GL50803_113030

Species: G.lamblia
Alias: GL50803_113030, GK147
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_113030.AA Protein None 680 None Fasta, JSON
GL50803_113030.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of GL50803_113030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_113030.AA Pkinase 181-302 20 1.1e-16 60.14 Pfam 136-293 (293) Show / Hide
Range on Protein: 181-302
Range on HMM: 136-293/293
Sequence Identity: 20% (33 aa)

PDNIMFAGDGRR---VVLADFGFCE---GISSGAAK--AGDPAYMAPETLL-RGDVTPASAVWSLGAVAYELATLRKPDFLRGK------EPAEVFVTEW
|.||..  .|     | ..|||...     ... ..  .| | ||||| .. . . .|.. .||.| . ||... ..| |  |.      .. ....   
PENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFP-GHCWHDNHDQMQMICRIM

RPDLSGIAD-----------------------DLARSVLEKMLVLDPAERPTAKGLAHL--I
.|.|.   .                       . ........| .||..||||. . .   .
GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

S_TKc GL50803_113030.AA S_TKc 49-302 21 8.2e-15 40.29 SMART 1-231 (231) Show / Hide
Range on Protein: 49-302
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

ECKDEPLGTGGFYTIHASNERP---KFTMRKIQLDGLDQHRVDAIKRRLAALLSASHPGVLKYHQVLTDGNTILVVTDRCCG---DLRQFITDHRD--IH
  . ...| |.| . .   ..    .. . .|          . |.| .. | .  || . |.. |  | . . .|.. | |   ||...| ...    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

ESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAI----LEPDNIMFAGDGRRVVLADFGFCEGISSGAAKAGDPAYMAPETLLRGDVTP-ASAVWS
   |   . ... |.. ||.|.| .|           |    | |.||..     .. ..|||..  .       | | ||||| |     .. .. .||
FPFPE-HARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGAVAYELATLRKPDFLRGKEPAEVFVTEWRPDLSGIADDLARSVLEKMLVLDPAERPTAKGLAH---------LI
.| . ||... ..| |    .....|            .. |.. ..|.|. ||..||||  . .          .
CGCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_113030.AA AGC 181-245 20 9.5e-13 27.79 In-house 183-300 (395) Show / Hide
Range on Protein: 181-245
Range on HMM: 183-300/395
Sequence Identity: 20% (25 aa)

PDNIMFAGDGRRVVLADFGFCEGISSGA----------------------------------------------------AK--AG--DPAYMAPETLLR
|.||..  |   . |.|||.|  . ..                                                     ..   |   | ||||| |  
PENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--

GDVTPASAVWS--LGAVAYELAT
   ..|   ||  ||.. ||. |
--YGKACDWWSFGLGCLMYEMLT

Kinase GL50803_113030.AA STE 181-296 20 2e-11 36.76 In-house 180-349 (359) Show / Hide
Range on Protein: 181-296
Range on HMM: 180-349/359
Sequence Identity: 20% (37 aa)

PDNIMFAGDGRRVVLADFGFCEGISSGAA----------------K----AGDPAYMAPETLLR------GDVTPASAVWSLGAVAYELATLRKP----D
|.||..      | |.|||.|  ...  |                |    .| | .|||| ...      .. .  . .|||| .. |.|| . |     
PANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH

FLRGKEPAE------------VFVTEWRPDLSGIAD-------------------DLARSVLEKMLVLDPAERPTAK
 .|   ..               | .  | |    .                   .  .  ..| |. || .||||.
PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS

Kinase GL50803_113030.AA Ciliate-E2 181-296 16 8.2e-11 33.33 In-house 189-357 (365) Show / Hide
Range on Protein: 181-296
Range on HMM: 189-357/365
Sequence Identity: 16% (31 aa)

PDNIMFAGDGRRVVLADFGFCEGISS--------GAAK---------------------------AGDPAYMAPETLLRGD---------VTPASAVWSL
|.||.|      . ..|||..  ..           .|                           .| | ||||| | ...          . .. .|||
PENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GAVAYELATLRKPDFLRGKEPAEVFVTEWRPDLS------------------GIADDLARSVLEK----MLVLDPAERPT-AK
| . ||. . . |         .    .   |..                     .. .   . |    ||. || .|.| ..
GVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

Kinase GL50803_113030.AA Ciliate-E2-Unclassified 179-296 20 3e-10 31.77 In-house 170-344 (352) Show / Hide
Range on Protein: 179-296
Range on HMM: 170-344/352
Sequence Identity: 20% (35 aa)

LEPDNIMFAGDGR--RVVLADFGFCEGISS-------------------GAAKAGDPAYM----APETLLRGDVT----PASAVWSLGAVAYELATLRKP
. |.||.|  .|.  .. ..|||..  . .                      ..| | ||    ||| | .         .. .|||| ..||. . . |
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP

DF----------------------LRGKEPAEVFVTEWRP------DLSGIADDLARSVLEKMLVLDPAERPTAK
 .                      |. .  .  .   . |      ..|  | |. .  | |||. .| .|.|..
FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFE

Kinase GL50803_113030.AA CAMK 181-241 17 2.5e-09 25.46 In-house 207-325 (425) Show / Hide
Range on Protein: 181-241
Range on HMM: 207-325/425
Sequence Identity: 17% (21 aa)

PDNIMFAGDG----------------RRVVLADFGFCEGISSGA---------------------------AKAGDPAYMA-PETLLR------------
|.||..  ..                  . ..||||   . .|                               | |.||| || |..            
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDE

--GDVTPASAVWSLGAVAY
    ..|.. .||.| . |
EKPYYGPKCDMWSCGVILY

TyrKc GL50803_113030.AA TyrKc 49-302 17 4.1e-09 -75.24 SMART 1-280 (280) Show / Hide
Range on Protein: 49-302
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

ECKDEPLGTGGFYTIHASNERPKF-----TMRKIQLDGLDQHRVDAIKRRLAALLSA--SHPGVLKYHQVLTDG-------NTILVVTDRCC-GDLRQFI
  ... || | | ...    .        ....          . .. | .  . .   .|| ... . | |..         ...|.  .. |||....
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

TDHRDIHESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAI---LEPDNIMFAGDGRRVVLADFGFCEGISSG--------AAKA----GDP----
 .||.    ....  ||   | |   .|||            . |   |   |.. . .. .|  .||| .  | ..          ..    |      
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

-AYMAPETLLRGDVTPASAVWSLGAVAYELATLRKPDF-------LRGKEPAEVFVTEWRPDLSGI---------ADDLARSVLEKMLVLDPAERPTAKG
   ||||..  |  |..| ||| | . .|. |. ..         .  .|  |   .  |..              |.. . . ..    ||..||| . 
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSE

LAHLI
. ...
IHECF

Kinase GL50803_113030.AA TK-Unique 215-246 42 2.5e-08 24.95 In-house 201-235 (294) Show / Hide
Range on Protein: 215-246
Range on HMM: 201-235/294
Sequence Identity: 42% (15 aa)

AYMAPETLL--RGDV-TPASAVWSLGAVAYELATL
..|||| |.  .|   |. | |||.| . .|..||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL

Kinase GL50803_113030.AA NEK6 86-249 28 4.6e-08 22.36 In-house 43-202 (252) Show / Hide
Range on Protein: 86-249
Range on HMM: 43-202/252
Sequence Identity: 28% (49 aa)

RVDAIKRRLAALLSASHPGVLKYHQVLTDGNTILVVTDRC-CGDLRQFITDHRDIHESVPNELVLSLLGQLAGALAYLHGLGGDVDDDLLPRAILEPDNI
| | ||  .  | .  || |.|| .   . | . .| .    ||. . |   .     .|   .     ||. ||. .|         .. | |  | |.
RQDCIK-EIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH------SKRVMHRDI-KPANV

MFAGDGRRVVLADFGFCEGISSGAAKA----GDPAYMAPETLLRGDVTPASAVWSLGAVAYELATLRKP
   ..|  | | | |     ||    |    | | ||.|| .        | .|||| . ||.| |  |
FITANG-IVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP

Kinase GL50803_113030.AA MSK 181-243 32 6.9e-08 22.74 In-house 129-203 (277) Show / Hide
Range on Protein: 181-243
Range on HMM: 129-203/277
Sequence Identity: 32% (24 aa)

PDNIMFAGD--GRRVVLADFGFCEGISSGAAKAGDP-----AYMAPETLLR---GDV--TPASAVWSLGAVAYEL
| ||.|...  ...|.| ||||     .. ..   .      ||||| | |   .|.   .|  .||||.. |..
PENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM

Kinase GL50803_113030.AA TKL 181-302 14 2.2e-07 22.65 In-house 168-364 (364) Show / Hide
Range on Protein: 181-302
Range on HMM: 168-364/364
Sequence Identity: 14% (28 aa)

PDNIMFAGDGR-------------RVVLADFGFCEGISSGAA-----------------------KAGDPAYMAPETLL----------------RGDVT
..||.   ...             .. ..|||..  .|                           . | |..|||| |                  .. .
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

PASAVWSLGAVAYELATLRKPDF-LRGKEPA------EVFVT----EWRPDLS------------GIADDLARSVLEKMLVLDPAERPTAKGLAHLI
... |.| | | .|..| ..| . .   ..       | |.       || .               ...  .. ...    || .||... . . .
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase GL50803_113030.AA TK 186-302 17 6.1e-07 18.49 In-house 283-486 (486) Show / Hide
Range on Protein: 186-302
Range on HMM: 283-486/486
Sequence Identity: 17% (35 aa)

FAGDGRRVVLADFGFC---------------EGISSGAAKAGDPA-----------------------YMAPETLL---------RGDVTPASAVWSLGA
| |.|. . .|||| .               .  ...  ..|.|.                       .||||.|.          |  |..| |||.| 
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

VAYELATLRKPDFLR----------GKEPAEVFVTEWR------------------PDLSGIAD-------------DLARSVLEKMLVLDPAERPTAKG
. .|. |. .  .            | ...||.    |                  |   .  |             ..   .. .   .||..||| . 
LMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQ

LAHLI
| . .
LHEQL

Kinase GL50803_113030.AA CAMK 88-166 14 0.000456 8.21 In-house 76-199 (425) Show / Hide
Range on Protein: 88-166
Range on HMM: 76-199/425
Sequence Identity: 14% (18 aa)

DAIKRRLAALLSAS-------HPGVLKYHQVLTDGNT-------------------ILVVT---DRCCG-----DLRQFITDHRD----------IHES-
. ..| .. . . .       || ..| ..|  |..                    .  |.   . | |     || ..|..|..          . |. 
KNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERG

-VPNELVLSLLGQLAGALAYLHGLG
 .. . .  .  |.. |..|.| ..
RFTEREARRYFRQICSAVHYCHSHN

Kinase GL50803_113030.AA TK 93-163 11 0.000579 8.33 In-house 90-251 (486) Show / Hide
Range on Protein: 93-163
Range on HMM: 90-251/486
Sequence Identity: 11% (18 aa)

RLAALLS---ASHPGVLKYHQVLTDGNT------------ILVVTDRCC-GD----LRQFITDHR-----------------------------------
. .....     || ... . | |.| .            ...|.  .. ||    ||..  ..|                                   
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE

-----------------DIHESVPNELVLS-------------------LLGQLAGALAYLH
                 |. ....    |.                      |.| ...|||
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLH

Kinase GL50803_113030.AA Ciliate-E2 97-163 20 0.001327 8.22 In-house 86-177 (365) Show / Hide
Range on Protein: 97-163
Range on HMM: 86-177/365
Sequence Identity: 20% (19 aa)

LLSASHPGVLKYHQVLT--DGNTILVVTDRCCG-DLRQFITDHRDIHESVPN-------ELVLSLLGQLAG---------------ALAYLH
| . .|| ..|.. .    | |.|  |.. | | ||...| ...  . . ..       . .. .  |..                || |||
LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH

Kinase GL50803_113030.AA CAMK 270-296 26 0.002258 5.93 In-house 384-417 (425) Show / Hide
Range on Protein: 270-296
Range on HMM: 384-417/425
Sequence Identity: 26% (9 aa)

