GL50803_15953

Species: G.lamblia
Alias: GL50803_15953, GK231
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15953.AA Protein None 1117 None Fasta, JSON
GL50803_15953.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of GL50803_15953.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_15953.AA S_TKc 8-282 16 1.2e-10 -20.53 SMART 1-231 (231) Show / Hide
Range on Protein: 8-282
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

YQVSDIVSNDVYLKISQGKRRSDGALVTFRELDYHNLISANMPLNFYELEAHSKINHYAICRIEEMHHDQHRSRLFLVTEFWDN--KTLADLTSAHKQ--
|.. ...    . |  ... ...| .|   ...              |.. ..| .|  |... .. .|   ..|..|.|. |.   .| |.   ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TGVPVPEDLVWRILVHANEGLFYYHSVFKSNAPDVRRILHRHITPQSIVMRNNGAVKI--------VHPEIPYLIAIRDHSNISPEEKKYVAPEVLGGRG
...| ||  .....    ..| | ||         ..|.|| . |. | . .   .||        .            .. .   .  |.|||||   |
LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPW--YMAPEVL---G

FSD-RSDIYALGCIIYQLCTLRNFADVFKNDISYYTNPRTTVPNPEPNGGRMYTALLPNYSQELNEIIGNMTAFDETRRFTSNDVRN----------F
..  ..|....|||.| ... .   .   ..   . . .                     |.|. ..| ..  .| ..| |  .. .          |
YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_15953.AA NEK2 185-216 40 9.8e-10 28.83 In-house 230-261 (319) Show / Hide
Range on Protein: 185-216
Range on HMM: 230-261/319
Sequence Identity: 40% (13 aa)

YVAPEVLGGRGFSDRSDIYALGCIIYQLCTLR
|  ||.. |.  ...||| ..||.|| .|.|.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALH

Kinase GL50803_15953.AA PDK1 185-212 53 3.7e-09 23.67 In-house 205-232 (307) Show / Hide
Range on Protein: 185-212
Range on HMM: 205-232/307
Sequence Identity: 53% (15 aa)

YVAPEVLGGRGFSDRSDIYALGCIIYQL
|| ||.| .   . ..|| ||||||||.
YVSPELLTDKECTPSCDIWALGCIIYQM

Kinase GL50803_15953.AA PLK2 185-210 65 7.2e-09 24.4 In-house 169-194 (257) Show / Hide
Range on Protein: 185-210
Range on HMM: 169-194/257
Sequence Identity: 65% (17 aa)

YVAPEVLGGRGFSDRSDIYALGCIIY
|.|||||.  | |  ||| ||||| |
YIAPEVLNRQGHSCESDIWALGCIMY

Kinase GL50803_15953.AA NEK-Unclassified 185-220 44 8.8e-09 24.88 In-house 163-198 (258) Show / Hide
Range on Protein: 185-220
Range on HMM: 163-198/258
Sequence Identity: 44% (16 aa)

YVAPEVLGGRGFSDRSDIYALGCIIYQLCTLRNFAD
. .|||.    . .|||. .|||||| .||   | |
WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFD

Kinase GL50803_15953.AA Ciliate-E2-Unclassified 185-214 34 1.1e-08 26.3 In-house 228-265 (352) Show / Hide
Range on Protein: 185-214
Range on HMM: 228-265/352
Sequence Identity: 34% (13 aa)

YV----APEVLGGRGFSDR----SDIYALGCIIYQLCT
|     |||||.| . ...    .||..||.|.|....
YMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

Kinase GL50803_15953.AA AGC 185-214 34 1.3e-08 16.88 In-house 273-300 (395) Show / Hide
Range on Protein: 185-214
Range on HMM: 273-300/395
Sequence Identity: 34% (11 aa)

YVAPEVLGGRGFSDRSDIYA--LGCIIYQLCT
|.|||.|     .   |...  |||..|.. |
YMAPEIL----YGKACDWWSFGLGCLMYEMLT

Kinase GL50803_15953.AA Pkinase 185-214 35 5.1e-08 29.45 Pfam 177-207 (293) Show / Hide
Range on Protein: 185-214
Range on HMM: 177-207/293
Sequence Identity: 35% (11 aa)

YVAPEVLG-GRGFSDRSDIYALGCIIYQLCT
|.||||.  |.. . ..|....|||.|....
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC

Kinase GL50803_15953.AA Ciliate-E2 185-214 30 5.2e-08 23.56 In-house 253-291 (365) Show / Hide
Range on Protein: 185-214
Range on HMM: 253-291/365
Sequence Identity: 30% (12 aa)

YVAPEVLGGRG---------FSDRSDIYALGCIIYQLCT
|.|||.|.| .          .  .||..||.|.|....
YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

Kinase GL50803_15953.AA NEK 185-216 41 9.8e-08 23.73 In-house 190-223 (286) Show / Hide
Range on Protein: 185-216
Range on HMM: 190-223/286
Sequence Identity: 41% (14 aa)

YVAPEVLGGRGFSDRSDIYALGCIIYQLCTL--R
| .|||. ... . .||| .|||..|..|||  .
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK

Kinase GL50803_15953.AA Ciliate-E3 185-213 41 6e-07 18.03 In-house 174-202 (202) Show / Hide
Range on Protein: 185-213
Range on HMM: 174-202/202
Sequence Identity: 41% (12 aa)

YVAPEVLGGRGFSDRSDIYALGCIIYQLC
| |||..    .|  ||.| .| .. |||
YAAPEQNDQQQISKESDYYSVGAVFCQLC

Kinase GL50803_15953.AA STE-Unique 185-239 20 1.3e-05 15.33 In-house 514-577 (616) Show / Hide
Range on Protein: 185-239
Range on HMM: 514-577/616
Sequence Identity: 20% (13 aa)

YVAPEVLGGR-----GFSDRSDIYALGCIIYQLCTLRNFADVFKNDIS--YYTNPRTTVPN--P
| .|||. .|     ... ..||. |||..  .|..   .  . . ..  .. .. .. |.  |
YMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCP

Kinase GL50803_15953.AA STE-Unique 82-162 25 9.8e-05 12.1 In-house 369-452 (616) Show / Hide
Range on Protein: 82-162
Range on HMM: 369-452/616
Sequence Identity: 25% (24 aa)

LFLVTEFWDNKTLADLTSAHKQTGVP--------VPEDLVWRILVHANEGLFYYHSVFKSNAPDVRR--ILHRHITPQSIVMRNNG-----AVKIV
. .. |. ...|| ...   |..| |         ||..| ... .. ||| | ||         ..  |.|| . |  |.  . |      |||.
VWIFMEYCEHGTLQQII---KRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHS---------QHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC

Kinase GL50803_15953.AA Ciliate-E2-Unclassified 62-161 18 0.000688 9.4 In-house 76-188 (352) Show / Hide
Range on Protein: 62-161
Range on HMM: 76-188/352
Sequence Identity: 18% (22 aa)

INHYAICRIEEMHHDQHRSRLFLVTEFWDNKTLADLTS-------------AHKQTGVPVPEDLVW-----RILVHANEGLFYYHSVFKSNAPDVR-RIL
.||. .... .....| .  ...|.|. ....| .  .              .....  ..|  .      ... .  .|| |.|.            |.
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---------KNNII

HRHITPQSIVMRNNG---AVKI
|| |.|. |.. |||    .||
HRDIKPENILFDNNGKNYYIKI

Kinase GL50803_15953.AA Ciliate-E3 60-94 25 0.04656 2.56 In-house 57-91 (202) Show / Hide
Range on Protein: 60-94
Range on HMM: 57-91/202
Sequence Identity: 25% (9 aa)

SKINHYAICRIEEMHHDQHRSRLFLVTEFWDNKTL
..||.  .  ...   ||    .|.| |.  |  |
QQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDL

Kinase GL50803_15953.AA NEK2 254-273 50 0.072912 1.92 In-house 288-307 (319) Show / Hide
Range on Protein: 254-273
Range on HMM: 288-307/319
Sequence Identity: 50% (10 aa)

YSQELNEIIGNMTAFDETRR
||..|||||  | . |   |
YSRHLNEIIHFMINVDHYHR

Kinase GL50803_15953.AA NEK 251-265 38 0.445038 0.02 In-house 249-266 (286) Show / Hide
Range on Protein: 251-265
Range on HMM: 249-266/286
Sequence Identity: 38% (7 aa)

LP-N--YSQELNEIIGNM
.| .  |||.|...| .|
IPSHRMYSQDLQNLISQM

Pkinase GL50803_15953.AA Pkinase 55-97 21 1.358256 3.18 Pfam 50-94 (293) Show / Hide
Range on Protein: 55-97
Range on HMM: 50-94/293
Sequence Identity: 21% (10 aa)

ELEAHSKINHYAICRIEEMHHDQHRSRLFLVTEFWDNK----TLADL
|.. . ..||  |.|. .. .|  .... .|.|. ..      |.|.
EIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

Ank GL50803_15953.AA Ank 753-771 26 0.116921 10.24 Pfam 1-19 (33) Show / Hide
Range on Protein: 753-771
Range on HMM: 1-19/33
Sequence Identity: 26% (5 aa)

NDLTPLMRAAIRNDVDAVE
.  |||. |....... |.
DGFTPLHLACRCGHTEVVK

Ank GL50803_15953.AA Ank 784-801 27 0.005781 14.95 Pfam 1-18 (33) Show / Hide
Range on Protein: 784-801
Range on HMM: 1-18/33
Sequence Identity: 27% (5 aa)

TGNTALMMAASKNNYNVI
 |.|.|..|.......|.
DGFTPLHLACRCGHTEVV

Ank GL50803_15953.AA Ank 815-840 50 0.00011 21.16 Pfam 1-26 (33) Show / Hide
Range on Protein: 815-840
Range on HMM: 1-26/33
Sequence Identity: 50% (13 aa)

DGLTALNYAAYYGHVESVKLLMDHEA
|| |.| .|...||.| ||.|..| |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_15953.AA Ank 846-866 42 0.000331 19.43 Pfam 1-21 (33) Show / Hide
Range on Protein: 846-866
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

YGQTALMAACDRQHLNIVKLL
.|.|.|. || . |...||.|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_15953.AA Ank 877-899 39 0.003034 15.96 Pfam 1-23 (33) Show / Hide
Range on Protein: 877-899
Range on HMM: 1-23/33
Sequence Identity: 39% (9 aa)

VGETALMRAVKAGNTFIVQELLD
 |.|.|. |.. |.| .|..||.
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_15953.AA Ank 908-929 40 0.000114 21.1 Pfam 1-22 (33) Show / Hide
Range on Protein: 908-929
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

DGETALMLAAHAGNMSLCRALL
||.|.|.||.. |... .. ||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_15953.AA Ank 939-969 24 7.4e-07 29.0 Pfam 1-33 (33) Show / Hide
Range on Protein: 939-969
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

YGQTALMVAAQRNNMQLCELLIG--REVNLKDN
.|.|.|..|....... ...|..   .||..|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_15953.AA Ank 970-995 34 0.85692 7.12 Pfam 1-26 (33) Show / Hide
Range on Protein: 970-995
Range on HMM: 1-26/33
Sequence Identity: 34% (9 aa)

SEETALMKAARVGATDAVRFLMNFEA
  .|.|. |.| | |. |..|..  |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_15953.AA Ank 1001-1022 40 4e-06 26.34 Pfam 1-22 (33) Show / Hide
Range on Protein: 1001-1022
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

DGITALMIAAEEGHKDIVQLLI
|| |.|..|.. ||...|..|.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_15953.AA Ank 1032-1052 52 0.000552 18.63 Pfam 1-21 (33) Show / Hide
Range on Protein: 1032-1052
Range on HMM: 1-21/33
Sequence Identity: 52% (11 aa)

DGSSALMLAVCTRHLEVVKLL
|| ..|.||..  |.||||.|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_15953.AA Ank 1063-1086 29 0.118423 10.22 Pfam 1-24 (33) Show / Hide
Range on Protein: 1063-1086
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

TGETAMIIAIRNKRPECARLLLEY
 |.|.  .|.|. ..|....||..
DGFTPLHLACRCGHTEVVKMLLQH