Gene GL50803_16122 (G.lamblia)

GL50803_16122

Species: G.lamblia
Alias: GK242, GL50803_16122
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16122.AA Protein None 1401 None Fasta, JSON
GL50803_16122.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GL50803_16122.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16122.AA S_TKc 10-276 27 3.2e-57 197.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-231/231
Sequence Identity: 27% (75 aa)

YTDCKKLAEGGFASLFLVRRAQDRVLVVVKEASASQDDDAKAIKSARNEFNIVMRLSSPYIVNYYAVRTHDNGSIYHIEMEYCSG--GSVQQLIQRIRS-
|.  .|. .|.|.. ...|   .  .| .|. .          ...|.| .| ..   |.||..| |  .   . ... ||||.|  |.. ..|.. .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-ARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGLIRLCDFGLSMALQAGNPPAAAKRSGTTSYMAPEIQALGAVTT-ISDI
  |...||  .. ...|...||.|.||      .||.|||.||||.|.|.   | .|||||.  |            ||  |||||.      ..  .|.
GLRFPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCTIWAICTLKHPRFSRRDLLEGPVVDFLGYTTPLRKFVRLLLQPDPKARPTAEQLLSDENVVNALKRI
||.||...  .. . |     ...   ..     . ... |.| .|| ||. |||| ..| || ....   .
WSCGCILYEMLCGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_16122.AA STE 10-269 21 9.9e-51 174.86 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-269
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

YTDCKKLAEGGFASLFLVRRAQ---------------DRVLVVVKEASASQDD--------------DAKAIKSARNEFNIVMRLS--SPYIVNYYAVRT
... .|. .|.| . .. ..                   ... .|. . ....              . . ...  .| .| ....  .|.||.||    
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HD-----NGSIYHIEMEYCSGGSVQQLIQRIRSARSKLP----------ESAVWEIVAQVLKA-LQYLHSWCQKGYLGIVHRDIKPENLLIDTRGLIRLC
..     |..  .| |||..|||. ..|..  .    |.          || .  |. |.||. |.||||      ..|.|||||| | |.     . ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS------HHIIHRDIKPANILL-----VKLC

DFGLSMALQAGNP-----------PAAAKRS----GTTSYMAPEIQAL------GAVTTISDIWSLGCTIWAICTLKHPRFSRRDL--------------
|||..  |.  ..              ....    ||  .||||.         .  .| .|||||||||.  .| |.| .   ..              
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

-------LEGPVVDFLG--------------------YTTPLRKFVRLLLQPDPKARPTAEQLLS--DENV
       ..||   .                      .. ... |... || ||. ||||.|||.   . .
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_16122.AA Pkinase 10-269 25 5.5e-48 170.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-269
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

YTDCKKLAEGGFASLFLVRRAQDRVLVVVKEASASQDDDAKAIKSAR-NEFNIVMRLSSPYIVNYYAVRTHDNGSIYHIEMEYCSGG----SVQQLIQRI
|.  .|. .|.|.. .. ..  .. .|.||. . . ... | .  .| .|  |  ||..|.|| .| . .  ...|| . |||| ||    .   .|.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYIST-

RSARSKL--PESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGLI----RLCDFGLSMALQAGNPPAAAKRSGTTSYMAPEIQA-LGA
 ... ..  .|  .  .. |.|..|.|.|| .     ||.|||.||||.||| .| |    ..|||||.  ..  | . .  . ||  |||||.      
-WRHGCFYFSEWECKFYMYQILRGLEYCHS-M-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

VTTISDIWSLGCTIWAICTLKHPRFSRR----DLLEGPVVDFLGYT-------------------------------TPLRKFVRLLLQPDPKARPTAEQ
 .. .|.||.||...  .. ..| |. .    . ..  .. ..                                   ....|.. .|..||| ||||||
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLSDENV
.| .. .
ILQHPWF
Kinase GL50803_16122.AA Ciliate-E2 10-269 20 1.3e-40 137.07 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-269
Range on HMM: 1-365/365
Sequence Identity: 20% (79 aa)

