Gene GL50803_16205 (G.lamblia)

GL50803_16205

Species: G.lamblia
Alias: GK227, GL50803_16205
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16205.AA Protein None 640 None Fasta, JSON
GL50803_16205.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of GL50803_16205.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_16205.AA S_TKc 25-287 29 5.8e-80 272.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-231/231
Sequence Identity: 29% (83 aa)

YCLKKVLGAGSYGKVYLAMDLENDTEVAIKLINYSELPQSLKVIQDEEITLLKTIRHPHIVRMIDSYHDRQQNLICTVLPLFPR--GDLARFIRHNRE--
| . ...| |..||||.. . . . .|||| |.              || .||  .||.||...|...|   . .. |. . .   ||| ..|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--TPIPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSVYLTDFGIFRYIDGNTKALTFAGTRCYMAPEQLYRQAYDC-KVDIWAL
   |.|| ... ...|. .|| ..||      .||||||.||.|||.|.   . ..|||. | .       || ||. ||||| |    |.. |.|.|..
LRFPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVTLYEIMCRKALFKLSDDEFIKKSIKAIRPLLDSISIYSTELKEVLKKLLTINPTQRISTEELCE-------HPIL
|..||| .|.. .|   ... . | |.            | |.|. ..|.|. .|..|..  |. .       || .
GCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_16205.AA Pkinase 25-287 29 1e-71 249.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-293/293
Sequence Identity: 29% (89 aa)

YCLKKVLGAGSYGKVYLAMDLENDTEVAIKLINYSELPQSLKVIQDE---EITLLKTIRHPHIVRMIDSYHDRQQNLICTVLPLFPRG----DLARFIRH
|......|.||.|.||....  .  .||.| |...    | | ...    || ..| ..||.|||..|...|   . |. |... . |    ||...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

NRETPI--PEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSV----YLTDFGI---FRYIDGNTKALTFAGTRCYMAPEQLY-RQA
 |....  .| ..   . |. ..| ..||       ||||||.||.|||||||  .     ..|||.   |. .  |. . ||.||. ||||| .  .| 
WRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YDCKVDIWALGVTLYEIMCRKALFKLS------DDEFIKKSIKAIRPLLDSISIYS-------------------TELKEVLKKLLTINPTQRISTEELC
|. |||.|..|..||| .|.. .|. .      |. .. . |.  ..  |.   .|                    |.|...|..|. .|..|.. |...
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EHPIL
.|| .
QHPWF
Kinase GL50803_16205.AA CAMK 30-287 19 2.4e-58 186.3 In-house 1-425 (425) Show / Hide 
Range on Protein: 30-287
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

VLGAGSYGKVYLAMDLEND------------TEVAIKLINYSELPQ------------------------SLKVIQ--DEEITLLKT-------IRHPHI
.|| ||.|||.|... ..             ..|||| |. . |.                         . |  .    || ..|.       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRMIDSYHDRQ-----------------QNLICTVL---PLFPRG----DLARFIRHNRE-------------TPIPEPQIWWLLAQMGSALRFLHSGGN
..... | |..                 .. .. |.    . . |    ||  .|. ..                ..| .   .  |. ||....||   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

GACRGIIHRDVKPANILIDNN-----------------LSVYLTDFGIFRYIDG------------------------NTKALTFAGTRCYMA-PEQLYR
   ..|.||| || |||.|.|                   . ..|||  ...|.                        . |  || || .||| || | .
---HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------------QAYDCKVDIWALGVTLYEIMCRKALFKLS-------------DDEFIKKSIKAIRP--LLDSISI--------------------Y
              . |. |.|.|..|| ||   | .  |  .             .|. ... |.. .     . .|.                     
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

STELKEVLKKLLTINPTQRISTEELCEHPIL
|.| |  ..|.|. .|..|.. |.  .|| .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_16205.AA NEK 25-226 33 5.5e-58 198.96 In-house 1-219 (286) Show / Hide 
Range on Protein: 25-226
Range on HMM: 1-219/286
Sequence Identity: 33% (74 aa)