SGIADD-------LARSVLEKMLVLDPAERPTAK
..| |.        ... . |||. || .|.|..
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIE

Kinase GL50803_113030.AA AGC 277-297 33 0.013195 0.96 In-house 358-378 (395) Show / Hide
Range on Protein: 277-297
Range on HMM: 358-378/395
Sequence Identity: 33% (7 aa)

ARSVLEKMLVLDPAERPTAKG
|.. ..|.|. ||..|....|
AKDLIKKLLCKDPEKRLGCGG

Kinase GL50803_113030.AA Pkinase 94-166 20 0.017416 9.87 Pfam 51-128 (293) Show / Hide
Range on Protein: 94-166
Range on HMM: 51-128/293
Sequence Identity: 20% (16 aa)

LAALLSASHPGVLKYHQVLTDGNTILVVTDRC-CG----DLRQFIT--DHRDIHESVPNELVLSLLGQLAGALAYLHGLG
.. ... .|| ..... . .|.. | .|.. | .|    ||  .|.  .|. .    . . . . . |.. .|.|.|  |
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY--FSEWECKFYMYQILRGLEYCHSMG

Kinase GL50803_113030.AA Ciliate-E2-Unclassified 97-163 23 0.059717 2.58 In-house 75-160 (352) Show / Hide
Range on Protein: 97-163
Range on HMM: 75-160/352
Sequence Identity: 23% (20 aa)

LLSASHPGVLKYHQVLTDGNTILVVTDRC-CGDLRQFITD------------HRDIH-ESVPNELVL-----SLLGQLAGALAYLH
||.  || ..|.. . .| ..|  |.. |  |||.|.|..            |.  . . .. . ..      .. |.  .| |||
LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH

Ank GL50803_113030.AA Ank 406-422 35 22.641373 1.99 Pfam 6-22 (33) Show / Hide
Range on Protein: 406-422
Range on HMM: 6-22/33
Sequence Identity: 35% (6 aa)

LMRAVDRNDVEAVKALI
|. |. ....| || |.
LHLACRCGHTEVVKMLL

Ank GL50803_113030.AA Ank 442-462 38 1.256871 6.52 Pfam 1-21 (33) Show / Hide
Range on Protein: 442-462
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

YEGTALIRAAVYGYTEIVELL
.  |.|  |. .|.||.|..|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_113030.AA Ank 473-496 37 4.7e-05 22.49 Pfam 1-24 (33) Show / Hide
Range on Protein: 473-496
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

NGWTALMYTARTGHADCLKLLLEK
.|.|.|.. .| ||....|.||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_113030.AA Ank 504-534 39 1e-06 28.52 Pfam 1-33 (33) Show / Hide
Range on Protein: 504-534
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

KGRTALMSAASAGHLECIKLLLK--NEVGMQDN
 |.|.|. |.. ||.|..|.||.   .| .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_113030.AA Ank 535-565 36 1e-05 24.91 Pfam 1-33 (33) Show / Hide
Range on Protein: 535-565
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

DGETALMAAAGNGHRDCVELLLE--REGGIQDN
||.|.|. |. .|| ..|..||.   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_113030.AA Ank 566-589 33 0.000784 18.08 Pfam 1-24 (33) Show / Hide
Range on Protein: 566-589
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

SKWTALMIAAEQGYTDCAKLLLER
  .|.|..|.. |.|...|.||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_113030.AA Ank 597-620 37 2e-06 27.64 Pfam 1-24 (33) Show / Hide
Range on Protein: 597-620
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

DGWTALMWAAKNGHAGCVRLLVEK
||.|.|..|...||. .|..|...
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_113030.AA Ank 628-657 24 0.004928 15.2 Pfam 1-33 (33) Show / Hide
Range on Protein: 628-657
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

HGWPALTVAAQSGYIECARLLVR---EKNIRDN
.|. .| .|...|..|....|.    . |..|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_113030.AA Ank 658-678 23 41.491427 1.04 Pfam 1-21 (33) Show / Hide
Range on Protein: 658-678
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

MDETALDMAKLWRRHEIIALL
. .|.| .| .. ..|.. .|
DGFTPLHLACRCGHTEVVKML