GL50803_16943

Species: G.lamblia
Alias: GL50803_16943, GK239
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_16943.AA Protein None 946 None Fasta, JSON
GL50803_16943.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of GL50803_16943.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_16943.AA Pkinase 11-132 18 4e-12 43.95 Pfam 1-124 (293) Show / Hide
Range on Protein: 11-132
Range on HMM: 1-124/293
Sequence Identity: 18% (24 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNILPILEIY-DNPDLCTIHIISPYRAGE----SVAELLIA
|...  ||.|.||... |..|....| . |......  |  .|. |. .|..   .|.| ||. ..... |.....   .. .|  |     . .... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY---MVMEYCEGGLYVMDLFDYIST

TQANSQGI--PEQDIWKLMDGLCQALQFL
   .. ..  .|... . |  ....|...
--WRHGCFYFSEWECKFYMYQILRGLEYC

Kinase GL50803_16943.AA S_TKc 11-278 17 7.1e-12 -2.79 SMART 1-231 (231) Show / Hide
Range on Protein: 11-278
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNILPILEIYDNPDLCTIHIISPYRAG--ESVAELLIATQA
||.|  ||.|.||... ||.|.. .|   |...            ... |..  .. .| ||  .......     ....  |  |   .. ...   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

NS--QGIPEQDIWKLMDGLCQALQFLCTSAPSPSTSPAHLNLI------PSNIFLSS--------LSSVLTSEPCITRFIFAADSIRKDETYMPPETRGT
.   ...|| .....|  .|.||...            | . |      |.||.|..        |. .| .  | |..  |   .              
HGLRFPFPE-HARFYMYQICCALEYC------------HSHGIIHRDLKPENILLDEHIKICDFGLARQL-TTFCGTPWYMAPEVL--------------

TIATLQGNIWTVGSIAYELATGRRASDLLSLTSPTNLKVELPEQYSASLSLLLAQMLSPNEDNRPSLASWRSEIRN-FEKRKRHSFI
   .    .| .| | ||...|.   .    .  . .|. .    | ..  .. ..|  . ..||.      |. .  .. | | ..
GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPT----A-EALQDEWDIKCHPWF

Kinase GL50803_16943.AA AGC 11-40 30 3.2e-09 18.47 In-house 1-36 (395) Show / Hide
Range on Protein: 11-40
Range on HMM: 1-36/395
Sequence Identity: 30% (11 aa)

YEKLASIGRGTFGECFVCRNK------DSSEILCAK
.| |  ||.|.||... .| |      |. ..   |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK

Kinase GL50803_16943.AA STE 11-103 14 2.5e-08 25.64 In-house 1-128 (359) Show / Hide
Range on Protein: 11-103
Range on HMM: 1-128/359
Sequence Identity: 14% (19 aa)

YEKLASIGRGTFGECFVCRNK------DSSEI---------LCAKEVNYKS-------------LGSHSPQITRLKTELEKSMHLK--HRNILPILEIYD
.|..  ||.|.||. . ..|.      .. |.            |..|...               ... .. ... |..  ....  | ||   .  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NPDLC-----TIHIISPYRAGESVAELL
. . .     ...|.  | .| |. ...
KEGHNHKNDDELWICMEYMDGGSLDDII

Kinase GL50803_16943.AA NEK2 11-49 41 3.8e-08 23.4 In-house 1-39 (319) Show / Hide
Range on Protein: 11-49
Range on HMM: 1-39/319
Sequence Identity: 41% (16 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGS
|| |..||.| || |   | |   .||  || .| ....
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQE

Kinase GL50803_16943.AA CDK9 11-41 48 1.3e-07 22.02 In-house 1-31 (340) Show / Hide
Range on Protein: 11-41
Range on HMM: 1-31/340
Sequence Identity: 48% (15 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKE
||||| || ||||. .  |    ||.  |..
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARH

Kinase GL50803_16943.AA CDK5 11-42 46 1.5e-07 19.38 In-house 1-32 (287) Show / Hide
Range on Protein: 11-42
Range on HMM: 1-32/287
Sequence Identity: 46% (15 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEV
|||.  || ||.|  .  |||.. ||   |.|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV

Kinase GL50803_16943.AA STE11 11-45 31 1.9e-07 23.26 In-house 1-35 (303) Show / Hide
Range on Protein: 11-45
Range on HMM: 1-35/303
Sequence Identity: 31% (11 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYK
. | . ||.|.|| .. |.|.|  |..  |.. ..
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQ

Kinase GL50803_16943.AA NDR 11-36 42 2.2e-07 18.15 In-house 1-26 (350) Show / Hide
Range on Protein: 11-36
Range on HMM: 1-26/350
Sequence Identity: 42% (11 aa)

YEKLASIGRGTFGECFVCRNKDSSEI
.|..  ||.| ||| ...| ||. .|
FEIIKIIGKGAFGEVWLVRKKDTGHI

Kinase GL50803_16943.AA PLK1 11-72 35 3.7e-07 19.31 In-house 1-61 (253) Show / Hide
Range on Protein: 11-72
Range on HMM: 1-61/253
Sequence Identity: 35% (22 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVNYKSLGSHSPQITRLKTELEKSMHLKHRNI
||| . .|.| | .|.  |.||  |.. .| |  |||   . |  ..  |..   .|.||.|
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVP-KSLLIKQHQRDKMTQEIQIHRQLHHRHI

Kinase GL50803_16943.AA NEK 11-47 26 4.1e-07 21.53 In-house 1-42 (286) Show / Hide
Range on Protein: 11-47
Range on HMM: 1-42/286
Sequence Identity: 26% (11 aa)

YEKLASIGRGTFGECFVCRNKDSSEI-----LCAKEVNYKSL
||..  ||.| ||... .| |  . .     .. |..|....
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNM

Kinase GL50803_16943.AA NEK1 11-43 30 1.1e-05 15.82 In-house 1-33 (276) Show / Hide
Range on Protein: 11-43
Range on HMM: 1-33/276
Sequence Identity: 30% (10 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCAKEVN
|...  || |.||  .  . | ..  .. || |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEIN

Kinase GL50803_16943.AA TyrKc 11-266 13 4.9e-05 -141.21 SMART 1-280 (280) Show / Hide
Range on Protein: 11-266
Range on HMM: 1-280/280
Sequence Identity: 13% (42 aa)

YEKLASIGRGTFGECFVCRNKDSSEILCA-KEVNYKSLGSHSPQITRLKTELEKSMHL--KHRNILPILEIYDNPDLCTIH-----------IISPYRAG
 ...  .|.| ||| . .. |    | .| | ..  .       .  .  |..  ..|  .| ||. .. .      || .           |.  | ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGV------CTQQGRNFMYIEPLMIVMEYMPH

ESVAELLIATQANSQGIPEQDIWKLMDGLCQALQFLCTSAPSPSTSPAHLNLI-----PSNIFLSSLSSVLTSEPCITRFIFAA-------DSIRK----
 .  . | ... .   .. .|  . .   ..  ..|              |.|       |. ...   |  |    .|.|          | .||    
GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

DET------YMPPETRGTTIATLQGN-----------------IWTVGSIAYEL-----ATGRRASDLLSLTSPTNLKVELPEQ--------YSASLSLL
..        |.||.        . .                 | | |   |.       . ...  ..     .    . |.          .. .  .
GGKTMLPIRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK----QGYRMPQPPNDYPMSFVCCPDEMYQI

LAQMLSPNEDNRPSLASWRSEI
  |    . ..||. .  ....
MKQCWHEDPEDRPTFSEIHECF

Kinase GL50803_16943.AA NEK 233-258 39 0.00105 9.38 In-house 249-276 (286) Show / Hide
Range on Protein: 233-258
Range on HMM: 249-276/286
Sequence Identity: 39% (11 aa)

LPEQ--YSASLSLLLAQMLSPNEDNRPS
.|..  ||  |. |. ||| .. ..|||
IPSHRMYSQDLQNLISQMLQKDPEQRPS

Kinase GL50803_16943.AA NEK1 233-258 42 0.009397 5.58 In-house 241-266 (276) Show / Hide
Range on Protein: 233-258
Range on HMM: 241-266/276
Sequence Identity: 42% (11 aa)

LPEQYSASLSLLLAQMLSPNEDNRPS
.|  ||  |. |..||.. |  .|||
IPPHYSYELQSLVSQMFKRNPRHRPS

Kinase GL50803_16943.AA NEK2 233-258 34 0.021261 3.75 In-house 284-309 (319) Show / Hide
Range on Protein: 233-258
Range on HMM: 284-309/319
Sequence Identity: 34% (9 aa)

LPEQYSASLSLLLAQMLSPNEDNRPS
.|.|||  |. . . |.  .   |||
IPYQYSRHLNEIIHFMINVDHYHRPS

Kinase GL50803_16943.AA Pkinase 201-215 46 9.959873 0.12 Pfam 195-209 (293) Show / Hide
Range on Protein: 201-215
Range on HMM: 195-209/293
Sequence Identity: 46% (7 aa)

IWTVGSIAYELATGR
.| .| | ||...||
MWSCGCILYEMLCGR

Ank GL50803_16943.AA Ank 315-340 30 0.133696 10.03 Pfam 1-26 (33) Show / Hide
Range on Protein: 315-340
Range on HMM: 1-26/33
Sequence Identity: 30% (8 aa)

GGTTALMLAADQNFPAAISVLLKYEA
 | |.|.||.  . .  .. ||.. |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_16943.AA Ank 346-366 57 0.000521 18.72 Pfam 1-21 (33) Show / Hide
Range on Protein: 346-366
Range on HMM: 1-21/33
Sequence Identity: 57% (12 aa)

DGDTALLMACKKDHQEVVKLL
||.|.| .||...| ||||.|
DGFTPLHLACRCGHTEVVKML

Ank GL50803_16943.AA Ank 452-473 36 1.820091 5.94 Pfam 1-21 (33) Show / Hide
Range on Protein: 452-473
Range on HMM: 1-21/33
Sequence Identity: 36% (8 aa)

KGRTALSLAAEHGCCALIIGML
 |.|.| ||...| .. .. ||
DGFTPLHLACRCG-HTEVVKML

Ank GL50803_16943.AA Ank 531-553 34 0.000508 18.76 Pfam 1-23 (33) Show / Hide
Range on Protein: 531-553
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

DRWTALMFAAYYGKVDVVRLLVS
| .|.|. |...| ..||..|..
DGFTPLHLACRCGHTEVVKMLLQ

Ank GL50803_16943.AA Ank 563-584 36 0.005389 15.06 Pfam 1-22 (33) Show / Hide
Range on Protein: 563-584
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

YKHTALMLATKAGHLPCVELLI
.  |.|.|| . ||. .|..|.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_16943.AA Ank 594-619 26 0.000239 19.94 Pfam 1-26 (33) Show / Hide
Range on Protein: 594-619
Range on HMM: 1-26/33
Sequence Identity: 26% (7 aa)

NGETALMIAVSRGDMRIAAVLVKYEA
.|.|.|..|...|.....  |... |
DGFTPLHLACRCGHTEVVKMLLQHGA

Ank GL50803_16943.AA Ank 656-688 36 1e-06 27.93 Pfam 1-33 (33) Show / Hide
Range on Protein: 656-688
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

EETTALMLAASKGNSEVVKMLVGKSIDIGKKNK
.  |.|.||...|. ||||||...  |.  ...
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_16943.AA Ank 689-712 29 0.002042 16.58 Pfam 1-24 (33) Show / Hide
Range on Protein: 689-712
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

YGYTALMAAAQEDALECITVLLSY
.|.|.|. |.. . .|... ||..
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_16943.AA Ank 625-655 33 0.063346 11.2 Pfam 1-33 (33) Show / Hide
Range on Protein: 625-655
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

VRETALFKAITLGHTDIAKLLLS--AEAHIADE
  .|.|  |.  |||...|.||.  |. .. | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_16943.AA Ank 720-750 33 1.8e-05 23.96 Pfam 1-33 (33) Show / Hide
Range on Protein: 720-750
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGMTALMLAAARNLERSVKLLLD--HELGAKDH
.|.|.|.||. .. .. ||.||.   .. |.| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_16943.AA Ank 751-760 50 24.286877 1.88 Pfam 1-10 (33) Show / Hide
Range on Protein: 751-760
Range on HMM: 1-10/33
Sequence Identity: 50% (5 aa)

DGDTALLIAI
||.|.| .|.
DGFTPLHLAC

Ank GL50803_16943.AA Ank 783-804 27 15.148295 2.62 Pfam 1-22 (33) Show / Hide
Range on Protein: 783-804
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

NDCYPIMLATQLNLQSVVCALI
. . | .|| . .  .||  |.
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_16943.AA Ank 815-835 38 0.157836 9.77 Pfam 1-21 (33) Show / Hide
Range on Protein: 815-835
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NTLTPLMYAANQGSVELVDIL
.  |||..|.  |..| |  |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_16943.AA Ank 860-880 38 0.125427 10.13 Pfam 1-21 (33) Show / Hide
Range on Protein: 860-880
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGWTALMFAVDKRCTGAVEVL
||.|.|. |. . .|  |. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_16943.AA Ank 891-912 27 0.276818 8.89 Pfam 1-22 (33) Show / Hide
Range on Protein: 891-912
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

NGNSALSIAVALGDIASIQLLL
.|...| .|.  |..  ...||
DGFTPLHLACRCGHTEVVKMLL