Gene GL50803_14742 (G.lamblia)

GL50803_14742

Species: G.lamblia
Alias: GL50803_14742, GK253
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14742.AA Protein None 287 None Fasta, JSON
GL50803_14742.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of GL50803_14742.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_14742.AA Pkinase 10-283 20 1.5e-22 80.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

YEMVRQVNAGPYAYVYLVRNKADGEEVVAKCISLADISTEMRQSLRL--ARRIGLELKHHNIIHAMKSPMDDGEHIMIQITRYYSDR----DLLTYIQRC
|. .|.. .| .. ||. ..| .|..|. |.|.. ... ...|..|.    .| ..|.| ||.    . .| . ||   .. |        || .||.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYIST-

KEASQFI--PEESVWRCAICLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDGNY----VLTGFSHCVEMQETGLNPPETPDSTPKNRNVT--YM
 ...  .  .|. . ...  .. ...|.|| .         | |  . |.|.|||..|.      .. |  .  ..       . ..| .. . .|  ||
-WRHGCFYFSEWECKFYMYQILRGLEYCHS-M--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYM

APETIE-NKPWDGRVDVWGIGCTLYEMCTGMKYVEAV------TPKFALKEITTTEMPLQLLGYS--------------------PDVVDLVSRMLSADL
||| |  ..... .||.|..||.||||..|             .... ...|  .. . .    .                    ..  |.....|  | 
APEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

HKRPQISDLLSDERV
.||| . ..| .. .
KKRPTAEQILQHPWF
S_TKc GL50803_14742.AA S_TKc 10-283 22 2e-22 81.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

YEMVRQVNAGPYAYVYLVRNKADGEEVVAKCISLADISTEMRQSLRLARRIGLELKHHNIIHAMKSPMDDGEHIMIQITRYYSD--RDLLTYIQRCKEAS
||..|..  | .. ||..|.| .|..|  |.|.         ...|  ..|  . .| ||..   .  |   . .  .. | .    ||..||....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

QF--IPEESVWRCAICLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDGNYVLTGFSHCVEMQETGLNPPETPDSTPKNRNVTYMAPETIENKPW
    .||  ... .  ...|..|.|| .         | |  . |.|.|.|.  .  .. |  . ..         |   ||      ||||| .   ..
LRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTP-----WYMAPEVL---GY

DG-RVDVWGIGCTLYEMCTGMKYVEAVTPKFALKEITTTEMPLQLLGYSPDVVDLVSRMLSADLHKRPQISDLLS-------DERV
.. ..|.| .||.||||..|    .  ...  .| |            ||.. |.....|  |  ||| . ..|        .. .
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_14742.AA Ciliate-E2-Unclassified 10-283 14 1.7e-21 71.35 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-283
Range on HMM: 1-352/352
Sequence Identity: 14% (55 aa)

YEMVRQVNAGPYAYVYLVRNKADGEEV-----------VAKCISLADISTEMRQSLRLARR--------------IGLELKHHNIIHAMKSPMDDGEHIM
|....| . | .. ||....| .. ..           ..... .  .  .|.. ... ..              | | ..| .|.. .    |.   ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IQITRYYSDRDLLTYIQRCKEAS-------------QFIPEESVW-----RCAICLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDG---NYVL
  .. |  . ||. ||. .|  .             . ..|. .      . . .....  |||..        . | | .|.|.|.|.|..|   .  .
--VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK--------NNIIHRDIKPENILFDNNGKNYYIKI

TGFSHCV----------------------EMQETGLNPPETPDSTPKNRNVTYMAPETIENKPWDGR----VDVWGIGCTLYEMCTGMKYVEAVT---PK
..|. .                       .|. .  .|   | .        | ||| ....  |..    .|.|. |. ||||..|    .. .    .
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q--------YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQ

FALKEITTT-----EMPLQLL----------------GYSPDVVDLVS----RMLSADLHKRPQISDLLSDERV
.  ....       ..  . .                . || . |...    .||  .. ||......|     
QLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_14742.AA Ciliate-E2 121-283 20 1.7e-16 53.08 In-house 168-365 (365) Show / Hide 
Range on Protein: 121-283
Range on HMM: 168-365/365
Sequence Identity: 20% (45 aa)

CLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDGNYVLTGFSH----------------CVEMQETGLNPPETPD---------------STPKN
|.|||. |||| .        .| | .| |.|.|.       .. |                  | .... . .   ||                 ||  
CIILALEYLHSKN--------NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPG-

RNVTYMAPETIENKP---------WDGRVDVWGIGCTLYEMCTGMKYVEAVTPKFALKEITTTEMPLQ-----------------LLGYSPDVVDLVSR-
    ||||| ...|.         .|  .|.| .|..||||..|            ...|   .  ..                  .  |... || .. 
----YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---MLSADLHKRPQ-ISDLLSDERV
   ||  |  ||.. ....|  .  
GKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_14742.AA STE 104-283 21 3.6e-16 53.69 In-house 143-359 (359) Show / Hide 
Range on Protein: 104-283
Range on HMM: 143-359/359
Sequence Identity: 21% (52 aa)

KEASQFIPEESVWRCAICLILA-VAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDGNYVLTGFSHCVEMQE---------------TGLNPPETPDSTP
.. ....||. . . .  .. .  .|||| |         | |  | |.|.|.       |. | .|  ...               |.     |   ||
QH-QHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP

KNRNVTYMAPETIEN------KPWDGRVDVWGIGCTLYEMCTGMKYVEAVTPKFALKEITTT--------------EMPLQLLG----------------
      .|||| |..      |. | ..|.| .|||. ||.||       .|  |. .|..               . | .|                  
------WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTT

----YSPDVVDLVSRMLSADLHKRPQISDLLS--DERV
    .||.  | ... |  | .|||  |.||.   . .
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_14742.AA STE-Unique 108-283 19 1.9e-15 50.81 In-house 398-616 (616) Show / Hide 
Range on Protein: 108-283
Range on HMM: 398-616/616
Sequence Identity: 19% (45 aa)

QFIPEESVWRCAICLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDG-----NYVLTGFSHCVEMQETGLNP-----------PETPD-------
| .||. | . .  . ..  |||| |        || | .. |.|.....||     . ..  | | ...|. ..               .         
QLFPETEVIWYTYQILEGLEYLHSQHN-------PIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTA

------------STPKNRNVT--YMAPETIENK-----PWDGRVDVWGIGCTLYEMCTGMKYVEAVTPK---FALKEITTTEMP-----LQLLGYSPDVV
            .|.|. . |  ||.||.|. .     | | .||.| .||.. .||.|       ..    . .  . ... |     .  . ..|. .
QQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQ

DLVSRMLSADLHKRPQISDLLSDERV
..    |. . |.|| ...|| ..  
QFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GL50803_14742.AA TKL 16-281 13 2.1e-13 44.6 In-house 1-364 (364) Show / Hide 
Range on Protein: 16-281
Range on HMM: 1-364/364
Sequence Identity: 13% (51 aa)

VNAGPYAYVYLVRNKA--------DGEEVVAKCISLADISTEMRQS---------------------LRLARRIGLE----LKHHNIIHAMKSPMDDGE-
.  | .. ||  . .         .|..|. | ..  . . ....|                     .|  ..  .     |.| ||.. | . .. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------HIMIQITRYYSDRDLLTYIQRCKEASQFIPEESVWRCAICLILAVAYLHSSH---AKDNSTLKPIAHKNIQPSNVLIDKDGN-------
           ...| .. |..  .|| |..           .   | |.   ....||||..    .     .||.| .. ..|.|.|....       
CVCMHPVGPWGQLCI-VMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILVDENWTNVSNYMY

-------YVLTGFSHCVEMQETGLNPPETPD-------------STPKNRNVTYMAPETIENK----------------PWDGRVDVWGIGCTLYEMCTG
         .. |  . .|...| .     .             . ..  .  .|||| ....                . . ..||.  |  |.|..|.
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

MKYVEAVTP-------------KFALKEITTTEMP---------LQLLGYSPDVVDLVSRMLSADLHKRPQISDLLSDE
 .  .   .             . . ..    ..|          .     |.. .|  .  ..| .|||  ...|.  
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_14742.AA Aur 194-224 45 4.1e-12 27.75 In-house 167-197 (257) Show / Hide 
Range on Protein: 194-224
Range on HMM: 167-197/257
Sequence Identity: 45% (14 aa)

YMAPETIENKPWDGRVDVWGIGCTLYEMCTG
||.|| .|... | .||.| .|  .||.|.|
YMPPEMVEGQMHDHKVDIWCLGVLCYELCHG
Kinase GL50803_14742.AA NEK-Unclassified 194-223 50 1.1e-11 34.66 In-house 163-192 (258) Show / Hide 
Range on Protein: 194-223
Range on HMM: 163-192/258
Sequence Identity: 50% (15 aa)

YMAPETIENKPWDGRVDVWGIGCTLYEMCT
.|.|| .. .|.. | |||  || .|||||
WMSPEVCQDQPYNNRSDVWSLGCIIYEMCT
Kinase GL50803_14742.AA NEK4 194-283 33 1e-10 34.9 In-house 168-257 (257) Show / Hide 
Range on Protein: 194-283
Range on HMM: 168-257/257
Sequence Identity: 33% (30 aa)

YMAPETIENKPWDGRVDVWGIGCTLYEMCTGMKYVEAVTPKFALKEITTTEMPLQLLGYSPDVVDLVSRMLSADLHKRPQISDLLSDERV
|| ||   |.|.| . |.| .|| .||| |     .|      .  |    .|     ||.|  .||  ||.    ||| | |..    .
YMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_14742.AA NEK 194-223 56 7.7e-10 31.24 In-house 190-219 (286) Show / Hide 
Range on Protein: 194-223
Range on HMM: 190-219/286
Sequence Identity: 56% (17 aa)

YMAPETIENKPWDGRVDVWGIGCTLYEMCT
||.|| ..||| . ..|.| .|| ||||||
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCT
Kinase GL50803_14742.AA NEK2 194-223 40 1.3e-09 28.39 In-house 230-259 (319) Show / Hide 
Range on Protein: 194-223
Range on HMM: 230-259/319
Sequence Identity: 40% (12 aa)

YMAPETIENKPWDGRVDVWGIGCTLYEMCT
|| || ..  . . . |.| .|| .||||.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCA
Kinase GL50803_14742.AA TyrKc 10-287 15 2.3e-08 -87.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-287
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)

YEMVRQVNAGPYAYVYLVRNKADGEEVVAKCISLADISTEMRQSLRLARRIGLEL--KHHNIIHAMKSPMDDG------EHIMIQITRYYSDRDLLTYIQ
 .. ..   | .  ||. . |   ..|  |..         |. ..   ||  .|  .| ||.      ...|      | .|| .. | .  ||. |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI-VMEYMPHGDLKDYLR

RCKEASQFIPEESVWRCAICLILAVAYLHSSHAKDNSTLKPIAHKNIQPSNVLIDKDGNYVLTGFSHCVEMQET---GLNPPETPDST--PKN--RNVTY
....    .. .     ..      .||||          .. |  .   |.|.....    . |  . .  .    | .      ..   ..    .  
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPETIENKPWDGRVDVWGIGCTLYEMCT-GMKYVEA-----VTPKFALKEITTTEMPLQLLG--------YSPDVVDLVSRMLSADLHKRPQISDLLSD
||||.|  .      |||  | ...|..| |..  .      .... ... . . ... |            .... .. ..   .| ..||  |..   
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---

ERVQSRM
    ...
---HECF
Kinase GL50803_14742.AA NEK 252-283 34 2.1e-07 22.56 In-house 255-286 (286) Show / Hide 
Range on Protein: 252-283
Range on HMM: 255-286/286
Sequence Identity: 34% (11 aa)

YSPDVVDLVSRMLSADLHKRPQISDLLSDERV
||.|  .|.|.||  | ..|| ....|..  .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_14742.AA NEK4 10-70 31 5.7e-07 21.27 In-house 1-61 (257) Show / Hide 
Range on Protein: 10-70
Range on HMM: 1-61/257
Sequence Identity: 31% (19 aa)

YEMVRQVNAGPYAYVYLVRNKADGEEVVAKCISLADISTEMRQSLRLARRIGLELKHHNII
|. ...|  | |  |.|||.. |.   | | . |   | . |.      ..   ||| ||.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIV
Kinase GL50803_14742.AA NEK2 252-283 25 1.4e-05 14.58 In-house 288-319 (319) Show / Hide 
Range on Protein: 252-283
Range on HMM: 288-319/319
Sequence Identity: 25% (8 aa)

YSPDVVDLVSRMLSADLHKRPQISDLLSDERV
|| .  .....|.  |. .|| |  .| . ..
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_14742.AA NEK 95-131 30 3.1e-05 14.83 In-house 93-132 (286) Show / Hide 
Range on Protein: 95-131
Range on HMM: 93-132/286
Sequence Identity: 30% (12 aa)

DLLTY---IQRCKEASQFIPEESVWRCAICLILAVAYLHS
||      |...|.. ....|| .|.  | ..||. |.|.
DLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_14742.AA NEK 10-52 31 0.003494 7.52 In-house 1-48 (286) Show / Hide 
Range on Protein: 10-52
Range on HMM: 1-48/286
Sequence Identity: 31% (15 aa)

YEMVRQVNAGPYAYVYLVRNKADGEE-----VVAKCISLADISTEMRQ
|| ....  | .  ||.|| | || .     .| | |..   | . .|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQ
Kinase GL50803_14742.AA NEK-Unclassified 252-283 21 0.004269 5.75 In-house 227-258 (258) Show / Hide 
Range on Protein: 252-283
Range on HMM: 227-258/258
Sequence Identity: 21% (7 aa)

YSPDVVDLVSRMLSADLHKRPQISDLLSDERV
|| |  ...  ||  .  .||   .... . .
YSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase GL50803_14742.AA NEK2 95-161 27 0.006499 5.51 In-house 86-165 (319) Show / Hide 
Range on Protein: 95-161
Range on HMM: 86-165/319
Sequence Identity: 27% (23 aa)

DLLTYIQRCKEASQFIPEESVWRCAICLILAVAYLHS--------------SHAKDN-STLKPIAHKNIQPSNVLIDKDGN-Y
||   |..|.   |...|| .||    | .|    |                  .|.  |   | |  | | |.  | |.| |
DLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHT---ILHRDIKPANIFLDYDHNDY