Gene GL50803_15479 (G.lamblia)

GL50803_15479

Species: G.lamblia
Alias: GL50803_15479, GK255
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15479.AA Protein None 369 None Fasta, JSON
GL50803_15479.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of GL50803_15479.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15479.AA Ciliate-E2-Unclassified 217-347 16 2.1e-16 53.41 In-house 164-352 (352) Show / Hide 
Range on Protein: 217-347
Range on HMM: 164-352/352
Sequence Identity: 16% (32 aa)

GFLHRNITSKSVFVADDG---TVLLSGFDFACPLT--------------LLADKEQLQVYGSRAYA----PPELEDR-VLT----TASDVWALGCLVYEM
...||.|.   ... ..|    . ...| ..  .                . .... .. |.  |     .||. ..         ..|.|.||.. |||
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

CTCSLLFVDAVQES-------------RKEFQISDIALQTP-----------ELS--------KLCQRMLSLDPTERITVDEILEDQRV
..  . | |  .|.             ||...   .. ..             .|        .|.|.||  .| .||| ..||. .  
LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
S_TKc GL50803_15479.AA S_TKc 85-347 19 3.2e-16 61.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 85-347
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

LLCTETIWIGAHSVIYRAIDPATSNIYAVREVDCSELSDDSVYFHMLRQEGPLLDSLEHSNIDSPVLYSADYDDNTLWLVFPLYKH--GSLSDVLERFRK
    ..|  || .. |....  |  |.|. ...            ..|.|  .| .  | ||    || . .| . |..|. .  .  |.| |.... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNI--VKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

--SNALPSVQFIYSVMNALSRALQYLHTSATFGDYTGFLHRNITSKSVFVADDGTVLLSGFDFACPLTLLADKEQLQVYGSRAYAPPELEDRVLTT-ASD
   .   .   . ..|  . .||.|.|      .  |..|| .    ... .  .. .. | .|. |          . |.. | .||.     .. ..|
HGLRFPFPE-HARFYMYQICCALEYCH------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--GYGKCKCD

VWALGCLVYEMCTCSLLFVDAVQESRKEFQISDIALQTPELSKLCQRMLSLDPTERITVDEILE-------DQRV
.|..||..|||..   .|         .... .. . .||.  . ...|  ||..|.|. |.|.       .. .
WWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_15479.AA TKL 120-343 14 3.7e-16 54.7 In-house 61-362 (364) Show / Hide 
Range on Protein: 120-343
Range on HMM: 61-362/364
Sequence Identity: 14% (45 aa)

ELSDDSVYFHMLRQEGPLLDSLEHSNIDSPVLYSA-DYDDNT-------------LWLVFPLYKHGSLSDVLERFRKSNALPSVQFIYSVMNALSRALQY
.  . | ..  ...|  .. .| | ||   |.. . . . .              |..|  ....||| ..|            . . . .   .|...|
NDPEASWFRFFEEEEIMMMSRLRHPNI---VQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNY

LHTSA----TFGDYTGFLHRNITSKSVFVADDGT--------------VLLSGFDFACPLTLLADKEQLQ------------------VYGSRAYAPPEL
||..     |     . .||...|| ..| ...|              . .. | ..  ..   ...  .                  . |. .. .||.
LHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

-----------------EDRVLTTASDVWALGCLVYEMCTCSLLFVDAVQESRK------EFQISDI-ALQTPELS--------------------KLCQ
                 . .  ....||.. | . .|..|. . . |   ....      |... ..   . |..                     ||.|
LRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQ

RMLSLDPTERITVDEILE
.  . ||..| . .|||.
DCWDHDPEKRPSFQEILK
Kinase GL50803_15479.AA Pkinase 260-347 16 8.1e-13 46.4 Pfam 173-293 (293) Show / Hide 
Range on Protein: 260-347
Range on HMM: 173-293/293
Sequence Identity: 16% (20 aa)

GSRAYAPPEL--EDRVLTTASDVWALGCLVYEMCTCSLLFVDA------------VQESRKEFQISDIALQT-------------------PELSKLCQR
|.. |..||.  ...  ....|.|..||..|||..  ..| ..            ..  ....  .   . .                   .|. ... .
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

MLSLDPTERITVDEILEDQRV
.| .||..|.| ..||..  .
CLCKDPKKRPTAEQILQHPWF
Kinase GL50803_15479.AA Ciliate-E2 157-347 15 1.4e-12 39.49 In-house 105-365 (365) Show / Hide 
Range on Protein: 157-347
Range on HMM: 105-365/365
Sequence Identity: 15% (44 aa)

