Gene GL50803_16943 (G.lamblia)
GL50803_16943
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16943.AA | Protein | None | 946 | None | Fasta, JSON |
| GL50803_16943.kin_dom | Protein Kinase Domain | None | 257 | None | Fasta, JSON |
Protein domains of GL50803_16943.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | GL50803_16943.AA | Pkinase | 11-132 | 18 | 4e-12 | 43.95 | Pfam | 1-124 (293) | Show / Hide |
Range on Protein: 11-132 Range on HMM: 1-124/293 Sequence Identity: 18% (24 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNILPILEIY-DNPDLCTIHIISPYRAGE----SVAELLIA |... ||.|.||... |..|....| . |...... | .|. |. .|.. .|.| ||. ..... |..... .. .| | . .... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLYVMDLFDYIST TQANSQGI--PEQDIWKLMDGLCQALQFL .. .. .|... . | ....|... --WRHGCFYFSEWECKFYMYQILRGLEYC |
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| Kinase | GL50803_16943.AA | S_TKc | 11-278 | 17 | 7.1e-12 | -2.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 11-278 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNILPILEIYDNPDLCTIHIISPYRAG--ESVAELLIATQA ||.| ||.|.||... ||.|.. .| |... ... |.. .. .| || ....... .... | | .. ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR NS--QGIPEQDIWKLMDGLCQALQFLCTSAPSPSTSPAHLNLI------PSNIFLSS--------LSSVLTSEPCITRFIFAADSIRKDETYMPPETRGT . ...|| .....| .|.||... | . | |.||.|.. |. .| . | |.. | . HGLRFPFPE-HARFYMYQICCALEYC------------HSHGIIHRDLKPENILLDEHIKICDFGLARQL-TTFCGTPWYMAPEVL-------------- TIATLQGNIWTVGSIAYELATGRRASDLLSLTSPTNLKVELPEQYSASLSLLLAQMLSPNEDNRPSLASWRSEIRN-FEKRKRHSFI . .| .| | ||...|. . . . .|. . | .. .. ..| . ..||. |. . .. | | .. GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPT----A-EALQDEWDIKCHPWF |
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| Kinase | GL50803_16943.AA | AGC | 11-40 | 30 | 3.2e-09 | 18.47 | In-house | 1-36 (395) | Show / Hide |
Range on Protein: 11-40 Range on HMM: 1-36/395 Sequence Identity: 30% (11 aa) YEKLASIGRGTFGECFVCRNK------DSSEILCAK .| | ||.|.||... .| | |. .. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK |
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| Kinase | GL50803_16943.AA | STE | 11-103 | 14 | 2.5e-08 | 25.64 | In-house | 1-128 (359) | Show / Hide |
Range on Protein: 11-103 Range on HMM: 1-128/359 Sequence Identity: 14% (19 aa) YEKLASIGRGTFGECFVCRNK------DSSEI---------LCAKEVNYKS-------------LGSHSPQITRLKTELEKSMHLK--HRNILPILEIYD .|.. ||.|.||. . ..|. .. |. |..|... ... .. ... |.. .... | || . | WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF NPDLC-----TIHIISPYRAGESVAELL . . . ...|. | .| |. ... KEGHNHKNDDELWICMEYMDGGSLDDII |
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| Kinase | GL50803_16943.AA | NEK2 | 11-49 | 41 | 3.8e-08 | 23.4 | In-house | 1-39 (319) | Show / Hide |
Range on Protein: 11-49 Range on HMM: 1-39/319 Sequence Identity: 41% (16 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGS || |..||.| || | | | .|| || .| .... YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQE |
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| Kinase | GL50803_16943.AA | CDK9 | 11-41 | 48 | 1.3e-07 | 22.02 | In-house | 1-31 (340) | Show / Hide |
Range on Protein: 11-41 Range on HMM: 1-31/340 Sequence Identity: 48% (15 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKE ||||| || ||||. . | ||. |.. YEKLAKIGQGTFGQVLQGRKSRNSEVFKARH |
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| Kinase | GL50803_16943.AA | CDK5 | 11-42 | 46 | 1.5e-07 | 19.38 | In-house | 1-32 (287) | Show / Hide |
Range on Protein: 11-42 Range on HMM: 1-32/287 Sequence Identity: 46% (15 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEV |||. || ||.| . |||.. || |.| YEKMEKIGEGTYGTVYKARNKETHEIVALKRV |
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| Kinase | GL50803_16943.AA | STE11 | 11-45 | 31 | 1.9e-07 | 23.26 | In-house | 1-35 (303) | Show / Hide |
Range on Protein: 11-45 Range on HMM: 1-35/303 Sequence Identity: 31% (11 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYK . | . ||.|.|| .. |.|.| |.. |.. .. WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQ |
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| Kinase | GL50803_16943.AA | NDR | 11-36 | 42 | 2.2e-07 | 18.15 | In-house | 1-26 (350) | Show / Hide |
Range on Protein: 11-36 Range on HMM: 1-26/350 Sequence Identity: 42% (11 aa) YEKLASIGRGTFGECFVCRNKDSSEI .|.. ||.| ||| ...| ||. .| FEIIKIIGKGAFGEVWLVRKKDTGHI |
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| Kinase | GL50803_16943.AA | PLK1 | 11-72 | 35 | 3.7e-07 | 19.31 | In-house | 1-61 (253) | Show / Hide |
Range on Protein: 11-72 Range on HMM: 1-61/253 Sequence Identity: 35% (22 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNI ||| . .|.| | .|. |.|| |.. .| | ||| . | .. |.. .|.||.| YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVP-KSLLIKQHQRDKMTQEIQIHRQLHHRHI |
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| Kinase | GL50803_16943.AA | NEK | 11-47 | 26 | 4.1e-07 | 21.53 | In-house | 1-42 (286) | Show / Hide |
Range on Protein: 11-47 Range on HMM: 1-42/286 Sequence Identity: 26% (11 aa) YEKLASIGRGTFGECFVCRNKDSSEI-----LCAKEVNYKSL ||.. ||.| ||... .| | . . .. |..|.... YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNM |
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| Kinase | GL50803_16943.AA | NEK1 | 11-43 | 30 | 1.1e-05 | 15.82 | In-house | 1-33 (276) | Show / Hide |
Range on Protein: 11-43 Range on HMM: 1-33/276 Sequence Identity: 30% (10 aa) YEKLASIGRGTFGECFVCRNKDSSEILCAKEVN |... || |.|| . . | .. .. || | YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEIN |
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| Kinase | GL50803_16943.AA | TyrKc | 11-266 | 13 | 4.9e-05 | -141.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 11-266 Range on HMM: 1-280/280 Sequence Identity: 13% (42 aa) YEKLASIGRGTFGECFVCRNKDSSEILCA-KEVNYKSLGSHSPQITRLKTELEKSMHL--KHRNILPILEIYDNPDLCTIH-----------IISPYRAG ... .|.| ||| . .. | | .| | .. . . . |.. ..| .| ||. .. . || . |. | .. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGV------CTQQGRNFMYIEPLMIVMEYMPH ESVAELLIATQANSQGIPEQDIWKLMDGLCQALQFLCTSAPSPSTSPAHLNLI-----PSNIFLSSLSSVLTSEPCITRFIFAA-------DSIRK---- . . | ... . .. .| . . .. ..| |.| |. ... | | .|.| | .|| GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK DET------YMPPETRGTTIATLQGN-----------------IWTVGSIAYEL-----ATGRRASDLLSLTSPTNLKVELPEQ--------YSASLSLL .. |.||. . . | | | |. . ... .. . . |. .. . . GGKTMLPIRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK----QGYRMPQPPNDYPMSFVCCPDEMYQI LAQMLSPNEDNRPSLASWRSEI | . ..||. . .... MKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_16943.AA | NEK | 233-258 | 39 | 0.00105 | 9.38 | In-house | 249-276 (286) | Show / Hide |
Range on Protein: 233-258 Range on HMM: 249-276/286 Sequence Identity: 39% (11 aa) LPEQ--YSASLSLLLAQMLSPNEDNRPS .|.. || |. |. ||| .. ..||| IPSHRMYSQDLQNLISQMLQKDPEQRPS |
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| Kinase | GL50803_16943.AA | NEK1 | 233-258 | 42 | 0.009397 | 5.58 | In-house | 241-266 (276) | Show / Hide |
Range on Protein: 233-258 Range on HMM: 241-266/276 Sequence Identity: 42% (11 aa) LPEQYSASLSLLLAQMLSPNEDNRPS .| || |. |..||.. | .||| IPPHYSYELQSLVSQMFKRNPRHRPS |
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| Kinase | GL50803_16943.AA | NEK2 | 233-258 | 34 | 0.021261 | 3.75 | In-house | 284-309 (319) | Show / Hide |
Range on Protein: 233-258 Range on HMM: 284-309/319 Sequence Identity: 34% (9 aa) LPEQYSASLSLLLAQMLSPNEDNRPS .|.||| |. . . |. . ||| IPYQYSRHLNEIIHFMINVDHYHRPS |
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| Kinase | GL50803_16943.AA | Pkinase | 201-215 | 46 | 9.959873 | 0.12 | Pfam | 195-209 (293) | Show / Hide |
Range on Protein: 201-215 Range on HMM: 195-209/293 Sequence Identity: 46% (7 aa) IWTVGSIAYELATGR .| .| | ||...|| MWSCGCILYEMLCGR |
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| Ank | GL50803_16943.AA | Ank | 315-340 | 30 | 0.133696 | 10.03 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 315-340 Range on HMM: 1-26/33 Sequence Identity: 30% (8 aa) GGTTALMLAADQNFPAAISVLLKYEA | |.|.||. . . .. ||.. | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_16943.AA | Ank | 346-366 | 57 | 0.000521 | 18.72 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 346-366 Range on HMM: 1-21/33 Sequence Identity: 57% (12 aa) DGDTALLMACKKDHQEVVKLL ||.|.| .||...| ||||.| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16943.AA | Ank | 452-473 | 36 | 1.820091 | 5.94 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 452-473 Range on HMM: 1-21/33 Sequence Identity: 36% (8 aa) KGRTALSLAAEHGCCALIIGML |.|.| ||...| .. .. || DGFTPLHLACRCG-HTEVVKML |
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| Ank | GL50803_16943.AA | Ank | 531-553 | 34 | 0.000508 | 18.76 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 531-553 Range on HMM: 1-23/33 Sequence Identity: 34% (8 aa) DRWTALMFAAYYGKVDVVRLLVS | .|.|. |...| ..||..|.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_16943.AA | Ank | 563-584 | 36 | 0.005389 | 15.06 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 563-584 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) YKHTALMLATKAGHLPCVELLI . |.|.|| . ||. .|..|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16943.AA | Ank | 594-619 | 26 | 0.000239 | 19.94 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 594-619 Range on HMM: 1-26/33 Sequence Identity: 26% (7 aa) NGETALMIAVSRGDMRIAAVLVKYEA .|.|.|..|...|..... |... | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_16943.AA | Ank | 656-688 | 36 | 1e-06 | 27.93 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 656-688 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) EETTALMLAASKGNSEVVKMLVGKSIDIGKKNK . |.|.||...|. ||||||... |. ... DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16943.AA | Ank | 689-712 | 29 | 0.002042 | 16.58 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 689-712 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) YGYTALMAAAQEDALECITVLLSY .|.|.|. |.. . .|... ||.. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_16943.AA | Ank | 625-655 | 33 | 0.063346 | 11.2 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 625-655 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) VRETALFKAITLGHTDIAKLLLS--AEAHIADE .|.| |. |||...|.||. |. .. | DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16943.AA | Ank | 720-750 | 33 | 1.8e-05 | 23.96 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 720-750 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) NGMTALMLAAARNLERSVKLLLD--HELGAKDH .|.|.|.||. .. .. ||.||. .. |.| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_16943.AA | Ank | 751-760 | 50 | 24.286877 | 1.88 | Pfam | 1-10 (33) | Show / Hide |
Range on Protein: 751-760 Range on HMM: 1-10/33 Sequence Identity: 50% (5 aa) DGDTALLIAI ||.|.| .|. DGFTPLHLAC |
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| Ank | GL50803_16943.AA | Ank | 783-804 | 27 | 15.148295 | 2.62 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 783-804 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) NDCYPIMLATQLNLQSVVCALI . . | .|| . . .|| |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16943.AA | Ank | 815-835 | 38 | 0.157836 | 9.77 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 815-835 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) NTLTPLMYAANQGSVELVDIL . |||..|. |..| | | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16943.AA | Ank | 860-880 | 38 | 0.125427 | 10.13 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 860-880 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) DGWTALMFAVDKRCTGAVEVL ||.|.|. |. . .| |. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_16943.AA | Ank | 891-912 | 27 | 0.276818 | 8.89 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 891-912 Range on HMM: 1-22/33 Sequence Identity: 27% (6 aa) NGNSALSIAVALGDIASIQLLL .|...| .|. |.. ...|| DGFTPLHLACRCGHTEVVKMLL |
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