YTDCKKLAEGGFASLFLVRRAQDRV-----------------------LVVVKEASASQDDDAKAIKSAR----------NEFNIVMRLSSPYIVNYY-A
|   ||. .|.|.| ..... ...                        .. .|  . .|    | ...            || ||  .|..|.|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VRTHDNGSIYHIEMEYCSGGSVQQLIQ--RIRS------ARSKLPESAVWEIVAQVLK---------------ALQYLHSWCQKGYLG-IVHRDIKPENL
  . |. .|| . ||||.||. ...|.  .. .      .  .. |  . .| .|.|.               ||.||||       . |.||||||||.
FQEKDDNNIY-LVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS------KNNIIHRDIKPENI

LIDTRGLIRLCDFGLS-----------------MALQAGNPPAAAKR--------------SGTTSYMAPEIQALGA---------VTTISDIWSLGCTI
|.     | ..|||||                 . .. .|      .               ||  ||||||   .           .. .||||||...
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

WAICTLKHPRFSRRDLLEGPVV------------------DFLGYTTPLRKFVRL----LLQPDPKARPT-AEQLLSDENV
   .. |.|    .  .....                   ...  .     . .     .|| ||. |.| .||.|  .  
YEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_16122.AA Ciliate-E2-Unclassified 10-269 20 7.6e-34 114.79 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-269
Range on HMM: 1-352/352
Sequence Identity: 20% (74 aa)

YTDCKKLAEGGFASLFLVRRAQDRVLVVVKEASASQDDDAKAIKS---------ARNEFN-------------IVMRLSSPYIVNYYAVRTHDNGSIYHI
|.  |.. .|||.. ..... ..  . . |... .|... | |..         . |. .             |   . .|.||... . . ..     |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ--NIYI

EMEYCSGGSVQQLIQ-------------RIRSARSKLPESAVW-----EIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRG---LIRLCDFGL
 |||| ||. .| |.             . .  | ...| ..       . ||.|..|.|||.   |.  .|.||||||||.|.|  |    |...|||.
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---KN--NIIHRDIKPENILFDNNGKNYYIKIIDFGI

SMALQAGN--------------PPAAAKRSGTTSYM----APEIQALGAVTTI----SDIWSLGCTIWAICTLKHPRF----------------------
|. .|  |              .  .  ..|| .||    |||.       .     .||||||. . .... ..| .                      
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

SRRDLLEGPVVDFL--------GYTTPLRKFVR----LLLQPDPKARPTAEQLLSDENV
 ... .....  .         .       |..     .|. .|. |.|.||.|     
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_16122.AA CAMK 15-209 17 1e-32 102.18 In-house 1-322 (425) Show / Hide 
Range on Protein: 15-209
Range on HMM: 1-322/425
Sequence Identity: 17% (57 aa)

KLAEGGFASLFLVRRAQDR------------VLVVVKE------------------------ASASQDD-DAKAIKSARNEFNIVMRLS-------SPYI
.| .|.|.  .|... ..             . | .|                         .. .... ..|  |. |.| .| ..|.        | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNYYAVRTHDN-----------------GSIYHIEM---EYCSGG----SVQQLIQRIRS----------ARSK--LPESAVWEIVAQVLKALQYLHSWC
.. | |   ..                  . ... |   ||||||     . . |.. ..          . ..  ..|. .  .. |.. |..|.||  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS--

QKGYLGIVHRDIKPENLLIDTR-----------------GLIRLCDFGLSMALQAGN----------------------PPAAAKRSGTTSYMA-PEIQA
    ..|||||.||||.|.|..                 . | ..|||..  .. |.                       .    . || .||| ||.  
----HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

--------------LGAVTTISDIWSLGC
                 ..  .|.||.|.
GKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase GL50803_16122.AA STE11 10-211 26 9.9e-32 111.74 In-house 1-228 (303) Show / Hide 
Range on Protein: 10-211
Range on HMM: 1-228/303
Sequence Identity: 26% (63 aa)

YTDCKKLAEGGFASLFLVRRAQDRVLVVVKEASASQDDD-----------AKAIKSARNEFNIVMRLSSPYIVNYYAVRTHDN-GSIYHIEMEYCSGGSV
.. .... .| | . .. .     .|..||.     ..             |..|  . | ..   |. . || || .  |||  . . | ||||.|||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

