCSAASVMWSLGVITYELATGIRP
| |||||  .  . |  ||| ||.|| . |.| |
YVAPEILNYDPITMATDMWSIGVLTYVMLTHISP

Kinase GL50803_10744.AA SNRK 186-274 32 2.1e-07 20.01 In-house 165-254 (254) Show / Hide
Range on Protein: 186-274
Range on HMM: 165-254/254
Sequence Identity: 32% (29 aa)

YSAPEILIHNRCSAASV-MWSLGVITYELATGIRPNFRRTTDPRLVFVQDWKPDLILVRDKEIKKIIERLLVVTEEHRITAPELVNLLRS
|||||||.     |  | .|||||| | |  |  |  .      |  . | |  .  .  .| . .|...||   ..| .  |.|.    
YSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV

Kinase GL50803_10744.AA AGC 183-219 43 8.6e-07 12.04 In-house 270-304 (395) Show / Hide
Range on Protein: 183-219
Range on HMM: 270-304/395
Sequence Identity: 43% (17 aa)

TCFYSAPEILIHNRCSAASVMWS--LGVITYELATGIRP
|  | |||||    .. |   ||  ||.. ||. ||. |
TPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPP

Kinase GL50803_10744.AA Pkinase 64-133 21 2e-06 23.97 Pfam 51-125 (293) Show / Hide
Range on Protein: 64-133
Range on HMM: 51-125/293
Sequence Identity: 21% (16 aa)

LHLATTLSHPNIIPIESIFETSSVIYASMERPPCTLETLIKEA----KDSKRKI--PSDTVLLAILQIAEAITYLH
...   |.||||. .  .||... ||  ||  ...|. ..  .     ......  . ...   ..||.... |.|
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH

Kinase GL50803_10744.AA MSK 186-219 41 1.8e-05 14.47 In-house 171-209 (277) Show / Hide
Range on Protein: 186-219
Range on HMM: 171-209/277
Sequence Identity: 41% (16 aa)

YSAPEILI----HNR-CSAASVMWSLGVITYELATGIRP
| |||.|     ..   ..|  .||||||.|.. || .|
YMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVP

TyrKc GL50803_10744.AA TyrKc 19-272 16 1.9e-05 -134.39 SMART 1-280 (280) Show / Hide
Range on Protein: 19-272
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

PELGPVVGSGYLGQVR--TLTNSPGHITEEVRLDV----LQESEKTSIRRILHLATTL--SHPNIIPIESIFETS-------SVIYASME--RPPCTLET
 .|| . |.|  |.|.  |..           ..|    |.|. .  ..| . . . |  .||||. .  .  ..         ..  ||     . .. 
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LIKEAKDSKRKIPSDTVLLAILQIAEAITYLHGFATASGDTIKTSKVTYKALQPSNVFVGCNG-CRFLISAIGICIEHEQT----------------DTC
| |  ..    .. .. |   .|||.   |||             ..    |   |. || |. ..  ||  | . ...                  .. 
LRKHRPK----LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVK--ISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-----FYSAPEILIHNRCSAASVMWSLGVITYELATGIRPNFRR-----TTDPRLV-FVQDW-KPDLILV--------RDKEIKKIIERLLVVTEEHRIT
        ||| . ..... .|  || ||  .|. |   .          .. ... .|..   ..              .|. .|...      | | |
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

APELVNLL
  |.. ..
FSEIHECF

Kinase GL50803_10744.AA RTKK 188-219 51 1.9e-05 14.21 In-house 186-218 (272) Show / Hide
Range on Protein: 188-219
Range on HMM: 186-218/272
Sequence Identity: 51% (17 aa)

APEILIHNRCSAASVMWSLGVITYEL-ATGIRP
.|| ||| | | ||  ||||.   |  . | ||
SPESLIHRRFSPASDVWSLGMTAWEICSNGQRP

Kinase GL50803_10744.AA CAMK 70-133 16 2.8e-05 12.19 In-house 95-196 (425) Show / Hide
Range on Protein: 70-133
Range on HMM: 95-196/425
Sequence Identity: 16% (17 aa)

LSHPNIIPIESIFE------------TSSV--------IYASM---ERPPCT------LETLIKE-----------AKDSKRKIPSDTVLLAILQIAEAI
|.||||| .  ..|            | |         .|  |   |  .        .. ...               ...... . .   . ||..|.
LDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAV

TYLH
 |.|
HYCH

Kinase GL50803_10744.AA CAMK-Unique 69-133 14 2.9e-05 13.11 In-house 72-174 (363) Show / Hide
Range on Protein: 69-133
Range on HMM: 72-174/363
Sequence Identity: 14% (15 aa)

TLSHPNIIPIESI----FETSS---------------VIYASMERPPCT-LETLIKEA----------------KDSKRKIPS--DTVLLAILQIAEAIT
...|||||... .    |...                 .|  ||. ..  |  .| .                 |.....       ... ......|. 
MVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVA

YLH
|.|
YMH

Kinase GL50803_10744.AA DAPK 186-219 52 3e-05 10.09 In-house 172-205 (264) Show / Hide
Range on Protein: 186-219
Range on HMM: 172-205/264
Sequence Identity: 52% (18 aa)

YSAPEILIHNRCSAASVMWSLGVITYELATGIRP
| ||||.     | |  ||| ||||| . .|| |
YVAPEIVNYEPLSLATDMWSIGVITYIMLSGISP

Kinase GL50803_10744.AA CAMK-Unique 197-219 56 0.000122 11.02 In-house 270-292 (363) Show / Hide
Range on Protein: 197-219
Range on HMM: 270-292/363
Sequence Identity: 56% (13 aa)

CSAASVMWSLGVITYELATGIRP
|| ||  ||||||.|....|. |
CSPASDIWSLGVIMYYMLCGCPP

Kinase GL50803_10744.AA CAMK 186-270 18 0.000258 9.02 In-house 285-421 (425) Show / Hide
Range on Protein: 186-270
Range on HMM: 285-421/425
Sequence Identity: 18% (25 aa)

YSA-PEILIHNR--------------CSAASVMWSLGVITYELATGIRPNFRRTT-----------DPRLVFVQDWKPDLILVRDK--------------
| | ||.|  ..              .. .. |||.|||.| . .|  |    .            ...  | .  | .     ..              
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

------------EIKKIIERLLVVTEEHRITAPELVN
            | |  | ..|.|  |.|.|. .  |
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN

Kinase GL50803_10744.AA PSK 70-93 41 0.001399 6.95 In-house 53-76 (258) Show / Hide
Range on Protein: 70-93
Range on HMM: 53-76/258
Sequence Identity: 41% (10 aa)

LSHPNIIPIESIFETSSVIYASME
..||.||  . .|||.. .|  ||
VRHPYIIQLMEVFETQDRVYMVME

Kinase GL50803_10744.AA PSK 186-219 44 0.002924 5.91 In-house 166-199 (258) Show / Hide
Range on Protein: 186-219
Range on HMM: 166-199/258
Sequence Identity: 44% (15 aa)

YSAPEILIHNRCSAASVMWSLGVITYELATGIRP
| |||.|.      .  || .|||.| |  || |
YIAPEVLLRKPYTQSVDMWAVGVIAYILMSGIMP

Kinase GL50803_10744.AA Ciliate-E2 49-133 18 0.07387 2.14 In-house 52-177 (365) Show / Hide
Range on Protein: 49-133
Range on HMM: 52-177/365
Sequence Identity: 18% (23 aa)

LDVLQESEKTSIRRILHLAT----------------TLSHPNIIPIESIFE--TSSVIYASMERPPC-TLETLIKEAKDSKRKIPS-------DTVLLAI
. ....... .| ...|.                  .|.||||| .   |.  . . ||  ||     .|. .||. | .. ....         ..  .
MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIM

LQIAE---------------AITYLH
 ||..               |. |||
KQILQGFKTKAEFYIACIILALEYLH

Ank GL50803_10744.AA Ank 364-385 36 0.001065 17.6 Pfam 1-22 (33) Show / Hide
Range on Protein: 364-385
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

IGRTALMRAADKGDAEMVRLLI
 |.|.|. |. .|..|.|..|.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_10744.AA Ank 405-428 37 0.014776 13.48 Pfam 1-24 (33) Show / Hide
Range on Protein: 405-428
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

QNRTALMGAAVNGHLEAVRALLDY
  .|.|. |. .||.| |. ||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_10744.AA Ank 436-462 48 0.000102 21.27 Pfam 1-25 (33) Show / Hide
Range on Protein: 436-462
Range on HMM: 1-25/33
Sequence Identity: 48% (13 aa)

DGLTALMLATCNGHTEAARILVEKEHG
|| |.|.|| ..|||| .. |..  ||
DGFTPLHLACRCGHTEVVKMLLQ--HG

Ank GL50803_10744.AA Ank 498-526 31 0.000144 20.73 Pfam 1-29 (33) Show / Hide
Range on Protein: 498-526
Range on HMM: 1-29/33
Sequence Identity: 31% (9 aa)

NGWTALMRAAEKGYKKLIRLLLQLEAKIH
.|.|.|. |...|... ...|||  | ..
DGFTPLHLACRCGHTEVVKMLLQHGADVN

Ank GL50803_10744.AA Ank 467-497 18 0.000376 19.23 Pfam 1-33 (33) Show / Hide
Range on Protein: 467-497
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

