Gene GL50803_16862 (G.lamblia)

GL50803_16862

Species: G.lamblia
Alias: GK258, GL50803_16862
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16862.AA Protein None 329 None Fasta, JSON
GL50803_16862.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of GL50803_16862.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_16862.AA STE 216-306 27 1.8e-19 65.49 In-house 224-359 (359) Show / Hide 
Range on Protein: 216-306
Range on HMM: 224-359/359
Sequence Identity: 27% (38 aa)

IGSSYHMAPEMAQGEQGA---TYTTKIDIWSLGCVLLEVATMKLPP---FDPR---EIM----------------GTPQVFIK-----------------
.|.  .||||. |.....    |.|| |||||||...| || | |     ..|   .|.                |.|  .                   
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

--DFSFQLSRFIHRCLIFDPVIRPSAKDLLT--NCEI
   .|  .  || .||. ||  ||.|..||      |
PHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_16862.AA TKL 117-301 15 2.3e-18 62.74 In-house 120-361 (364) Show / Hide 
Range on Protein: 117-301
Range on HMM: 120-361/364
Sequence Identity: 15% (42 aa)

CANGT-LEQLLADQRNGLAQMPITENLIWEIAAQLLKALEYLHH--PEPSDQSAPEAESMHSP--IVHHNINPSCIYFDSSGN--------------VKL
| .|. |..|.              ...  .| .  ....|||   | ..            .  |.| ..... |  |. ..              .|.
CPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCT-----------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

GGFEHAKTGPSFT--------------------RGFLAIGSSYHMAPEMAQGE-------------QGATYTTKIDIWSLGCVLLEVATMKLPPFDPR--
. |  ...    .                    .    .|. ..||||. .|.             .| .|..|.|..| | || |..| ..| .|.   
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

------------EIMG----TPQVF-----------IKDFSFQLSRFIHRCLIFDPVIRPSAKDLL
            .. .     | .             .|.  .... . .|   ||  |||....|
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEIL
S_TKc GL50803_16862.AA S_TKc 38-302 23 2.4e-14 33.55 SMART 1-220 (231) Show / Hide 
Range on Protein: 38-302
Range on HMM: 1-220/231
Sequence Identity: 23% (62 aa)

YSDTVFLRKFYCGDVYRAVSIGNARPCILYRIDLETIDDEALENVSRDYRFCSQLSCPFIRRYTRILEEKSTVILESEDCAN--GTLEQLLADQRNGLAQ
|     . |   | ||... ..  | . . .|.         |.. |  . ...  .|.| ..  . .. . . .  | | .  |.| ... ... .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

MPITENLIWEIAAQLLKALEYLHHPEPSDQSAPEAESMHSPIVHHNINPSCIYFDSSGNVKLGGFEHAKTGPSFTRGFLAIGSSYHMAPEMAQGEQGATY
 |..|  .. ...|...||||.|               |  |.|  . |. | .|.  ..|.. |  |.           .|. . ||||.        |
FPFPE-HARFYMYQICCALEYCH--------------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL------GY

TT-KIDIWSLGCVLLEVATMKLPPFDPREIMGTPQVFIKDFSFQLSRFIHRCLIFDPVIRPSAKDLLT
.. |.|.||.||.| | ..   |||.    | .    |.  | ..  || .|| .||  ||.| ..|.
GKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase GL50803_16862.AA STE-Unique 117-306 22 3.9e-14 46.07 In-house 376-616 (616) Show / Hide 
Range on Protein: 117-306
Range on HMM: 376-616/616
Sequence Identity: 22% (59 aa)

CANGTLEQLLADQRNGL------AQMPITENLIWEIAAQLLKALEYLHHPEPSDQSAPEAESMHSPIVHHNINPSCIYFDSSG-----NVKLGGFEHAKT
| .||| |..  .|.|        |. . | ..  .. |.|..|||||             | | ||.|... |. | ....|     .||.. | ||..
CEHGTLQQII--KRCGCPGNPNNLQL-FPETEVIWYTYQILEGLEYLH-------------SQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATC

GPSF---------------------------------------TRGFLAIGSSYHMAPEMAQGE--QGATYTTKIDIWSLGCVLLEVATMKLPPFDPREI
.                                            ..  .|   .|.||   ..      | || |||||||.... ..  .||.  |  
CQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG-CPPWHQRYH

M---------GTPQVF-------IKDFSFQLSRFIHRCLIFDPVIRPSAKDLLTNCEI
|         .. |          .... ..  ||  ||  .|. ||||..||     
MQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase GL50803_16862.AA STE20 216-302 33 5.8e-13 44.0 In-house 183-284 (288) Show / Hide 
Range on Protein: 216-302
Range on HMM: 183-284/288
Sequence Identity: 33% (34 aa)

IGSSYHMAPEMAQGEQG--ATYTTKIDIWSLGCVLLEVATMKLPPFD----------PREIMGTPQVFI---KDFSFQLSRFIHRCLIFDPVIRPSAKDL
.|. | ||||. |...|    |..| ||||||  ..| |. . | ||          |.. ...|       . .| ..  |. .||  ||  ||.|..|
VGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQL

LT
|.
LK
Kinase GL50803_16862.AA Ciliate-E2 171-301 19 9e-13 40.15 In-house 174-360 (365) Show / Hide 
Range on Protein: 171-301
Range on HMM: 174-360/365
Sequence Identity: 19% (39 aa)

ESMHS-P-IVHHNINPSCIYFDSSGNVKLGGFEHAK--------------TGPSFTRG----------------FLA---IGSSYHMAPEMAQGEQ----
|..||   |.| .| |. | |     .|.  |  .|               .     .                ...   .|. . ||||. .|..    
EYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

--GATYTTKIDIWSLGCVLLEVATMKLPPFDPREIMGTPQVFIKDFSFQLS--------------------------RFIHR----CLIFDPVIRPS-AK
  .  |..|.||||||..| |  . |.|           |  ||.  ....                           .| .    .|  ||  |.. ..
QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE

DLL
..|
QIL
Kinase GL50803_16862.AA TAO 137-306 26 1.7e-11 33.56 In-house 95-254 (254) Show / Hide 
Range on Protein: 137-306
Range on HMM: 95-254/254
Sequence Identity: 26% (48 aa)

PITENLIWEIAAQLLKALEYLHHPEPSDQSAPEAESMHSPIVHHNINPSCIYFDSSGNVKLGGFEHAKTGPSFTRGFLAIGSSYHMAPEMAQGEQGATYT
|. |  |  |. . |..|.|||  .                .|  |  . |     | |||. |  |    .  . |  .|  |.||||.        |.
PMQEVEIAAICHGALQGLRYLHSHK---------------MIHRDIKAGNILLTEHGQVKLADFGSASMV-CPANSF--VGTPYWMAPEVILAMDEGQYD

TKIDIWSLGCVLLEVATMKLPPFDPREIMG--------TPQVFIKDFSFQLSRFIHRCLIFDPVIRPSAKDLLTNCEI
 |.|.||||   .|.|  | | |.   .           | .  ...| .  .|.. ||   |  ||||...|.   .
GKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQQNEWSDCFHQFVDKCLQKMPQERPSAEECLRHEFV
Kinase GL50803_16862.AA STE7-Unclassified 215-301 28 8.3e-11 34.41 In-house 180-295 (301) Show / Hide 
Range on Protein: 215-301
Range on HMM: 180-295/301
Sequence Identity: 28% (33 aa)

AIGSSYHMAPEMAQGE--QGATYTTKIDIWSLGCVLLEVATMKLPP------------FDP---------REIMGTPQVFIKD------FSFQLSRFIHR
..| .  |.||  ||.  . ..|. | |||||| ...|.|| | |             |.|           |...|   ..|      .|  .  || .
WVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISK

CLIFDPVIRPSAKDLL
|.. .|  ||.. .||
CCKKHPRERPDIHQLL
Kinase GL50803_16862.AA Pkinase 217-301 26 1.3e-10 38.63 Pfam 173-288 (293) Show / Hide 
Range on Protein: 217-301
Range on HMM: 173-288/293
Sequence Identity: 26% (31 aa)