DDNTLWLVFPLYKHGSLSDVLE---RFRKSNAL----PSVQFIYSVMNALSR---------------ALQYLHTSATFGDYTG-FLHRNITSKSVFVADD
|||.. ||. ....|.| | ..    .|...      .. . |  .|  . .               ||.|||         .  .||.|    ...   
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK-------NNIIHRDIKPENILF---

GTVLLSGFDFA------------CPLTLLADKEQLQ-------------------VYGSRAYAPPELEDRV----------LTTASDVWALGCLVYEMCT
  . .. | ..            ...  .    . .                   ..|.  | .||   .            ....|.|.||.. |||..
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

CSLLFVDAVQESRK-EFQIS----------------DIALQTPELSKLCQR----MLSLDPTERIT-VDEILEDQRV
  . |    |.  . .....                .    ..|   |...    ||  || .|||  ..||. .  
GKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_15479.AA SCY1 199-347 17 8.9e-12 37.14 In-house 133-337 (337) Show / Hide 
Range on Protein: 199-347
Range on HMM: 133-337/337
Sequence Identity: 17% (36 aa)

LSRALQYLHTSATFGDYTGFLHRNITSKSVFVADDGTVLLSG---------FDFACPLT-------LLADKEQ-------------LQVYGSRAYAPPE-
...||..|| ..       ..|.||. .|.||  .|.  ..|         .|| |. .        ....|              .. | . ....|. 
ILDALSFLHNDCH------MVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWREMDYISVSSTKPDNKYPPPCQPNPDW

------LED------------RVLTTASDVWALGCLVYEMCTCSLLFVDAVQES-------------RKEFQISDIALQTPEL-SKLCQRMLSLDPTERI
      .||            ...|.|||.. ||||.... .   .. .... .             ...   ..|  ...|. .   ...|. ||| | 
LAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWDHIPKELQEHLGHCYCHLLHQDPTCRP

TVDEILEDQRV
.....|.. . 
DPQQFLQHCYF
Kinase GL50803_15479.AA AGC 260-341 19 4.4e-11 23.38 In-house 267-389 (395) Show / Hide 
Range on Protein: 260-341
Range on HMM: 267-389/395
Sequence Identity: 19% (25 aa)

G--SRAYAPPELEDRVLTTASDVWA--LGCLVYEMCTCSLLFVD--------------AVQESRKEFQ---ISDIALQ-------------TPELSKLCQ
|  .  | .||      . | | |.  |||| ||| |    | .               . .. .. .     .. .              .||.  |..
GPCTPEYMAPEIL---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIK

RMLSLDPTERIT----------VDEI
..|  ||..|..          ..||
KLLCKDPEKRLGCGGNDFGDKGAEEI
Kinase GL50803_15479.AA NEK-Unclassified 219-293 36 1.5e-10 30.83 In-house 119-193 (258) Show / Hide 
Range on Protein: 219-293
Range on HMM: 119-193/258
Sequence Identity: 36% (28 aa)

LHRNITSKSVFVADDGTVLLSGFDFACPLTLLADKEQLQVYGSRAYAPPE-LEDRVLTTASDVWALGCLVYEMCTC
.||      .|  || || .  |  .  .    || .  | |.  .  || ..|      ||||.|||..||||||
IHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCV-GTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC
Kinase GL50803_15479.AA NEK2 278-292 66 3.4e-08 23.55 In-house 245-259 (319) Show / Hide 
Range on Protein: 278-292
Range on HMM: 245-259/319
Sequence Identity: 66% (10 aa)

SDVWALGCLVYEMCT
||.|..|||.||||.
SDIWSVGCLIYEMCA
Kinase GL50803_15479.AA TyrKc 85-345 17 7.9e-08 -96.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 85-345
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

LLCTETIWIGAHSVIYRAIDPATSNIYAVREVDCSELSDDSVYFHMLRQEGPLLDSL--EHSNIDSPVLYSADYDD-------NTLWLVFPLYKHGSLSD
.   ...  ||  ..|...          ..|    | .|.    ....|  .. .|  .| ||    || .  ..         |..|. . .||.| |
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVR--LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLERFRKSNALPSVQFIYSVMNALSRALQYLHTSATFGDYTGFLHRNITSKSVFVADDGTVLLSGFDFACPLTLLADKE-------QLQVY----GSR--
 | . |.   |.  ....    . ..  .|||         .. || .    . |....||  |  ||   |.   . .       .  .     |..  
YLRKHRPK--LCMKDLLSFCWQI-ACGMEYLHSK-------NCIHRDLAARNCLVGENHTVKIS--DFG--LSRDIYDDDQQGESKDYYRKKEHKGGKTM

