Gene GL50803_16392 (G.lamblia)

GL50803_16392

Species: G.lamblia
Alias: GL50803_16392, GK059
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16392.AA Protein None 730 None Fasta, JSON
GL50803_16392.kin_dom Protein Kinase Domain None 237 None Fasta, JSON

Protein domain

Protein domains of GL50803_16392.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_16392.AA Ciliate-E1 111-162 28 1.5e-09 27.72 In-house 105-156 (202) Show / Hide 
Range on Protein: 111-162
Range on HMM: 105-156/202
Sequence Identity: 28% (15 aa)

EVKAWKLIRDLSSALLYLQQHTKKGICHGNIKPQNIISTPEGIYVFTDVGIC
. . ......   ..  |..   ..|.|..||||||. . .|.||..| ||.
QFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGIS
S_TKc GL50803_16392.AA S_TKc 1-269 16 2.9e-09 -41.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-269
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

MKALRPVSSSPSCTTFFAED--SGNRVVVKLYFIKNLGLSEWFYQKRLGILRGILDSLSTVSHSSLPTYRLDRCFEPNDLFGADLYYARDYIEG--NSLD
 . ||.. .    . . . .  .| .| .|     .  ..|    |.      |   . .  .                    .||   .|..|   .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-------------------DHLYMVMEYCDGDLGDLF

LIIPTNKNEHPR--ALEVKAWKLIRDLSSALLYLQQHTKKGICHGNIKPQNIISTPEGIYVFTDVGICPHFLTSVTTLSALHSSVQTSRLYQPKEFYSTV
 .|  .. . .|    |  |..... . .|| |.  | . ||.|  .||.||  .       .| |.. ..           ...  .. | . |     
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYC--HSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---

DIAP-SFDIWSLGCVLCEFLSGEPLYADKAQPIRQDIITLRRFPYSNSLLHLAHWMLAVESTTRIELATLVD-------ISIK
   . . |.||.||.| |.|.|.|..    | . . |        | .....   .| .. . |.    .             
GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_16392.AA Ciliate-B2 136-161 53 3.8e-08 15.16 In-house 125-150 (197) Show / Hide 
Range on Protein: 136-161
Range on HMM: 125-150/197
Sequence Identity: 53% (14 aa)

ICHGNIKPQNIISTPEGIYVFTDVGI
| |  ||||||  . .| ||..| ||
ILHLDIKPQNILFMQNGNYVYCDFGI
Kinase GL50803_16392.AA TKL 88-146 20 1.1e-07 23.76 In-house 118-171 (364) Show / Hide 
Range on Protein: 88-146
Range on HMM: 118-171/364
Sequence Identity: 20% (13 aa)

DYIEGNS-LDLIIPTNKNEHPRALEVKAWKLIRDLSSALLYLQQHT-----KKGICHGNIKPQNI
.|..| | |....             .  ....| .... || ...     |..| | ..|..||
EYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI
Kinase GL50803_16392.AA Ciliate-A5 115-152 47 1.2e-07 22.7 In-house 102-136 (275) Show / Hide 
Range on Protein: 115-152
Range on HMM: 102-136/275
Sequence Identity: 47% (18 aa)

WKLIRDLSSALLYLQQHTKKGICHGNIKPQNIISTPEG
| ..  |.|...||||   ..||||.|.||||. |..|
WYIMDCLISVCMYLQQ---NNICHGDIRPQNICLTQDG
Kinase GL50803_16392.AA Ciliate-E2-Unclassified 131-222 23 1.7e-07 22.05 In-house 160-273 (352) Show / Hide 
Range on Protein: 131-222
Range on HMM: 160-273/352
Sequence Identity: 23% (28 aa)

HTKKGICHGNIKPQNIISTPEG---IYVFTDVGIC---------------------PHFLTSVT-TLSALHSSVQTSRLYQPKEFYSTVDIAPS----FD
| |..|.| .|||.||. . .|       .| ||.                     .. ..... |.. .  .      |.. | .       |     |
HHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYDHSKAYKCD

IWSLGCVLCEFLSGEPLYADK
|||||..| |.| |.. . |.
IWSLGVILYEMLFGYYPFYDN
Kinase GL50803_16392.AA NEK6 115-222 38 2.9e-07 19.7 In-house 106-207 (252) Show / Hide 
Range on Protein: 115-222
Range on HMM: 106-207/252
Sequence Identity: 38% (42 aa)

WKLIRDLSSALLYLQQHTKKGICHGNIKPQNIISTPEGIYVFTDVGICPHFLTSVTTLSALHSSVQTSRLYQPKEFYSTVDIAPSFDIWSLGCVLCEFLS
||    |.|||  .  | |. . |  ||| |.  | .||    |.|.   |  | ||  | || | |     |     .     | |||||||.| |   
WKYFVQLCSALEHM--HSKR-VMHRDIKPANVFITANGIVKLGDLGLG-RFFSSKTT--AAHSLVGTPYYMSPERIHENGYNFKS-DIWSLGCLLYEMAA

-GEPLYADK
   | | ||
LQSPFYGDK
Kinase GL50803_16392.AA AGC 201-222 41 2.9e-07 13.27 In-house 285-308 (395) Show / Hide 
Range on Protein: 201-222
Range on HMM: 285-308/395
Sequence Identity: 41% (10 aa)

DIWS--LGCVLCEFLSGEPLYADK
|.||  |||...|.|.| | . ..
DWWSFGLGCLMYEMLTGYPPFYGD
Kinase GL50803_16392.AA Pkinase 201-258 19 2e-06 23.52 Pfam 194-282 (293) Show / Hide 
Range on Protein: 201-258
Range on HMM: 194-282/293
Sequence Identity: 19% (17 aa)

DIWSLGCVLCEFLSGEPLYA--------DKAQPIRQDIITLRRFPYS-----------------------NSLLHLAHWMLAVESTTRI
|.||.||.| |.|.|.|..         |. | |...  .  .|...                        .....  |.|..  . |.
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase GL50803_16392.AA DYRK1 182-220 41 4e-06 16.86 In-house 166-204 (321) Show / Hide 
Range on Protein: 182-220
Range on HMM: 166-204/321
Sequence Identity: 41% (16 aa)

SRLYQPKEFYSTVDIAPSFDIWSLGCVLCEFLSGEPLYA
|| |   |    ..   . |.|||||.| |   ||||..
SRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFS
Kinase GL50803_16392.AA GSK 201-218 61 2e-05 11.86 In-house 201-218 (328) Show / Hide 
Range on Protein: 201-218
Range on HMM: 201-218/328
Sequence Identity: 61% (11 aa)

DIWSLGCVLCEFLSGEPL
|.||.|||. | | |.||
DVWSCGCVMAEMLKGQPL
Kinase GL50803_16392.AA Ciliate-C4 199-219 52 6.1e-05 11.38 In-house 252-272 (361) Show / Hide 
Range on Protein: 199-219
Range on HMM: 252-272/361
Sequence Identity: 52% (11 aa)

SFDIWSLGCVLCEFLSGEPLY
| ||||.|||. | ..| |..
SIDIWSMGCVMMEIITGIPHW
Kinase GL50803_16392.AA Ciliate-C4 116-146 38 0.000138 10.24 In-house 144-171 (361) Show / Hide 
Range on Protein: 116-146
Range on HMM: 144-171/361
Sequence Identity: 38% (12 aa)

KLIRDLSSALLYLQQHTKKGICHGNIKPQNI
|.|... .||..|.|   . . |..||| ||
KFIQHICHALWHLHQ---NKWVHCDIKPENI
Kinase GL50803_16392.AA GSK 124-146 60 0.000591 7.31 In-house 128-147 (328) Show / Hide 
Range on Protein: 124-146
Range on HMM: 128-147/328
Sequence Identity: 60% (14 aa)

ALLYLQQHTKKGICHGNIKPQNI
.| ||. |   ||||  ||||||
GLAYLHSH---GICHRDIKPQNI
Kinase GL50803_16392.AA TKL 201-221 42 0.006799 6.27 In-house 271-291 (364) Show / Hide 
Range on Protein: 201-221
Range on HMM: 271-291/364
Sequence Identity: 42% (9 aa)

DIWSLGCVLCEFLSGEPLYAD
|..| | ||.| |.... |.|
DVYSFGIVLWEILTRCRPYYD