GL50803_15397

Species: G.lamblia
Alias: GK022, GL50803_15397
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15397.AA Protein None 340 None Fasta, JSON
GL50803_15397.kin_dom Protein Kinase Domain None 325 None Fasta, JSON

Protein domain

Protein domains of GL50803_15397.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15397.AA CMGC 10-334 22 1.5e-92 304.4 In-house 1-513 (513) Show / Hide
Range on Protein: 10-334
Range on HMM: 1-513/513
Sequence Identity: 22% (122 aa)

YEFISQIGEGTYGTVSKCSL----------------HGQLLAVKRIK---MDSSSK------GVPATTLREVAILKALNAK-----QRELVEQGKLESLS
|| |..|||||||.| ||                   ... |.|.||   ..   |      |.| ..|||. ||| || .     ||    . . ..  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQR---RD-DPDNKH

QANVVNLLDVVYDLS-----------------NIFLVFEYCHVDLDQYLKHNV----------LSPYQ------------IKKFM------YQLLQGLS-
  |.|.|.|..|.                   ...|||||.  || ||.|.|           ||. .            ||.||      ||.|.||  
HNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-LVHKNE--ILHRDIKPNNILLA-----------------FRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN-------------------
   |..   |.|||.|| |||.                   .                   ..| .||| ||||||.|...                   
KYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-------------------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD

--VTSISANVVSLWYRAPELVLASKTYS---------TAVDMWSMGCIMYFLANK--------RALFQ-----------VRKDADLLQLAFSYFYVD---
  .  .. .||..||||||. | .| |.         |..|||| |||.. . ..        . ||.            ... | |.. |  .      
KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWM

-------------SSSISDLISLPNWNMYVG---------ENQVIDLAALNAPGRKPREVDINID-----------------------------------
             .  . . |.||..|..           .       ... ..|.|.   ...                                    
IQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQ

-------DVGKDLFYKLLMLNPSKRISCDEALQHPWF
       . . ||  |.| ..|.|||....|||||.|
FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase GL50803_15397.AA S_TKc 10-334 24 1.5e-75 258.25 SMART 1-231 (231) Show / Hide
Range on Protein: 10-334
Range on HMM: 1-231/231
Sequence Identity: 24% (84 aa)

YEFISQIGEGTYGTVSKCSLHG--QLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHV--
||.. .||.|..|.| ||  ..  .. |.|.||          ...||..|||                     |.|.|.|| .| .....|.|||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-----------------HHPNIVKLYDVFQD-DHLYMVMEYCDGDL

-DLDQYLKHNV-------LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGINVTS
 || .|.|..        ... .....|||....|   |.. |.|||.|| ||||                          ..||.|||||| .      
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------HIKICDFGLARQL------

ISANVVSLWYRAPELVLASKTYST-AVDMWSMGCIMYFLANKRALFQVRKDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVIDLAALNAPGRKP
 .  ....||.|||..     |.. ..|.|| |||.| ..  . .|.   .. ....                                           
-TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------------------

REVDINIDDVGKDLFYKLLMLNPSKRISCDEALQ-------HPWF
       .. .||.  |.|  .|.||... ||||       ||||
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_15397.AA Pkinase 10-334 27 8.5e-69 239.67 Pfam 1-293 (293) Show / Hide
Range on Protein: 10-334
Range on HMM: 1-293/293
Sequence Identity: 27% (94 aa)

YEFISQIGEGTYGTVSKCSLHGQ--LLAVKRIKMDSSSKGVPATTLR--EVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYC-H
|.....||.|..|.| ||  .|   . |||.|| .. ..... | .|  |..|.| ||                  |.| |.|...| ..| .|.||| .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----------------HPNIVRLYDWFEDKDHIYMVMEYCEG

V----DLDQYLK---HNVL--SPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSY-GIN
     ||  |..   |...  |. ..|..|||.|.||   |.. |.|||.|| |||.  .|. ..                   .||.|||||. .   |
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLAKQFDY-N

VTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQVR----KDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVIDLAALN
 .  .  ....||.|||... .. |...|||||.|||.| ....| .|. .    . .| .|. .   . . .. ..  . . . . .   .        
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------

APGRKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
   . .... .|... .||. ...| ..|.||......||||||
---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GL50803_15397.AA CDC2 82-243 38 6.1e-62 188.93 In-house 62-210 (301) Show / Hide
Range on Protein: 82-243
Range on HMM: 62-210/301
Sequence Identity: 38% (66 aa)

NVVNLLDVVYDLSNIFLVFEYCHVDLDQYLK-----HNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDAD
|.| | ||..  .....||||.. || .|..       ...|  .|..|||.|||..  | . |.|||.|| |||.   |.                   
NIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-------------------

NCVLKITDFGLARSYGINVTSIS--ANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFL---ANKRALFQ
   .|| ||||||  ||..  .    .|| |||||||. | .|.|||.||||| |||.. .   ..|..||.
---IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFH

Kinase GL50803_15397.AA Ciliate-E2 10-334 20 3.8e-56 191.24 In-house 1-365 (365) Show / Hide
Range on Protein: 10-334
Range on HMM: 1-365/365
Sequence Identity: 20% (88 aa)

YEFISQIGEGTYGTVSKC--SLHGQLL------------------AVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDV
|.|| .||.|..|.| ||   . ...                   ..| . | . .|     ...|  |.. .| ... . |.  ||.|.  |.... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VY--DLSNIFLVFEYCHV-DLDQYLKHN------------VLSPYQIKKFMYQLLQ---------------GLSLVHKNE-ILHRDIKPNNILLAFRGDA
 .  | .||.||.|||   || .|.|.|             .. ..||..|.|.||               .|   |..  |.||||||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

GEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN----------VTSISAN----------------------VVSLWYRAPELVL--------ASKT
                     .||.||||.. | ..             .  .                      . .. | ||| .         ..| 
---------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG

YSTAVDMWSMGCIMYFLANKRALFQVRKDADLLQLAFSYFYVDSSSISDLISLPNWNMYVGENQVI--DLAALNAPGRKPREVDIN---------IDDVG
|....|.||.|.|.|..  ..  |                                     ..| .  ..   ..  .|.    ..         ... .
YDYKCDIWSLGVILYEMLFGKPPF-------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQEC

KDLFYK----LLMLNPSKRIS-CDEALQHPWF
|||. |    .|  .|.|||.  ...|.||||
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_15397.AA Ciliate-E2-Unclassified 10-334 22 3.6e-54 186.29 In-house 1-352 (352) Show / Hide
Range on Protein: 10-334
Range on HMM: 1-352/352
Sequence Identity: 22% (90 aa)

YEFISQIGEGTYGTVSKC--SLHGQLLAVKRIK--MDSSSKGVPATTLREVAILKALNAKQ--------RELVEQGKLESLSQANVVNLLDVVYDLSNIF
|..| |||.| .|.| ||  . ..|. | | .|  .. ..| .     ... ..|..| |.        ... .   | ..   ..|.....  |  ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIY

LVFEYC-HVDLDQYLKH------------------NVLSPYQIK-----KFMYQLLQGL-SLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPN
.| ||| . || ||.|.                  . .. .|.|     ....|.|||| .| ||| |.||||||.|||.   |                
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------------

PDADNCVLKITDFGLARSYGINVTS---------------ISANVVSLWYR----APELVLASKTYS---TAVDMWSMGCIMYFLANKRALFQVRKDAD-
    |  .||.|||... |. |. .               .. .. .. |     |||.    . .     ..|.||.|.|.|..   .  |. ... . 
----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQH

---------------LLQLAFSY-FYVDSSSI-SDLISLPNWNMYVGENQVIDLAALNAPGRKPREVDINIDDVGK----DLFYKLLMLNPSKRISCDEA
               |.|  .   .......  .                                .. .... .|    ||. |.|  ||.|||. ...
QQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ--------------------------------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI

LQHPWF
|.||||
LNHPWF

Kinase GL50803_15397.AA CDK5 10-156 39 3.1e-37 114.88 In-house 1-135 (287) Show / Hide
Range on Protein: 10-156
Range on HMM: 1-135/287
Sequence Identity: 39% (60 aa)

YEFISQIGEGTYGTVSKCSLH--GQLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHVDL
|| .  ||||||||| |      . . | ||...||   |||.| .||...|| |  |                |.| | ||.     . ||||.|  ||
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHK----------------NIVRLHDVIHSEKKLTLVFEFCDQDL