YCLKKVLGAGSYGKVYLAMDLENDTE-----VAIKLINYSELPQSLKVIQD-EEITLLKTIRHPHIVRMIDSYHDRQQNLICTVLPLFP-RGDLARF---
| . |..| ||.||||.. . ..  .     ...| ||.... .  |     .|. .|| ..||.||. .||. ..| | .| |       |||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRHNR--ETPIPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLS----VYLTDFGIFRYIDGNT-KALT-FAGTRCYMAPEQLYRQ
| ...   ....| |||. ..|| .||...|.   |  | |.||| ||.|| ...| .    | . |||| .  . .| .| | . || .||.||..  .
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

AYDCKVDIWALGVTLYEIMC
 |. |.|||.||. |||...
PYNNKSDIWSLGCVLYEMCT
Kinase GL50803_16205.AA ULK 25-287 26 1.3e-56 194.42 In-house 1-324 (324) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YCLKKVLGAGSYG-KVYLAMDLEN---DTEVAIKLINYSELPQSLKV--------IQDEEITLLKTIR---HPH--IVRMIDSYHDRQQNLICTVLPLFP
|||...|| ||.| ||| . . ..   .  ||.| |. ... .. .          .. || ..|..    ||.  ||...| . . . | |. .. . .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RGDLARFIRHNRETP-------IPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSVY------------LTDFGIFRYIDGN---
 |||  .|  |.. |       ..|...   . |  .....||.      ..||||| ||.|||| |.   .            ..|||  . .| |   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

-TKALTFA------GTRCYMAPEQLY----RQAYD-CKVDIWALGVTLYEIMCRKALFKLS-DDEF--IKKSIKA---------IRPL-LD---SISIYS
 ..  |.       ||  ||||. |     .. |.  |.||| ||. .||.   |  |. .  |..  |.| |.           .|.  .   .. . |
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

TELKEVLKKLLTINPTQRISTEELCEHPIL
 |.|. ....|......||| ||. .||..
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_16205.AA ULK 25-287 26 1.2e-55 191.18 In-house 1-329 (329) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-329/329
Sequence Identity: 26% (90 aa)

YCLKKVLGAGSYGKVYLAMDLEN----DTEVAIKLINYSELPQSLKV--------IQDEEITLLKTIR--------HPHIVRMIDSYHDRQQNLICTVLP
|||...|| ||.|||| . . ..    .  ||.| |  ... |...           . || ..|..         ||.||...| . . . | |  .. 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LFPRGDLARFIRHNRETP--------IPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSVY------------LTDFGIFRYIDG
. . |||  .|  |.. |        ..|...   . |  .....||.      ..||||| ||.||||.|.   .            ..|||  . .| 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

NT----KALTFA------GTRCYMAPEQLYRQ-----AYDCKVDIWALGVTLYEIMCRKALFKLS-DDEF---IKKS----------IKAIRPLLD---S
..     ..|.       ||  ||||. | .|      || |.||| ||. .||.   |  |. .  |..   |.|           || . .  .   .
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGN

ISIYSTELKEVLKKLLTINPTQRISTEELCEHPIL
. . | |.|. ....|......||| ||| .||..
DPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_16205.AA STE 25-287 22 1.7e-55 190.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YCLKKVLGAGSYGKVYLAMDL------ENDTE---------VAIKLINYSELPQ---------------SLKVIQDEEITLLKTIR--HPHIVRMIDSYH
. . ...| |..|.||.||.       ... .         .||| .|...  .               . .    .|| ..|  .  ||.||. ...| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DRQQNLICTVLPLFPRGDLARFIRHNRET------------PIPEPQIWWLLAQMGSA-LRFLHSGGNGACRGIIHRDVKPANILIDNNLSVYLT
     . . . .. .. . . | |  .|.|. ..            ..||.|| . . |   . | .||| .      |||||.||||||.     | |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH------IIHRDIKPANILL-----VKLC