EGWSALMYAAESNQVDIAQLLLN--TEKALQNS
.|...|..|...........||.   .  .|. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 529-550 40 0.000335 19.41 Pfam 1-22 (33) Show / Hide
Range on Protein: 529-550
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

HGLTALMYSAWSGHSEIVALLL
.| |.|.. . .|| |.| .||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_10744.AA Ank 560-590 33 7.2e-07 29.04 Pfam 1-33 (33) Show / Hide
Range on Protein: 560-590
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

DGWTALMYAAYNGHSDVVQILMD--TEKRAVNK
||.|.|..|...|| .||. |..   .  |...
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 591-621 36 5.3e-05 22.3 Pfam 1-33 (33) Show / Hide
Range on Protein: 591-621
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

DGRSALMRAAENGHTEAVRLLVG--QEKGIQDN
||...|. |...|||| |..|..   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 622-645 25 0.084428 10.75 Pfam 1-24 (33) Show / Hide
Range on Protein: 622-645
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

NGLSSMMYAVWNNYTDIVEVLHDH
.| .  ..|. ...|..|. | .|
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_10744.AA Ank 653-673 33 0.296957 8.78 Pfam 1-21 (33) Show / Hide
Range on Protein: 653-673
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

EGWTALLYAIDKKNTDAVQIL
.|.|.| .|. . .|. |. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_10744.AA Ank 684-705 27 16.991725 2.44 Pfam 1-22 (33) Show / Hide
Range on Protein: 684-705
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

GNHTALEYALQSGYSDAIRILL
   |.| .| ..|. . .. ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_10744.AA Ank 714-735 36 0.000508 18.76 Pfam 1-22 (33) Show / Hide
Range on Protein: 714-735
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

LGRTALMRAADRGDTDMVSLLI
 |.|.|. |. .|.|..|..|.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_10744.AA Ank 755-775 42 1.531925 6.21 Pfam 1-21 (33) Show / Hide
Range on Protein: 755-775
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

CYRTALMGAVANGHTASVKIL
. .|.|. |. .|||  || |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_10744.AA Ank 817-846 36 4.2e-05 22.65 Pfam 1-33 (33) Show / Hide
Range on Protein: 817-846
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

SGRTALMLAAQNGSYEVATILLD---SERALTD
 |.|.|.||...|..||.. ||.   .  | .|
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 786-816 21 0.001484 17.08 Pfam 1-33 (33) Show / Hide
Range on Protein: 786-816
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

DGWTALMVAACINNAEAAAILVG--KERCIRTS
||.|.|..|.. ...| .  |..   . .... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 848-871 25 9.446981 3.36 Pfam 1-24 (33) Show / Hide
Range on Protein: 848-871
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

SARTATMTAAWTNYPEIVNILLKY
  .|. . |.  ...|.|  ||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_10744.AA Ank 879-900 50 0.000146 20.71 Pfam 1-22 (33) Show / Hide
Range on Protein: 879-900
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

DGWTALMCAAVQGHVEPLKLLL
||.|.|..|.  ||.| .|.||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_10744.AA Ank 910-942 30 7.3e-05 21.79 Pfam 1-33 (33) Show / Hide
Range on Protein: 910-942
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

DGWTALMLAANNSHAEATRLLMTCPEELQASES
||.|.|.||. . |.|  ..|. .  .. |   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 971-993 30 0.05793 11.34 Pfam 1-23 (33) Show / Hide
Range on Protein: 971-993
Range on HMM: 1-23/33
Sequence Identity: 30% (7 aa)

RGRTALMIAAENDWPEVLVPLID
 |.|.|..|.... .||.  |..
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_10744.AA Ank 1002-1022 47 0.025262 12.64 Pfam 1-21 (33) Show / Hide
Range on Protein: 1002-1022
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DGCTALMLAGRNGSLESARIL
||.|.|.|| |.|..| .. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_10744.AA Ank 1033-1063 30 0.000112 21.13 Pfam 1-33 (33) Show / Hide
Range on Protein: 1033-1063
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

NGQTALMEAAKGGYPDVVQVLVE--YEKCLQDA
.|.|.|. |.. |...||. |..   . ..|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_10744.AA Ank 1064-1084 42 0.000226 20.03 Pfam 1-21 (33) Show / Hide
Range on Protein: 1064-1084
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

DGNTALMVAVAEGCQDVVEIL
||.|.|..|.  |. .||. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_10744.AA Ank 1095-1112 38 60.038757 0.46 Pfam 1-18 (33) Show / Hide
Range on Protein: 1095-1112
Range on HMM: 1-18/33
Sequence Identity: 38% (7 aa)

AGQTALDLARSSGREEML
 |.|.| || ..|..|..
DGFTPLHLACRCGHTEVV