QQLIQRIRSARSK--LPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGL-IRLCDFGLSMALQAGNPPAAAKRS---------GTT
 ....   . . .  ..|. .   . |.|..||||||       ||.|||||..|.|.|. |  ..| ||| .  |.. .. .. ..          || 
SSMLR---HKWGPMKFDEMVIRKYTKQILEGLQYLHS------HGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTP

S--------YMAPEIQALGA---VTTISDIWSLGCTI
         .||||.   .     .. .||||||||.
YNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTV
Kinase GL50803_16122.AA NEK 10-167 29 9.5e-31 105.72 In-house 1-170 (286) Show / Hide 
Range on Protein: 10-167
Range on HMM: 1-170/286
Sequence Identity: 29% (50 aa)

YTDCKKLAEGGFASLFLVRRAQDRVL-----VVVKEASASQDDDAKAIKSAR-NEFNIVMRLSSPYIVNYYAVRTHDNGSIYHIEMEYCS-GGSVQQL--
|.  ||. .| | . ..||| .|        .| |. .  .  . |  . |  || .|  .| .|.|| ||    .....  .|.||||  ||  .|.  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKIN-MGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK

-IQRIRSARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGL----IRLCDFGLS
 |.. . ..  ..|. .|.. .| ..||.|.|.    .   |.|||||| |. .. ..     ... |||.|
SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase GL50803_16122.AA STE7-Unclassified 58-220 32 6.8e-30 102.55 In-house 54-224 (301) Show / Hide 
Range on Protein: 58-220
Range on HMM: 54-224/301
Sequence Identity: 32% (58 aa)

EFNIVMRLS-SPYIVNYYAVRTHDNG--SIYHIEMEYCSGGSVQ---QLIQRIRS----ARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIK
| ...   . .|||| ||   .|.    .| || |||  .||.     .  .         ...||. .  |. ||...| |||    . .  |.|||||
ELKTLHKCQPHPYIVHYYGAYYHECMDCKI-HICMEYMDCGSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLH----EKHH-IIHRDIK

PENLLIDTRGLIRLCDFGLSMALQAGN--PPAAAKRSGTTSYMAPEIQALG-----AVTTISDIWSLGCTIWAICTLKHP
|.|.|.. .| . .|||| . .|..       ..   |...||.||..        . .  ||||||| |||   |.|.|
PGNILVNSKGQVKICDFGVCGQLENTLDEAKTWV---GCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYP
Kinase GL50803_16122.AA TKL 16-220 19 5.4e-29 101.55 In-house 1-288 (364) Show / Hide 
Range on Protein: 16-220
Range on HMM: 1-288/364
Sequence Identity: 19% (60 aa)

LAEGGFASLFLVRRAQDR--------VLVVVKEASASQ-----------------------DDDAKAIKSARNEFNIVMR-LSSPYIVNYYA--------
. .|||.  .  .  . .          |.||  .  .                       |..|. ..  ..|   .|. |. | || ...        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VRTH--DNGSIYHIEMEYCSGGS-VQQLIQRIRSARSKLPESAVWEIVAQVLKALQYLHS----WCQKGYLGIVHRDIKPENLLIDTRGL---------
 |  |  .. . ..| ||||.|||   .|.            .    .. .. ....||||    ||.    .|.|||.|..|.|.|  .          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----IRLCDFGLSMAL-------------------QAGNPPAAAKRSGTTSYMAPEI-QAL---------------GAVTTISDIWSLGCTIWAICTLK
     . .||||||  .                   |  |  .  .. ||. .||||. .                 .  .. .|..| |  .| |.| .
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

HP
.|
RP
Kinase GL50803_16122.AA STE20 10-208 26 4e-26 92.67 In-house 1-214 (288) Show / Hide 
Range on Protein: 10-208
Range on HMM: 1-214/288
Sequence Identity: 26% (58 aa)

YTDCKKLAEGGFASLFLVRRAQDRVL----VVVKEASASQDDDA-KAIKSARNEFNIVMRLSSPYIVNYYAVRTHD---NGSIYHIEMEYCSGGSVQQLI
|.. .|. .|.. . ....  .   .    | .|  . ...|.  . ...  .| .|  .. .|.||.||     |   . ... . ||||.|||.....
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIV-MEYCGGGSLTDIM