---AYAPPE-LEDRVLTTASDVWALGCLVYEMCT------CS-----LLFVDAVQESRKEFQISDIAL--------QTPELSKLCQRMLSLDPTERITVD
      .|| . ... ||.||||. | . .|..|             .   ....  .. .     .          ..|. .. ..    || .| |  
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

EILEDQ
|| |. 
EIHECF
Kinase GL50803_15479.AA NAK 273-291 47 2e-06 17.3 In-house 217-235 (299) Show / Hide 
Range on Protein: 273-291
Range on HMM: 217-235/299
Sequence Identity: 47% (9 aa)

VLTTASDVWALGCLVYEMC
. .. .|.|||||. | ||
PIDEKVDIWALGCMLYKMC
Kinase GL50803_15479.AA NEK 278-293 68 2e-06 19.18 In-house 205-220 (286) Show / Hide 
Range on Protein: 278-293
Range on HMM: 205-220/286
Sequence Identity: 68% (11 aa)

SDVWALGCLVYEMCTC
||.|.|||..|||||.
SDIWSLGCVLYEMCTL
Kinase GL50803_15479.AA Pkinase_Tyr 266-292 42 7e-06 20.58 Pfam 182-209 (270) Show / Hide 
Range on Protein: 266-292
Range on HMM: 182-209/270
Sequence Identity: 42% (12 aa)

PPE-LEDRVLTTASDVWALGCLVYEMCT
.|| . ... ||.||||. | | .|..|
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase GL50803_15479.AA NEK6 85-238 25 1.4e-05 14.09 In-house 1-144 (252) Show / Hide 
Range on Protein: 85-238
Range on HMM: 1-144/252
Sequence Identity: 25% (40 aa)

LLCTETIWIGAHSVIYRAIDPATSNIYAVREVDCSELSDDSVYFHMLRQEGPLLDSLEHSNIDSPVLYSADY-DDNTLWLVFPLYKHGSLSDVLERFRKS
      |  |  | .|||         |.. |   |. |       .. |  || .|.| |.   . | | . ..| | .|  |   | .| ..  |.| 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIK-EIDLLKQLNHPNV---IKYYASFIENNELNIVLELADAGDMSRMIKHFKKQ

NALPSVQFIYSVMNALSRALQYLHTSATFGDYTGFLHRNITSKSVFVADDGTVLL
  |   . |.     |..||. .|           .|| |    ||.  .| | |
KRLIPERTIWKYFVQLCSALEHMHSKR-------VMHRDIKPANVFITANGIVKL
Pkinase GL50803_15479.AA Pkinase 85-207 20 1.6e-05 20.6 Pfam 1-125 (293) Show / Hide 
Range on Protein: 85-207
Range on HMM: 1-125/293
Sequence Identity: 20% (27 aa)

LLCTETIWIGAHSVIYRAIDPATSNIYAVREVDCSELSDDSVYFHMLRQEGPLLDSLEHSNIDSPV-LYSADYDDNTLWLVFPLYKHG----SLSDVLE-
. . ..|  |. .. |....  |. |.|| ... .. ...  . | ...|  .. .| | ||   | || . .|.. ...|...  .|    .|.|... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI---VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

RFRKSN--ALPSVQFIYSVMNALSRALQYLH
. ...       ..|.   |  . |.|.|.|
WRHGCFYFSEWECKFY---MYQILRGLEYCH
Kinase GL50803_15479.AA NEK 318-347 33 2.7e-05 15.03 In-house 257-286 (286) Show / Hide 
Range on Protein: 318-347
Range on HMM: 257-286/286
Sequence Identity: 33% (10 aa)

PELSKLCQRMLSLDPTERITVDEILEDQRV
..|..| ..||  ||..| ....|||.  .
QDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_15479.AA NEK2 319-347 24 4.5e-05 12.9 In-house 291-319 (319) Show / Hide 
Range on Protein: 319-347
Range on HMM: 291-319/319
Sequence Identity: 24% (7 aa)

ELSKLCQRMLSLDPTERITVDEILEDQRV
.|...  .|. .|.  |  ..|||.. ..
HLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_15479.AA NEK6 278-290 76 0.000356 9.36 In-house 184-196 (252) Show / Hide 
Range on Protein: 278-290
Range on HMM: 184-196/252
Sequence Identity: 76% (10 aa)

SDVWALGCLVYEM
||.|.||||.|||
SDIWSLGCLLYEM
Kinase GL50803_15479.AA NAK 319-345 25 0.009633 4.89 In-house 273-299 (299) Show / Hide 
Range on Protein: 319-345
Range on HMM: 273-299/299
Sequence Identity: 25% (7 aa)

ELSKLCQRMLSLDPTERITVDEILEDQ
.. .| . ||  || .|......|.  
QMHDLIRYMLTPDPEQRPNIYQVLNQL