Gene GL50803_16986 (G.lamblia)
GL50803_16986
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_16986.AA | Protein | None | 652 | None | Fasta, JSON |
| GL50803_16986.kin_dom | Protein Kinase Domain | None | 307 | None | Fasta, JSON |
Protein domains of GL50803_16986.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_16986.AA | Ciliate-E2 | 215-316 | 22 | 6.6e-16 | 51.08 | In-house | 240-365 (365) | Show / Hide |
Range on Protein: 215-316 Range on HMM: 240-365/365 Sequence Identity: 22% (30 aa) QRDKFKSIQGYLSYLAPEVLQ--TYK-------HLPASDIWSLGIIALEMFSSRKPKVPPYGPDAVDYFSTWTPP----------------DTSSFPSEV | . |..| | . |.|||.|. | . ..||||||.| || . . | . | .. . . |. QQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQEC AYFLES----TLAIRPEDRIT-AGDLLQLPFI .. | || ||| . ..|. |.. KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_16986.AA | Pkinase | 228-316 | 21 | 1.9e-15 | 55.71 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 228-316 Range on HMM: 177-293/293 Sequence Identity: 21% (26 aa) YLAPEVLQ-TYKHLPASDIWSLGIIALEMFSSRKPKVPPYGPD------AVDYFSTWTPPDTSSFP-------------------------SEVAYFLES |.||||.. .. |..|.||.|.| ||.. . ||. . .. . . .|. .| |... YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC----GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW TLAIRPEDRITAGDLLQLPFI |. |..|.|| ..|| |.. CLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_16986.AA | STE | 218-316 | 22 | 9.2e-15 | 48.66 | In-house | 219-359 (359) | Show / Hide |
Range on Protein: 218-316
Range on HMM: 219-359/359
Sequence Identity: 22% (33 aa)
KFKSIQGYLSYLAPEVLQTYK------HLPASDIWSLGIIALEMFSSRKPKVPPY---GPDAVDYFST----------------WTPP----DTS-----
| ... | . ||||.| . . .||||||. ..|| . ||. | . . . .|| ..|
KRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK----PPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMI
-----------SFPSEVAYFLESTLAIRPEDRITAGDLLQ--LPFI
.. .| |.. | . |..| || .||. |||
SYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
|
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| S_TKc | GL50803_16986.AA | S_TKc | 10-316 | 18 | 1.4e-14 | 36.88 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-316
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)
YKYETILGDVKASRTSKCSDTSSSRVVAVRFVQEEFYISEDSKAKTSADYPEGDRVKIDRSKGVYIEQISFLLGLKNQYLLSYDKLTSGIATGRFYLPMT
|. ..| .. || .... |.||. . . .. | |. | . .. . ...|. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------EHIRRE-IQILKK-HHPNIVKLYDVFQD---DHLYMVME
FVRG--GSLRDWMVERKESKTP--LTPVELWRLLSPVISALAYLHGSYKTEKYTTAAGTQKPIRQLYHGGVHPGNILLTEGGSTLLTDPCICRTATMSTF
.. | |.|.| ...|. ... ... . .... ...||.|.| .. | . | ||||.| ..| ..|
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS-----------------HGIIHRDLKPENILLDE--HIKICDFGLARQL-----
ILDLENAQKQRDKFKSIQGYLSYLAPEVLQTYKHLP-ASDIWSLGIIALEMFSSRKPKVPPYGPDAVDYFSTWTPPDTSSFPSEVAYFLESTLAIRPEDR
... | . |.||||| .. . ..|.||.|.| ||.. ..| | . | ..|. |.. | ||.|
--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKR
ITAGDLLQ-------LPFI
.|| ..|| |..