DQYLK--HNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
  |.      ...  || ||||||.||.. |....|||| || | |   .|
KKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNG

Kinase GL50803_15397.AA CDK 176-243 44 1.3e-33 104.78 In-house 143-226 (284) Show / Hide
Range on Protein: 176-243
Range on HMM: 143-226/284
Sequence Identity: 44% (37 aa)

DNCV-----LKITDFGLARSYGI------NVTSISANVVSLWYRAPELVLASKTYS--TAVDMWSMGCIMYFLAN---KRALFQ
.| .     |||.|||||| .||      ..   . .|| |||||||| | ||.||  |..|||| |||.. ...   ...||.
NNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFP

Kinase GL50803_15397.AA PCTAIRE 10-156 37 1.7e-29 101.34 In-house 1-134 (291) Show / Hide
Range on Protein: 10-156
Range on HMM: 1-134/291
Sequence Identity: 37% (57 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIKMDSSSKGVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDVVYDLSNIFLVFEYCHVDL
|  .   ||||| || ||   | . | | | |...    | | |  |||  || |                  ||.| | |...      |||||   ||
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLK----------------HANIVTLHDIIHTHHQLTLVFEYMDMDL

DQYLKHNV--LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
 ||. ...  ..   .| |..||| ||   |.  ||||| || | |.  ||
KQYMDDCGNIMNMHNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERG

Kinase GL50803_15397.AA CDK 81-152 37 2.2e-29 91.06 In-house 67-141 (284) Show / Hide
Range on Protein: 81-152
Range on HMM: 67-141/284
Sequence Identity: 37% (31 aa)

ANVVNLLDVVYDL-----------SNIFLVFEYCHVDLDQYLKHNVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILL
.|.|.|.||...            .....||||.. || .|..        || .|.|||.||.  |.| |.|||.||.|||.
PNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI

Kinase GL50803_15397.AA CDK5 177-255 48 4e-29 88.8 In-house 134-213 (287) Show / Hide
Range on Protein: 177-255
Range on HMM: 134-213/287
Sequence Identity: 48% (39 aa)

NCVLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLA-NKRALFQVRKDADLLQLAF
|. ||  |||||| .|| |   |. || ||||.|   . ||.||| .||||.|||.  .| . | ||    . | | . |
NGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIF

Kinase GL50803_15397.AA PITSLRE 179-243 56 9.7e-29 101.8 In-house 144-208 (295) Show / Hide
Range on Protein: 179-243
Range on HMM: 144-208/295
Sequence Identity: 56% (37 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQ
.||| |||||| || .. ... .|| |||||||| | .|.|||.||||| |||.  .  .. |||
ILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQ

Kinase GL50803_15397.AA CDK4 10-153 34 4.6e-28 93.22 In-house 1-144 (290) Show / Hide
Range on Protein: 10-153
Range on HMM: 1-144/290
Sequence Identity: 34% (54 aa)

YEFISQIGEGTYGTVSKC-SLH-GQLLAVKRIKMDSSSK--GVPATTLREVAILKALNAKQRELVEQGKLESLSQANVVNLLDV--VYDLSN----IFLV
|. .  |||| |||| .  .|| |.  | |...  ..    |.|  |.||..... |...               .|.| |.||  | |       | .|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEH-------------PNIVKLMDVCHVMDTDRAEMKITMV

FEYCHVDLDQYLKHNVL---SPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLA
|| |  || .||        .| .||. | ||| |.   | . | ||| || |||..
FEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT

Kinase GL50803_15397.AA CDK7 179-232 55 3e-27 69.24 In-house 140-193 (288) Show / Hide
Range on Protein: 179-232
Range on HMM: 140-193/288
Sequence Identity: 55% (30 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIM
.|||.||||||.||      . .||  |||||||    . | |.|||||.|||.
QLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIF

Kinase GL50803_15397.AA CDK7 82-157 44 1.5e-26 67.35 In-house 63-140 (288) Show / Hide
Range on Protein: 82-157
Range on HMM: 63-140/288
Sequence Identity: 44% (35 aa)

NVVNLLDVVYDLSNIFLVFEYCHVDLDQYLKHN--VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGD
||..|.|.   .||| |||..   ||.   | .  .| |  || .| ..||||   |.| |||||.|||| |.   |.
NVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQ

Kinase GL50803_15397.AA CDK4 180-249 47 3.4e-21 69.3 In-house 149-216 (290) Show / Hide
Range on Protein: 180-249
Range on HMM: 149-216/290
Sequence Identity: 47% (33 aa)

LKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALFQVRKDAD
.|..|||||| |. . .     || |||||||  |.| .| | ||||| |||.  . . |.||    ..|
VKLADFGLARIYS-FQMALTPVVVTLWYRAPEVLLQS-YYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKD

Kinase GL50803_15397.AA PCTAIRE 179-242 46 1.4e-19 65.83 In-house 135-198 (291) Show / Hide
Range on Protein: 179-242
Range on HMM: 135-198/291
Sequence Identity: 46% (30 aa)

VLKITDFGLARSYGINVTSISANVVSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLANKRALF
.||  ||||||   .     |  ||.|||| |. .. |  ||| .|||  ||| | ..  |.||
ELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLF

Kinase GL50803_15397.AA CDC2 10-63 43 5.8e-19 54.42 In-house 1-58 (301) Show / Hide
Range on Protein: 10-63
Range on HMM: 1-58/301
Sequence Identity: 43% (25 aa)

YEFISQIGEGTYGTVSKCSLH--GQLLAVKRIKMDSSSKG--VPATTLREVAILKALN
|. |  ||||||| | ||     .|. |.|.|. .. . |  || |..||  .||.|.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK

Kinase GL50803_15397.AA CDK 10-62 36 2e-18 55.43 In-house 1-65 (284) Show / Hide
Range on Protein: 10-62
Range on HMM: 1-65/284
Sequence Identity: 36% (24 aa)

YEFISQIGEGTYGTVSKCSLHG-------QLLAVKRIKMDS-----SSKGVPATTLREVAILKAL
|| . .|||||||.| |.  .        |. | |.|.|..        |.| |..||...|| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL

Kinase GL50803_15397.AA CDK 267-334 25 8.8e-16 46.81 In-house 251-284 (284) Show / Hide
Range on Protein: 267-334
Range on HMM: 251-284/284
Sequence Identity: 25% (17 aa)

DLISLPNWNMYVGENQVIDLAALNAPGRKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
.. .||..                                  ||  |.|...|.||||...|||||.|
GVTKLPDY----------------------------------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase GL50803_15397.AA CDC2 295-334 45 1.5e-14 40.61 In-house 263-301 (301) Show / Hide
Range on Protein: 295-334
Range on HMM: 263-301/301
Sequence Identity: 45% (18 aa)

KPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
|...  . .|. | ||  ..| ..|.|||| .||||||.|
KKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF

Kinase GL50803_15397.AA CDK7 10-60 38 8.7e-14 32.67 In-house 1-57 (288) Show / Hide
Range on Protein: 10-60
Range on HMM: 1-57/288
Sequence Identity: 38% (22 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIK----MDSSSKGVPATTLREVAILK
|| |..||||...||.|     .||  |.|.||     .    |.  | .||. ||.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQ

Kinase GL50803_15397.AA CDK5 302-334 48 3.5e-13 37.53 In-house 255-287 (287) Show / Hide
Range on Protein: 302-334
Range on HMM: 255-287/287
Sequence Identity: 48% (16 aa)

NIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
. |  | ||  |.|..|| .||| ..||.||.|
KLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF

Kinase GL50803_15397.AA CDK7 309-334 38 5.5e-12 27.78 In-house 263-288 (288) Show / Hide
Range on Protein: 309-334
Range on HMM: 263-288/288
Sequence Identity: 38% (10 aa)

DLFYKLLMLNPSKRISCDEALQHPWF
||  ... .||.||..| ..|..| |
DLMCGMWTMNPCKRWTCTQCLKMPYF

Kinase GL50803_15397.AA TyrKc 10-269 17 6.4e-12 -29.97 SMART 1-280 (280) Show / Hide
Range on Protein: 10-269
Range on HMM: 1-280/280
Sequence Identity: 17% (58 aa)

YEFISQIGEGTYGTVSKCSLHGQLLAVKRIKMDSSSKGVPATTLREVAILKAL--NAKQRELVEQGKLESLSQANVVNLLDVVYDL-------SNIFLVF
 ... ..||| .|.| |. .  .  ||| .| |.      .  .||  |.. |  . .                |.|.|. |. .          ...|.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHP----------------NIVRLYGVCTQQGRNFMYIEPLMIVM

EYC-HVDLDQYLKHNV--LSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARSYGIN---
||. | ||..||. .   |.. .  .|..|  .| .  |.. . |||.   |.|.. ..                      . ||.||||.|  .     
EYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------TVKISDFGLSRDIYDDDQQ

-----VTSI----SAN-VVSLWYRAPELVLASKTYSTAVDMWSMGCIMY----------------FLANKRALFQVRKD--ADLLQL--------AFSYF
     . .     ... .. .   ||| ..  ....|. | || |  |.                .. |.... .|..    .  .         . .  
GESKDYYRKKEHKGGKTMLPIRWMAPE-CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM

YV--------------DSSSISDLI
|                 | | ...
YQIMKQCWHEDPEDRPTFSEIHECF

Kinase GL50803_15397.AA PITSLRE 303-334 50 1.9e-11 38.12 In-house 264-295 (295) Show / Hide
Range on Protein: 303-334
Range on HMM: 264-295/295
Sequence Identity: 50% (16 aa)

IDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
| |.| ||  ..| .|| .||. ..||.||||
ISDTGFDLLNQMLTYNPKNRITASDALKHPWF

Kinase GL50803_15397.AA PITSLRE 10-63 37 4.9e-11 36.6 In-house 1-59 (295) Show / Hide
Range on Protein: 10-63
Range on HMM: 1-59/295
Sequence Identity: 37% (22 aa)

YEFISQIGEGTYGTVSKCS--LHGQLLAVKRIKMD--SSSKGVPATTLREVA-ILKALN
.. . .|.||||| |..    . .   | ||.||.      | | | |||.  ||.||.
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQ

Kinase GL50803_15397.AA CDK4 294-334 36 7e-09 26.38 In-house 250-290 (290) Show / Hide
Range on Protein: 294-334
Range on HMM: 250-290/290
Sequence Identity: 36% (15 aa)

RKPREVDINIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF
|.....   ..  |.||  | |  |..||.|  ..||||.|
RPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF

Kinase GL50803_15397.AA PCTAIRE 307-334 35 2.3e-07 22.0 In-house 264-291 (291) Show / Hide
Range on Protein: 307-334
Range on HMM: 264-291/291
Sequence Identity: 35% (10 aa)

GKDLFYKLLMLNPSKRISCDEALQHPWF
. ||  .|| . . .|.| ..|..||.|
CQDLLTMLLQYESKNRVSAEKAMKHPYF

Kinase GL50803_15397.AA PITSLRE 82-156 34 2.5e-07 22.96 In-house 62-143 (295) Show / Hide
Range on Protein: 82-156
Range on HMM: 62-143/295
Sequence Identity: 34% (28 aa)

NVVNLLDVV--YDLSNIFLVFEYCHVDLDQYL-KHN----VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRG
|.||.. .|   ..  |..|.||   ||   . ...      .| .|| .| ||| | .  |.| |.||| |  |.|.   |
NIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKG

Kinase GL50803_15397.AA Pkinase_Tyr 82-189 26 0.000164 15.9 Pfam 65-159 (270) Show / Hide
Range on Protein: 82-189
Range on HMM: 65-159/270
Sequence Identity: 26% (31 aa)

NVVNLLDVVY-DLSN--IFLVFEYC-HVDLDQYLKHN-----VLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNILLAFRGDAGEQLAANASVTTPN
|.|.|. |.. .     |..|.||. | ||. ||. .      |.. .. .. .|  .|..  . . . |||.   |.|..                   
NIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-------------------

PDADNCVLKITDFGLAR
   .| | ||.||||||
---ENNVVKICDFGLAR

Kinase GL50803_15397.AA Pkinase_Tyr 10-46 25 0.000887 13.42 Pfam 1-43 (270) Show / Hide
Range on Protein: 10-46
Range on HMM: 1-43/270
Sequence Identity: 25% (11 aa)

YEFISQIGEGTYGTVSKCSLH------GQLLAVKRIKMDSSSK
 .|. ..||| .|.| |. ..      ..  ||| .| .....
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHE