Gene GL50803_112518 (G.lamblia)

GL50803_112518

Species: G.lamblia
Alias: GL50803_112518, GK108
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_112518.AA Protein None 697 None Fasta, JSON
GL50803_112518.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GL50803_112518.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_112518.AA S_TKc 25-285 20 2.1e-28 101.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-285
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

EGLDDVLSESAAGTVYSLKDYP---SLAVKVIQLSGLDKDSVDAAKAKLTVLLTLSYIGVLKHYQVIEYKGLIYVVTDRYNK---TLEHLLAEHKRRK--
  . ... . | |.||  ..       |.|.|          . ..  . .|       . | | |..  . .|.|..  .    .| ... ...|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IPVPIAMILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCKDALWSGSTLIGIMAYVAPEVLLRNDTSP-ASDVWSLGVI
 | |  .. ....|.. ||.|.||      .| .|.|| |.|.|..    .  |.||||..      .|..|   |.|||||     .. ..|.||.|.|
FPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IYELVTLRRPNFLGGKEPAEVFVDEWTPDLSGVADGFIKNVLERIFVLEPKERLTARELHE--TLTAADIPV
.||... . |     ..  .. .           . ..   ...... .|..|.|| |. .   . ...  .
LYEMLCGYPPFP-QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_112518.AA TKL 104-278 17 1.5e-26 92.61 In-house 124-364 (364) Show / Hide 
Range on Protein: 104-278
Range on HMM: 124-364/364
Sequence Identity: 17% (43 aa)

TLEHLLAEHKRRKIPVPIAMILSVLRQVAAALAYLHSVN---GANTRGLVHCDLRPANVLISADGE-------------RFVIADFGLCKDALWSGS---
.|.|.|           .  ...  ...| ...|||| |   .  .....|.|| ..|.|.  ...             .  |.||||...  .||.   
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND

----------------TLIGIM---AYVAPEVLLRN----------------DTSPASDVWSLGVIIYELVTLRRPNF-LGGKEPA---------EVFVD
                |.. .    .. |||||  .                . |...||.| |....|..| .|| . ..  ..          .. .|
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD

-EWTPDLS------------GVADGFIKNVLERIFVLEPKERLTARELHETL
    | .               ..  .|. ...    .|..|... |. ..|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_112518.AA Pkinase 85-278 23 3.7e-26 93.59 Pfam 66-293 (293) Show / Hide 
Range on Protein: 85-278
Range on HMM: 66-293/293
Sequence Identity: 23% (55 aa)

YQVIEYKGLIYVVTDRYNKTLEHLLAEHK-----RRKIPV--PIAMILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER---FVIADFG
| . |.|. ||.|..  ...|.  ... .     .|. ..  .   . ....|.. .|.|.||       | .|.|| |.|.||. .|.    . |.|||
YDWFEDKDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDLKPENILIDNNGHIDACVKICDFG

LCKDA-LWSGS--TLIGIMAYVAPEVLL-RNDTSPASDVWSLGVIIYELVTLRRPNFLGG------KEPAEVFVDEWTPDLSGVADG-------------
|.| . . ..|  |. |   |.||||.. ... .|..|.||.|.|.||... .|| | |        . . .. . ..|  .                  
LAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF

---------FIKNVLERIFVLEPKERLTARELHET--L
           | ...... . ||.|.||... .   .
HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_112518.AA AGC 130-221 24 4.3e-24 57.8 In-house 161-300 (395) Show / Hide 
Range on Protein: 130-221
Range on HMM: 161-300/395
Sequence Identity: 24% (37 aa)

QVAAALAYLHSVNGANTRGLVHCD-LRPANVLISADGERFVIADFGLCKDALWSG---------------------------------------------
... || ||||      .| .| | | | |.|. .|     ..||||||    .|                                             
CIVLALEYLHSH-----MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDT

--------STLIG--IMAYVAPEVLLRNDTSPASDVWS--LGVIIYELVT
        .|. |     |.|||.|     ..| | ||  ||...||..|
TRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_112518.AA Ciliate-E2 72-225 20 2e-20 66.82 In-house 85-295 (365) Show / Hide 
Range on Protein: 72-225
Range on HMM: 85-295/365
Sequence Identity: 20% (45 aa)

VLLTLSYIGVLKHYQVIE--YKGLIYVVTDRYNK-TLEHLLA--EHKRRKI-----PVPIAMILSVLRQVAA---------------ALAYLHSVNGANT
.| .|.   ..| | . .   .  || |.. ..  .|....    .|| ..     .  .  |. . .|..                || ||||      
ILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS------

RG-LVHCDLRPANVLISADGERFVIADFGLCKDA--------------LWSGST---------------------LIGIMAYVAPEVLLRND--------
..  .| |. | |.|.        |.||||.|..              ..                         ..|   |.|||.| . .        
KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

-TSPASDVWSLGVIIYELVTLRRP
  . ..|.||||||.||... ..|
GYDYKCDIWSLGVILYEMLFGKPP
Kinase GL50803_112518.AA Ciliate-E2-Unclassified 109-274 20 5.6e-20 66.01 In-house 125-346 (352) Show / Hide 
Range on Protein: 109-274
Range on HMM: 125-346/352
Sequence Identity: 20% (46 aa)

LAEHKRRKIPVPIAMIL-----SVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGE--RFVIADFGLCKDALWS------------------G
| ......  ..   ..       ..|.  .| |||. |.      .| |. | |.|.. .|.  .  |.|||..|    .                   
LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-----IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMM

STLIGIMAYV----APEVLLRNDTS----PASDVWSLGVIIYELVTLRRPNF----------------------LGGKEPAEVFVDEWTP------DLSG
.| .|   |     ||||| ..  .     ..|.||||||.||... ..| .                      |  .  .  .   . |      ..| 
WTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSP

VADGFIKNVLERIFVLEPKERLTAREL
 |  ||.. | ....  |..|.|. ..
EAKDFINDLLQKMLKKNPNKRITFEQI
Kinase GL50803_112518.AA TK 91-278 14 8.6e-20 62.33 In-house 127-486 (486) Show / Hide 
Range on Protein: 91-278
Range on HMM: 127-486/486
Sequence Identity: 14% (51 aa)

KGLIYVVTDRYNKT-----LEHLLAEHKRRKIP-------------------------------------------------------------------
.. ...|.   ..      | . | ........                                                                   
QEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCL

-----VPIAMILSVLRQVAAALAYLHSVN--GANTRGLVHCDLRPANVLISADGER----------FVIADFG--------LCKDAL-------------
     .. .  |   .|.|....|||| |  .    ..|| ||   |.|.. .. .            |||||        |..|               
TCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGT

-----------WSGSTLIGIMA-----YVAPEVLL---------RNDTSPASDVWSLGVIIYELVTLRRPNFLG----------GKEPAEVFVDEWT---
           |.  ..    .     . |||.|.          .  ...|||||.|| ..|..|. .  . |          | ...||.    .   
GRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGR

---------------PDLSGVAD-------------GFIKNVLERIFVLEPKERLTARELHETL
               |   .  |              ..  .. . . ..|..| | ..||| |
LCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_112518.AA CAMKK 126-225 22 2.3e-18 54.51 In-house 180-325 (396) Show / Hide 
Range on Protein: 126-225
Range on HMM: 180-325/396
Sequence Identity: 22% (34 aa)

SVLRQVAAALAYLH-SVN---------------GANTRGLVHCDLRPANVLISADG--ERFVIADFGLCKDALWSGSTLIGI--------------MAYV
...|... .| ||| ...                 .    .| |. | | ||. .|  |...||||| ..    . .||..                |. 
KYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQ--DIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFM

APEVLLR-NDTS---------------PASDVWSLGVIIYELVTLRRP
|||.. . |...               .| |.|.||| .| .|....|
APELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCP
Kinase GL50803_112518.AA CAMK 129-221 22 2.7e-17 51.62 In-house 186-329 (425) Show / Hide 
Range on Protein: 129-221
Range on HMM: 186-329/425
Sequence Identity: 22% (33 aa)

RQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADG----------------ERFVIADFGLCKDALWSGS--------------------------TL
||.. |..|.||      .. ||.|| | |.|.. ..                    |.|||. .    . .                          | 
RQICSAVHYCHS------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTF

IGIMAYVA-PEVLLRND--------------TSPASDVWSLGVIIYELVT
 |  .|.| ||||...                .|..|.||.||| | ...
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase GL50803_112518.AA RSK 127-221 29 4.4e-16 55.58 In-house 109-207 (278) Show / Hide 
Range on Protein: 127-221
Range on HMM: 109-207/278
Sequence Identity: 29% (31 aa)

VLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISA--DGERFVIADFGLCKDALWS-GS---TLIGIMAYVAPEVLL----RNDTSPASDVWSLGVII
...... |. .||.      .| .| || | |.|     . .. .. |||.|| .  . ..   | ..  .|.|||.|     ..  . | |.|||||..
YMAEIVLAVEHLHQ------QGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM

YELVT
||. |
YEMLT
Kinase GL50803_112518.AA ULK 124-225 23 6.6e-16 52.09 In-house 132-255 (329) Show / Hide 
Range on Protein: 124-225
Range on HMM: 132-255/329
Sequence Identity: 23% (30 aa)

ILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER-----------FVIADFGLCKDAL-W-----SGSTLI------GIMAYVAPEVLL-
......| .... .||.      .. .|.|. |.|.||. . .            . |||||..|    .        |        |   | ||..|  
AIQFFKQILNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQG

---RNDTSPA-SDVWSLGVIIYELVTLRRP
   . . . . .|.||||.|.||... . |
QGEQKPYYDYKCDIWSLGCIFYEMLYGKPP
Kinase GL50803_112518.AA ULK 124-225 22 7.7e-16 52.74 In-house 128-251 (324) Show / Hide 
Range on Protein: 124-225
Range on HMM: 128-251/324
Sequence Identity: 22% (29 aa)

ILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGER-----------FVIADFGLCKDALW--SGSTLI----------GIMAYVAPEVLL-
......| .... .||.      .. .|.|. |.| ||. . .            . |||||..|         ...          |   | ||..|  
AIQFFKQICNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQG

---RNDTSPA-SDVWSLGVIIYELVTLRRP
   . . . . .|.||||.|.||... . |
QGEQKPYYDYKCDIWSLGCIFYEMLYGKYP
Kinase GL50803_112518.AA Pkinase_Tyr 113-222 28 7e-14 47.64 Pfam 99-210 (270) Show / Hide 
Range on Protein: 113-222
Range on HMM: 99-210/270
Sequence Identity: 28% (34 aa)

KRR---KIPVPIAMILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCKDA-------LWSGSTLIGIMAYVAPEVLLRND
...   | |... ..|.  .|.|....||.| |      ..| ||.  |.|.. ..    |.||||..|          .|.. . |    |||..  . 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPI-KWMAPECINYGK

TSPASDVWSLGVIIYELVTL
 . .||||| || ..|..|.
FTTKSDVWSFGVLMWEIFTY
TyrKc GL50803_112518.AA TyrKc 25-278 20 2.6e-11 -39.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-278
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

EGLDDVLSESAAGTVYS--LKDYPSLAVKVIQLSGLDKDSVDAAKAKLTVLLTL--SYIGVLKHYQVIEYK-------GLIYVVTDRYNK-TLEHLLAEH
  |...| | | |.||   .|     |||... .      . .    . ..  |  .   ... | |.  .       . ...|.    .  | . | .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KRRKIPVPIAMILSVLRQVAAALAYLHSVNGANTRGLVHCDLRPANVLISADGERFVIADFGLCKDALWS------GSTLI-----GIM-----AYVAPE
...   .. .  ||   |.|.  .||||       ...| ||   |.|..... .  |.||||..|          ...       |          |||
RPK---LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLLRNDTSPASDVWSLGVIIYELVTLRRPNFLGG----KEPAEV--FVDEW-TPDLSGV--------ADGFIKNVLERIFVLEPKERLTARELHETL
..  .  ...||||| || ..|. |.  .   |     ....||  .|..   ..            .   . .. ..    .|..| | .|.|| .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_112518.AA APH 98-170 16 0.000178 16.15 Pfam 124-197 (248) Show / Hide 
Range on Protein: 98-170
Range on HMM: 124-197/248
Sequence Identity: 16% (13 aa)

TDRYNKTLEHLLAEHKRRKIPVPIAM---ILSVLRQ-VAAALAYLHSVNGANTRGLVHCDLRPANVLIS--ADGERF--VI
.... . .. |..... . ....      ..  ...  |. .| ..       ....|.|..| ||...  .||.|.  ||
GRWRLYHWRQLMDWCR-CWVDPEWFDEDRQWWLWQRLWAWLEAHWP------PPCWCHGDFHPGNVMWDPRPDGGRVTGVI
Kinase GL50803_112518.AA Pkinase_Tyr 264-278 46 1.912495 2.13 Pfam 256-270 (270) Show / Hide 
Range on Protein: 264-278
Range on HMM: 256-270/270
Sequence Identity: 46% (7 aa)

EPKERLTARELHETL
.|..| | .|.|| |
DPEDRPTFSEIHEQL
Ank GL50803_112518.AA Ank 412-435 33 0.029823 12.38 Pfam 1-24 (33) Show / Hide 
Range on Protein: 412-435
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

QKMTALMHAAQQGHIGPVKLLVEK
  .|.|. |.. ||.  ||.|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_112518.AA Ank 443-463 42 2.6e-05 23.44 Pfam 1-21 (33) Show / Hide 
Range on Protein: 443-463
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

NGWTALMHAAHCNHSEIVEIL
.|.|.|. |..|.| |.|. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_112518.AA Ank 474-495 27 0.254772 9.02 Pfam 1-22 (33) Show / Hide 
Range on Protein: 474-495
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

NNRTALMIIAEEGHAEAASVLV
. .|.|.. .. ||.| .. |.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_112518.AA Ank 505-513 44 3.512719 4.91 Pfam 1-9 (33) Show / Hide 
Range on Protein: 505-513
Range on HMM: 1-9/33
Sequence Identity: 44% (4 aa)

EGNTALMIA
.|.|.|..|
DGFTPLHLA
Ank GL50803_112518.AA Ank 562-584 39 0.000329 19.44 Pfam 1-23 (33) Show / Hide 
Range on Protein: 562-584
Range on HMM: 1-23/33
Sequence Identity: 39% (9 aa)

FGVTALMIAASVGNVEIVKLLVG
 | |.|..|.. |..|.||.|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_112518.AA Ank 531-561 33 0.269839 8.93 Pfam 1-33 (33) Show / Hide 
Range on Protein: 531-561
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

LGRTRLMRAAIRGCIETAKLVIK--YDGGAQDI
 |.| |. |...|..| .|. ..   |  ||| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_112518.AA Ank 593-615 34 0.011016 13.94 Pfam 1-23 (33) Show / Hide 
Range on Protein: 593-615
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

SETTALMNAASAGNVEIVKLLVD
   |.|. |.. |..|.||.|..
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_112518.AA Ank 624-656 30 0.458384 8.1 Pfam 1-33 (33) Show / Hide 
Range on Protein: 624-656
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

EEMTALECGAVNGHLEVVKLLFEKEGHLIDKSD
. .|.| . . .||.||||.| ..   .  . |
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD