Gene GL50803_14855 (G.lamblia)

GL50803_14855

Species: G.lamblia
Alias: GK310, GL50803_14855
External Links: GiardiaDB ,
Annotation:

Classification

Group: PKL
Family: PI3K

Sequence

Name Sequence Type Origin Length Description Download
GL50803_14855.AA Protein None 2155 None Fasta, JSON
GL50803_14855.kin_dom Protein Kinase Domain None 412 None Fasta, JSON

Protein domain

Protein domains of GL50803_14855.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Ka GL50803_14855.AA PI3Ka 1573-1642 26 9.2e-08 28.25 Pfam 92-169 (211) Show / Hide 
Range on Protein: 1573-1642
Range on HMM: 92-169/211
Sequence Identity: 26% (21 aa)

MNLLASAQTD--PIIRGFAVSVLNT-YSSYDLEPHIMQLVELCKYD-----MVNAGLASFLIRMAIKEFPTFGYPLYW
..|| .. .|  | .| .||..|..  | ..|.  . |||.  ||.       .  |..||.. |.. .  .| ...|
LELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFW
PI3Ka GL50803_14855.AA PI3Ka 1492-1678 16 8.9e-07 -5.75 SMART 1-232 (232) Show / Hide 
Range on Protein: 1492-1678
Range on HMM: 1-232/232
Sequence Identity: 16% (39 aa)

DYTFSV----CTKLEALSPFLTYPLTYLTKLEYQHLWEYKDLAL-CDPVLLF-----RLSQSINYKNKDSVQSFYNILSAKKI--EDVTLDTVMNLLASA
|| . .     .. . .  .   |.. ||. |....|.. .. |   |  |      .. ...| .. | |   | ..  ..   . .  .  ..|| ..
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLM--HQWWWPPIDPEDALELLDPK

QTD---PIIRGFAVSVLNTYSSYDLEPHIMQLVELCKYD---------------------------MVNAGLASFLIRMAIKEFPTFGYPLYWAFRCEM-
 .|   | .| .||..|.  | ..|.  . |||.  ||.                            ..  |. ||.. |..   ..|  .||  ..|| 
FPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMY

----RLNLVFSSAYSLFMLKILLHL-PENQRRSII
      .  ... . . .   .  .  .. |... 
DHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
Kinase GL50803_14855.AA PI3Kc 1778-2145 21 1.4e-60 208.48 SMART 1-336 (336) Show / Hide 
Range on Protein: 1778-2145
Range on HMM: 1-336/336
Sequence Identity: 21% (96 aa)

KCLFKTHDDLRQDSLVLRTFSYIQNVWYNN----NINLAMKVYSCVATGPFEGLIELVPDSETLGSIEH-------------------------------
  .||..|||||| ...  |. ....| ..    . .| |. |.|..|||  |.||.||..||| .| .                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------------------------TFGGARGAFARGPIMKWLVDSINLHDEEFLRVQKNAQHNNSLTQEMRYSLLLEPEDDNRASETSELTISDVEQSVL
                         |.||...|   .. .|...  .  ..                                                 
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEH-FPDPN-------------------------------------------------

NKGYDDTNQGLFNTTASVPTTLNTRSLYSKSSRDSIFQSVSQLSLIQKHTATRYTQMISNYLTSIAAYCVATCILGLGDRHNDNIMLC-QDGTFFHIDFG
                                                    .. ....|.  | |.||..| |||.||||||||||. ..|  ||||||
---------------------------------------------------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

HFLGNFKKKFNYE---RERGPFFFIPDMAFVLKHHDYVNG-----TEYEKCFEKMSADALLAIRHHSSALISLFTIMIPSGI-PQLTSR-EDVQWIEDHL
|..|...||. ..   ||| || . .||  |        |     ..|.. | ..   |..|.|.|| ....|| .|. ..| |....  .|.. ... .
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVM-------GGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRF

FLD-MSESEAHRHFIR----LIHEAE-RSKRYLYNNMFHILAHY
.|| .|. || ..| .    ...|..  |.   ...||| .|.|
RLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase GL50803_14855.AA PI3_PI4_kinase 1776-2096 17 7.1e-47 166.85 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1776-2096
Range on HMM: 1-300/300
Sequence Identity: 17% (71 aa)

NYKCLFKTHDDLR--QDSLVLRTF-----------------------SYIQNVWYNNNINLA----MKVYSCVATGPFEGLIELVPDSETLGSIEHTFGG
.|. .|| .||||  ||....  .                       . . ..| ...  .     |  |.|..|||  |.||.||...|.  |  |.. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

