Gene GL50803_137676 (G.lamblia)

GL50803_137676

Species: G.lamblia
Alias: GK143, GL50803_137676
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137676.AA Protein None 394 None Fasta, JSON
GL50803_137676.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of GL50803_137676.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_137676.AA Pkinase 108-310 20 2.1e-21 76.73 Pfam 59-293 (293) Show / Hide 
Range on Protein: 108-310
Range on HMM: 59-293/293
Sequence Identity: 20% (50 aa)

HPDVLKYHQVLTDGNTILVVTDRC-CG----DLRQFITDYRDIHEPI--PSKLMLSLLGQLAGALAHLHGFSRGAHSGLPSSVV---LEPDNVLFAGDGR
|| ..... . .|.. | .|.. | .|    ||  .|.   . | ..  . .   . . |.. .|...|            ...   | |.|.|.  .| 
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGH

R---VVLADFGFCE---GISSGAAK--AGDPAYMAPETLL-CGDMTQASDVWSLGAIAYELATLRKPDFLGD-----RDPAEVFVDGWRPDLSGIAD---
    | ..|||...     ... ..  .| | ||||| .. . . ....|.||.| | ||... ..| | |.     .|. ....   .|.|.   .   
IDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWC

--------------------DLARSVLERMLVLDPAERPTARELARLLQM
                    . ........| .||..||||...     .
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_137676.AA AGC 187-251 21 8e-17 38.57 In-house 183-300 (395) Show / Hide 
Range on Protein: 187-251
Range on HMM: 183-300/395
Sequence Identity: 21% (26 aa)

PDNVLFAGDGRRVVLADFGFCEGISSGA----------------------------------------------------AK--AG--DPAYMAPETLLC
|.|.|.  |   . |.|||.|  . ..                                                     ..   |   | ||||| |  
PENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--

GDMTQASDVWS--LGAIAYELAT
   ..| | ||  ||.. ||. |
--YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_137676.AA STE 187-304 21 1.7e-15 51.3 In-house 180-351 (359) Show / Hide 
Range on Protein: 187-304
Range on HMM: 180-351/359
Sequence Identity: 21% (39 aa)

PDNVLFAGDGRRVVLADFGFCEGISSGAA----------------K----AGDPAYMAPETLLC------GDMTQASDVWSLGAIAYELATLRKP----D
|.|.|.      | |.|||.|  ...  |                |    .| | .|||| ...      .. .  .|.||||  . |.|| . |     
PANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH

FLGD--RDPAE----------VFVDGWRPDLSGIAD-------------------DLARSVLERMLVLDPAERPTAREL
 .    . | .            |.|  | |    .                   .  .  ... |. || .|||| .|
PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQL
S_TKc GL50803_137676.AA S_TKc 55-310 22 7e-14 26.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 55-310
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

MGVWGACSAGALSVIYSLRGCP---YLVVREIRLDGLDQHSVDAIRRRLTALLGTLHPDVLKYHQVLTDGNTILVVTDRCCG---DLRQFITDYRD--IH
  .      || .. |  |      .  . .|.         . ||| .  |    || . |.. |  | . . .|.. | |   ||...| ...    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EPIPSKLMLSLLGQLAGALAHLHGFSRGAHSGLPSSVVLEPDNVLFAGDGRRVVLADFGFCEGISSGAAKAGDPAYMAPETLLCGDMTQ-ASDVWSLGAI
 |.|     ... |.. ||...|   .  |        | |.|.|.     .. ..|||..  .       | | ||||| |     .  ..|.||.| |
FPFPE-HARFYMYQICCALEYCHSH-GIIHRD------LKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

AYELATLRKPDFLGDRDPAEVFVDGWRPDLSGIADDLARSVLERMLVLDPAERPTARELAR-------LLQM
 ||... ..| |    .....|            .. |.. ....|. ||..|||| |. .          .
LYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_137676.AA TKL 187-308 15 1.9e-13 44.77 In-house 168-364 (364) Show / Hide 
Range on Protein: 187-308
Range on HMM: 168-364/364
Sequence Identity: 15% (30 aa)

PDNVLFAGDGR-------------RVVLADFGFCEGISSGAA-----------------------KAGDPAYMAPETLL----------------CGDMT
..|.|   ...             .. ..|||..  .|                           . | |..|||| |                 ... .
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

QASDVWSLGAIAYELATLRKPDF-LGDRDPA---------EVFVD-GWRPDLS------------GIADDLARSVLERMLVLDPAERPTARELARLL
...||.| | . .|..| ..| . .. ...          .. .| | || .               ...  .. ...    || .||.. |.   |
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_137676.AA NEK6 108-261 32 6.2e-13 38.65 In-house 58-207 (252) Show / Hide 
Range on Protein: 108-261
Range on HMM: 58-207/252
Sequence Identity: 32% (51 aa)

HPDVLKYHQVLTDGNTILVVTDRC-CGDLRQFITDYRDIHEPIPSKLMLSLLGQLAGALAHLHGFSRGAHSGLPSSVVLEPDNVLFAGDGRRVVLADFGF
||.|.|| .   . | . .| .    ||. . |  ..     || . .     ||. ||.|.|   |  |        . | ||   ..|  | | | | 
HPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMH-SKRVMH------RDIKPANVFITANG-IVKLGDLGL

CEGISSGAAKA----GDPAYMAPETLLCGDMTQASDVWSLGAIAYELATLRKPDFLGDR
    ||    |    | | ||.|| .        ||.|||| . ||.| |  | | ||.
GRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSP-FYGDK
Kinase GL50803_137676.AA Ciliate-E2 187-304 15 2.1e-12 38.86 In-house 189-359 (365) Show / Hide 
Range on Protein: 187-304
Range on HMM: 189-359/365
Sequence Identity: 15% (31 aa)

PDNVLFAGDGRRVVLADFGFCEGISS--------GAAK---------------------------AGDPAYMAPETLLCGD---------MTQASDVWSL
|.|.||      . ..|||..  ..           .|                           .| | ||||| |  ..          . ..|.|||
PENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GAIAYELATLRKPDFLGDRDPAEVFVDGWRPDLSGIADDLA-------------------------------RSVLER----MLVLDPAERPT-AREL
| | ||. . . |                      .   .                                   . .    ||. || .|.| . ..
GVILYEMLFGKPPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GL50803_137676.AA TK 192-308 17 1.7e-11 34.03 In-house 283-486 (486) Show / Hide 
Range on Protein: 192-308
Range on HMM: 283-486/486
Sequence Identity: 17% (36 aa)

FAGDGRRVVLADFGFC---------------EGISSGAAKAGDPA-----------------------YMAPETLL---------CGDMTQASDVWSLGA
| |.|. . .|||| .               .  ...  ..|.|.                       .||||.|.          |  | .|||||.| 
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

IAYELATLRKPDFLGDRDP------------AEVFVDG---------------WRPDLSGIAD-------------DLARSVLERMLVLDPAERPTAREL
  .|. |. .  . |. .              |  ..|                .|   .  |             ..   .. .   .||..||| ..|
LMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

ARLL
 . |
HEQL
Kinase GL50803_137676.AA Ciliate-E2-Unclassified 185-255 25 7e-11 34.0 In-house 170-269 (352) Show / Hide 
Range on Protein: 185-255
Range on HMM: 170-269/352
Sequence Identity: 25% (25 aa)

LEPDNVLFAGDGR--RVVLADFGFCEGISS-------------------GAAKAGDPAYM----APETLLCGDMT----QASDVWSLGAIAYELATLRKP
. |.|.||  .|.  .. ..|||..  . .                      ..| | ||    ||| |           ..|.|||| |.||. . . |
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase GL50803_137676.AA Fer 222-309 21 1.1e-10 32.75 In-house 184-283 (283) Show / Hide 
Range on Protein: 222-309
Range on HMM: 184-283/283
Sequence Identity: 21% (21 aa)

YMAPETLLCGDMTQASDVWSLGAIAYELATLRKPDFLG-----------DRDPAEVFVDGWRPDLS-GIADDLARSVLERMLVLDPAERPTARELARLLQ
..||||.  |  . ..|||| |  ..|  |  . ...|           ... . . ..| .. .  . ...... ....  . || .|||. |. . | 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase GL50803_137676.AA CAMK 187-247 18 2.4e-09 25.51 In-house 207-325 (425) Show / Hide 
Range on Protein: 187-247
Range on HMM: 207-325/425
Sequence Identity: 18% (22 aa)

PDNVLFAGDG----------------RRVVLADFGFCEGISSGA---------------------------AKAGDPAYMA-PETLLC------------
|.|.|.  ..                  . ..||||   . .|                               | |.||| || |.             
PENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDE

--GDMTQASDVWSLGAIAY
     ....|.||.| | |
EKPYYGPKCDMWSCGVILY
TyrKc GL50803_137676.AA TyrKc 66-308 18 4e-09 -75.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-308
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

LSVIYSLRGCPYLVVRE-----------IRLDGLDQHSVDAIRRRLTALLGT--LHPDVLKYHQVLTDG-------NTILVVTDRCC-GDLRQFITDYRD
.. .  |  . . .|..           .. |      . ...| .  .      || ... . | |..         ...|.  .. |||.... ..|.
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

IHEPIPSKLMLSLLGQLAGALAHLHGFSRGAHSGLPSSVV---LEPDNVLFAGDGRRVVLADFGFCEGISSG--------AAKA----GDP-----AYMA
    .. | .||   | |   ..||             ..   |   |.| . .. .|  .||| .  | ..          ..    |         ||
K---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PETLLCGDMTQASDVWSLGAIAYELATLRKPDFLGD----RDPAEVF---VDGWRPDLSGI---------ADDLARSVLERMLVLDPAERPTARELARLL
||..  |  | .||||| |   .|. |. ..   |.     ...||.    .| |..              |.. . . ..    ||..||| .|. ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_137676.AA WEE 201-251 35 4.2e-09 26.76 In-house 173-231 (297) Show / Hide 
Range on Protein: 201-251
Range on HMM: 173-231/297
Sequence Identity: 35% (21 aa)

LADFGFCEGIS-----SGAAKAGDPAYMAPETLLCG--DMTQA--SDVWSLGAIAYELAT
..||| .  ..     .. .  ||. ||||| .| |  ..| .  .|. |||.  ||||.
IGDFGHVTDMNSNNNNPHQEQEGDSRYMAPE-ILQGYYHYTHLYKADIFSLGITIYELAC
Kinase GL50803_137676.AA TK 108-169 12 0.001084 7.4 In-house 102-251 (486) Show / Hide 
Range on Protein: 108-169
Range on HMM: 102-251/486
Sequence Identity: 12% (19 aa)

HPDVLKYHQVLTDGNT------------ILVVTDRCC-GD----LRQFITDYR-----------------------------------------------
|| ... . | |.| .            ...|.  .. ||    ||..  . |                                               
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

-----DIHEPIPSKLMLS-------------------LLGQLAGALAHLH
     |. .|.. | .|.                      |.| ....||
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLH
Kinase GL50803_137676.AA CAMK 276-303 22 0.003032 5.51 In-house 384-418 (425) Show / Hide 
Range on Protein: 276-303
Range on HMM: 384-418/425
Sequence Identity: 22% (8 aa)

SGIADD-------LARSVLERMLVLDPAERPTARE
..| |.        ... . .||. || .|.|. .
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ
Kinase GL50803_137676.AA WEE 284-310 25 0.026618 3.61 In-house 271-297 (297) Show / Hide 
Range on Protein: 284-310
Range on HMM: 271-297/297
Sequence Identity: 25% (7 aa)

RSVLERMLVLDPAERPTARELARLLQM
....  |.  ||  |||...| .   .
KQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase GL50803_137676.AA Ciliate-E2-Unclassified 274-310 24 0.052391 2.78 In-house 316-352 (352) Show / Hide 
Range on Protein: 274-310
Range on HMM: 316-352/352
Sequence Identity: 24% (9 aa)

DLSGIADDLARSVLERMLVLDPAERPTARELARLLQM
..|  | |. .  | .||. .| .|.|. ..     .
HWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF