Gene GL50803_16889 (G.lamblia)
GL50803_16889
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16889.AA | Protein | None | 561 | None | Fasta, JSON |
| GL50803_16889.kin_dom | Protein Kinase Domain | None | 264 | None | Fasta, JSON |
Protein domains of GL50803_16889.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_16889.AA | S_TKc | 24-289 | 14 | 2.3e-11 | -10.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-289 Range on HMM: 1-231/231 Sequence Identity: 14% (44 aa) DDIGESIREGGSFGGVFRLKSTR--DRVVQKIVDNSTSCSTVAKDMELLLNADSHLLIKCHQIVVDSSACCVYAILDYYPK---YLLDILNSRKAYGTA- .|.. | . |.|| |.. . .. .| ||.. .. . ...| . . ..|.. . .| ..| ...| . |.|.. .|. |. YEILRKIGK-GAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -VDLSTFLAIAYDIAQGLAYFHTRHYT-----------DSNRDKNNI------STRTYFHGNLNSSTIMFNEDETHCVLTYPKFHVRTLKENKAASSNAR . . ..| |...|.| | .. |. .| . | . . PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------------------------TTFCGTPW YAAPEIRAGAEYSS-AADMWCLGVVLYELVGGNLKLLPTSTLPFAESQDEAFLDALSVNDTFIRKVLGYLLKLNPHERITVMPLLH------ILELY | |||. |. ..|.| .|..|||.. | |... .. . . .. . .|. .| .|.|. .|. . . YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_16889.AA | TKL | 104-230 | 17 | 4.3e-10 | 32.53 | In-house | 125-285 (364) | Show / Hide |
Range on Protein: 104-230
Range on HMM: 125-285/364
Sequence Identity: 17% (32 aa)
LLDILNSRKAYGTAVDLSTFLAIAYDIAQGLAYFHTRH---YTDSNRDKNNISTRTYFHGNLNSSTIMFNEDETH-------------CVLTYPKFHV--
||..|. .. .. .|.|||.|..| |... .| .. | .|.|. |. .|. |. | .. .
LLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT----------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM
--------------------RTLKENKAASSNARYAAPEIRAGA----------------EYSSAADMWCLGVVLYELVGG
.. | . . |. |||. |. ||| ..|.. |.||.|.. .
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
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| Kinase | GL50803_16889.AA | Pkinase | 199-286 | 17 | 3.6e-09 | 33.5 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 199-286 Range on HMM: 176-293/293 Sequence Identity: 17% (22 aa) RYAAPEIRA-GAEYSSAADMWCLGVVLYELVGGNLKLLPTSTLPFAES-------QDEAFLDALS---------VND-------------------TFIR .|.|||. | .|....||| .|..|||.. |. .|| .. |.. . .. .. . WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR--------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK KVLGYLLKLNPHERITVMPLLHI--L ... ..|...|..|.| . .|. . DFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_16889.AA | MARK | 200-232 | 47 | 1.3e-08 | 24.49 | In-house | 171-204 (262) | Show / Hide |
Range on Protein: 200-232 Range on HMM: 171-204/262 Sequence Identity: 47% (16 aa) YAAPEIRAGAEYS-SAADMWCLGVVLYELVGGNL |.|||| . .| ..|.| |||||| .| |.. YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYF |
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| Kinase | GL50803_16889.AA | Ciliate-E2 | 200-232 | 38 | 4.3e-08 | 23.85 | In-house | 253-294 (365) | Show / Hide |
Range on Protein: 200-232 Range on HMM: 253-294/365 Sequence Identity: 38% (16 aa) YAAPEIRAGAE---------YSSAADMWCLGVVLYELVGGNL | |||| | . |. ..|.|.|||.|||.. |.. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP |
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| Kinase | GL50803_16889.AA | Ciliate-E2-Unclassified | 200-232 | 40 | 4.7e-08 | 24.06 | In-house | 232-268 (352) | Show / Hide |
Range on Protein: 200-232 Range on HMM: 232-268/352 Sequence Identity: 40% (15 aa) YAAPEIRAGAEYS----SAADMWCLGVVLYELVGGNL |.|||. | .|. ..|.|.|||.|||.. |.. YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY |
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| Kinase | GL50803_16889.AA | PKC | 200-227 | 46 | 1.1e-07 | 20.82 | In-house | 166-193 (262) | Show / Hide |
Range on Protein: 200-227 Range on HMM: 166-193/262 Sequence Identity: 46% (13 aa) YAAPEIRAGAEYSSAADMWCLGVVLYEL | |||| .. ||. . | | .|| .||. YIAPEILQYQEYGKSVDWWAFGVLMYEM |
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| Kinase | GL50803_16889.AA | SGK | 200-230 | 45 | 1.6e-07 | 18.84 | In-house | 191-221 (283) | Show / Hide |
Range on Protein: 200-230 Range on HMM: 191-221/283 Sequence Identity: 45% (14 aa) YAAPEIRAGAEYSSAADMWCLGVVLYELVGG | |||. ...... . | |||| ||||. | YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYG |
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| Kinase | GL50803_16889.AA | MSK | 200-230 | 38 | 2e-07 | 21.17 | In-house | 171-206 (277) | Show / Hide |
Range on Protein: 200-230 Range on HMM: 171-206/277 Sequence Identity: 38% (14 aa) YAAPEIRA----GAE-YSSAADMWCLGVVLYELVGG |.|||. . . . |..| |.| |||.||.. | YMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTG |
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| Kinase | GL50803_16889.AA | AGC | 200-230 | 42 | 2.2e-07 | 13.62 | In-house | 273-301 (395) | Show / Hide |
Range on Protein: 200-230 Range on HMM: 273-301/395 Sequence Identity: 42% (14 aa) YAAPEIRAGAEYSSAADMWC--LGVVLYELVGG | |||| |. |.| |. ||...||.. | YMAPEIL----YGKACDWWSFGLGCLMYEMLTG |
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| Kinase | GL50803_16889.AA | QIK | 200-232 | 55 | 3.5e-07 | 24.23 | In-house | 183-216 (272) | Show / Hide |
Range on Protein: 200-232 Range on HMM: 183-216/272 Sequence Identity: 55% (19 aa) YAAPEIRAGAEYS-SAADMWCLGVVLYELVGGNL |||||. | || .| | .||||| || | | YAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGAL |
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| TyrKc | GL50803_16889.AA | TyrKc | 20-286 | 10 | 5e-06 | -125.03 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 20-286
Range on HMM: 1-280/280
Sequence Identity: 10% (34 aa)
DDLRDDIGESIREGGSFGGVFRLKSTRDRVVQKIVDNSTSCSTVAKDMELLLNA--DSHLLIKCHQIVVD--------SSACCVYAILDYYPKYLLDILN
| . .|| | || |.. . . | | . ... . .... . . ..... .... . | .. |.| |
ITLGKKLGE-----GAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLR
SRKAYGTAVDLSTFLAIAYDIAQGLAYFHTRHYTDSNRDKNNISTRTYFHGNLNSSTIMFNEDETHCV----------LTYPKFHV--------RTLKEN
... . ....| ....||.| .| | . .|. .. .. .| | ...
KHRPK---LCMKDLLSFCWQIACGMEYLHSK----------------------------------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDD
---------KAASS--NAR------YAAPEIRAGAEYSSAADMWCLGVVLYELV--GGNLKLL-----PTSTLPFAESQDEAFLDALSV--------NDT
. ... ... ||| ..... | | ||...|. |. . . .. .. .. .
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPD
FIRKVLGYLLKLNPHERITVMPLLHIL
. .. . .|..| | . ...
EMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | GL50803_16889.AA | Dicty4-Unclassified | 124-140 | 52 | 6.2e-05 | 12.8 | In-house | 112-128 (263) | Show / Hide |
Range on Protein: 124-140 Range on HMM: 112-128/263 Sequence Identity: 52% (9 aa) LAIAYDIAQGLAYFHTR ...| |||||... ||| IKYAFDIAQGMQHLHTR |
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| Kinase | GL50803_16889.AA | Dicty4-Unclassified | 202-231 | 30 | 0.00025 | 10.69 | In-house | 176-205 (263) | Show / Hide |
Range on Protein: 202-231 Range on HMM: 176-205/263 Sequence Identity: 30% (9 aa) APEIRAGAEYSSAADMWCLGVVLYELVGGN .||. . | ...| . ...||||. |. SPECLMHESYNQKSDVYSYAMMLYELATGD |
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| Kinase | GL50803_16889.AA | MARK | 261-279 | 42 | 0.127219 | 1.27 | In-house | 235-253 (262) | Show / Hide |
Range on Protein: 261-279 Range on HMM: 235-253/262 Sequence Identity: 42% (8 aa) IRKVLGYLLKLNPHERITV .|. . ||..||.||.|. CRNLIQRLLTVNPEERPTI |
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| Ank | GL50803_16889.AA | Ank | 368-382 | 33 | 6.35984 | 3.98 | Pfam | 1-15 (33) | Show / Hide |
Range on Protein: 368-382 Range on HMM: 1-15/33 Sequence Identity: 33% (5 aa) DGVTALMRFADSGNL || |.|. . .|.. DGFTPLHLACRCGHT |
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| Ank | GL50803_16889.AA | Ank | 409-429 | 33 | 0.005599 | 15.0 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 409-429 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) KGRTALMGAALHNRLEIVEIL |.|.|. |......|.|. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16889.AA | Ank | 441-471 | 36 | 0.000142 | 20.76 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 441-471 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DNATALMMAAFMGHEEVVNILVD--REKCMVDD | |.|..|...||.||| |.. . ...|| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16889.AA | Ank | 472-502 | 27 | 0.00018 | 20.38 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 472-502 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) SGYTALMYAVLQKHLSIVSTLVS--CEAGAQSK |.|.|..|.. |...|. |.. .. || . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16889.AA | Ank | 503-528 | 30 | 0.00292 | 16.02 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 503-528 Range on HMM: 1-26/33 Sequence Identity: 30% (8 aa) DGSTALMMAASINYIDAASILVSHEA || |.|..|.. .... .. |..| | DGFTPLHLACRCGHTEVVKMLLQHGA |
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