GSSYHMAPEMAQGEQGATYTTKIDIWSLGCVLLEVATMKLPPFDP------------REIMGTPQVFIKDFS---------------------FQLSRFI
|... ||||  .   |  |..|.|.||.||.| |... ..|  .             ..|||.|  |  . .                       .  ||
GTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

HRCLIFDPVIRPSAKDLL
 .|| .||  ||.|...|
KWCLCKDPKKRPTAEQIL
Kinase GL50803_16862.AA Ciliate-E2-Unclassified 171-301 19 6.9e-10 30.5 In-house 157-347 (352) Show / Hide 
Range on Protein: 171-301
Range on HMM: 157-347/352
Sequence Identity: 19% (38 aa)

ESMHSP--IVHHNINPSCIYFDSSG---NVKLGGFEHAK---TGPSFTRGFL-----------A---IGSSYHM----APEMAQG-EQGATYTTKIDIWS
|..|.   |.| .| |. | ||..|   ..|. .|  .|   . . .. ..            .   .|. . |    |||. || ... .   |.||||
EYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWS

LGCVLLEVATMKLPPFDPRE----------------IMGTPQVFI---------------KDFSFQLS----RFIHRCLIFDPVIRPSAKDLL
||..| |  . . .||. .                 ..   | ..               |. |..      ......|  .|  |......|
LGVILYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase GL50803_16862.AA Dicty3 213-252 39 1.2e-08 24.41 In-house 253-291 (351) Show / Hide 
Range on Protein: 213-252
Range on HMM: 253-291/351
Sequence Identity: 39% (16 aa)

FLAIGSSYHMAPEMAQGEQG-ATYTTKIDIWSLGCVLLEVA
.. .|.. .|||| . . |. |..  | |||||||...| .
YSICGTIHYMAPEIKLNNQCCACR--KSDIWSLGCTVWEMV
Kinase GL50803_16862.AA NEK 278-306 34 1e-06 19.84 In-house 258-286 (286) Show / Hide 
Range on Protein: 278-306
Range on HMM: 258-286/286
Sequence Identity: 34% (10 aa)

QLSRFIHRCLIFDPVIRPSAKDLLTNCEI
.|...|...|  ||  |||....| .. |
DLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_16862.AA NEK 117-158 28 2e-06 19.21 In-house 88-131 (286) Show / Hide 
Range on Protein: 117-158
Range on HMM: 88-131/286
Sequence Identity: 28% (13 aa)

CA-NGTLEQL---LADQRNGLAQMPITENLIWEIAAQLLKALEYLH
|  .|.|.|.   .  |..  .  .. |. ||.. .|...|| |.|
CEGGGDLYQKIKSIKKQKQ--KGKYFEEEQIWDWFIQMCLALKYMH
Kinase GL50803_16862.AA NEK 220-260 50 2e-06 18.87 In-house 189-227 (286) Show / Hide 
Range on Protein: 220-260
Range on HMM: 189-227/286
Sequence Identity: 50% (21 aa)

YHMAPEMAQGEQGATYTTKIDIWSLGCVLLEVATMK-LPPFD
| |.||. |..    |. | ||||||||| | .| |  .||.
YYMSPEVCQNKP---YNNKSDIWSLGCVLYEMCTLKPKHPFE
Kinase GL50803_16862.AA Ciliate-E2-Unclassified 90-159 24 3e-06 17.72 In-house 76-161 (352) Show / Hide 
Range on Protein: 90-159
Range on HMM: 76-161/352
Sequence Identity: 24% (21 aa)

SQLSCPFIRRYTRILEEKSTVILESEDCANGTLEQLLADQ-----------RNGLAQMPITENLIW-----EIAAQLLKALEYLHH
... .||| ..  . . | ....  | | .|.|.| . ..           .| . .  .||. .       ..||.|..||||||
LNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH
Kinase GL50803_16862.AA Dicty3 282-301 35 3.3e-05 12.95 In-house 332-351 (351) Show / Hide 
Range on Protein: 282-301
Range on HMM: 332-351/351
Sequence Identity: 35% (7 aa)

FIHRCLIFDPVIRPSAKDLL
|| .|...||. |...  |.
FIQHCWQIDPNHRWDMHELI
Kinase GL50803_16862.AA STE 71-158 19 7.1e-05 13.3 In-house 64-169 (359) Show / Hide 
Range on Protein: 71-158
Range on HMM: 64-169/359
Sequence Identity: 19% (21 aa)

LETIDDEALENVSRDYRFCSQLS--CPFIRRYTRILEEK-------STVILESEDCANGTLEQLLA---DQRNGLA-----QMPITENLIWEIAAQLLKA
||....| .... .. .......  .|.| .|    . .       ... .  | ...|.|....       ..|      | .. |..|  |. |.||.
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKG

-LEYLH
 |.|||
LLYYLH
Kinase GL50803_16862.AA Ciliate-E2 75-158 19 8.7e-05 12.34 In-house 59-177 (365) Show / Hide 
Range on Protein: 75-158
Range on HMM: 59-177/365
Sequence Identity: 19% (23 aa)

DDEALENVSRDYR-------------FCSQLSCPFIRRYTRILE--EKSTVILESEDCANGTLEQLLADQ-RNGLAQMP----ITENLIWEIAAQLLK--
. |..... . .|              ..||..|.| ..    .   .... |  | |  |.|.... ..  . . . .    .||. | .| .|.|.  
QIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGF

-------------ALEYLH
             ||||||
KTKAEFYIACIILALEYLH
TyrKc GL50803_16862.AA TyrKc 41-313 15 0.000237 -152.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 41-313
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

TVFLRKFYCG---DVYRAVSIGNARPCILYRIDLE----TIDDEALENVSRDYRFCSQL--SCPFIRRYTRILEEK-------STVILESEDCANGTLEQ
 ....|  .|    ||... .            ..    .. ..|.|   |  |  ..|  . | | |   .  ..         . .  | ...| | .
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLADQRNGLAQMPITENLIWEIAAQLLKALEYLHHPEPSDQSAPEAESMHSPIVHHNINPSCIYFDSSGNVKLGGFEHAKTGPSF-TRGFLAIGSSYH--
 | . |.      ..     ... |  .  ||||.                ...|  .    .  .. . || . |  .. . .  ..|  . .. |.  
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSK---------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKK

-------------MAPEMAQGEQGATYTTKIDIWSLGCVLLEVATM-KLPP-------FDPREIMGTPQVFIKDFSFQL-------------SRFIHRCL
             ||||     .  ..||| |.|| | .. |. |  . |.        ...|..   .        .               . . .| 
EHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

IFDPVIRPSAKDLLTNCEIKIALERL
 .||  ||. ...          |..
HEDPEDRPTFSEI---------HECF
Kinase GL50803_16862.AA Dicty3 137-158 36 0.019638 3.62 In-house 107-128 (351) Show / Hide 
Range on Protein: 137-158
Range on HMM: 107-128/351
Sequence Identity: 36% (8 aa)

PITENLIWEIAAQLLKALEYLH
.. | .| .|...|.|.| |.|
RFNEHEISKIICDLVKTLNYIH
Kinase GL50803_16862.AA STE7-Unclassified 146-158 53 0.080175 2.33 In-house 124-136 (301) Show / Hide 
Range on Protein: 146-158
Range on HMM: 124-136/301
Sequence Identity: 53% (7 aa)

IAAQLLKALEYLH
|| |....|.|||
IAYQVIHGLWYLH
Kinase GL50803_16862.AA Pkinase 137-158 29 0.197631 6.14 Pfam 102-125 (293) Show / Hide 
Range on Protein: 137-158
Range on HMM: 102-125/293
Sequence Identity: 29% (7 aa)

PI--TENLIWEIAAQLLKALEYLH
..  .|. .  .. |.|..|||.|
CFYFSEWECKFYMYQILRGLEYCH