QRIRSARS-----KLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGLIRLCDFGLSMALQA--GNPPAAA-KRS---GTTSYMAP
..  .        .. |. .  |  .||..|.||||       .|.|||||  | |....| . |.|||... |.   .   . . ||    ||  .|||
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS------NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAP

EIQAL-----GAVTTISDIWSLG
|. .      .  .. .||||||
EVIQCMEGPDKGYDYKCDIWSLG
Kinase GL50803_16122.AA STE11-Unclassified 44-167 33 4.1e-20 68.03 In-house 39-154 (308) Show / Hide 
Range on Protein: 44-167
Range on HMM: 39-154/308
Sequence Identity: 33% (42 aa)

SQDDDAKAI--KSARNEFNIVMRLSSPYIVNYYAVRTHDNGSIYHIEMEYCSGGSVQQLIQRIRSARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGI
||. |.. .  .| . | ..   |. . ||.|| .  |. .... | |||..|||. ..... .    .. |.     . |.|. |.||||       ||
SQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNKYG----CFDEMVIKKYTKQILEGLAYLHS------HGI

VHRDIKPENLLIDTRGLIRLCDFGLS
.|||||..|.|||. | . | |||..
IHRDIKGANILIDFDGICKLTDFGCA
Kinase GL50803_16122.AA TyrKc 10-273 20 1.4e-14 13.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-273
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YTDCKKLAEGGFASLFLVRRAQDRVLVVVKEASASQDDDAKAIKSARNEFNIVMRL--SSPYIVNYYAVRTHDN------GSIYHIEMEYCSGGSVQQLI
 |  ||| || |   .. .     . | ||   ..       ..  ..| .| ..|  . | ||. |.| |..       . .. . |||...|. .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV-MEYMPHGDLKDYL

QRIRSARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLIDTRGLIRLCDFGLSMALQAG---------NPPAA--AKRS-GTTSYMA
.. |     |. .   ..  |. .  .||||       ...|||.   | |.. .. .. .||||| ..  .           ..    ...      ||
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEIQALGAVTTISDIWSLGCTIWAICTL-KHPRFS-----------RRDLLEGPVVDFLGY---------TTPLRKFVRLLLQPDPKARPTAEQLLSDEN
||    |  || ||.|| | ..| |.|. . |              .... .|   .   .         .. . .  .   . ||. ||| ...     
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----

VVNAL
 .  .
-HECF
Kinase GL50803_16122.AA NEK 238-269 31 8.9e-09 27.44 In-house 255-286 (286) Show / Hide 
Range on Protein: 238-269
Range on HMM: 255-286/286
Sequence Identity: 31% (10 aa)

YTTPLRKFVRLLLQPDPKARPTAEQLLSDENV
| . |.......||.||. ||...|.|..  .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16122.AA STE11 239-269 41 8.3e-07 20.96 In-house 273-303 (303) Show / Hide 
Range on Protein: 239-269
Range on HMM: 273-303/303
Sequence Identity: 41% (13 aa)

TTPLRKFVRLLLQPDPKARPTAEQLLSDENV
. ..| |.|. ...||| |||| ||| .  .
SEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_16122.AA STE11-Unclassified 183-211 42 6e-06 17.08 In-house 194-228 (308) Show / Hide 
Range on Protein: 183-211
Range on HMM: 194-228/308
Sequence Identity: 42% (15 aa)

GTTS---YMAPEIQA---LGAVTTISDIWSLGCTI
||     .||||.      .. .. |||||||||.
GTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTV
Kinase GL50803_16122.AA NEK 202-220 66 6e-06 17.32 In-house 205-225 (286) Show / Hide 
Range on Protein: 202-220
Range on HMM: 205-225/286
Sequence Identity: 66% (14 aa)

SDIWSLGCTIWAICTL--KHP
|||||||| .  .|||  |||
SDIWSLGCVLYEMCTLKPKHP
Kinase GL50803_16122.AA STE11-Unclassified 231-269 41 1e-05 16.39 In-house 268-308 (308) Show / Hide 
Range on Protein: 231-269
Range on HMM: 268-308/308
Sequence Identity: 41% (17 aa)

