Gene GL50803_15397 (G.lamblia)

GL50803_15397

Species: G.lamblia
Alias: GK022, GL50803_15397
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15397.AA Protein None 340 None Fasta, JSON
GL50803_15397.kin_dom Protein Kinase Domain None 325 None Fasta, JSON

Protein domain

Protein domains of GL50803_15397.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15397.AA CMGC 10-334 22 1.5e-92 304.4 In-house 1-513 (513) Show / Hide 
Range on Protein: 10-334
Range on HMM: 1-513/513
Sequence Identity: 22% (122 aa)

YEFISQIGEGTYGTVSKCSL----------------HGQLLAVKRIK---MDSSSK------GVPATTLREVAILKALNAK-----QRELVEQGKLESLS
|| |..|||||||.| ||                   ... |.|.||   ..   |      |.| ..|||. ||| || .     ||    . . ..  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQR---RD-DPDNKH

QANVVNLLDVVYDLS-----------------NIFLVFEYCHVDLDQYLKHNV----------LSPYQ------------IKKFM------YQLLQGLS-
  |.|.|.|..|.                   ...|||||.  || ||.|.|           ||. .            ||.||      ||.|.||  
HNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-LVHKNE--ILHRDIKPNNILLA-----------------FRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN-------------------
   |..   |.|||.|| |||.                   .                   ..| .||| ||||||.|...                   
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-------------------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD

--VTSISANVVSLWYRAPELVLASKTYS---------TAVDMWSMGCIMYFLANK--------RALFQ-----------VRKDADLLQLAFSYFYVD---
  .  .. .||..||||||. | .| |.         |..|||| |||.. . ..        . ||.            ... | |.. |  .      
KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWM

-------------SSSISDLISLPNWNMYVG---------ENQVIDLAALNAPGRKPREVDINID-----------------------------------
             .  . . |.||..|..           .       ... ..|.|.   ...                                    
IQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQ

-------DVGKDLFYKLLMLNPSKRISCDEALQHPWF
       . . ||  |.| ..|.|||....|||||.|
FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_15397.AA S_TKc 10-334 24 1.5e-75 258.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-334
Range on HMM: 1-231/231
Sequence Identity: 24% (84 aa)

YEFISQIGEGTYGTVSKCSLHG--QLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHV--
||.. .||.|..|.| ||  ..  .. |.|.||          ...||..|||                     |.|.|.|| .| .....|.|||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-----------------HHPNIVKLYDVFQD-DHLYMVMEYCDGDL

-DLDQYLKHNV-------LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGINVTS
 || .|.|..        ... .....|||....|   |.. |.|||.|| ||||                          ..||.|||||| .      
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------HIKICDFGLARQL------

ISANVVSLWYRAPELVLASKTYST-AVDMWSMGCIMYFLANKRALFQVRKDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVIDLAALNAPGRKP
 .  ....||.|||..     |.. ..|.|| |||.| ..  . .|.   .. ....                                           
-TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------------------

REVDINIDDVGKDLFYKLLMLNPSKRISCDEALQ-------HPWF
       .. .||.  |.|  .|.||... ||||       ||||
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_15397.AA Pkinase 10-334 27 8.5e-69 239.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-334
Range on HMM: 1-293/293
Sequence Identity: 27% (94 aa)

YEFISQIGEGTYGTVSKCSLHGQ--LLAVKRIKMDSSSKGVPATTLR--EVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYC-H
|.....||.|..|.| ||  .|   . |||.|| .. ..... | .|  |..|.| ||                  |.| |.|...| ..| .|.||| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----------------HPNIVRLYDWFEDKDHIYMVMEYCEG

V----DLDQYLK---HNVL--SPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSY-GIN
     ||  |..   |...  |. ..|..|||.|.||   |.. |.|||.|| |||.  .|. ..                   .||.|||||. .   |
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLAKQFDY-N

VTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQVR----KDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVIDLAALN
 .  .  ....||.|||... .. |...|||||.|||.| ....| .|. .    . .| .|. .   . . .. ..  . . . . .   .        
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------

APGRKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
   . .... .|... .||. ...| ..|.||......||||||
---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_15397.AA CDC2 82-243 38 6.1e-62 188.93 In-house 62-210 (301) Show / Hide 
Range on Protein: 82-243
Range on HMM: 62-210/301
Sequence Identity: 38% (66 aa)

NVVNLLDVVYDLSNIFLVFEYCHVDLDQYLK-----HNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDAD
|.| | ||..  .....||||.. || .|..       ...|  .|..|||.|||..  | . |.|||.|| |||.   |.                   
NIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-------------------

NCVLKITDFGLARSYGINVTSIS--ANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFL---ANKRALFQ
   .|| ||||||  ||..  .    .|| |||||||. | .|.|||.||||| |||.. .   ..|..||.
---IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFH
Kinase GL50803_15397.AA Ciliate-E2 10-334 20 3.8e-56 191.24 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-334
Range on HMM: 1-365/365
Sequence Identity: 20% (88 aa)

YEFISQIGEGTYGTVSKC--SLHGQLL------------------AVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDV
|.|| .||.|..|.| ||   . ...                   ..| . | . .|     ...|  |.. .| ... . |.  ||.|.  |.... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VY--DLSNIFLVFEYCHV-DLDQYLKHN------------VLSPYQIKKFMYQLLQ---------------GLSLVHKNE-ILHRDIKPNNILLAFRGDA
 .  | .||.||.|||   || .|.|.|             .. ..||..|.|.||               .|   |..  |.||||||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

GEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN----------VTSISAN----------------------VVSLWYRAPELVL--------ASKT
                     .||.||||.. | ..             .  .                      . .. | ||| .         ..| 
---------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG

YSTAVDMWSMGCIMYFLANKRALFQVRKDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVI--DLAALNAPGRKPREVDIN---------IDDVG
|....|.||.|.|.|..  ..  |                                     ..| .  ..   ..  .|.    ..         ... .
YDYKCDIWSLGVILYEMLFGKPPF-------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQEC

KDLFYK----LLMLNPSKRIS-CDEALQHPWF
|||. |    .|  .|.|||.  ...|.||||
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_15397.AA Ciliate-E2-Unclassified 10-334 22 3.6e-54 186.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-334
Range on HMM: 1-352/352
Sequence Identity: 22% (90 aa)

YEFISQIGEGTYGTVSKC--SLHGQLLAVKRIK--MDSSSKGVPATTLREVAILKALNAKQ--------RELVEQGKLESLSQANVVNLLDVVYDLSNIF
|..| |||.| .|.| ||  . ..|. | | .|  .. ..| .     ... ..|..| |.        ... .   | ..   ..|.....  |  ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIY

LVFEYC-HVDLDQYLKH------------------NVLSPYQIK-----KFMYQLLQGL-SLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPN
.| ||| . || ||.|.                  . .. .|.|     ....|.|||| .| ||| |.||||||.|||.   |                
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------------

PDADNCVLKITDFGLARSYGINVTS---------------ISANVVSLWYR----APELVLASKTYS---TAVDMWSMGCIMYFLANKRALFQVRKDAD-
    |  .||.|||... |. |. .               .. .. .. |     |||.    . .     ..|.||.|.|.|..   .  |. ... . 
----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQH

---------------LLQLAFSY-FYVDSSSI-SDLISLPNWNMYVGENQVIDLAALNAPGRKPREVDINIDDVGK----DLFYKLLMLNPSKRISCDEA
               |.|  .   .......  .                                .. .... .|    ||. |.|  ||.|||. ...
QQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ--------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI

LQHPWF
|.||||
LNHPWF
Kinase GL50803_15397.AA CDK5 10-156 39 3.1e-37 114.88 In-house 1-135 (287) Show / Hide 
Range on Protein: 10-156
Range on HMM: 1-135/287
Sequence Identity: 39% (60 aa)

YEFISQIGEGTYGTVSKCSLH--GQLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHVDL
|| .  ||||||||| |      . . | ||...||   |||.| .||...|| |  |                |.| | ||.     . ||||.|  ||
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHK----------------NIVRLHDVIHSEKKLTLVFEFCDQDL

DQYLK--HNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
  |.      ...  || ||||||.||.. |....|||| || | |   .|
KKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNG
Kinase GL50803_15397.AA CDK 176-243 44 1.3e-33 104.78 In-house 143-226 (284) Show / Hide 
Range on Protein: 176-243
Range on HMM: 143-226/284
Sequence Identity: 44% (37 aa)

DNCV-----LKITDFGLARSYGI------NVTSISANVVSLWYRAPELVLASKTYS--TAVDMWSMGCIMYFLAN---KRALFQ
.| .     |||.|||||| .||      ..   . .|| |||||||| | ||.||  |..|||| |||.. ...   ...||.
NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFP
Kinase GL50803_15397.AA PCTAIRE 10-156 37 1.7e-29 101.34 In-house 1-134 (291) Show / Hide 
Range on Protein: 10-156
Range on HMM: 1-134/291
Sequence Identity: 37% (57 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHVDL
|  .   ||||| || ||   | . | | | |...    | | |  |||  || |                  ||.| | |...      |||||   ||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLK----------------HANIVTLHDIIHTHHQLTLVFEYMDMDL

DQYLKHNV--LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
 ||. ...  ..   .| |..||| ||   |.  ||||| || | |.  ||
KQYMDDCGNIMNMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERG
Kinase GL50803_15397.AA CDK 81-152 37 2.2e-29 91.06 In-house 67-141 (284) Show / Hide 
Range on Protein: 81-152
Range on HMM: 67-141/284
Sequence Identity: 37% (31 aa)

ANVVNLLDVVYDL-----------SNIFLVFEYCHVDLDQYLKHNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILL
.|.|.|.||...            .....||||.. || .|..        || .|.|||.||.  |.| |.|||.||.|||.
PNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase GL50803_15397.AA CDK5 177-255 48 4e-29 88.8 In-house 134-213 (287) Show / Hide 
Range on Protein: 177-255
Range on HMM: 134-213/287
Sequence Identity: 48% (39 aa)

NCVLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLA-NKRALFQVRKDADLLQLAF
|. ||  |||||| .|| |   |. || ||||.|   . ||.||| .||||.|||.  .| . | ||    . | | . |
NGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIF
Kinase GL50803_15397.AA PITSLRE 179-243 56 9.7e-29 101.8 In-house 144-208 (295) Show / Hide 
Range on Protein: 179-243
Range on HMM: 144-208/295
Sequence Identity: 56% (37 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQ
.||| |||||| || .. ... .|| |||||||| | .|.|||.||||| |||.  .  .. |||
ILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQ
Kinase GL50803_15397.AA CDK4 10-153 34 4.6e-28 93.22 In-house 1-144 (290) Show / Hide 
Range on Protein: 10-153
Range on HMM: 1-144/290
Sequence Identity: 34% (54 aa)

YEFISQIGEGTYGTVSKC-SLH-GQLLAVKRIKMDSSSK--GVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDV--VYDLSN----IFLV
|. .  |||| |||| .  .|| |.  | |...  ..    |.|  |.||..... |...               .|.| |.||  | |       | .|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEH-------------PNIVKLMDVCHVMDTDRAEMKITMV

FEYCHVDLDQYLKHNVL---SPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLA
|| |  || .||        .| .||. | ||| |.   | . | ||| || |||..
FEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT
Kinase GL50803_15397.AA CDK7 179-232 55 3e-27 69.24 In-house 140-193 (288) Show / Hide 
Range on Protein: 179-232
Range on HMM: 140-193/288
Sequence Identity: 55% (30 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIM
.|||.||||||.||      . .||  |||||||    . | |.|||||.|||.
QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIF
Kinase GL50803_15397.AA CDK7 82-157 44 1.5e-26 67.35 In-house 63-140 (288) Show / Hide 
Range on Protein: 82-157
Range on HMM: 63-140/288
Sequence Identity: 44% (35 aa)