DFGIFRYIDGN-----------------TKALTFAGTRCYMAPEQLYR------QAYDCKVDIWALGVTLYEIMCRKALF-KLSDD---EFIKKSI----
|||.   .. .                  |  ||.||  .|||| . .      . ||.|.||| || |. |  . |  . ....      | ...    
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

---------KAIRPLLDSIS----------------IYSTELKEVLKKLLTINPTQRISTEELCE--HPIL
         . . || | .|                 .| |.|. ..| |...| .| ....| .  || .
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_16205.AA Ciliate-E2 25-287 21 8.1e-54 183.12 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-365/365
Sequence Identity: 21% (84 aa)

YCLKKVLGAGSYGKVYLAMDLENDT------------------EVAIKLINYSELPQSLKVIQDEEITLLKTIR----------------HPHIVRMIDS
| . |..| |..|.||.. . ...                   .|.||...   . .. . ..  || ....|.                ||.|..|...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YHDRQQNLICTVLPLFPRGDLARFIRHN----------------RETP-IPEPQIW-------WLLAQMGSALRFLHSGGNGACRG-IIHRDVKPANILI
. . ..| |  |. ..  |||  .|..|                .|   | . ..          .|.. .||..|||      .. ||||| || |||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS------KNNIIHRDIKPENILF

DNNLSVYLTDFGIFRYIDGN--------------------------------TKALTFAGTRCYMAPEQLYRQA---------YDCKVDIWALGVTLYEI
     . ..|||. ...| .                                  . |..||  ||||| | ..          || |.|||.|||.||| 
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

MCRKALFKLSDDEFIKKSIKAIRPLLD--------------SISIYSTELKEVLKK----LLTINPTQRIS-TEELCEHPIL
.. |  |      ....  . |.                  |    | | |  .||    .|  .| .||.  |.. .||..
LFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_16205.AA CAMKL 25-287 27 3e-53 168.21 In-house 1-297 (297) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-297/297
Sequence Identity: 27% (84 aa)

YCLKKVLGAGSYGKVYLAMD-LENDTEVAIKLINYSELP---QSLKV------IQDE----EITLLKTIR---HPHIVRMIDSYHDRQQ----NLICTVL
| . |.|| ||.||| ||.. . . ..|||| |. . .    ...|        .|.    || ..| ..   ||.|... . . ...     . |. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

PLFPRGD--LARFIRHNRE--TPIPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLS--VYLTDFGIFRYID-G----NTKALTFA
 . . |.  |  .|. ...   ..||..   .  |. ||. ..||      .||.||| || |||.|.| .  . ..|||   ... .    . |  || 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS------HGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFC

GTRCYMAPEQLYR--QAYD-CKVDIWALGVTLYEIMCRKALFKLSDDE-----FIKKSIKAIRPLLDSISIY---STELKEVLKKLLTINPTQRISTEEL
|. .||||| . .  . ||  |||||..||.|| ..| .  |.  ...      | .  . |. .   . |.   | ...  ..|.|. ||..|.. ...
GSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

CEHPIL
 .|| .
MNHPWM
Kinase GL50803_16205.AA Ciliate-E2-Unclassified 25-287 24 4.7e-53 182.36 In-house 1-352 (352) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

YCLKKVLGAGSYGKVYLAMDLENDTEV-----AIKLINYS--ELPQSLKVIQDEEITLLKT----------------IRHPHIVRMIDSYHDRQQNLICT
| . |..| |..||||.. . ... ..     ..| ..|.     ..   |  |.... .                 . |||.... . |...... |. 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLPLFPRGDLARFIR-------------HNRET--PIPEPQIW-----WLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNL---SVYLTDFGI
|. ... |||  .|.             ||...   ..| |.       ..||  ..| .||. .|     ||||| || |||.|||     . ..||||
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-----IIHRDIKPENILFDNNGKNYYIKIIDFGI

FRYID----------------GNTKALTFAGTRCYM----APEQLYRQAYD----CKVDIWALGVTLYEIMCRKALFK-LSDDE---------------F
.....                 . .. ||.|| .||    ||| | .| ||     |.|||.||| |||..  .  |.  ....                
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

IKKSIKAIRPLLDSIS------IYSTELKEVLK----KLLTINPTQRISTEELCEHPIL
... ||.  .  .. .      . | | |. ..    |.|  || .||. |....||..
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_16205.AA CAMK-Unique 25-287 21 9.3e-50 162.32 In-house 1-363 (363) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-363/363
Sequence Identity: 21% (78 aa)

YCLKKVLGAGSYGKVYLAMDLENDTEVAIKLINYSELPQSLKVIQ-------------------DEEITLLKTIRHPHIVRMIDS----YHDRQQ-----
| . ...| |..|.|| .|| |. .. |.|...  . ... | .|                   ..|. ..|.  ||.|..  |     ..||.      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKK-QTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------NLICTVLPLFPRGDLARFIRHN------------------RETPIPE--PQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDN
         .. . |. . . |||   | ..                   ...  |   .. .. ..  ||. ..||       .|.||| |. ||.. .
IIKTPRALPYMYI-VMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHS------QDIVHRDLKLENIMVCY

N----------------LSVYLTDFGIFRYIDGNTKAL---TFAGTRCYMAP--------------EQLYRQAYDCKV----DIWALGVTLYEIMCRKAL
.                . . |.|||. .....| .     |. || |||||              | . .| ||...    |||.|||..|.  | .  
SFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP

FKLSDDE--------FIKKSIKAIRP---LLDSISI---YSTELKEVLKKLLTINPTQRISTEELCEHPIL
|  ....         | ..|.. ..     .  ..    | |.| ..|...|. | .|.| .|| ||. .
FDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase GL50803_16205.AA CMGC 25-232 19 6.2e-43 138.33 In-house 1-344 (513) Show / Hide 
Range on Protein: 25-232
Range on HMM: 1-344/513
Sequence Identity: 19% (69 aa)

YCLKKVLGAGSYGKVYLAMD--------------LENDTEVAIKLINYSELPQSLKV----------IQDEEITLLKTIR-----------------HPH
|   |..| |.||.|| . |               |.. .|||| |   .  .  .           .   || .|| ..                 |..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRMIDSYHDRQ---------------QNLICTVLPLFPRGDLARFIRHNR-------ETPIPEPQ------------IWWLL------AQMGSALR--F
||...|......                | .. |  . .  ||...|..|.         | .| .            |  ..       |.  .|   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSGG-NGACRGIIHRDVKPANILIDNN--------------------LSVYLTDFGIFRYIDGN---------------------TKALT-FAGTRCYM
.|| . |     ||||| ||.||||..|                      . . |||  |... .                     ....|    || | 
CHSHWGN-----IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYR

APEQLYRQA----------YDCKVDIWALGVTLYEIMCR--------KALFK
||| | .            |....|.|..|  ..|.. .        | ||.
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFP
Kinase GL50803_16205.AA Pkinase_Tyr 25-227 25 1.1e-18 63.85 Pfam 1-210 (270) Show / Hide 
Range on Protein: 25-227
Range on HMM: 1-210/270
Sequence Identity: 25% (55 aa)

YCLKKVLGAGSYGKVYLAMDL----ENDTEVAIKLI-NYSELPQ--SLKVIQDEEITLLKTI-RHPHIVRMIDSYHDRQQN-LICTVLPLFPRGDLARFI
  . |.||.|..|.||..       .....||.| . ...  .|  . . ..  |. ..|.. .||.|||..    |...   |. |... | |||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR--EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RHN--RETPIPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSVYLTDFGIFRYI--DGNT-KALTFAGTR-CYMAPEQLYRQAYD
| .   . |.. ...    .|  ... .|.| .      .||||.   |.|...|. |  .|||  |.|  |..  .. . .      |||| .    . 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

CKVDIWALGVTLYEIMCR
 | |.|. ||...||. .
TKSDVWSFGVLMWEIFTY
Kinase GL50803_16205.AA TyrKc 25-287 21 1.2e-15 30.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-287
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YCLKKVLGAGSYGKVYLAMDLENDTEVAIKLINYSELPQSLKVIQD--EEITLLKTI--RHPHIVRMIDSYHDRQQ-----NLICTVLPLFPRGDLARFI
  |.|.|| | .|.||...     ..||.| .. .        ..|  .|. ... .  .||.|||..    . .        .. |. . | |||  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RHNRETPIPEPQIWWLLAQMGSALRFLHSGGNGACRGIIHRDVKPANILIDNNLSVYLTDFGIFRYIDGN------TKALTFA---GTR--C---YMAPE
| .|.. .. ..      |  .  ..|||       ..||||    |.|...|. |  .|||  |.|.        ..  . .   |..       ||||
RKHRPK-LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

QLYRQAYDCKVDIWALGVTLYEIMCRKALFK-------LSDDEFIKKSIKAIRPLLDSISI--------YSTELKEVLKKLLTINPTQRISTEELCEHPI
 .    .  | |.|. ||...||. . .          .|..| |..  .  |  ..             ..|. .. |.    .| .| . .|.  | .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR--MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

L
.
F
Kinase GL50803_16205.AA NEK 255-287 30 9.6e-10 30.89 In-house 254-286 (286) Show / Hide 
Range on Protein: 255-287
Range on HMM: 254-286/286
Sequence Identity: 30% (10 aa)

IYSTELKEVLKKLLTINPTQRISTEELCEHPIL
.||..|.... ..|. .|.|| |.... |.|..
MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16205.AA CMGC 257-287 32 3.5e-08 22.0 In-house 483-513 (513) Show / Hide 
Range on Protein: 257-287
Range on HMM: 483-513/513
Sequence Identity: 32% (10 aa)

STELKEVLKKLLTINPTQRISTEELCEHPIL
. .. . |||.|...|..||. |. ..|| .
DPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Ank GL50803_16205.AA Ank 370-395 42 7.8e-05 21.7 Pfam 1-26 (33) Show / Hide 
Range on Protein: 370-395
Range on HMM: 1-26/33
Sequence Identity: 42% (11 aa)

HGVTALMFAAAYGNTRAVELLVQHEA
.| |.|. |. .|.|. |..|.|| |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_16205.AA Ank 401-431 27 0.000577 18.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 401-431
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

DGLSAIFYAVYANALDAVKLLLD--AEHDMRDN
|| ..  .|.. . .. ||.||.  |. ...|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_16205.AA Ank 432-452 47 0.05264 11.49 Pfam 1-21 (33) Show / Hide 
Range on Protein: 432-452
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

RGCTPLVTAARQGRKEIVAFL
 |.|||  |.| |..|.| .|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_16205.AA Ank 463-486 20 0.019075 13.08 Pfam 1-24 (33) Show / Hide 
Range on Protein: 463-486
Range on HMM: 1-24/33
Sequence Identity: 20% (5 aa)

SGWTALMAAATSDSVDCINELVTY
 |.|.|. |. ....... .|. .
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_16205.AA Ank 494-515 36 0.001542 17.02 Pfam 1-22 (33) Show / Hide 
Range on Protein: 494-515
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

HGETALMKAARCDSVNAISLLL
.|.|.|. |.||.... ...||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16205.AA Ank 525-546 31 0.50445 7.95 Pfam 1-22 (33) Show / Hide 
Range on Protein: 525-546
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

DGKTALMSAAELSKNNALHLLL
|| |.|. |..    . . .||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16205.AA Ank 555-576 50 0.000411 19.09 Pfam 1-22 (33) Show / Hide 
Range on Protein: 555-576
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

DGMTALMFAARKGNIEGVEVLL
||.|.|. |.|.|..| |. ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_16205.AA Ank 617-637 33 1.085234 6.75 Pfam 1-21 (33) Show / Hide 
Range on Protein: 617-637
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

SGTTPLMHAQMQGLLDLCQLL
 | |||. | . | .. ...|
DGFTPLHLACRCGHTEVVKML