PVVDFLG--YTTPLRKFVRLLLQPDPKARPTAEQLLSDENV
|| ||     .. ...| |. .| ||| |||| |||..   
PVCDFISCWISQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase GL50803_16122.AA CAMK 245-269 40 1e-05 13.62 In-house 401-425 (425) Show / Hide 
Range on Protein: 245-269
Range on HMM: 401-425/425
Sequence Identity: 40% (10 aa)

FVRLLLQPDPKARPTAEQLLSDENV
..| .||.||. |.|.|| |... .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_16122.AA STE20 238-269 40 1.5e-05 16.55 In-house 257-288 (288) Show / Hide 
Range on Protein: 238-269
Range on HMM: 257-288/288
Sequence Identity: 40% (13 aa)

YTTPLRKFVRLLLQPDPKARPTAEQLLSDENV
... .. || . || ||. ||||.|||. . .
WSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_16122.AA Pkinase_Tyr 57-167 28 0.000165 15.89 Pfam 52-158 (270) Show / Hide 
Range on Protein: 57-167
Range on HMM: 52-158/270
Sequence Identity: 28% (33 aa)

NEFNIVMRL-SSPYIVNYYAVRTHDNGS--IYHIEMEYCSGGSVQQLIQRIRSARSKLPESAVWEIVAQVLKALQYLHSWCQKGYLGIVHRDIKPENLLI
.| .| . | . | ||..|.| |.. ..  || | |||. .|.     .. |. . .|. .   .. .|. |...||.|        ..|||.   | |.
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIY-IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLV

DTRGLIRLCDFGLS
.  . .. |||||.
TENNVVKICDFGLA
Kinase GL50803_16122.AA Pkinase_Tyr 188-217 50 1.669365 2.33 Pfam 181-210 (270) Show / Hide 
Range on Protein: 188-217
Range on HMM: 181-210/270
Sequence Identity: 50% (15 aa)

MAPEIQALGAVTTISDIWSLGCTIWAICTL
||||  . |  || ||.|| | ..| |.|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Ank GL50803_16122.AA Ank 337-360 33 1.493302 6.25 Pfam 1-24 (33) Show / Hide 
Range on Protein: 337-360
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

QCQTPLMAAVSKGDHVSAQNLLMH
  .|||. |...|..  .. || |
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16122.AA Ank 367-387 28 1.879123 5.89 Pfam 1-21 (33) Show / Hide 
Range on Protein: 367-387
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

EGFSALLYAIEVDSLPCVQLL
.||..| .|.. ... .|..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 398-423 38 0.054695 11.43 Pfam 1-26 (33) Show / Hide 
Range on Protein: 398-423
Range on HMM: 1-26/33
Sequence Identity: 38% (10 aa)

NGDSPLIYALKSGKIELLSELAQHCA
.|..|| .| ..| .| ...| || |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_16122.AA Ank 429-450 36 0.019694 13.03 Pfam 1-22 (33) Show / Hide 
Range on Protein: 429-450
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

SGNTALCIAIRCNDLPAIELLL
 |.|.| .|.||...  ...||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 542-563 36 0.000603 18.49 Pfam 1-22 (33) Show / Hide 
Range on Protein: 542-563
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

CGRTALMLAAQKNSAQYVQFLL
.|.|.|.||....... |..||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 629-650 31 0.000555 18.62 Pfam 1-22 (33) Show / Hide 
Range on Protein: 629-650
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

DGSTALMYAAVSNNHAAIRMLI
|| |.|..|. ....  ..||.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 660-681 40 6.3e-05 22.03 Pfam 1-22 (33) Show / Hide 
Range on Protein: 660-681
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

NGFTALMMAARHNSLDAAKELL
.|||.|..|.|..... .|.||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 691-711 38 0.00532 15.08 Pfam 1-21 (33) Show / Hide 
Range on Protein: 691-711
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

AGMSALMHASQCGHVQLVSLL
 |...|. |..|||.. |..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 722-742 28 8.694859 3.49 Pfam 1-21 (33) Show / Hide 
Range on Protein: 722-742
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

MGRTAFLHAVANRHSGCVHAL
.|.|.   |. . |  .|  |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 788-808 33 0.227114 9.2 Pfam 1-21 (33) Show / Hide 
Range on Protein: 788-808
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

NGQTVTMIAASLSATDIVKLL
.|.|  ..|..   |..||.|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 819-842 29 0.066666 11.12 Pfam 1-24 (33) Show / Hide 
Range on Protein: 819-842
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

LGRTALMYATEVCSLDVMTILLDK
 |.|.|..| .  ...|.. ||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16122.AA Ank 850-870 38 0.001121 17.52 Pfam 1-21 (33) Show / Hide 
Range on Protein: 850-870
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NGETALMLAVRSGYSRCIHIL
.|.|.|.||.|.|. ...  |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 881-913 27 13.248697 2.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 881-913
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

QYMTALGLAVELDLPEVVTILAPYEASISVRKN
  .|.| ||.. . .|||. |  . |.. .. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16122.AA Ank 953-968 31 5.119167 4.32 Pfam 1-16 (33) Show / Hide 
Range on Protein: 953-968
Range on HMM: 1-16/33
Sequence Identity: 31% (5 aa)

SGRTPLLAAVLSNRID
 |.|||  |.......
DGFTPLHLACRCGHTE
Ank GL50803_16122.AA Ank 994-1014 38 2.703835 5.32 Pfam 3-23 (33) Show / Hide 
Range on Protein: 994-1014
Range on HMM: 3-23/33
Sequence Identity: 38% (8 aa)

CTALQLSVRLNHLDCTKLLLS
.|.| | .| .|... |.||.
FTPLHLACRCGHTEVVKMLLQ
Ank GL50803_16122.AA Ank 1022-1048 33 2.107941 5.71 Pfam 1-26 (33) Show / Hide 
Range on Protein: 1022-1048
Range on HMM: 1-26/33
Sequence Identity: 33% (9 aa)

GSETALMQAAHMGLLESARLLLPEAGA
  .|.|. |...| .| ...||  .||
DGFTPLHLACRCGHTEVVKMLLQ-HGA
Ank GL50803_16122.AA Ank 1052-1073 59 6e-06 25.78 Pfam 1-22 (33) Show / Hide 
Range on Protein: 1052-1073
Range on HMM: 1-22/33
Sequence Identity: 59% (13 aa)

EGYTALMLAAIGGHSEVVKLLL
.|.|.|.||.. || ||||.||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 1083-1115 21 0.001217 17.39 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1083-1115
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

AGRTALMLASAYAKEDCIALLVEQEARLCDHRG
 |.|.|.||. .  .... .|... | .. .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16122.AA Ank 1145-1166 27 0.018833 13.1 Pfam 1-22 (33) Show / Hide 
Range on Protein: 1145-1166
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

NGYSALMYAVIDNNMVLVRELL
.|...|..|.. ...  |..||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16122.AA Ank 1175-1207 24 9.386885 3.37 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1175-1207
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

LGETALSLAAVYERSAIYDLLVEYIVDNNIALQ
 |.|.| ||. . .  .  .|...  | |.   
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16122.AA Ank 1245-1265 38 0.000234 19.97 Pfam 1-21 (33) Show / Hide 
Range on Protein: 1245-1265
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

QGYTALMYAATYGYVEIVEIL
 |.|.|..|. .|..|.|. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16122.AA Ank 1276-1293 38 0.015451 13.41 Pfam 1-18 (33) Show / Hide 
Range on Protein: 1276-1293
Range on HMM: 1-18/33
Sequence Identity: 38% (7 aa)

KGCTALMLAAKDGHVDCL
 |.|.|.||.. ||....
DGFTPLHLACRCGHTEVV
Ank GL50803_16122.AA Ank 1307-1329 34 0.075745 10.92 Pfam 1-23 (33) Show / Hide 
Range on Protein: 1307-1329
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

DGTSSLMFAALAGQSDCVAQLLS
|| . |. |.. |. ..|  ||.
DGFTPLHLACRCGHTEVVKMLLQ