GL50803_15548

Species: G.lamblia
Alias: GK056, GL50803_15548
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15548.AA Protein None 1066 None Fasta, JSON
GL50803_15548.kin_dom Protein Kinase Domain None 315 None Fasta, JSON

Protein domain

Protein domains of GL50803_15548.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15548.AA Trio 794-888 26 1.4e-09 20.07 In-house 93-191 (258) Show / Hide
Range on Protein: 794-888
Range on HMM: 93-191/258
Sequence Identity: 26% (27 aa)

SERRIRVFIRSLLQAINFLYSNDTKLIHRDLRPNQIWVKKNSNGDPVAKIYHMGFMYPLSAN--EPMEHNTI---WVAPEVVCG-GIDTKSDIWSVGTLT
.|. ...... .|.|.. | ..    .| |..|  . . .   | |  ||   |.  .|.    || .| .     .|||.. | ...  .||||.| ||
CESEVKTYMWQMLEAVHYLHNC--HILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLT

F
.
Y

S_TKc GL50803_15548.AA S_TKc 661-1055 12 1.6e-09 -37.27 SMART 1-231 (231) Show / Hide
Range on Protein: 661-1055
Range on HMM: 1-231/231
Sequence Identity: 12% (51 aa)

YDAGLK-------SVMAAICTTFPPVAVIKNRFIILPQKTKITAGYGFSTKMPKTNSFNVMLPAWDLLQHTVLSAKIFPMTLSGKQFLRVYRQLSHRGIL
|. . |       .|. .. .    .  ||                                                 ....  | |.      |  | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------------------EHIRREIQILKK----HHPNIV

SFVGCGTAINNAFYVFTESPPK--IKLSRVFQYDEE-ALQLFRSERRIRVFIRSLLQAINFLYSNDTKLIHRDLRPNQIWVKKNSNGDPVAKIYHMGFMY
 . ..     . .|...|  .     | .. .      |.   .| ..| ... ...|.... |.  . ||||| |  | . .      . ||   |.  
KLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLAR

PLSANEPMEHNTIWVAPEVVCGGIDT-KSDIWSVGTLTFRLLETLVNLHQGRRGHNLNNLFCPSFADISKVPSFAPGSGERSLLVANNSSVIYQMMLMSS
 |     .     ..||||.  | .. |.|.||.| . . .|     . .     ... .|                                       
QL---TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG-----------------------------------

DKVEVAPNRYAVYTVKNCDAAIEKAKVPWSMRRAYFASTGILPWYDLNYAKPGAQKEECGNLDTFFETAIYSQIISANAVDFIKRCWTFNLDLRWSPELM
                                                                           |  | |||..|.... . |..    
---------------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LT-------HPWL
|.       |||.
LQDEWDIKCHPWF

Kinase GL50803_15548.AA CAMK-Tt 1024-1055 50 4.8e-09 26.85 In-house 365-396 (396) Show / Hide
Range on Protein: 1024-1055
Range on HMM: 365-396/396
Sequence Identity: 50% (16 aa)

ISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
|| .| | ||.| | | . |  |. || |||.
ISEEAKDLIKKCLTINPEQRIKPDQMLQHPWI

Kinase GL50803_15548.AA STE 1020-1055 26 5.6e-08 24.38 In-house 322-359 (359) Show / Hide
Range on Protein: 1020-1055
Range on HMM: 322-359/359
Sequence Identity: 26% (10 aa)

YSQIISANAVDFIKRCWTFNLDLRWSPELMLT--HPWL
|.   | .  |||..| . . . |.... .|   ||..
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GL50803_15548.AA CMGC 1014-1055 21 8.8e-07 17.32 In-house 460-513 (513) Show / Hide
Range on Protein: 1014-1055
Range on HMM: 460-513/513
Sequence Identity: 21% (12 aa)

FFETAIYSQ---------------IISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
|  . || .                ..  |.|..|.. ... | |...|  | ||..
F-NW-IY-EEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase GL50803_15548.AA CDK4 1021-1055 20 4e-06 16.89 In-house 256-290 (290) Show / Hide
Range on Protein: 1021-1055
Range on HMM: 256-290/290
Sequence Identity: 20% (7 aa)

SQIISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
.. ..  . |..... ..|...| | .  | ||..
CPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF

Kinase GL50803_15548.AA Ciliate-E2-Unclassified 866-891 41 6e-06 16.68 In-house 234-264 (352) Show / Hide
Range on Protein: 866-891
Range on HMM: 234-264/352
Sequence Identity: 41% (13 aa)

APEVVCG-GID----TKSDIWSVGTLTFRLL
|||| .| . |     |.||||.| . . .|
APEVLQGQNYDHSKAYKCDIWSLGVILYEML

Kinase GL50803_15548.AA CAMK-Unique 1015-1055 37 8e-06 14.96 In-house 321-363 (363) Show / Hide
Range on Protein: 1015-1055
Range on HMM: 321-363/363
Sequence Identity: 37% (16 aa)

FETAIYSQI--ISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
|..  ..    || .| ||.|.| |  .| ||| .  | |.|.
FDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase GL50803_15548.AA STE 864-884 50 1.2e-05 16.06 In-house 228-255 (359) Show / Hide
Range on Protein: 864-884
Range on HMM: 228-255/359
Sequence Identity: 50% (14 aa)

WVAPEVVCG-------GIDTKSDIWSVG
| ||||. .       | |||.||||.|
WMAPEVIQQNGQGRDKGYDTKCDIWSLG

Kinase GL50803_15548.AA STE20 1025-1055 25 1.9e-05 16.24 In-house 258-288 (288) Show / Hide
Range on Protein: 1025-1055
Range on HMM: 258-288/288
Sequence Identity: 25% (8 aa)

SANAVDFIKRCWTFNLDLRWSPELMLTHPWL
| .  ||...| . . . |.... .|.||..
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase GL50803_15548.AA DYRK 1029-1055 40 2e-05 16.59 In-house 294-320 (320) Show / Hide
Range on Protein: 1029-1055
Range on HMM: 294-320/320
Sequence Identity: 40% (11 aa)

VDFIKRCWTFNLDLRWSPELMLTHPWL
.||||.| ... . |..|.  | |||.
KDFIKKCLQWDPHKRITPSQALQHPWF

Kinase GL50803_15548.AA CAMK 1024-1055 25 3e-05 12.09 In-house 386-425 (425) Show / Hide
Range on Protein: 1024-1055
Range on HMM: 386-425/425
Sequence Identity: 25% (10 aa)

ISAN--------AVDFIKRCWTFNLDLRWSPELMLTHPWL
|| .        . |.|... . . . |.. |  | |||.
ISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase GL50803_15548.AA Pkinase 1024-1055 37 4.9e-05 18.89 Pfam 262-293 (293) Show / Hide
Range on Protein: 1024-1055
Range on HMM: 262-293/293
Sequence Identity: 37% (12 aa)

ISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
.| .. ||||.|....   |...|  | |||.
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GL50803_15548.AA STE20 864-884 48 5.2e-05 14.58 In-house 188-214 (288) Show / Hide
Range on Protein: 864-884
Range on HMM: 188-214/288
Sequence Identity: 48% (13 aa)

WVAPEVVCG------GIDTKSDIWSVG
| ||||...      | |.|.||||.|
WMAPEVIQCMEGPDKGYDYKCDIWSLG

Kinase GL50803_15548.AA CMGC 796-826 27 6.4e-05 11.08 In-house 170-212 (513) Show / Hide
Range on Protein: 796-826
Range on HMM: 170-212/513
Sequence Identity: 27% (12 aa)

RR----IRVFI------RSLLQAIN--FLYSNDTKLIHRDLRP
||    |. |.      . .|....  .. |.. . ||||| |
RRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKP

Kinase GL50803_15548.AA DYRK 796-826 35 0.000136 13.4 In-house 103-132 (320) Show / Hide
Range on Protein: 796-826
Range on HMM: 103-132/320
Sequence Identity: 35% (11 aa)

RRIRVFIRSLLQAINFLYSNDTKLIHRDLRP
...|.|....|... ||..|  ..|| || |
NLVRKFAQQILTCLKFLHKNE-NIIHCDLKP

Kinase GL50803_15548.AA CAMK 865-888 25 0.000226 9.21 In-house 286-325 (425) Show / Hide
Range on Protein: 865-888
Range on HMM: 286-325/425
Sequence Identity: 25% (10 aa)

VA-PEVVCG---------------GIDTKSDIWSVGTLTF
.| |||. |               ... |.|.||.| ...
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY

Kinase GL50803_15548.AA Ciliate-E2-Unclassified 1021-1055 30 0.000675 9.43 In-house 314-352 (352) Show / Hide
Range on Protein: 1021-1055
Range on HMM: 314-352/352
Sequence Identity: 30% (12 aa)

SQIISANAVDFIK----RCWTFNLDLRWSPELMLTHPWL
....| .| |||.    ..   |.. | ..|  | |||.
PKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_15548.AA CAMK-Unique 865-892 23 0.001157 7.74 In-house 242-288 (363) Show / Hide
Range on Protein: 865-892
Range on HMM: 242-288/363
Sequence Identity: 23% (11 aa)

VAP--------------EVVC-GGIDTKS----DIWSVGTLTFRLLE
.||              ||.   ..| ..    |||| | ... .|.
MAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLC

Kinase GL50803_15548.AA Pkinase 794-824 29 0.001515 13.62 Pfam 106-134 (293) Show / Hide
Range on Protein: 794-824
Range on HMM: 106-134/293
Sequence Identity: 29% (9 aa)

SERRIRVFIRSLLQAINFLYSNDTKLIHRDL
||. .. ... .|.......|.  . |||||
SEWECKFYMYQILRGLEYCHSM--GIIHRDL

Kinase GL50803_15548.AA CAMK 794-826 33 0.003185 5.44 In-house 177-207 (425) Show / Hide
Range on Protein: 794-826
Range on HMM: 177-207/425
Sequence Identity: 33% (11 aa)

SERRIRVFIRSLLQAINFLYSNDTKLIHRDLRP
.||  | ..| ...|.... |..   .|||| |
TEREARRYFRQICSAVHYCHSHN--IVHRDLKP

Kinase GL50803_15548.AA CDK4 794-831 36 0.003603 6.48 In-house 108-143 (290) Show / Hide
Range on Protein: 794-831
Range on HMM: 108-143/290
Sequence Identity: 36% (14 aa)

SERRIRVFIRSLLQAINFLYSNDTKLIHRDLRPNQIWV
..  |.   . || .. || |.    ||||| |  | |
PPCTIKHMMHQLLRGVDFLHSH--RIIHRDLKPQNILV

Kinase GL50803_15548.AA Ciliate-E2-Unclassified 794-827 23 0.003651 6.85 In-house 136-173 (352) Show / Hide
Range on Protein: 794-827
Range on HMM: 136-173/352
Sequence Identity: 23% (9 aa)

SERRIR-----VFIRSLLQAINFLYSNDTKLIHRDLRPN
.|. ..      ... .||....| ..  . ||||. |.
TEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPE

Kinase GL50803_15548.AA CMGC 866-884 33 0.011063 3.6 In-house 293-322 (513) Show / Hide
Range on Protein: 866-884
Range on HMM: 293-322/513
Sequence Identity: 33% (10 aa)

APEVVCGGI-----------DTKSDIWSVG
|||. .|             .|. |.||||
APEILLGWKHYTNHNYSMHYTTPIDMWSVG

Kinase GL50803_15548.AA CAMK-Unique 794-824 33 0.015714 3.94 In-house 153-183 (363) Show / Hide
Range on Protein: 794-824
Range on HMM: 153-183/363
Sequence Identity: 33% (11 aa)

SE--RRIRVFIRSLLQAINFLYSNDTKLIHRDL
||  . ..  ...||.|.... |.|   .||||
SERCWDTCFIMQCLLSAVAYMHSQD--IVHRDL

Kinase GL50803_15548.AA Trio 1024-1055 31 0.038008 0.58 In-house 227-258 (258) Show / Hide
Range on Protein: 1024-1055
Range on HMM: 227-258/258
Sequence Identity: 31% (10 aa)

ISANAVDFIKRCWTFNLDLRWSPELMLTHPWL
.| ||..||.         | . .  | |||.
VSQNAKHFICKVLQEDPWKRPCASECLQHPWF

Kinase GL50803_15548.AA Pkinase 864-884 39 0.042779 8.49 Pfam 177-199 (293) Show / Hide
Range on Protein: 864-884
Range on HMM: 177-199/293
Sequence Identity: 39% (9 aa)

WVAPEV-V-CGGIDTKSDIWSVG
..||||   . ....|.|.||.|
YMAPEVIRGGQYYGPKVDMWSCG

Kinase GL50803_15548.AA STE 794-826 32 0.078537 2.4 In-house 149-180 (359) Show / Hide
Range on Protein: 794-826
Range on HMM: 149-180/359
Sequence Identity: 32% (11 aa)

SERRIRVFIRSLLQA-INFLYSNDTKLIHRDLRP
.|  |....|..|..  ..| |.    ||||. |
PESQIAYICRQILKGLLYYLHSHH--IIHRDIKP