PTA-EALQDEWDIKCHPWF
|
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| Kinase | GL50803_16986.AA | AGC | 207-255 | 26 | 1.9e-10 | 21.72 | In-house | 238-298 (395) | Show / Hide |
Range on Protein: 207-255 Range on HMM: 238-298/395 Sequence Identity: 26% (17 aa) LDLENAQKQR------------DKFKSIQG--YLSYLAPEVLQTYKHLPASDIWS--LGIIALEM ....|.|... |. ... | |.|||.| . .| |.|| ||.. || CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEM |
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| Kinase | GL50803_16986.AA | CAMK | 214-316 | 17 | 1.9e-10 | 29.14 | In-house | 271-425 (425) | Show / Hide |
Range on Protein: 214-316 Range on HMM: 271-425/425 Sequence Identity: 17% (27 aa) KQRDKFKSIQGYLSYLA-PEVLQT--------------YKHLPASDIWSLGIIALEMFSSRKPKVPPYGPD-------------------AVDYFSTWTP .. .|.| | ..| | ||||. . |..|.||.|.| | . . | ... . . .| . . TEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPY PDTSS------------------FPSEVAYFLESTLAIRPEDRITAGDLLQLPFI ...| . |. .. . | ||.|.|. . |. |.. FSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | GL50803_16986.AA | ASK | 220-316 | 29 | 2.2e-10 | 30.56 | In-house | 153-254 (254) | Show / Hide |
Range on Protein: 220-316 Range on HMM: 153-254/254 Sequence Identity: 29% (30 aa) KSIQGYLSYLAPEVLQTYK--HLPASDIWSLGIIALEMFSSRKPKVPPYGPDA----VDYFSTWTPPDTSSFPSEVAYFLESTLAIRPEDRITAGDLLQL .. .| | |.||||. . . .. ||||.| .|| .. | . | | | .. . |. ... | |. .. .. |..| .| |||| ETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKH-PEIPEELSAECKNFILRCFEPDPCKRASAQDLLQD PFI ||. PFL |
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| Kinase | GL50803_16986.AA | STE11-Unclassified | 213-261 | 36 | 1.7e-08 | 26.29 | In-house | 183-237 (308) | Show / Hide |
Range on Protein: 213-261 Range on HMM: 183-237/308 Sequence Identity: 36% (20 aa) QKQRDKFKSIQGYLS---YLAPEVLQ---TYKHLPASDIWSLGIIALEMFSSRKP ..| . ||.|| . . ||||. . .|. .||||||| . .||.. . | NSQQNHCKSMQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHP |
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| Kinase | GL50803_16986.AA | Ciliate-A9 | 103-151 | 24 | 3.8e-08 | 14.58 | In-house | 95-143 (392) | Show / Hide |
Range on Protein: 103-151 Range on HMM: 95-143/392 Sequence Identity: 24% (12 aa) RFYLPMTFVRGGSLRDWMVERKESKTPLTPVELWRLLSPVISALAYLHG ... | ....|.|. | ||| .. ... | . . .||..|.|. NIHIVMEYMKCGTLQQLMKERKKNNQWFNEQEISQIMKCIMSAVMYMHQ |
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| Kinase | GL50803_16986.AA | Ciliate-E2-Unclassified | 173-261 | 25 | 9.9e-08 | 22.91 | In-house | 167-269 (352) | Show / Hide |
Range on Protein: 173-261 Range on HMM: 167-269/352 Sequence Identity: 25% (29 aa) HGGVHPGNILLTEGGSTLLTDPCICRTATMSTFILDLENAQK------------------QRDKFKSIQGYLSYL----APEVL--QTYKHL--PASDIW | | |||....|. | |. .. | ........ | ..|. ||||| | | | ..||| HRDIKPENILFDNNGK------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIW SLGIIALEMFSSRKP |||.|. || . | SLGVILYEMLFGYYP |
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| Kinase | GL50803_16986.AA | MST | 228-255 | 57 | 1.7e-07 | 19.8 | In-house | 163-190 (254) | Show / Hide |
Range on Protein: 228-255 Range on HMM: 163-190/254 Sequence Identity: 57% (16 aa) YLAPEVLQTYKHLPASDIWSLGIIALEM ..||||.| | ||||||| |.|| WMAPEVIQEIKYDCKADIWSLGITAIEM |
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| Kinase | GL50803_16986.AA | Ciliate-A9 | 292-316 | 32 | 3.7e-07 | 12.17 | In-house | 368-392 (392) | Show / Hide |
Range on Protein: 292-316 Range on HMM: 368-392/392 Sequence Identity: 32% (8 aa) FLESTLAIRPEDRITAGDLLQLPFI |. ....| |..| .|. |. |.| FIQKMTNINPSNRYNAFQCLKHPWI |
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| Kinase | GL50803_16986.AA | STE11 | 215-261 | 29 | 4.1e-07 | 22.08 | In-house | 181-237 (303) | Show / Hide |
Range on Protein: 215-261 Range on HMM: 181-237/303 Sequence Identity: 29% (17 aa) QRDKFKSIQGYLS--------YLAPEVLQTYK---HLPASDIWSLGIIALEMFSSRKP | ||..| . . ||||. . . ..|||||| . .||.. . | QN-HCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPP |
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| Kinase | GL50803_16986.AA | STE11-Unclassified | 292-316 | 52 | 5.4e-07 | 20.89 | In-house | 284-308 (308) | Show / Hide |
Range on Protein: 292-316 Range on HMM: 284-308/308 Sequence Identity: 52% (13 aa) FLESTLAIRPEDRITAGDLLQLPFI ||. .. |.|..| || ||| ||| FLRKCFQIDPKKRPTANQLLQHPFI |
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| Kinase | GL50803_16986.AA | MST | 292-316 | 52 | 8.3e-07 | 17.58 | In-house | 230-254 (254) | Show / Hide |
Range on Protein: 292-316 Range on HMM: 230-254/254 Sequence Identity: 52% (13 aa) FLESTLAIRPEDRITAGDLLQLPFI |. . |.. ||.| || .||| ||| FVCKCLQKNPEQRWTAEQLLQHPFI |
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| Kinase | GL50803_16986.AA | STE11 | 278-316 | 33 | 3e-06 | 19.05 | In-house | 259-303 (303) | Show / Hide |
Range on Protein: 278-316 Range on HMM: 259-303/303 Sequence Identity: 33% (15 aa) TPPDTSSFP------SEVAYFLESTLAIRPEDRITAGDLLQLPFI .|| ... | || .. . |..| || .||| ||| HPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI |
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| TyrKc | GL50803_16986.AA | TyrKc | 47-319 | 13 | 2.1e-05 | -135.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 47-319
Range on HMM: 1-280/280
Sequence Identity: 13% (46 aa)
ISEDSK-------------------AKTSADYPEGDRVKIDRSKGVYIEQISFLLGL--KNQYLLSYDKLTSGIAT---------GRFYLPMTFVRGGSL
|. . | |. .. . .. .. . | ... .. |..| . .. | .. .|.|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRL----YGVCTQQGRNFMYIEPLMIVMEYMPHGDL
RDWMVERKESKTPLTPVELWRLLSPVISALAYLHGSYKTEKYTTAAGTQKPIRQLYHGGVH----PGNILLTEGGSTLLTDPCICRTATMS-TFILDLEN
.| .... |.. .| . . .||| . .| |.|..|.. .| .| . .
KDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----
AQKQRDKFKS-IQGY----LSYLAPEVLQTYKHLPASDIWSLGIIALEMFSSRKPKVPPYG-----------PDAVDYFSTWTPPDTSS------FPSEV
. |. . |. .| . .|||.....| ..||.|| |. |.|. . |..| |. .|. |.|.
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM
AYFLESTLAIRPEDRITAGDLLQLPFIQRI
.. . |||| | .. ....
YQIMKQCWHEDPEDRPTFSEI-----HECF
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| Kinase | GL50803_16986.AA | Ciliate-E2-Unclassified | 288-316 | 27 | 0.000129 | 11.96 | In-house | 320-352 (352) | Show / Hide |
Range on Protein: 288-316 Range on HMM: 320-352/352 Sequence Identity: 27% (9 aa) EVAYFLE----STLAIRPEDRITAGDLLQLPFI |.. |.. . | .|. |||. ..|. |.. EAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_16986.AA | Ciliate-E2-Unclassified | 101-150 | 14 | 0.256971 | 0.35 | In-house | 93-160 (352) | Show / Hide |
Range on Protein: 101-150 Range on HMM: 93-160/352 Sequence Identity: 14% (10 aa) TGRFYLPMTFVRGGSLRDWMV-------------ERKESKTPLTPVELW-----RLLSPVISALAYLH . .|. | ...||.|.... ...... .| . ... ....| ||| KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH |
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| Kinase | GL50803_16986.AA | Pkinase | 110-150 | 17 | 5.689925 | 0.98 | Pfam | 81-125 (293) | Show / Hide |
Range on Protein: 110-150 Range on HMM: 81-125/293 Sequence Identity: 17% (8 aa) FVRGG----SLRDWMVERKESKTPL--TPVELWRLLSPVISALAYLH ...|| .| |.. ...... .. |. . . ....|.|.| YCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCH |
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| Ank | GL50803_16986.AA | Ank | 452-473 | 40 | 0.044023 | 11.77 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 452-473 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) NGLTAMAHAAILGRSEVVELLL .| |. |.. |. |||..|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_16986.AA | Ank | 496-518 | 30 | 61.981102 | 0.41 | Pfam | 4-26 (33) | Show / Hide |
Range on Protein: 496-518 Range on HMM: 4-26/33 Sequence Identity: 30% (7 aa) TSMMLAASEGNDAVIRVLQDCEA | .||.. |. |.. | .. | TPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_16986.AA | Ank | 525-547 | 30 | 0.002411 | 16.32 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 525-547 Range on HMM: 1-23/33 Sequence Identity: 30% (7 aa) HCRTALMAAAACGYPSIVSLLVK . .|.|. |. ||....|..|.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_16986.AA | Ank | 556-579 | 41 | 0.00074 | 18.17 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 556-579 Range on HMM: 1-24/33 Sequence Identity: 41% (10 aa) NGTTALMLSARGGRLECVSILVQQ .| |.|.| .| |..|.|. |.|. DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_16986.AA | Ank | 587-607 | 38 | 0.145265 | 9.9 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 587-607 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) WGNSALVLAAVNGHMSCVDVL |...| ||. .||...| | DGFTPLHLACRCGHTEVVKML |
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