Gene GL50803_13963 (G.lamblia)
GL50803_13963
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_13963.AA | Protein | None | 379 | None | Fasta, JSON |
| GL50803_13963.kin_dom | Protein Kinase Domain | None | 277 | None | Fasta, JSON |
Protein domains of GL50803_13963.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_13963.AA | Ciliate-E2-Unclassified | 164-288 | 17 | 2.2e-14 | 46.34 | In-house | 177-352 (352) | Show / Hide |
Range on Protein: 164-288 Range on HMM: 177-352/352 Sequence Identity: 17% (30 aa) LDNLG---VVTVAQIRMSKYIETN----------------NVDCQSANTARYL----SPEILMGKQAT----WASDIWSLGCFMYEFYLGVPYIQGTCLS .|| | . .. ||....| . .. . | .|. .||.|.|.. ..||||||. .||. | . .... FDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCE E---------------ILHSIS-APPSFKSDPLL----TGKDANIISLLS----QMLAPEPSQRIYAKQILKLNTV . .|... . . ... . . . . ... .|| |..|| ..|||. QHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_13963.AA | Pkinase | 193-284 | 22 | 3.9e-13 | 47.52 | Pfam | 174-289 (293) | Show / Hide |
Range on Protein: 193-284 Range on HMM: 174-289/293 Sequence Identity: 22% (26 aa) TARYLSPEILM-GKQATWASDIWSLGCFMYEFYLGVPYIQGT------CLSEILHSISAPPSFKSDPLLTGKD-----------------ANIISLLSQM | .|..||... |. . ..|.||.|| .||...| | .| . ... | || . | . . . ..... . TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LAPEPSQRIYAKQILK |.. |..|. |.|||. LCKDPKKRPTAEQILQ |
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| Kinase | GL50803_13963.AA | AGC | 193-277 | 23 | 5.8e-13 | 28.36 | In-house | 270-374 (395) | Show / Hide |
Range on Protein: 193-277 Range on HMM: 270-374/395 Sequence Identity: 23% (26 aa) TARYLSPEILMGKQATWASDIWS--LGCFMYEFYLGVPYIQGT----------CLSEILHSISAPPSFKSDPLL------------TGKDANIISLLSQM |. |..|||| . | |.|| |||.|||. | | .| |. ..| . |..... . . .|.... TPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKL LAPEPSQRI | ..|..|. LCKDPEKRL |
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| Kinase | GL50803_13963.AA | Ciliate-E2 | 193-288 | 24 | 1.8e-12 | 39.07 | In-house | 250-365 (365) | Show / Hide |
Range on Protein: 193-288 Range on HMM: 250-365/365 Sequence Identity: 24% (30 aa) TARYLSPEILMGKQ---------ATWASDIWSLGCFMYEFYLGVPYIQGTCLSEILH-SISAPPSFKSDPLLTGKD-----------ANIISLLSQ---- |. |..||||.||. . ..||||||. .||. | | . .|. |. |. .. .. .. . . . |... TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKR MLAPEPSQRIY-AKQILKLNTV || .|..|| ..|||. MLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_13963.AA | Akt | 196-228 | 55 | 6.6e-12 | 34.26 | In-house | 168-201 (264) | Show / Hide |
Range on Protein: 196-228 Range on HMM: 168-201/264 Sequence Identity: 55% (19 aa) YLSPEILMGKQATWASDIWS-LGCFMYEFYLGVP ||.|||| |. .| |.|.|. |||.|||.. | | YLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRP |
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| Kinase | GL50803_13963.AA | PDK1 | 193-228 | 50 | 1.5e-10 | 28.01 | In-house | 202-237 (307) | Show / Hide |
Range on Protein: 193-228 Range on HMM: 202-237/307 Sequence Identity: 50% (18 aa) TARYLSPEILMGKQATWASDIWSLGCFMYEFYLGVP || | ||| | .|..| ..|||.||| | . | | TAEYVSPELLTDKECTPSCDIWALGCIIYQMVAGQP |
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| Kinase | GL50803_13963.AA | PLK1 | 193-288 | 31 | 3.5e-10 | 29.41 | In-house | 162-253 (253) | Show / Hide |
Range on Protein: 193-288 Range on HMM: 162-253/253 Sequence Identity: 31% (30 aa) TARYLSPEILMGKQATWASDIWSLGCFMYEFYLGVPYIQGTCLSEILHSISAPPSFKSDPLLTGKDANIISLLSQMLAPEPSQRIYAKQILKLNTV | |. ||.| | .. ||||.|| || .| | || | | . | . |. .|. .|| |.|..| ..|.|. . . TPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKK--NEYRIPSHISQPAA--QLIRKMLDPDPTRRPTIEQVLNDEFF |
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| S_TKc | GL50803_13963.AA | S_TKc | 12-288 | 13 | 9.2e-10 | -33.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-288
Range on HMM: 1-231/231
Sequence Identity: 13% (42 aa)
YELGSVCQKTAHGFLYLAVDRYTYRPCVCKRLIYSKLSLSLLSQLHLNISLTRTLRHPNLMEYLEIAEGDSIGSSFLVMKDMRT---DSLKMHQRLRFGT
||.. . | | | |..... | | . .|.. .. |.. . .|||. .... . .. ..|| . . | ... .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
GSYQLPTFSSPSKQTFWLVLMQLAELLAYLHSP-------------------------SKRNAPDISTVILRSLDPAGIYLDNLGVVTVAQIRMSKYIET
. ...| . . .. |... |.|.|| ...
LRFPFP------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------
NNVDCQSANTARYLSPEILMGKQATW-ASDIWSLGCFMYEFYLGVPYIQGTCLSEILHSISAPPSFKSDPLLTGKDANIISLLSQMLAPEPSQRIYAKQI
| |..||.| . . ..|.||.|| .||.. | | . . .... | . .......| .|..|. | ..
----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EA
LK-------LNTV
|. .
LQDEWDIKCHPWF
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| Kinase | GL50803_13963.AA | Ciliate-C4 | 202-228 | 44 | 1.1e-08 | 23.62 | In-house | 244-270 (361) | Show / Hide |
Range on Protein: 202-228 Range on HMM: 244-270/361 Sequence Identity: 44% (12 aa) LMGKQATWASDIWSLGCFMYEFYLGVP | . ...| .||||.||.|.| .|.| LQNYECPWSIDIWSMGCVMMEIITGIP |
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| Kinase | GL50803_13963.AA | RTKL | 195-229 | 52 | 1.3e-08 | 18.41 | In-house | 171-206 (259) | Show / Hide |
Range on Protein: 195-229 Range on HMM: 171-206/259 Sequence Identity: 52% (19 aa) RYLSPEILMGKQATWASDIWSLGCFMYEFYLG-VPY | .||| | || .| |||.| | || | ||| RWMSPETLNGKPHTMASDVWAFGVVCYEVITGQVPY |
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| Kinase | GL50803_13963.AA | WEE | 194-222 | 46 | 6e-08 | 22.82 | In-house | 197-228 (297) | Show / Hide |
Range on Protein: 194-222 Range on HMM: 197-228/297 Sequence Identity: 46% (15 aa) ARYLSPEILMG-KQATWA--SDIWSLGCFMYE .||..||||.| ...| . .|| |||. .|| SRYMAPEILQGYYHYTHLYKADIFSLGITIYE |
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| TyrKc | GL50803_13963.AA | TyrKc | 12-286 | 14 | 3e-06 | -121.0 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-286 Range on HMM: 1-280/280 Sequence Identity: 14% (46 aa) YELGSVCQKTAHGFLYLAVDRYTYRPCVCKRLIYSKLSLSLLSQLHLNISLTRTL--RHPNLMEYLEIAEGD-----SIGSSFLVMKDMRTDSLKMHQRL .|| . | | |... . ... | | .. . .. ... . | .|||. . .. . .|. ..|| | ...| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYL RFGTGSYQLPTFSSPSKQTFWLVLMQLAELLAYLHSPSKRNAPDISTVILRSLDPAGI-----------YLDNLGVVTVAQIRMSKYIETN-------NV | . . ... | |. .|||| .. . .|. .| .. .|..|. . RKHRPK--------LCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDY DCQ----SAN---TARYLSPEILMGKQATWASDIWSLGCFMYEFY-LGVPYIQG-----TCLSEILHSISAPPSFKSDPLLTG--------KDANIISLL . ... | ..|| .. . | .||.|| | |.| . .| . | .|... . . . | . . .. YRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK---QGYRMPQPPNDYPMSFVCCPDEMYQIM SQMLAPEPSQRIYAKQILKLN .| . .|..| ..| .. KQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_13963.AA | CDC2 | 198-227 | 38 | 4e-06 | 14.33 | In-house | 173-203 (301) | Show / Hide |
Range on Protein: 198-227 Range on HMM: 173-203/301 Sequence Identity: 38% (12 aa) SPEILMGKQA-TWASDIWSLGCFMYEFYLGV .||||.|.. . . |.||.|| ..|... | APEILLGCKRYSTPVDMWSIGCIFAEMFMDV |
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| Kinase | GL50803_13963.AA | Ciliate-C4 | 257-288 | 28 | 7e-05 | 11.19 | In-house | 330-361 (361) | Show / Hide |
Range on Protein: 257-288 Range on HMM: 330-361/361 Sequence Identity: 28% (9 aa) KDANIISLLSQMLAPEPSQRIYAKQILKLNTV .| .. .|...|| |. || ||.... . IDQQLKDLIKKMLKFNPRERISPKQCCQHPWI |
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| Kinase | GL50803_13963.AA | CDC2 | 262-284 | 52 | 0.000165 | 9.2 | In-house | 275-297 (301) | Show / Hide |
Range on Protein: 262-284 Range on HMM: 275-297/301 Sequence Identity: 52% (12 aa) ISLLSQMLAPEPSQRIYAKQILK |.||.|||. .|..|| ||..|. IDLLMQMLQYDPQKRISAKEALQ |
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| Kinase | GL50803_13963.AA | WEE | 263-288 | 30 | 0.000653 | 9.09 | In-house | 272-297 (297) | Show / Hide |
Range on Protein: 263-288 Range on HMM: 272-297/297 Sequence Identity: 30% (8 aa) SLLSQMLAPEPSQRIYAKQILKLNTV .|. .|. | |.||. . |.|. . QLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Pkinase | GL50803_13963.AA | Pkinase | 27-79 | 16 | 0.428951 | 4.95 | Pfam | 16-70 (293) | Show / Hide |
Range on Protein: 27-79 Range on HMM: 16-70/293 Sequence Identity: 16% (9 aa) YLAVDRYTYRPCVCKRLIYSKLSLSLLSQLHL--NISLTRTLRHPNLMEYLEIAE |..... | . ..|.. ... . . . .. . |.. . |.||| ..... | YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFE |
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