Gene GL50803_15953 (G.lamblia)
GL50803_15953
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_15953.AA | Protein | None | 1117 | None | Fasta, JSON |
| GL50803_15953.kin_dom | Protein Kinase Domain | None | 277 | None | Fasta, JSON |
Protein domains of GL50803_15953.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_15953.AA | S_TKc | 8-282 | 16 | 1.2e-10 | -20.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-282 Range on HMM: 1-231/231 Sequence Identity: 16% (48 aa) YQVSDIVSNDVYLKISQGKRRSDGALVTFRELDYHNLISANMPLNFYELEAHSKINHYAICRIEEMHHDQHRSRLFLVTEFWDN--KTLADLTSAHKQ-- |.. ... . | ... ...| .| ... |.. ..| .| |... .. .| ..|..|.|. |. .| |. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG TGVPVPEDLVWRILVHANEGLFYYHSVFKSNAPDVRRILHRHITPQSIVMRNNGAVKI--------VHPEIPYLIAIRDHSNISPEEKKYVAPEVLGGRG ...| || ..... ..| | || ..|.|| . |. | . . .|| . .. . . |.||||| | LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPW--YMAPEVL---G FSD-RSDIYALGCIIYQLCTLRNFADVFKNDISYYTNPRTTVPNPEPNGGRMYTALLPNYSQELNEIIGNMTAFDETRRFTSNDVRN----------F .. ..|....|||.| ... . . .. . . . |.|. ..| .. .| ..| | .. . | YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_15953.AA | NEK2 | 185-216 | 40 | 9.8e-10 | 28.83 | In-house | 230-261 (319) | Show / Hide |
Range on Protein: 185-216 Range on HMM: 230-261/319 Sequence Identity: 40% (13 aa) YVAPEVLGGRGFSDRSDIYALGCIIYQLCTLR | ||.. |. ...||| ..||.|| .|.|. YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH |
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| Kinase | GL50803_15953.AA | PDK1 | 185-212 | 53 | 3.7e-09 | 23.67 | In-house | 205-232 (307) | Show / Hide |
Range on Protein: 185-212 Range on HMM: 205-232/307 Sequence Identity: 53% (15 aa) YVAPEVLGGRGFSDRSDIYALGCIIYQL || ||.| . . ..|| ||||||||. YVSPELLTDKECTPSCDIWALGCIIYQM |
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| Kinase | GL50803_15953.AA | PLK2 | 185-210 | 65 | 7.2e-09 | 24.4 | In-house | 169-194 (257) | Show / Hide |
Range on Protein: 185-210 Range on HMM: 169-194/257 Sequence Identity: 65% (17 aa) YVAPEVLGGRGFSDRSDIYALGCIIY |.|||||. | | ||| ||||| | YIAPEVLNRQGHSCESDIWALGCIMY |
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| Kinase | GL50803_15953.AA | NEK-Unclassified | 185-220 | 44 | 8.8e-09 | 24.88 | In-house | 163-198 (258) | Show / Hide |
Range on Protein: 185-220 Range on HMM: 163-198/258 Sequence Identity: 44% (16 aa) YVAPEVLGGRGFSDRSDIYALGCIIYQLCTLRNFAD . .|||. . .|||. .|||||| .|| | | WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFD |
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| Kinase | GL50803_15953.AA | Ciliate-E2-Unclassified | 185-214 | 34 | 1.1e-08 | 26.3 | In-house | 228-265 (352) | Show / Hide |
Range on Protein: 185-214 Range on HMM: 228-265/352 Sequence Identity: 34% (13 aa) YV----APEVLGGRGFSDR----SDIYALGCIIYQLCT | |||||.| . ... .||..||.|.|.... YMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_15953.AA | AGC | 185-214 | 34 | 1.3e-08 | 16.88 | In-house | 273-300 (395) | Show / Hide |
Range on Protein: 185-214 Range on HMM: 273-300/395 Sequence Identity: 34% (11 aa) YVAPEVLGGRGFSDRSDIYA--LGCIIYQLCT |.|||.| . |... |||..|.. | YMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_15953.AA | Pkinase | 185-214 | 35 | 5.1e-08 | 29.45 | Pfam | 177-207 (293) | Show / Hide |
Range on Protein: 185-214 Range on HMM: 177-207/293 Sequence Identity: 35% (11 aa) YVAPEVLG-GRGFSDRSDIYALGCIIYQLCT |.||||. |.. . ..|....|||.|.... YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | GL50803_15953.AA | Ciliate-E2 | 185-214 | 30 | 5.2e-08 | 23.56 | In-house | 253-291 (365) | Show / Hide |
Range on Protein: 185-214 Range on HMM: 253-291/365 Sequence Identity: 30% (12 aa) YVAPEVLGGRG---------FSDRSDIYALGCIIYQLCT |.|||.|.| . . .||..||.|.|.... YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_15953.AA | NEK | 185-216 | 41 | 9.8e-08 | 23.73 | In-house | 190-223 (286) | Show / Hide |
Range on Protein: 185-216 Range on HMM: 190-223/286 Sequence Identity: 41% (14 aa) YVAPEVLGGRGFSDRSDIYALGCIIYQLCTL--R | .|||. ... . .||| .|||..|..||| . YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK |
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| Kinase | GL50803_15953.AA | Ciliate-E3 | 185-213 | 41 | 6e-07 | 18.03 | In-house | 174-202 (202) | Show / Hide |
Range on Protein: 185-213 Range on HMM: 174-202/202 Sequence Identity: 41% (12 aa) YVAPEVLGGRGFSDRSDIYALGCIIYQLC | |||.. .| ||.| .| .. ||| YAAPEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | GL50803_15953.AA | STE-Unique | 185-239 | 20 | 1.3e-05 | 15.33 | In-house | 514-577 (616) | Show / Hide |
Range on Protein: 185-239 Range on HMM: 514-577/616 Sequence Identity: 20% (13 aa) YVAPEVLGGR-----GFSDRSDIYALGCIIYQLCTLRNFADVFKNDIS--YYTNPRTTVPN--P | .|||. .| ... ..||. |||.. .|.. . . . .. .. .. .. |. | YMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCP |
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| Kinase | GL50803_15953.AA | STE-Unique | 82-162 | 25 | 9.8e-05 | 12.1 | In-house | 369-452 (616) | Show / Hide |
Range on Protein: 82-162 Range on HMM: 369-452/616 Sequence Identity: 25% (24 aa) LFLVTEFWDNKTLADLTSAHKQTGVP--------VPEDLVWRILVHANEGLFYYHSVFKSNAPDVRR--ILHRHITPQSIVMRNNG-----AVKIV . .. |. ...|| ... |..| | ||..| ... .. ||| | || .. |.|| . | |. . | |||. VWIFMEYCEHGTLQQII---KRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHS---------QHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC |
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| Kinase | GL50803_15953.AA | Ciliate-E2-Unclassified | 62-161 | 18 | 0.000688 | 9.4 | In-house | 76-188 (352) | Show / Hide |
Range on Protein: 62-161 Range on HMM: 76-188/352 Sequence Identity: 18% (22 aa) INHYAICRIEEMHHDQHRSRLFLVTEFWDNKTLADLTS-------------AHKQTGVPVPEDLVW-----RILVHANEGLFYYHSVFKSNAPDVR-RIL .||. .... .....| . ...|.|. ....| . . ..... ..| . ... . .|| |.|. |. LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---------KNNII HRHITPQSIVMRNNG---AVKI || |.|. |.. ||| .|| HRDIKPENILFDNNGKNYYIKI |
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| Kinase | GL50803_15953.AA | Ciliate-E3 | 60-94 | 25 | 0.04656 | 2.56 | In-house | 57-91 (202) | Show / Hide |
Range on Protein: 60-94 Range on HMM: 57-91/202 Sequence Identity: 25% (9 aa) SKINHYAICRIEEMHHDQHRSRLFLVTEFWDNKTL ..||. . ... || .|.| |. | | QQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDL |
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| Kinase | GL50803_15953.AA | NEK2 | 254-273 | 50 | 0.072912 | 1.92 | In-house | 288-307 (319) | Show / Hide |
Range on Protein: 254-273 Range on HMM: 288-307/319 Sequence Identity: 50% (10 aa) YSQELNEIIGNMTAFDETRR ||..||||| | . | | YSRHLNEIIHFMINVDHYHR |
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| Kinase | GL50803_15953.AA | NEK | 251-265 | 38 | 0.445038 | 0.02 | In-house | 249-266 (286) | Show / Hide |
Range on Protein: 251-265 Range on HMM: 249-266/286 Sequence Identity: 38% (7 aa) LP-N--YSQELNEIIGNM .| . |||.|...| .| IPSHRMYSQDLQNLISQM |
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| Pkinase | GL50803_15953.AA | Pkinase | 55-97 | 21 | 1.358256 | 3.18 | Pfam | 50-94 (293) | Show / Hide |
Range on Protein: 55-97 Range on HMM: 50-94/293 Sequence Identity: 21% (10 aa) ELEAHSKINHYAICRIEEMHHDQHRSRLFLVTEFWDNK----TLADL |.. . ..|| |.|. .. .| .... .|.|. .. |.|. EIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY |
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| Ank | GL50803_15953.AA | Ank | 753-771 | 26 | 0.116921 | 10.24 | Pfam | 1-19 (33) | Show / Hide |
Range on Protein: 753-771 Range on HMM: 1-19/33 Sequence Identity: 26% (5 aa) NDLTPLMRAAIRNDVDAVE . |||. |....... |. DGFTPLHLACRCGHTEVVK |
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| Ank | GL50803_15953.AA | Ank | 784-801 | 27 | 0.005781 | 14.95 | Pfam | 1-18 (33) | Show / Hide |
Range on Protein: 784-801 Range on HMM: 1-18/33 Sequence Identity: 27% (5 aa) TGNTALMMAASKNNYNVI |.|.|..|.......|. DGFTPLHLACRCGHTEVV |
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| Ank | GL50803_15953.AA | Ank | 815-840 | 50 | 0.00011 | 21.16 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 815-840 Range on HMM: 1-26/33 Sequence Identity: 50% (13 aa) DGLTALNYAAYYGHVESVKLLMDHEA || |.| .|...||.| ||.|..| | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_15953.AA | Ank | 846-866 | 42 | 0.000331 | 19.43 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 846-866 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) YGQTALMAACDRQHLNIVKLL .|.|.|. || . |...||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_15953.AA | Ank | 877-899 | 39 | 0.003034 | 15.96 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 877-899 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) VGETALMRAVKAGNTFIVQELLD |.|.|. |.. |.| .|..||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_15953.AA | Ank | 908-929 | 40 | 0.000114 | 21.1 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 908-929 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) DGETALMLAAHAGNMSLCRALL ||.|.|.||.. |... .. || DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_15953.AA | Ank | 939-969 | 24 | 7.4e-07 | 29.0 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 939-969 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) YGQTALMVAAQRNNMQLCELLIG--REVNLKDN .|.|.|..|....... ...|.. .||..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_15953.AA | Ank | 970-995 | 34 | 0.85692 | 7.12 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 970-995 Range on HMM: 1-26/33 Sequence Identity: 34% (9 aa) SEETALMKAARVGATDAVRFLMNFEA .|.|. |.| | |. |..|.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_15953.AA | Ank | 1001-1022 | 40 | 4e-06 | 26.34 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 1001-1022 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) DGITALMIAAEEGHKDIVQLLI || |.|..|.. ||...|..|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_15953.AA | Ank | 1032-1052 | 52 | 0.000552 | 18.63 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 1032-1052 Range on HMM: 1-21/33 Sequence Identity: 52% (11 aa) DGSSALMLAVCTRHLEVVKLL || ..|.||.. |.||||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_15953.AA | Ank | 1063-1086 | 29 | 0.118423 | 10.22 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 1063-1086 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) TGETAMIIAIRNKRPECARLLLEY |.|. .|.|. ..|....||.. DGFTPLHLACRCGHTEVVKMLLQH |
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