Gene GL50803_137695 (G.lamblia)

GL50803_137695

Species: G.lamblia
Alias: GK032, GL50803_137695
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_137695.AA Protein None 860 None Fasta, JSON
GL50803_137695.kin_dom Protein Kinase Domain None 343 None Fasta, JSON

Protein domain

Protein domains of GL50803_137695.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_137695.AA DyrkP 514-856 39 3.6e-81 266.99 In-house 1-323 (323) Show / Hide 
Range on Protein: 514-856
Range on HMM: 1-323/323
Sequence Identity: 39% (138 aa)

YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYIN-KHDPTGKHFVRMTDYFYYGHRLIIIFELLTSNLFSYYS-AREAAL
| |        |||  ..  |.. .. .|.|.. | ||  || . ||.|| |||   |   |  .|. ||||    | || |||  ||. .|   ||   
YQIME-YLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRE---

PRTLLNPLATIFTMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDECSTYVQSRSYRCPEVILGLPYDGRADVW
     |     ||. ||| |  ||| .||..| | ..| ||| ||.|.        .....| ||| |. |  | |||||||| ||||.|  || | |.|
-----NEQQRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPK--CQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMW

SLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGPIPRDMILAGRESHKLFTKDLFL----FETREAILGNRDKAEGLRHAEIKGEDYVYVLP
||| || || || |.|    . |.       .||. ||||||.|  |.  ||  .  ||..  |    ||  .      |. .. |.    |   . | |
SLGCILAELWTGNVLF----QNDN----IQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRLLYMDVFEEADQSQNINDQQDMQRQRQKTGKIQILV-P

KKTTIKAMLGWDSHPEYCDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
|.  ..| |  |      | .|.||.  .. ||  .|||| |||.|||.
KHSNLRARLRTD------DHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase GL50803_137695.AA DYRK 514-856 33 3.9e-77 262.57 In-house 1-320 (320) Show / Hide 
Range on Protein: 514-856
Range on HMM: 1-320/320
Sequence Identity: 33% (117 aa)

YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTGK-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSAREA-AL
|||.. |     |.   |..| | ...|..|...|.|. ..| ..||..| |.|..||. | |.|.| ||||.   | |.||||  ||. ..  .    .
YEILEYIGK-GSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

PRTLLNPLATIFTMPRLQHIARQILESLDFLHRL-NILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDECSTYVQSRSYRCPEVILGLPYDGRADV
           |.. . . .|.|||..|.|||.. ||.| ||| || .|...  .  .| ..| ||| |  ....||.||| || ||||||.||.   |.
-----------FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDM

WSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGPIPRDMILAG--RESHKLFTKDLFLFETREAILGNRD--KAEGLRHAEIKGEDYVYVL
|||| || || ||...||    ..| .     .||. . ..|..|..|| .|  |  || |..  | ... .   . ..  .. . .   ..   ... .
WSLGCILAELFTGWPLFP---GENEYD-----QLACIMEVLGMPPKWMIDKGRCRRKHKFFDC--FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRP

PKKTTIKAMLGWDSHPEYCDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
|... ... .         |..|.|||.    .||.||.|...||.|||.
PGRRNWDPRHQ-CD-----DHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase GL50803_137695.AA CMGC 514-856 19 7.8e-60 194.89 In-house 1-513 (513) Show / Hide 
Range on Protein: 514-856
Range on HMM: 1-513/513
Sequence Identity: 19% (102 aa)

YEIYKTIFEDSAFSVTLKARD--------------LKEGKDVCLKVVNNEKDTLDQCL-------------NEIRLLTYIN-KHDPTG----------KH
||| | | |  ...|  |.||               . .. | .| . |..   .|..              ||..| ..| .||| .          .|
YEIIKKIGE-GTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHH

--FVRMTDYFYYGH-----------------RLIIIFELLTSNLFSYYSA--------REAALPRTLLN--------PLATIFTMPRLQHIARQILESLD
   |.. |.||. .                  | ..||..  .|. |           |   |.    |        ..   |..   . ...|||..|.
NNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLK

--FLHRLN--ILHLDLKHENLLLVNEDD----------------DSFDIRLVDIGSSAFLYDE------------------------CSTYVQSRSYRCP
  ..|. .  |.| ||| ||.|. .. .                ... ... | |.. .. ..                         ..||..| || |
LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP

EVILGLP----------YDGRADVWSLGPILTELITG--------KVMFP------IPQKADEDHKPYASMLAKLIGIIGPIPRDMILAGRESHKLFTKD
|..|| .          |.   |.||.| |. |..||        | .||      . ..   . | .  .|.| . ..|...  || .|. .|  |   
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPN-DD-K-NGKSHIDQLFKIFKVLGTPT-WMIQKGK-RH--F---

LFLFETREAILGNRDK--------------------AEGLRHAEIKGEDYVYVLP---KKTTIKAMLGWDSHPEY-------------------------
   | ..| .  |. |                     |. |..  .. ..  . |   |.   ..  . |   ..                         
-N-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRK

-CDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
 ||....|... ....|| ||.||..||.||..
CCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_137695.AA S_TKc 514-856 21 9.2e-49 169.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 514-856
Range on HMM: 1-231/231
Sequence Identity: 21% (77 aa)

YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTGKHFVRMTDYFYYGHRLIIIFELLTS---NLFSYYSAREAA
||| ..|    ||..  |.|. | |. | .|...      .. ..||..|          .. |.. |.|.  ..| ...|..     .||.|   |   
YEILRKI-GKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

LPRTLLNPLATIFTMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDECSTYVQSRSYRCPEVILGLPYDG-RAD
 .|         |.  . .....||.. |...|...|.| ||| ||.|| .       | . | |....|    .|.. .. |. |||.   .|.. ..|
GLR-------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCD

VWSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGPIPRDMILAGRESHKLFTKDLFLFETREAILGNRDKAEGLRHAEIKGEDYVYVLPKK
.||.| || |...|.  ||               ..... .||                                                         
WWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG---------------------------------------------------------

TTIKAMLGWDSHPEYCDDLFLDFIETIMRIDPRKRPTAAEALE-------HPWL
                .. ..|||. ... ||.||||| |||.       |||.
----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_137695.AA DYRK1 514-772 36 5.8e-36 123.54 In-house 1-240 (321) Show / Hide 
Range on Protein: 514-772
Range on HMM: 1-240/321
Sequence Identity: 36% (96 aa)

YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTGK-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSAREAALP
|||   |   | |    || | .| . | .|.. | |  ..| . |||||  .||||.  | . |..   | .   | ..||||  ||  |   |     
YEIDSLIGKGS-FGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNL--YDLLRNTHFR

RTLLNPLATIFTMPRLQHIARQILESLDFLH--RLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDECSTYVQSRSYRCPEVILGLPYDGRADV
   || |.  |        |.|.. .| |.    |.|.| ||| ||.||.|       |...| |||  | .    |.||| || |||.||..||   |.
GVSLN-LTRKF--------AQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDM

WSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGPIPRDMILAGRESHKLFTKD
|||| || |. ||  .|   .  |         . |.. ..|  |..||  .  .|| |.||
WSLGCILVEMHTGEPLFSGSNEVDQ--------MNKIVEVLGMPPKHMIDQAPKAHKYFEKD
Kinase GL50803_137695.AA DYRK2 623-728 46 3.6e-33 104.96 In-house 99-203 (318) Show / Hide 
Range on Protein: 623-728
Range on HMM: 99-203/318
Sequence Identity: 46% (50 aa)

FTMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYD-ECSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELI
|..      |..||..|.|||. || | ||| || || ..   | .| ..| ||| | .     ||.||| || ||||||..|..  | ||.| |. || 
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILL-KQWNRS-GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELY

TGKVMFP
||. .||
TGYPLFP
Kinase GL50803_137695.AA Pkinase 525-756 22 1.3e-31 112.89 Pfam 11-236 (293) Show / Hide 
Range on Protein: 525-756
Range on HMM: 11-236/293
Sequence Identity: 22% (56 aa)

AFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLN-----EIRLLTYINKHDPTGKHFVRMTDYFYYGHRLIIIFELLTS-----NLFSYYSAREAALPRT
.|..  |... ..|| |..|... ...  ... .     ||...  .|      .. ||. |.|... .. ...|..        ||.| |.        
SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------

LLNPLATIF--TMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSS----AFLYDECSTYVQSRSYRCPEVIL-GLPYDGR
      . |  ..  ......|||. |...|. .|.| ||| ||.|..|... . .... | |..       .  ..|.. .. |. ||||. | .|. .
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVWSLGPILTELITGKVMFPIPQKADEDHKPYASMLAKLIGIIGPIPR
.|.||.| || |...|.   |. . .. .|.. .......  | ||...
VDMWSCGCILYEMLCGR---PPFPGHC-WHDN-HDQMQMICRIMGPPLH
Kinase GL50803_137695.AA CAMK 629-714 22 6.9e-24 73.23 In-house 182-321 (425) Show / Hide 
Range on Protein: 629-714
Range on HMM: 182-321/425
Sequence Identity: 22% (31 aa)

QHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDS-------------FDIRLVDIGSSAFL--------------------------YDECSTYVQ
... |||.. ....| .|| |.||| ||.||.. .|||             ..| ..| | ....                           . ..|.. 
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG

SRSYRC-PEVILG--------------LPYDGRADVWSLG
. .| . |||..|               .|.  .|.||.|
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase GL50803_137695.AA CLK 514-662 28 1.8e-22 63.58 In-house 1-150 (350) Show / Hide 
Range on Protein: 514-662
Range on HMM: 1-150/350
Sequence Identity: 28% (45 aa)

YEIYKTIFEDSAFSVTLKARDLKEGK-DVCLKVVNNEKDTLDQCLNEIR-LLTYINKH-DPTGKHF---VRMTDYFYY-GHRLIIIFELLTSNLFSYYSA
|||..|  |  .|.  .. .| | ||  | ||.. | .   ..   ||.  .  ||.  || .|.    ..| |.| | . .  |.|||.  ....   .
YEIVCTLGE-GTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKS

REAALPRTLLNPLATIFTMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNE
  . .|     |    . .   .|.|.|..|.. ||| . . |.||| || ..|..
NNSKMPN-KYIP----YPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase GL50803_137695.AA PRP4 632-728 44 7.3e-21 73.13 In-house 112-206 (320) Show / Hide 
Range on Protein: 632-728
Range on HMM: 112-206/320
Sequence Identity: 44% (44 aa)

ARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYD-ECSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFP
|.|..  |  | ..|||| |.|  | .||||.     . ..| ||     . |   | .|| || ||.|.| |||   |.|| |  | || |||.|||
AQQLFLALKHLKKCNILHADIKPDN-ILVNESKNT--LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFP
Kinase GL50803_137695.AA YAK 634-720 40 5.5e-20 64.25 In-house 114-198 (347) Show / Hide 
Range on Protein: 634-720
Range on HMM: 114-198/347
Sequence Identity: 40% (35 aa)

QILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDECSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTEL
|||...  |   .| | ||| || .| .   .. .|...| |||        ||.|.| || ||.|.. .|    | |||| |. ||
QILDGMCVLENKQIIHCDLKPENIMLCKP--NKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase GL50803_137695.AA CLK 666-729 44 8.1e-20 55.43 In-house 183-249 (350) Show / Hide 
Range on Protein: 666-729
Range on HMM: 183-249/350
Sequence Identity: 44% (30 aa)

SFDIRLVDIGSSA---FLYDECSTYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFPI
...|...| ||     | .   || |..| || |||||||..  . |||| | || || ||  .|..
NTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase GL50803_137695.AA STE 628-725 29 1.5e-19 65.74 In-house 153-266 (359) Show / Hide 
Range on Protein: 628-725
Range on HMM: 153-266/359
Sequence Identity: 29% (37 aa)

LQHIARQILES-LDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYD-------------------ECSTYVQSRSYRCPEVILG------
. .|.||||.  |..||...| | |.|  | ||         . |.| | .. | |                   .. | | .  .  ||||..      
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRD

LPYDGRADVWSLGPILTELITGKV
 .|| ..|.||||  . |..|||.
KGYDTKCDIWSLGCTIIEMATGKP
Kinase GL50803_137695.AA DYRK2 514-603 37 1.2e-17 53.7 In-house 1-90 (318) Show / Hide 
Range on Protein: 514-603
Range on HMM: 1-90/318
Sequence Identity: 37% (34 aa)

YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTGKH-FVRMTDYFYYGHRLIIIFELLTSNLFSY
||| . |   | | . .|. | | .. |..|.. |.|  . | . ||| | .| ..|... .  |.| ||||.   ..| ||||  || .|
YEILEVIGKGS-FGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEY
Kinase GL50803_137695.AA CAMK 821-856 33 3.9e-12 34.67 In-house 391-425 (425) Show / Hide 
Range on Protein: 821-856
Range on HMM: 391-425/425
Sequence Identity: 33% (12 aa)

HPEYCDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
|. ....   |.|  ... || ||.|....|.|||.
HH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_137695.AA YAK 544-603 35 5.9e-11 33.05 In-house 30-94 (347) Show / Hide 
Range on Protein: 544-603
Range on HMM: 30-94/347
Sequence Identity: 35% (23 aa)

KVVNNEKDTLDQCLNEIRLLTYIN-KHDPTGKH----FVRMTDYFYYGHRLIIIFELLTSNLFSY
||. |    . |  |||..|   | .|||..|.    ..|| |.| .   . ..||.|  ||. |
KVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEY
Kinase GL50803_137695.AA CLK 825-856 34 1.4e-09 24.19 In-house 319-350 (350) Show / Hide 
Range on Protein: 825-856
Range on HMM: 319-350/350
Sequence Identity: 34% (11 aa)

CDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
. . . | |. .. .|| ||.|...|| ||. 
EHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase GL50803_137695.AA DYRK2 826-856 45 2.2e-09 26.34 In-house 288-318 (318) Show / Hide 
Range on Protein: 826-856
Range on HMM: 288-318/318
Sequence Identity: 45% (14 aa)

DDLFLDFIETIMRIDPRKRPTAAEALEHPWL
|..|.|||   .  || .| |...||.|||.
DENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase GL50803_137695.AA STE 821-856 26 5.8e-09 27.92 In-house 300-359 (359) Show / Hide 
Range on Protein: 821-856
Range on HMM: 300-359/359
Sequence Identity: 26% (16 aa)

HPEYCD----------------------DLFLDFIETIMRIDPRKRPTAAEALE--HPWL
.|   |                      . | |||.   ..||.||||| . |.  ||..
PPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_137695.AA YAK 827-856 36 5.6e-08 22.78 In-house 318-347 (347) Show / Hide 
Range on Protein: 827-856
Range on HMM: 318-347/347
Sequence Identity: 36% (11 aa)

DLFLDFIETIMRIDPRKRPTAAEALEHPWL
|.|.|||  .   .||.| ..  | .|| .
DCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase GL50803_137695.AA Pkinase 820-856 28 1.4e-07 27.94 Pfam 238-293 (293) Show / Hide 
Range on Protein: 820-856
Range on HMM: 238-293/293
Sequence Identity: 28% (16 aa)

SHPEYCD-------------------DLFLDFIETIMRIDPRKRPTAAEALEHPWL
. |. |.                   . ..|||. . . || |||||...|.|||.
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_137695.AA PRP4 829-856 42 2.4e-07 23.03 In-house 293-320 (320) Show / Hide 
Range on Protein: 829-856
Range on HMM: 293-320/320
Sequence Identity: 42% (12 aa)

FLDFIETIMRIDPRKRPTAAEALEHPWL
| |... ..  || || |  |||.|| .
FKDLLDKCLMLDPKKRITCNEALKHPFI
TyrKc GL50803_137695.AA TyrKc 502-856 13 1e-05 -130.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 502-856
Range on HMM: 1-280/280
Sequence Identity: 13% (55 aa)

MRFKK-------GAVLAGRYEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYI-NKHDPTGKHFVRMTDYFYYG-------
 ...|       | |  |..                         .|  |......  .   ..|.|... .  .|    .. ||.  .   .       
ITLGKKLGEGAFGEVYKGTWK-----------------------IQVAVKMLKEDA--REDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRNFMYI

HRLIIIFELLTS-NLFSYYSAREAALPRTLLNPLATIFTMPRLQHIARQILESLDFLHRLNILHLDLKHENLLLVNEDDDSFDIRLVDIGSSAFLYDE--
. | |..|.    .| .|  ...              ..|. | ... || .  ..||. |. | ||   | |. ..      ..  | | | ..||.  
EPLMIVMEYMPHGDLKDYLRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQ

----CSTYVQSR--SYR--------CPEVILGLPYDGRADVWSLGPILTELITGKVMFPIPQ----KADEDHKPYASMLAKLIGIIG--PIPRDMILAGR
     ..|...   . .         ||.|    .    |||| |  . |. |   . .  .    . ...   |      .       |.         
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------

ESHKLFTKDLFLFETREAILGNRDKAEGLRHAEIKGEDYVYVLPKKTTIKAMLGWDSHPEYCDDLFLDFIETIMRIDPRKRPTAAEALEHPWL
                                                        .    | |   . ...  . || .||| .|   |  .
--------------------------------------------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_137695.AA DYRK1 829-856 35 0.000456 9.62 In-house 294-321 (321) Show / Hide 
Range on Protein: 829-856
Range on HMM: 294-321/321
Sequence Identity: 35% (10 aa)

FLDFIETIMRIDPRKRPTAAEALEHPWL
| | |. ... ||..| |  .||.|...
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase GL50803_137695.AA PRP4 514-600 27 0.000622 10.38 In-house 1-90 (320) Show / Hide 
Range on Protein: 514-600
Range on HMM: 1-90/320
Sequence Identity: 27% (25 aa)

YEIYKTIFEDSAFSVTLKARDLKEGK-DVCLKVVNNEKDTLDQCLNEIRLLTYINKH--DPTGK-HFVRMTDYFYYGHRLIIIFELLTSNL
|..|  . .   ||   ..||.  |. .|  |.. |     .  | |.  |  .|    |.  | | ||| . |..   . ..|| .  ||
YRVYGYCGQ-GVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNL