Gene GL50803_14786 (G.lamblia)
GL50803_14786
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_14786.AA | Protein | None | 1084 | None | Fasta, JSON |
| GL50803_14786.kin_dom | Protein Kinase Domain | None | 284 | None | Fasta, JSON |
Protein domains of GL50803_14786.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_14786.AA | ULK | 214-293 | 22 | 8.9e-14 | 44.55 | In-house | 218-329 (329) | Show / Hide |
Range on Protein: 214-293 Range on HMM: 218-329/329 Sequence Identity: 22% (25 aa) MAPELLLDS-EEVSPS-GAVDIWSVGSVLYEMATGKTY---DSAIDPT-----TNLRT-----------------------YSFEFQSMLRSMLSIKQSD |||..| . |. .. .||||.| ..||| .||.. . | ... | |... .| || ....| MAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKD RPTFEDLLKAERI | ..|.|.. . . RISWEELFNHPWF |
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| Kinase | GL50803_14786.AA | AGC | 214-293 | 16 | 9.4e-14 | 30.45 | In-house | 274-395 (395) | Show / Hide |
Range on Protein: 214-293
Range on HMM: 274-395/395
Sequence Identity: 16% (21 aa)
MAPELLLDSEEVSPSGAVDIWS--VGSVLYEMATG--------------------KTYDSAI-------DPTTNL----------RTYSFEFQSMLRSML
|||| | . |.|.|| .| ..||| || ..... . .. . | | | .. .. .|
MAPEIL-------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLL
SIKQSDRPT----------FEDLLKAERI
..|.. .|.. . .
CKDPEKRLGCGGNDFGDKGAEEIKNHPWF
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| Kinase | GL50803_14786.AA | ULK | 214-293 | 21 | 3.4e-13 | 43.21 | In-house | 214-324 (324) | Show / Hide |
Range on Protein: 214-293 Range on HMM: 214-324/324 Sequence Identity: 21% (24 aa) MAPELLLDS-EEVSPS-GAVDIWSVGSVLYEMATGKTY---DSAIDPT-------------------TNLRTY--------SFEFQSMLRSMLSIKQSDR |||..| . |. .. .||||.| ..||| .||.. . . | .... . | |... .| || ....|| MAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR PTFEDLLKAERI ..|.... . . ISWEEIFNHPWF |
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| Kinase | GL50803_14786.AA | Ciliate-E2 | 214-293 | 19 | 2.1e-09 | 28.41 | In-house | 254-365 (365) | Show / Hide |
Range on Protein: 214-293 Range on HMM: 254-365/365 Sequence Identity: 19% (23 aa) MAPELLLDSEEVS------PSGAVDIWSVGSVLYEMATGKTYDSAIDPTTNLRTYSFEFQ--------------------------SMLRS----MLSIK |||| | .. . ..||||.| .|||| .||. . ..|. ... || . MAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKD QSDRPT-FEDLLKAERI .. |.| .|..|. . . PEKRITGWEQILNHPWF |
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| Kinase | GL50803_14786.AA | RSKL | 232-252 | 42 | 3.3e-08 | 14.31 | In-house | 360-380 (436) | Show / Hide |
Range on Protein: 232-252 Range on HMM: 360-380/436 Sequence Identity: 42% (9 aa) DIWSVGSVLYEMATGKTYDSA |.|| |.||||. .|... .. DWWSYGAVLYELLCGMSLYQC |
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| Kinase | GL50803_14786.AA | STE11-Unclassified | 214-247 | 47 | 4.4e-08 | 24.81 | In-house | 202-235 (308) | Show / Hide |
Range on Protein: 214-247 Range on HMM: 202-235/308 Sequence Identity: 47% (16 aa) MAPELLLDSEEVSPSGAVDIWSVGSVLYEMATGK ||||.. | . . ....||||.| . .|||||| MAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGK |
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| Kinase | GL50803_14786.AA | CDK | 215-247 | 47 | 1.8e-07 | 19.83 | In-house | 187-222 (284) | Show / Hide |
Range on Protein: 215-247 Range on HMM: 187-222/284 Sequence Identity: 47% (17 aa) APELLLDSEEVSPSGAVDIWSVGSVLYEMAT---GK |||||| |.. | . ..|.|||| ...||.| .| APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRK |
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| Kinase | GL50803_14786.AA | MSK | 211-247 | 41 | 2e-07 | 21.17 | In-house | 169-207 (277) | Show / Hide |
Range on Protein: 211-247 Range on HMM: 169-207/277 Sequence Identity: 41% (16 aa) LSHMAPELLLD--SEEVSPSGAVDIWSVGSVLYEMATGK | ||||.| . .... . |.|.||.| .||.| ||. LHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQ |
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| Kinase | GL50803_14786.AA | Pkinase | 214-248 | 42 | 2.9e-07 | 26.78 | Pfam | 178-210 (293) | Show / Hide |
Range on Protein: 214-248 Range on HMM: 178-210/293 Sequence Identity: 42% (15 aa) MAPELLLDSEEVSPSGAVDIWSVGSVLYEMATGKT ||||....... .| .||.||.| .||||..|.. MAPEVIRGGQYYGP--KVDMWSCGCILYEMLCGRP |
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| S_TKc | GL50803_14786.AA | S_TKc | 10-293 | 13 | 8.3e-07 | -77.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-293
Range on HMM: 1-231/231
Sequence Identity: 13% (42 aa)
YRFIGLANIGGDELIYKLLDETTEQEVFCTIFTFDQLRKRAYTELLSFIQIYTALDHRGLMRYRAIETEPADLRLFFMTSTYNVNLAKLNLLMRQEGKS-
|... . |. || . | ..| . | .... |. . .| . .. . . .|.. . . .| | .... |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----YCELALWQVAAQLIDTMTYCNLPR------------------------TRQFGHKSTRLAANSFPHCVLRPFIIVITNSFTQESDLLKLSTNSKQA
. | . ...|... . || . ||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--------------------------------------------
ALFPLSIKVMPGVLTVGQLRQFQTTAARSHLSHMAPELLLDSEEVSPSG-AVDIWSVGSVLYEMATGKT-YDSAIDPTTNLRTYSFEFQSMLRSMLSIKQ
| . ||||.| . .. ..|.||.| .||||..|.. .. .. . .. | |. ...| .|
------------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDP
SDRPTFEDLLK-------AERI
..||| ..|. . .
EKRPTA-EALQDEWDIKCHPWF
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| Kinase | GL50803_14786.AA | STE | 213-247 | 39 | 4e-06 | 17.91 | In-house | 228-265 (359) | Show / Hide |
Range on Protein: 213-247 Range on HMM: 228-265/359 Sequence Identity: 39% (15 aa) HMAPELLLDSE---EVSPSGAVDIWSVGSVLYEMATGK .|||| .. . . . .||||.| .. |||||| WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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| Kinase | GL50803_14786.AA | Ciliate-E2-Unclassified | 230-247 | 55 | 1.4e-05 | 15.4 | In-house | 250-267 (352) | Show / Hide |
Range on Protein: 230-247 Range on HMM: 250-267/352 Sequence Identity: 55% (10 aa) AVDIWSVGSVLYEMATGK ..||||.| .|||| .|. KCDIWSLGVILYEMLFGY |
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| Kinase | GL50803_14786.AA | Ciliate-E2-Unclassified | 263-293 | 25 | 0.007549 | 5.74 | In-house | 318-352 (352) | Show / Hide |
Range on Protein: 263-293 Range on HMM: 318-352/352 Sequence Identity: 25% (9 aa) SFEFQSMLR----SMLSIKQSDRPTFEDLLKAERI |.| . ... .|| ... |.|||..|. . SPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_14786.AA | STE | 265-293 | 32 | 0.042339 | 3.36 | In-house | 329-359 (359) | Show / Hide |
Range on Protein: 265-293 Range on HMM: 329-359/359 Sequence Identity: 32% (10 aa) EFQSMLRSMLSIKQSDRPTFEDLLK--AERI ||. .. | . ..||| ..||| . | EFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_14786.AA | Pkinase | 265-293 | 24 | 1.577706 | 2.95 | Pfam | 265-293 (293) | Show / Hide |
Range on Protein: 265-293 Range on HMM: 265-293/293 Sequence Identity: 24% (7 aa) EFQSMLRSMLSIKQSDRPTFEDLLKAERI |... ....| . ..|||.|..|. . . ECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Ank | GL50803_14786.AA | Ank | 451-474 | 37 | 0.000106 | 21.21 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 451-474 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) DGTSALMLAAENNSLEVAKLLVSY || ..|.||......||.|.|... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_14786.AA | Ank | 482-505 | 45 | 5e-06 | 26.01 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 482-505 Range on HMM: 1-24/33 Sequence Identity: 45% (11 aa) TGLTALMYAARRGHADLVSLLLNH | |.|..|.|.||.. |..||.| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_14786.AA | Ank | 513-545 | 27 | 0.000124 | 20.97 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 513-545 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) RGYTALMHAIDQGHLECIRILVKAETNYSAPNG |.|.|. |. ||.|... |... . | . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_14786.AA | Ank | 630-653 | 29 | 0.122265 | 10.17 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 630-653 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) THVTCLMLAAQHHSVELVQMFIHQ |.|.||... ..| |.|.. . DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_14786.AA | Ank | 660-680 | 33 | 0.607047 | 7.66 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 660-680 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) KGLTALHIAVQELFVDGVTLL | |.||.|.. .. |..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_14786.AA | Ank | 786-806 | 33 | 5.669587 | 4.16 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 786-806 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) TGKTALIAAATVGNALAVRAL | |.| |. |.. |. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_14786.AA | Ank | 817-849 | 15 | 4.094265 | 4.67 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 817-849 Range on HMM: 1-33/33 Sequence Identity: 15% (5 aa) KGWTAMMCCVCRASSTTAQNLCTYIECINALAP |.|. .. ... . .. | . ..|| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_14786.AA | Ank | 858-878 | 23 | 0.193611 | 9.45 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 858-878 Range on HMM: 1-21/33 Sequence Identity: 23% (5 aa) CGWTALVYASAYLNLACIEVL .|.|.| .|. . .. ... | DGFTPLHLACRCGHTEVVKML |
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