NVVNLLDVVYDLSNIFLVFEYCHVDLDQYLKHN--VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGD
||..|.|.   .||| |||..   ||.   | .  .| |  || .| ..||||   |.| |||||.|||| |.   |.
NVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQ
Kinase GL50803_15397.AA CDK4 180-249 47 3.4e-21 69.3 In-house 149-216 (290) Show / Hide 
Range on Protein: 180-249
Range on HMM: 149-216/290
Sequence Identity: 47% (33 aa)

LKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQVRKDAD
.|..|||||| |. . .     || |||||||  |.| .| | ||||| |||.  . . |.||    ..|
VKLADFGLARIYS-FQMALTPVVVTLWYRAPEVLLQS-YYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKD
Kinase GL50803_15397.AA PCTAIRE 179-242 46 1.4e-19 65.83 In-house 135-198 (291) Show / Hide 
Range on Protein: 179-242
Range on HMM: 135-198/291
Sequence Identity: 46% (30 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALF
.||  ||||||   .     |  ||.|||| |. .. |  ||| .|||  ||| | ..  |.||
ELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLF
Kinase GL50803_15397.AA CDC2 10-63 43 5.8e-19 54.42 In-house 1-58 (301) Show / Hide 
Range on Protein: 10-63
Range on HMM: 1-58/301
Sequence Identity: 43% (25 aa)

YEFISQIGEGTYGTVSKCSLH--GQLLAVKRIKMDSSSKG--VPATTLREVAILKALN
|. |  ||||||| | ||     .|. |.|.|. .. . |  || |..||  .||.|.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK
Kinase GL50803_15397.AA CDK 10-62 36 2e-18 55.43 In-house 1-65 (284) Show / Hide 
Range on Protein: 10-62
Range on HMM: 1-65/284
Sequence Identity: 36% (24 aa)

YEFISQIGEGTYGTVSKCSLHG-------QLLAVKRIKMDS-----SSKGVPATTLREVAILKAL
|| . .|||||||.| |.  .        |. | |.|.|..        |.| |..||...|| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL
Kinase GL50803_15397.AA CDK 267-334 25 8.8e-16 46.81 In-house 251-284 (284) Show / Hide 
Range on Protein: 267-334
Range on HMM: 251-284/284
Sequence Identity: 25% (17 aa)

DLISLPNWNMYVGENQVIDLAALNAPGRKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
.. .||..                                  ||  |.|...|.||||...|||||.|
GVTKLPDY----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_15397.AA CDC2 295-334 45 1.5e-14 40.61 In-house 263-301 (301) Show / Hide 
Range on Protein: 295-334
Range on HMM: 263-301/301
Sequence Identity: 45% (18 aa)

KPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
|...  . .|. | ||  ..| ..|.|||| .||||||.|
KKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase GL50803_15397.AA CDK7 10-60 38 8.7e-14 32.67 In-house 1-57 (288) Show / Hide 
Range on Protein: 10-60
Range on HMM: 1-57/288
Sequence Identity: 38% (22 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIK----MDSSSKGVPATTLREVAILK
|| |..||||...||.|     .||  |.|.||     .    |.  | .||. ||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQ
Kinase GL50803_15397.AA CDK5 302-334 48 3.5e-13 37.53 In-house 255-287 (287) Show / Hide 
Range on Protein: 302-334
Range on HMM: 255-287/287
Sequence Identity: 48% (16 aa)

NIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
. |  | ||  |.|..|| .||| ..||.||.|
KLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase GL50803_15397.AA CDK7 309-334 38 5.5e-12 27.78 In-house 263-288 (288) Show / Hide 
Range on Protein: 309-334
Range on HMM: 263-288/288
Sequence Identity: 38% (10 aa)

DLFYKLLMLNPSKRISCDEALQHPWF
||  ... .||.||..| ..|..| |
DLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GL50803_15397.AA TyrKc 10-269 17 6.4e-12 -29.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-269
Range on HMM: 1-280/280
Sequence Identity: 17% (58 aa)

YEFISQIGEGTYGTVSKCSLHGQLLAVKRIKMDSSSKGVPATTLREVAILKAL--NAKQRELVEQGKLESLSQANVVNLLDVVYDL-------SNIFLVF
 ... ..||| .|.| |. .  .  ||| .| |.      .  .||  |.. |  . .                |.|.|. |. .          ...|.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHP----------------NIVRLYGVCTQQGRNFMYIEPLMIVM

EYC-HVDLDQYLKHNV--LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN---
||. | ||..||. .   |.. .  .|..|  .| .  |.. . |||.   |.|.. ..                      . ||.||||.|  .     
EYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------TVKISDFGLSRDIYDDDQQ

-----VTSI----SAN-VVSLWYRAPELVLASKTYSTAVDMWSMGCIMY----------------FLANKRALFQVRKD--ADLLQL--------AFSYF
     . .     ... .. .   ||| ..  ....|. | || |  |.                .. |.... .|..    .  .         . .  
GESKDYYRKKEHKGGKTMLPIRWMAPE-CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM

YV--------------DSSSISDLI
|                 | | ...
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_15397.AA PITSLRE 303-334 50 1.9e-11 38.12 In-house 264-295 (295) Show / Hide 
Range on Protein: 303-334
Range on HMM: 264-295/295
Sequence Identity: 50% (16 aa)

IDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
| |.| ||  ..| .|| .||. ..||.||||
ISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase GL50803_15397.AA PITSLRE 10-63 37 4.9e-11 36.6 In-house 1-59 (295) Show / Hide 
Range on Protein: 10-63
Range on HMM: 1-59/295
Sequence Identity: 37% (22 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIKMD--SSSKGVPATTLREVA-ILKALN
.. . .|.||||| |..    . .   | ||.||.      | | | |||.  ||.||.
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQ
Kinase GL50803_15397.AA CDK4 294-334 36 7e-09 26.38 In-house 250-290 (290) Show / Hide 
Range on Protein: 294-334
Range on HMM: 250-290/290
Sequence Identity: 36% (15 aa)

RKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
|.....   ..  |.||  | |  |..||.|  ..||||.|
RPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase GL50803_15397.AA PCTAIRE 307-334 35 2.3e-07 22.0 In-house 264-291 (291) Show / Hide 
Range on Protein: 307-334
Range on HMM: 264-291/291
Sequence Identity: 35% (10 aa)

GKDLFYKLLMLNPSKRISCDEALQHPWF
. ||  .|| . . .|.| ..|..||.|
CQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase GL50803_15397.AA PITSLRE 82-156 34 2.5e-07 22.96 In-house 62-143 (295) Show / Hide 
Range on Protein: 82-156
Range on HMM: 62-143/295
Sequence Identity: 34% (28 aa)

NVVNLLDVV--YDLSNIFLVFEYCHVDLDQYL-KHN----VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
|.||.. .|   ..  |..|.||   ||   . ...      .| .|| .| ||| | .  |.| |.||| |  |.|.   |
NIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKG
Kinase GL50803_15397.AA Pkinase_Tyr 82-189 26 0.000164 15.9 Pfam 65-159 (270) Show / Hide 
Range on Protein: 82-189
Range on HMM: 65-159/270
Sequence Identity: 26% (31 aa)

NVVNLLDVVY-DLSN--IFLVFEYC-HVDLDQYLKHN-----VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPN
|.|.|. |.. .     |..|.||. | ||. ||. .      |.. .. .. .|  .|..  . . . |||.   |.|..                   
NIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-------------------

PDADNCVLKITDFGLAR
   .| | ||.||||||
---ENNVVKICDFGLAR
Kinase GL50803_15397.AA Pkinase_Tyr 10-46 25 0.000887 13.42 Pfam 1-43 (270) Show / Hide 
Range on Protein: 10-46
Range on HMM: 1-43/270
Sequence Identity: 25% (11 aa)

YEFISQIGEGTYGTVSKCSLH------GQLLAVKRIKMDSSSK
 .|. ..||| .|.| |. ..      ..  ||| .| .....
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHE