Gene GL50803_14436 (G.lamblia)

GL50803_14436

Species: G.lamblia
Alias: GL50803_14436, GK082
External Links: GiardiaDB ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: YSK

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14436.AA Protein None 807 None Fasta, JSON
GL50803_14436.kin_dom Protein Kinase Domain None 320 None Fasta, JSON

Protein domain

Protein domains of GL50803_14436.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_14436.AA STE 81-400 21 1.3e-80 274.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 81-400
Range on HMM: 1-359/359
Sequence Identity: 21% (91 aa)

YKLLKILGSGGFGSVYLALDEK---------------TMTYVAIKTVDLEQSL----------------SELDVVQKEVTLMTRLM--SNYTIRYYRSWC
.......|.|.||.||.|.. |               | ...||| ..||..                 .|.. ..||. .| ..   . . ..|| .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TE-------STLNIAMEAGLC-SVADILSIV--------------GPLNEATACFIMYHLVKG-VAYLHESKVIHRDLKCANILVTDDSTSSTVAQQPDG
 |       ..|.|.||     |. ||.  .              ....|   ..| . ..||  .|||. ..||||.|.||||.               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

LAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPRPNSDSAAALSLGIKLCDFGVSTTISS---------------TMSKRC-SFVGTPYWL
                                                       .|||||||.. ...               ||.... .||||| | 
-------------------------------------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WM

SPEAITK------NECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARN--------------SSSTSLFDD----------------KVEISKT
.|| |..      ...|  .||| .|... |.. |.||.|...|..|| .|..|                . .| |.                . . |. 
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

CRDFAACCLDRDKTNRWPASKLLT--HKWF
..|| . ||..|  .|. ||.||   |...
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_14436.AA S_TKc 81-400 21 1.9e-64 221.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 81-400
Range on HMM: 1-231/231
Sequence Identity: 21% (71 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAMEAGLC---SVADILSIVGP-----
|..|...|.|.||.||.. . ||  .|||| ..        . ...|. .. .    . ...| .. . . | . ||       .. |..   |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDDSTSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPRPNSD
 ..| .|.|.|| ......|.|. ..|||||| .|||...                                                            
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------------------------------------------

SAAALSLGIKLCDFGVSTTISSTMSKRCSFVGTPYWLSPEAITKNECDS-FSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEIS
        ||.||||... .        .|.|||....|| .     .   .|.|..|..|||.. | || .     ..|... .              |
-------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------S

KTCRDFAACCLDRDKTNRWPASKLLT-------HKWF
. ..||   ||..| ..|. | ..|.       | ||
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_14436.AA Pkinase 81-400 22 2.2e-61 215.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 81-400
Range on HMM: 1-293/293
Sequence Identity: 22% (81 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQK---EVTLMTRLMSNYTIRYYRSWCTESTLNIAMEAGLC-----SVADILS--IV
|......|||.||.||.. . .|   ||.|.....   |. |.      |. .| || . . .|.|... ... . . ||   .     . .|..|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--NEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVT-DDSTSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPR
|..   | ...|.|| ...|..|.|. ..|||||| .|||.  .. ...                                                   
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------------------------------------------

PNSDSAAALSLGIKLCDFGVSTTI-SSTMSKRCSFVGTPYWLSPEAIT-KNECDSFSDIWAVGICLYELIFGHPPHHKL----SPTKAMIEIARNSSSTS
            .|.||||..  .     |   .|.|||....|| |   .. .. .|.|..|. |||...|.||        .    |  |.|. .   
-----------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPL

LFDDKVEIS-------------------KTCRDFAACCLDRDKTNRWPASKLLTHKWF
 ||   ..|                   ..|.||  .||..| . |. |  .| |.||
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_14436.AA Ciliate-E2 81-400 16 3.1e-46 156.71 In-house 1-365 (365) Show / Hide 
Range on Protein: 81-400
Range on HMM: 1-365/365
Sequence Identity: 16% (72 aa)

YKLLKILGSGGFGSVYLA---LDEK--------------------TMTYVAIKTV---DLEQSLSELDVVQ---------KEVTLMTRLMSNYTIRYYRS
||..|..|.|.|||||..   .. |                    .. ..|.|..   ..|| ..|... .         .|  .. .| ... |..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WC--TESTLNIAMEAGLCSVADILSIVG--------------PLNEATACFIMYHLVK---------------GVAYLHESK-VIHRDLKCANILVTDDS
.   ..... . ||  .|.  | ...                ...|  ...||.....               .. |||. . .||||.|  |||.    
FQEKDDNNIYLVME--YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

TSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPRPNSDSAAALSLGIKLCDFGVSTTIS-----------STMSKRCS--
                                                                  ||..||| |. ..           . . .  .  
------------------------------------------------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KND