ARGAFA-----------------------------------RGPIMKWLVDSINLHD-EEFLRVQKNAQHNNSLTQEMRYSLLLEPEDDNRASETSELTI
 ... .                                   .. . .|.... |    ||...                                     
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKH-NPDAYEEWWE-------------------------------------

SDVEQSVLNKGYDDTNQGLFNTTASVPTTLNTRSLYSKSSRDSIFQSVSQLSLIQKHTATRYTQMISNYLTSIAAYCVATCILGLGDRHNDNIML---CQ
                                                                 ..|. .|.| .||.. |||.|||||||||.   . 
----------------------------------------------------------------ARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKT

DGTFFHIDFGHFLGNFKKKFNYERERGPFFFIP------DMAFVLKHH---DYVNGTEYEKCFEKMSADALLAIRHHSSALISLF-------TIMIPSGI
.|  |||||||.....| |.  ..|| || ...      .|  ..  .   |    ....  |...  .|..|.|.|. ....|.        .|. .|.
TGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDP---SGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGL

PQLTS
| ..|
PMWRS
Kinase GL50803_14855.AA PIKK 1977-2018 51 3.3e-09 30.04 In-house 187-229 (290) Show / Hide 
Range on Protein: 1977-2018
Range on HMM: 187-229/290
Sequence Identity: 51% (22 aa)

SNYLTSIAAYCVATCILGLGDRHNDNIMLCQD-GTFFHIDFGH
.||. | |  |..  |||||||| .|||.... |   |||||.
ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC
Kinase GL50803_14855.AA FRAP 1978-2017 56 3.3e-09 30.14 In-house 139-179 (251) Show / Hide 
Range on Protein: 1978-2017
Range on HMM: 139-179/251
Sequence Identity: 56% (23 aa)

NYLTSIAAYCVATCILGLGDRHNDNIML-CQDGTFFHIDFG
||  |.|   .|  ||||||||  ||||  . |   |||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase GL50803_14855.AA ATR 1977-2016 43 5.8e-08 22.77 In-house 165-205 (267) Show / Hide 
Range on Protein: 1977-2016
Range on HMM: 165-205/267
Sequence Identity: 43% (18 aa)

SNYLTSIAAYCVATCILGLGDRHNDNIMLCQ-DGTFFHIDF
.||. | |..|.   |.|||||| |||.. .  |   |.|.
ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY
Kinase GL50803_14855.AA ATM 1979-2017 45 4.3e-05 11.78 In-house 140-179 (304) Show / Hide 
Range on Protein: 1979-2017
Range on HMM: 140-179/304
Sequence Identity: 45% (18 aa)

YLTSIAAYCVATCILGLGDRHNDNIMLC-QDGTFFHIDFG
|  |.|   .   ||||||||  ||..  |     ||| |
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG
Kinase GL50803_14855.AA PIKK 1746-1840 28 0.000131 13.12 In-house 1-98 (290) Show / Hide 
Range on Protein: 1746-1840
Range on HMM: 1-98/290
Sequence Identity: 28% (28 aa)

LATFCVVECAVLSSKKAPLLLSLKTADGAFNYKCLFKTHDDLRQDSLVLRTFSYIQNVWYNN----NINLAMKVYSCVATGPFEGLIELVPDSETLGSI
 . |      |. .|..|  ....  || . |  |.| |.|||||  |.  |. . .  ...      .| . .|| .. ..  |||| |... ||. |
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKE-YPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEI
Kinase GL50803_14855.AA FRAP 1776-1807 40 0.00062 10.51 In-house 1-32 (251) Show / Hide 
Range on Protein: 1776-1807
Range on HMM: 1-32/251
Sequence Identity: 40% (13 aa)

NYKCLFKTHDDLRQDSLVLRTFSYIQNVWYNN
 |  | | |.|.|||  |.  |  |     ||
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNN
Kinase GL50803_14855.AA ATR 1745-1803 33 0.001028 8.05 In-house 2-58 (267) Show / Hide 
Range on Protein: 1745-1803
Range on HMM: 2-58/267
Sequence Identity: 33% (20 aa)

KLATFCVVECAVLSSKKAPLLLSLKTADGAFNYKCLFKTHDDLRQDSLVLRTFSYIQNV
 .| |  .   .|.| . |  .||| .|| | |  . | .||||.|    |. . |. .
YIAGFDDM-VEILASLQKPKKISLKGSDGKF-YIMMCKPKDDLRKDCREMRFNELINFC
Kinase GL50803_14855.AA ATM 1778-1797 45 0.032441 2.42 In-house 1-20 (304) Show / Hide 
Range on Protein: 1778-1797
Range on HMM: 1-20/304
Sequence Identity: 45% (9 aa)

KCLFKTHDDLRQDSLVLRTF
. | |  ||||||  .   |
RQLVKGRDDLRQDAVMQQVF