Gene GL50803_16839 (G.lamblia)
GL50803_16839
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16839.AA | Protein | None | 778 | None | Fasta, JSON |
| GL50803_16839.kin_dom | Protein Kinase Domain | None | 291 | None | Fasta, JSON |
Protein domains of GL50803_16839.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_16839.AA | S_TKc | 13-303 | 15 | 1.2e-12 | 8.74 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-303
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)
YLLGRLMREYHALDVYEAVRAHDSHPVYIYRIKRDKLKTMELVDMELSIRHLPFVTNPYITKCFSVQRHNGSSSSYVITDRPST--ETLLNLISSARAQG
| ..|. . || .. .. . | | .|| | . |..| . |.| |.. | .. .. |.... .. .|. .| . . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
EH--ISEAKIWYIFAQLLYALASIHDPVENQRLKNDSPPVHMDIRPSSISVTRDGNYL------LSVFSPNKFICQPSVEPISAHDYILFHYGPAEDIKE
. ..| ......|.. ||. .|. .. .| |. |. | ... . |. . .
LRFPFPE-HARFYMYQICCALEYCHS----HGI------IHRDLKPENILLDE---HIKICDFGLARQL-----------------------------TT
NAQQAIYTAPEWFLTGEYTA-ASDIWSLGALLYELCTFKPLFIAPSHMDKKDVAGLLQSVAAERRPIPQDYTDILRCTIYYMLNVNPTNRPLLSDLFE--
| ||| . |. ..|.||.| .|||... .|.| ... ... . .. .. | .|...|..|| ....
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDE
-----MRQV
. .
WDIKCHPWF
|
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| Kinase | GL50803_16839.AA | NEK4 | 209-303 | 37 | 6.3e-12 | 39.3 | In-house | 168-257 (257) | Show / Hide |
Range on Protein: 209-303 Range on HMM: 168-257/257 Sequence Identity: 37% (36 aa) YTAPEWFLTGEYTAASDIWSLGALLYELCTFKPLFIAPSHMDKKDVAGLL-QSVAAERRPIPQDYTDILRCTIYYMLNVNPTNRPLLSDLFEMRQV | || | | ||||||| .||. | | | | || |. | . |.|..| | .| ||. ||.|| . |.| | . YMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDA------KDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | GL50803_16839.AA | Pkinase | 209-303 | 17 | 1.9e-10 | 37.99 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 209-303 Range on HMM: 177-293/293 Sequence Identity: 17% (21 aa) YTAPEWFL-TGEYTAASDIWSLGALLYELCTFKPLFIAPSHMDKKDVAGLLQSVAAERR-----PIPQDYT-------------------DILRCTIYYM | |||. . .|. ..|.||.| .|||... .|.| . . .. . .| .. .. ..|.... . .. |... YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC LNVNPTNRPLLSDLFEMRQV |...|. || .... . LCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_16839.AA | Ciliate-E2 | 207-299 | 17 | 4.9e-10 | 30.64 | In-house | 251-361 (365) | Show / Hide |
Range on Protein: 207-299 Range on HMM: 251-361/365 Sequence Identity: 17% (24 aa) AIYTAPEWFLTGE---------YTAASDIWSLGALLYELCTFKPLFIAPSHMDKKDVAGLLQSVAAERRPIPQDYTDILRCTIY---------------- . | ||| . .. |. ..|||||| .|||... || | . |. | | PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------------QQQIKQCKIDFPCPEWQKDTQCIQCK ---Y-----------------MLNVNPTNRPL-LSDLFE . ||...| .|. ..... WKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | GL50803_16839.AA | RSKL | 209-242 | 50 | 4.9e-10 | 18.89 | In-house | 344-377 (436) | Show / Hide |
Range on Protein: 209-242 Range on HMM: 344-377/436 Sequence Identity: 50% (17 aa) YTAPEWFLTGEYTAASDIWSLGALLYELCTFKPL |.||| | | |.|.||.||.|||| . ..| YCAPEVGQIWELTEACDWWSYGAVLYELLCGMSL |
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| Kinase | GL50803_16839.AA | AGC | 209-238 | 46 | 8.8e-10 | 19.94 | In-house | 273-300 (395) | Show / Hide |
Range on Protein: 209-238 Range on HMM: 273-300/395 Sequence Identity: 46% (15 aa) YTAPEWFLTGEYTAASDIWS--LGALLYELCT | ||| . |. | |.|| ||.|.||. | YMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_16839.AA | TK-Unique | 211-239 | 43 | 1.5e-08 | 25.7 | In-house | 204-235 (294) | Show / Hide |
Range on Protein: 211-239 Range on HMM: 204-235/294 Sequence Identity: 43% (14 aa) APEWFL--TGEY-TAASDIWSLGALLYELCTF ||| .. .| | | ||.||.| |..|..|. APESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | GL50803_16839.AA | NEK | 98-134 | 30 | 2.5e-08 | 25.88 | In-house | 93-132 (286) | Show / Hide |
Range on Protein: 98-134 Range on HMM: 93-132/286 Sequence Identity: 30% (12 aa) TLLNL---ISSARAQGEHISEAKIWYIFAQLLYALASIHD .| .. | . .|....| .|| .|.|.. || .|| DLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD |
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| Kinase | GL50803_16839.AA | NEK | 224-241 | 65 | 1.5e-07 | 23.12 | In-house | 205-224 (286) | Show / Hide |
Range on Protein: 224-241 Range on HMM: 205-224/286 Sequence Identity: 65% (13 aa) SDIWSLGALLYELCTF--KP ||||||| .|||.||. |. SDIWSLGCVLYEMCTLKPKH |
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| Kinase | GL50803_16839.AA | NEK2 | 209-245 | 45 | 3.4e-07 | 20.16 | In-house | 230-266 (319) | Show / Hide |
Range on Protein: 209-245 Range on HMM: 230-266/319 Sequence Identity: 45% (17 aa) YTAPEWFLTGEYTAASDIWSLGALLYELCTFKPLFIA | || | |||||.| |.||.|. .| | | YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQA |
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| Kinase | GL50803_16839.AA | NEK1 | 220-240 | 71 | 4.8e-07 | 20.67 | In-house | 198-218 (276) | Show / Hide |
Range on Protein: 220-240 Range on HMM: 198-218/276 Sequence Identity: 71% (15 aa) YTAASDIWSLGALLYELCTFK |. ||||||| |||||| | YNNKSDIWSLGCVLYELCTLK |
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| Kinase | GL50803_16839.AA | NAK | 267-301 | 27 | 3e-06 | 16.63 | In-house | 263-299 (299) | Show / Hide |
Range on Protein: 267-301 Range on HMM: 263-299/299 Sequence Identity: 27% (10 aa) PIPQD--YTDILRCTIYYMLNVNPTNRPLLSDLFEMR .||.. |.. ... |.|||...| .|| .. . SIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | GL50803_16839.AA | Pkinase_Tyr | 210-239 | 43 | 4e-06 | 21.56 | Pfam | 181-210 (270) | Show / Hide |
Range on Protein: 210-239 Range on HMM: 181-210/270 Sequence Identity: 43% (13 aa) TAPEWFLTGEYTAASDIWSLGALLYELCTF .||| . .|..| .||.|| | |..|..|. MAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_16839.AA | NEK | 267-303 | 33 | 4e-06 | 18.01 | In-house | 248-286 (286) | Show / Hide |
Range on Protein: 267-303 Range on HMM: 248-286/286 Sequence Identity: 33% (13 aa) PIPQD--YTDILRCTIYYMLNVNPTNRPLLSDLFEMRQV |||. | . |. | ||...|..|| ....|| .. PIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_16839.AA | WEE | 99-134 | 25 | 7.6e-05 | 12.27 | In-house | 94-129 (297) | Show / Hide |
Range on Protein: 99-134 Range on HMM: 94-129/297 Sequence Identity: 25% (9 aa) LLNLISSARAQGEHISEAKIWYIFAQLLYALASIHD |...|.. . . ...|..|| |. ... .|. ||. LQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHS |
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| Kinase | GL50803_16839.AA | NEK2 | 266-303 | 31 | 0.000186 | 10.79 | In-house | 282-319 (319) | Show / Hide |
Range on Protein: 266-303 Range on HMM: 282-319/319 Sequence Identity: 31% (12 aa) RPIPQDYTDILRCTIYYMLNVNPTNRPLLSDLFEMRQV |.|| | . | | |.||.. || . . |. RRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_16839.AA | NEK2 | 102-137 | 36 | 0.000359 | 9.81 | In-house | 90-125 (319) | Show / Hide |
Range on Protein: 102-137 Range on HMM: 90-125/319 Sequence Identity: 36% (13 aa) LISSARAQGEHISEAKIWYIFAQLLYALASIHDPVE .|. .| . . | || |..||. || .| || MIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVE |
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| Kinase | GL50803_16839.AA | NAK | 224-237 | 57 | 0.001037 | 8.17 | In-house | 222-235 (299) | Show / Hide |
Range on Protein: 224-237 Range on HMM: 222-235/299 Sequence Identity: 57% (8 aa) SDIWSLGALLYELC .|||.|| .|| .| VDIWALGCMLYKMC |
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| Kinase | GL50803_16839.AA | WEE | 216-242 | 41 | 0.00132 | 8.05 | In-house | 205-235 (297) | Show / Hide |
Range on Protein: 216-242 Range on HMM: 205-235/297 Sequence Identity: 41% (13 aa) LTG--EYTAA--SDIWSLGALLYELCTFKPL | | .|| . .|| |||. .||| . ..| LQGYYHYTHLYKADIFSLGITIYELACNMDL |
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| Kinase | GL50803_16839.AA | WEE | 283-303 | 23 | 0.012731 | 4.7 | In-house | 277-297 (297) | Show / Hide |
Range on Protein: 283-303 Range on HMM: 277-297/297 Sequence Identity: 23% (5 aa) MLNVNPTNRPLLSDLFEMRQV |.. .|..|| ..|.. . MMHPDPEQRPTCQQLLQHPVL |
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| Kinase | GL50803_16839.AA | NEK1 | 267-303 | 29 | 0.030165 | 3.8 | In-house | 240-276 (276) | Show / Hide |
Range on Protein: 267-303 Range on HMM: 240-276/276 Sequence Identity: 29% (11 aa) PIPQDYTDILRCTIYYMLNVNPTNRPLLSDLFEMRQV |||. | |. . |...|| .|| .. | . PIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_16839.AA | NAK | 98-135 | 20 | 0.157161 | 0.78 | In-house | 100-138 (299) | Show / Hide |
Range on Protein: 98-135 Range on HMM: 100-138/299 Sequence Identity: 20% (8 aa) TLLNLISSAR-AQGEHISEAKIWYIFAQLLYALASIHDP .|..|. . . ..| ...|..|. || . ... .|.. SLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQC |
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| Ank | GL50803_16839.AA | Ank | 487-507 | 33 | 0.000949 | 17.78 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 487-507 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) DGRTALMVAAEQEMLDIVRLL ||.|.|..|.. ...|..| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16839.AA | Ank | 523-543 | 33 | 1.314311 | 6.45 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 523-543 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) EGETALMQVARRGFISAVTAL .|.|.|. .|.| .. |. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16839.AA | Ank | 554-580 | 37 | 0.000371 | 19.25 | Pfam | 1-25 (33) | Show / Hide |
Range on Protein: 554-580 Range on HMM: 1-25/33 Sequence Identity: 37% (10 aa) DGQTALMIAAQAQRKNVVDVLIHFEHG ||.|.|..|.. ...|| |. || DGFTPLHLACRCGHTEVVKMLLQ--HG |
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| Ank | GL50803_16839.AA | Ank | 585-610 | 34 | 0.018954 | 13.09 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 585-610 Range on HMM: 1-26/33 Sequence Identity: 34% (9 aa) DGWTALKIASNFGYPDIVESLVSFEA ||.|.| .|. |....|. |.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_16839.AA | Ank | 647-667 | 33 | 0.000227 | 20.02 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 647-667 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) EGQTALMCAAHKGYADICKLL .|.|.|..|...|.....|.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16839.AA | Ank | 616-646 | 27 | 0.203756 | 9.37 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 616-646 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) TGETSLMVAANKGFLDIVRSLQP--AEIKMQTT |.| |..|. .| ...|. | |.. .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16839.AA | Ank | 678-699 | 36 | 3.8e-05 | 22.84 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 678-699 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) DGTTALMCAAHSNSLDCVRLLL || |.|..|........|..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16839.AA | Ank | 715-747 | 18 | 7.460053 | 3.73 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 715-747 Range on HMM: 1-33/33 Sequence Identity: 18% (6 aa) AGYTALLLAIEQKAYSTAEYILTNSPVECQKTV |.|.| ||.. .. ... | . . .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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