-------------------FVGTPYWLSPEAITKNE---------CDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFD--------
                   ..|||. ..|| . . .          |  .|||..|..|||..|| ||         ...|  .  . . ..        
TSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCI

-----DKVEISKTCRDFAAC----CLDRDKTNRWP-ASKLLTHKWF
     .. ..|. | |.       .|..|  .|   ....| |.||
QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_14436.AA STE20 280-400 36 3.3e-44 153.2 In-house 156-288 (288) Show / Hide 
Range on Protein: 280-400
Range on HMM: 156-288/288
Sequence Identity: 36% (48 aa)

IKLCDFGVSTTISS----TMS-KRCSFVGTPYWLSPEAITK-----NECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDD--KV
.||.||||.  ...    ||. || .|||||||..|| | .     .. |. .|||..||.. |.. |.||.....|..|| .|..|.  .  . |  . 
VKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPH

EISKTCRDFAACCLDRDKTNRWPASKLLTHKWF
  |.  .|| . ||..|  .|. ||.||.|...
KWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_14436.AA YSK 280-400 40 2.6e-35 103.52 In-house 138-257 (257) Show / Hide 
Range on Protein: 280-400
Range on HMM: 138-257/257
Sequence Identity: 40% (50 aa)

IKLCDFGVSTTISSTMSKRCSFVGTPYWLSPEAITK--NECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISKTCRDFA
.|||||||.  |  |. ||  |||||||  || | .   . |.  ||| .||  ||.  |.||. .. | ..|  |  |   . | .   . ||   .| 
VKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPK-LEGR--SYSKMFKEFV

ACCLDRDKTNRWPASKLLTHKWF
.|||. |  .|  |. || ||  
ECCLNKDPEQRPSAKELLKHKFI
Kinase GL50803_14436.AA YSK 81-212 34 8.9e-35 101.87 In-house 1-135 (257) Show / Hide 
Range on Protein: 81-212
Range on HMM: 1-135/257
Sequence Identity: 34% (47 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAME-AGLCSVADILSI--VGPLNEAT
.. .   | | || || . | .|   ||||..|||..  | . .|.|..    . | |  .|| |    . | | ||  |  |..| .    ||.. |  
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDD
  .|.  . ||  |||. ..|||| | ||.|.. .
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEH
Kinase GL50803_14436.AA STE20 81-212 33 9.2e-33 115.16 In-house 1-153 (288) Show / Hide 
Range on Protein: 81-212
Range on HMM: 1-153/288
Sequence Identity: 33% (51 aa)

YKLLKILGSGGFGSVYLALDEKTMTY----VAIKTVDLEQSL---SELDVVQKEVTLMTRLMSNYTIRYYRSWCTE----STLNIAMEAGLC-SVADILS
|.||. .|.|..|.||.| . .|  |    |||| ..||.      |.. .|||.  | .... . ..|| |   .    . | |.||     |. ||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---IVG------PLNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDD
   . |      |.||.   .|.. ...| .|||. ..||||.| .|||.|.|
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTED
Kinase GL50803_14436.AA SLK 279-400 36 4.7e-30 98.48 In-house 135-259 (259) Show / Hide 
Range on Protein: 279-400
Range on HMM: 135-259/259
Sequence Identity: 36% (46 aa)

GIKLCDFGVSTTISSTMSKRCSFVGTPYWLSPEAIT-----KNECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISKTC
...| |||||    .|| || .|.|||||. || .       .  |  .|||..|| | |.  . |||| ..| . .. |..  |         . ||  
DVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKIQK--SEPPTLEQPSHWSKEF

RDFAACCLDRDKTNRWPASKLLTHKWF
.||   ||..|  |||....|. |.|.
KDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase GL50803_14436.AA MST 281-400 39 2.5e-29 90.32 In-house 137-254 (254) Show / Hide 
Range on Protein: 281-400
Range on HMM: 137-254/254
Sequence Identity: 39% (47 aa)

KLCDFGVSTTISSTMSKRCSFVGTPYWLSPEAITKNECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISKTCRDFAACC
|| |||||   . || || ...|||||..|| |...  |.  |||. ||.  |.  |.|| . . |. ||. |  . . |  | |  . |    || . |
KLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPT--FKDPEQWSQEFNDFVCKC

LDRDKTNRWPASKLLTHKWF
| ..   || |  || |  .
LQKNPEQRWTAEQLLQHPFI
Kinase GL50803_14436.AA KHS 81-212 34 1.8e-28 92.79 In-house 1-132 (258) Show / Hide 
Range on Protein: 81-212
Range on HMM: 1-132/258
Sequence Identity: 34% (46 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAME-AGLCSVADILSIVGPLNEATAC
| ||. .||| .| || | | .. . .|.| . .| .  .. |.|.|...|        . |. |.  .  | |.||  |  |. ||  . |||.|    
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPG-DDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIA

FIMYHLVKGVAYLHESKVIHRDLKCANILVTDD
..    ..|..|||  . .|||.| ||||.||.
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQ
Kinase GL50803_14436.AA PAKA 280-400 36 1.5e-25 86.69 In-house 142-260 (260) Show / Hide 
Range on Protein: 280-400
Range on HMM: 142-260/260
Sequence Identity: 36% (44 aa)

IKLCDFGVSTTISSTMSKRCSFVGTPYWLSPEAITKNECDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISKTCRDFAAC
.|. |||  . ..   .|| . |||||| .|| |.... |   |||  || . |.| | ||. .  | .||  || |   .  . |.   |.. .|| . 
VKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATN--GKPDIKDPDKWSQEFCDFLDK

CLDRDKTNRWPASKLLTHKWF
||. |  .|. |..||.|  .
CLCVDVDRRASAQELLHHPFL
Kinase GL50803_14436.AA MST 81-209 38 3.9e-25 76.79 In-house 1-130 (254) Show / Hide 
Range on Protein: 81-209
Range on HMM: 1-130/254
Sequence Identity: 38% (51 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWC--TESTLNIAME-AGLCSVADILSIVG-PLNEA
. .. .|| | .|||| |.. .|  .|||| |  .  |.|.    || . |    | |  .|| |     .... | ||  |  ||.||  | . .|||.
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEI---IKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQ

TACFIMYHLVKGVAYLHESKVIHRDLKCANILV
    | |   .| .||| .| ||||.| .|||.
QIACILYDTLQGLQYLHDNKKIHRDIKAGNILL
Kinase GL50803_14436.AA KHS 280-400 37 1.9e-24 79.01 In-house 135-258 (258) Show / Hide 
Range on Protein: 280-400
Range on HMM: 135-258/258
Sequence Identity: 37% (47 aa)

IKLCDFGVSTTISSTMSKRCSFVGTPYWLSPE--AITKNEC-DSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARNSSSTSLFDDKVEISKTCRDF
.|| |||||. |. |..|| ||.|||||. ||  |. ..   .   |||||||   ||    ||   | | .|.. ... .       ||   |.|  .|
VKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHF

AACCLDRDKTNRWPASKLLTHKWF
   .| ..   |  |.|||.|...
VKMALTKNPKKRPTAEKLLQHPFV
Kinase GL50803_14436.AA STE11 81-214 27 2.8e-23 81.2 In-house 1-154 (303) Show / Hide 
Range on Protein: 81-214
Range on HMM: 1-154/303
Sequence Identity: 27% (43 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLS-------ELDV------VQKEVTLMTRLMSNYTIRYYRSWC---TESTLNIAMEAGLC---
... .|.|.| ||.||.... .| . .|.| . .. . .       |..        |.|. ||  |  .  .||| . .    ....|| ||   |   
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFME--YCPGG

SVADILS-IVGP--LNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDDST
|....|.   ||  ..|.. ..    . .|..|||. ..||||.| ||||.  |..
SLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGN
Kinase GL50803_14436.AA Dicty2 81-210 33 3.6e-19 63.5 In-house 1-137 (264) Show / Hide 
Range on Protein: 81-210
Range on HMM: 1-137/264
Sequence Identity: 33% (46 aa)

YKLL-KILGSGGFGSVYLALDEKTMTYVAIKTVD-----LEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAM---EAGLCSVADILSIVG
|..   ..| |.|| || .|. .|   |||| ..       .| . .  . .|. |  .|  .   .|. .  ||. |.|..   | |  | ..|.   |
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENG--SLSKIIKKFG

PLNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVT
.. |   |   |   || .|||. .||||| | ||||.|
CFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILIT
Kinase GL50803_14436.AA Dicty2 280-350 45 3.2e-17 56.65 In-house 145-218 (264) Show / Hide 
Range on Protein: 280-350
Range on HMM: 145-218/264
Sequence Identity: 45% (34 aa)

IKLCDFGVSTTIS-STMSKRCSFVGTPYWLSPEAITKNE--CDSFSDIWAVGICLYELIFGHPPHHKLSPTKAM
||| |||| | |. |   .| ..||||||  || |  .   | . .||| .|  . ||  | ||   | |  ||
IKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDLNPMHAM
Kinase GL50803_14436.AA STE11 279-400 23 6.8e-17 57.85 In-house 154-303 (303) Show / Hide 
Range on Protein: 279-400
Range on HMM: 154-303/303
Sequence Identity: 23% (35 aa)

G-IKLCDFGVSTTISSTMSKRCS----------FVGTPY--------WLSPEAITKNE---CDSFSDIWAVGICLYELIFGHPPHHKLSPTKAMIEIARN
. .|| ||| .. ...  ..  .          . ||||        | .|| |..      .  .|||..| . .| . | || | ..  ..| .... 
NVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDH-NHMAAMFKI

SSS-TSLFDDKVEIS------KTCRDFAACCLDRDKTNRWPASKLLTHKWF
 .. ..      ..|        ||||   |. .|.  |. |. || |...
GMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_14436.AA SLK 81-212 26 4.3e-16 50.68 In-house 1-133 (259) Show / Hide 
Range on Protein: 81-212
Range on HMM: 1-133/259
Sequence Identity: 26% (36 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAMEAGLCSVAD--ILSIVGPLNEATA
....  || | || || | .  .  . | | ... ..  ||.    |. ... .   . .. | ..  .  | . .|       |  .. .  || |   
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEI-KDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQI

CFIMYHLVKGVAYLHESKVIHRDLKCANILVTDD
 .. .|.. .. .||. ||||||||  |||.| |
QYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMD
Kinase GL50803_14436.AA PAKA 81-209 24 6.2e-15 48.95 In-house 1-136 (260) Show / Hide 
Range on Protein: 81-209
Range on HMM: 1-136/260
Sequence Identity: 24% (34 aa)

YKLLKILGSGGFGSVYLALDEKTMTY--VAIKTVDLEQSLSELDVVQKEVTLMTRLMSNYTIRYYRSWCTESTLNIAME---AGLCSVADILSIVG----
|| .. .| |. |.||.| . || .   ||||. ....  .  . .  |  .|     .  ..|. |   .. | ..||   .|  .  |... .     
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQ-PKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGG--CLTDVITQCCNIQC

-PLNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILV
 ...|. . ..     .|  ..|. ..||||.|  |||.
NYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILL
Kinase GL50803_14436.AA TyrKc 81-400 18 1.2e-13 -2.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 81-400
Range on HMM: 1-280/280
Sequence Identity: 18% (67 aa)

YKLLKILGSGGFGSVYLALDEKTMTYVAIKTVDLEQSLSELDVVQKEVTLMTRL--MSNYTIRYYRSWCTE--------STLNIAME-AGLCSVADILSI
 .|.|.||.| || ||..      . ||.|..  .     .    .|  .|..|       .| |   ||.          | | || . . .  | |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VGP-LNEATACFIMYHLVKGVAYLHESKVIHRDLKCANILVTDDSTSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPRP
 .| |. .. . ...   .| .|||. ..||||| . |.||...                                                        
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------------------------------------------

NSDSAAALSLGIKLCDFGVSTTISST-------MSKRCSF-VGTP-----YWLSPEAITKNECDSFSDIWAVGICLYELI-FGHPPHHK-----LSPTKA
           .| .||| |  | .          .| .   |.       |..||.| .... . ||.|. |.|..|.  .| .|.       .|.. .
----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV

MIEIARNSSSTSLFD-----DKVEISKTCRDFAACCLDRDKTNRWPASKLLTHKWF
.  . .        .       |. ..   .   .| ..|  .|   | .  |. |
IEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_14436.AA Pkinase_Tyr 187-335 19 1.8e-09 32.73 Pfam 122-208 (270) Show / Hide 
Range on Protein: 187-335
Range on HMM: 122-208/270
Sequence Identity: 19% (30 aa)

KGVAYLHESKVIHRDLKCANILVTDDSTSSTVAQQPDGLAKRLIDLILGKPVSPGLFSETSRPRSSHGSYISTIARSFSPRPNSDSAAALSLGIKLCDFG
|| .||.. . ||||| . |.|||.                                                                 .. .| ||||
KGMEYLESKNCIHRDLAARNCLVTE-----------------------------------------------------------------NNVVKICDFG

VSTTI--SSTM-SKRCSFVGTPYWLSPEAITKNECDSFSDIWAVGICLYELI
 . .|   ..   || .      |..||.|  ... . ||.|. |....|..
LARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase GL50803_14436.AA Dicty2 369-400 40 6e-07 20.42 In-house 233-264 (264) Show / Hide 
Range on Protein: 369-400
Range on HMM: 233-264/264
Sequence Identity: 40% (13 aa)

ISKTCRDFAACCLDRDKTNRWPASKLLTHKWF
||. | ||   |  .| . |  |..|| |.|.
ISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase GL50803_14436.AA Pkinase_Tyr 81-134 27 0.000704 13.76 Pfam 1-60 (270) Show / Hide 
Range on Protein: 81-134
Range on HMM: 1-60/270
Sequence Identity: 27% (17 aa)

YKLLKILGSGGFGSVYLALDE----KTMTYVAIKTVDLEQSLSE---LDVVQKEVTLMTRL
 ...| ||.| ||.||..       .| . ||.|..  |.. .|   ..   .|. .|. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQL