Gene GL50803_17069 (G.lamblia)

GL50803_17069

Species: G.lamblia
Alias: GL50803_17069, GK260
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17069.AA Protein None 523 None Fasta, JSON
GL50803_17069.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of GL50803_17069.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17069.AA NEK 9-277 38 1.8e-116 393.21 In-house 1-286 (286) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-286/286
Sequence Identity: 38% (113 aa)

FEILGQIGKGSYGVVYKCKRKLDSRV-----YVLKEIRLAGATKKEIESAV-SECHILARIDSDYVVRYFDSFVESETETLWMVMEYCG-SGTLRNL---
.||. .||.||.|.|||..|| |...     ||.|.| . . . || . |. .|..||........|.|.|||.| . ..|  |||||   |.| ..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ITSTKT---RFTEEECWYYICQILLGVASIHAL-----KIIHRDIKSLNIFLAEN---SEPMKDKPYTKYLVKLGDMGVSKELQETQGLAQT-LVGSPYY
|   |     | ||. | . .|..|..  .|       ||.|||||. ||||  |   .           .||.|| |.||.|. |. .|.| .|| |||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY----------HNVKIGDFGISKVLNHTTDMAYTTQVGTPYY

LSPEICRSEKYNQKSDIWALGVTFYELMNMG-KHPFLAK--NQASLIVKILKG-KYEDLPDDC-YSQALRDLVYWCLRMNATGRPDVFTLLALPIV
.|||.|....||.|||||.||.  ||..    |||| |.  |. ||..|| || .|. .|.   ||| |..|.  .|. . . ||..  .|..|..
MSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_17069.AA S_TKc 9-277 27 2.3e-82 280.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-231/231
Sequence Identity: 27% (79 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAVSECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGS--GTLRNLITSTKTR-
.||| .||||..|.||||. | . |.. .|.|.         |.. .|  || . . ...|...|.|..   . |.||||||.   |.|. .| . ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKELQETQGLAQTLVGSPYYLSPEICRSEKYNQ-K
    |.| ....|..||..... .| ..|||||.|  ||.| |              .|..| |....|        |..|.|.|..||..   .|.  |
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCK

SDIWALGVTFYELMNMGKHPFLAKNQASLIVKILKGKYEDLPDDCYSQALRDLVYWCLRMNATGRPDVFTLLA-------LPIV
.|.|..|...||..  |. ||    |  .. |...           |. ..|..  ||... . || .  .|.        | .
CDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17069.AA NEK8 15-277 32 1.6e-76 217.99 In-house 7-278 (278) Show / Hide 
Range on Protein: 15-277
Range on HMM: 7-278/278
Sequence Identity: 32% (94 aa)

IGKGSYGVVYKCKRKLDS--RVYVLKEIRLAGATKKEIESAVSECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGSGTLRNLITSTKT-RFTEEE-
.|.|. |..  . || |.     ..|.| . . ..||  .| .|. .|.... . .. |.|.| |    ||  .|||.  |||  .| ...   | ||. 
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMED--NTLMIEMEYADGGTLYQMIQHQQNKLFEEERQ

----------------CWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKY--LVKLGDMGVSKELQETQGLAQT---LVGSPYYLSP
                   |  |....|. .|   | |||.| .|||.            |.   .||.|| | ||..  |  ..||   .|| |||.||
LKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFM------------TRHRMVVKIGDFGISKIM-NTKYHMQTTKTVVGTPYYMSP

EICRSEKYNQKSDIWALGVTFYELMNMGKHPFLAKNQASLIVKILKG-KYEDLPDDCYSQALRDLVYWCLRMNATGRPDVFTLLALPIV
|.| . .||||||.||||   ||.    |  | | |.  |..||  . .||...|  ||  .| ||  ||   .  ||..  ..| | .
EMCEGKPYNQKSDMWALGCVLYEMCCL-KRAFEASNLPALVWKIMQCRAYEPISDH-YSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_17069.AA NEK1 9-277 40 1.9e-76 260.28 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-276/276
Sequence Identity: 40% (113 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAVSECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGSGTLRNLITSTKTR---
.... |||.||.| ... |.| |...||.|||..    .||.| .. |  |||. .   .|.|..||.|     |  |||||  | |   |   | .   
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FTEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPM------KDKPYTKYLVKLGDMGVSKELQETQGLAQTLVGSPYYLSPEICRSEKYNQ
| | .   . ||| |..  ||  ||.|||||| ||||   .  |              |||||| |... |..|  .|.| .| |||||||||    ||.
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGVTFYELMNMGKHPFLAKNQASLIVKILKGKYEDLPDDCYSQALRDLVYWCLRMNATGRPDVFTLLALPIV
|||||.||.  |||.   |||| |.|   |. ||..| |  .|   ||. |. ||   .. |.  || | ..|  |..
KSDIWSLGCVLYELCTL-KHPFEANNWKNLVLKICQGTYPPIP-PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_17069.AA Pkinase 9-277 26 3.6e-72 250.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAVS--ECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGSG----TLRNLIT-S
..|...||.||.|.||||..| .......|.|.. .. ... ....   |..|..|......||..|.| .     ..||||||. |     |  .|. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

TKTRF--TEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKEL-QETQGLAQTLVGSPYYLSPEICR-SEKY
 ...|  .|.||  |. ||| |.. .|. .|||||.|. ||.. .| ..          ||..| |..| .    .. ..|..|.|.|..||..| ...|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

NQKSDIWALGVTFYELMNMGKHPFLAK------NQASLIVKILKGKYEDLPDDCYS-------------------QALRDLVYWCLRMNATGRPDVFTLL
 .|.|.|..|...||... |. ||  .      .|  .|..|......   .  .|                   ....|...|||... . ||    .|
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

ALPIV
  | .
QHPWF
Kinase GL50803_17069.AA STE 9-277 21 3.8e-69 236.05 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

FEILGQIGKGSYGVVYKCKRKL---------------DSRVYVLKEIRLAGATK---------------KEIESAVSECHILARID--SDYVVRYFDSFV
.|....||||..|.|||....                  ...  |...|   ..               .|...   |  |. . .  ....|.|.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----ESETETLWMVMEYCGSGTLRNLITSTK-------------TRFTEEECWYYICQILLG-VASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKY
     ... ..||..|||.. |.|. .| ...             .|| |..  |...||| |  . .| ..|||||||. ||.|               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

LVKLGDMGVSKELQE---------------TQG-LAQTLVGSPYYLSPEICRS------EKYNQKSDIWALGVTF-------YELMNMGKH----PFLAK
 ||| | ||.. |..               |..   .|.||.| . .||. .        .|. |.||| || |        .....|  .    ... .
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFN

NQAS----LIVKILKGKYEDLPDD------------------CYSQALRDLVYWCLRMNATGRPDVFTLLA--LPIV
. ..    .. .|..|.   |||.                   .|. ..| .  ||...   ||..  ||    | .
YHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_17069.AA NEK4 9-277 34 2.6e-61 209.99 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-257/257
Sequence Identity: 34% (92 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAVSECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGSGTLRNLITSTKTRFTE
.... ..|||||| |.  . . | . ||.| . |  | ..|   |  |  .| .     .| |..|.   .   |  || .| .| | .     |  | |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EE-CWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKELQETQGLAQTLVGSPYYLSPEICRSEKYNQKSDIWALG
|.       || ..   .|  .|.||| |  ||||             | ..|.||.|.|. |..   .|.|..| |||.|||.  .  |. |||||.||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTK-----------KNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG

VTFYELMNMGKHPFLAKNQASLIVKILKGKYEDLPDDCYSQALRDLVYWCLRMNATGRPDVFTLLALPIV
   ||.. . || | ||.  ||| .|..|.   .| . ||| | .|||  |    | || .| ..  | .
CCVYEMITL-KHAFDAKDMNSLIYQIIQGQPPPMPPN-YSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_17069.AA NEK2 9-277 31 1.6e-60 202.49 In-house 1-319 (319) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-319/319
Sequence Identity: 31% (101 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAVSECHILARIDSDYVVRYFDSFVESETETLWMVMEYCGSGTLRNLI---TSTKTR
 |.|. ||.||.|...| .|| | .. | |||     . ||    |||| ||      ..||| |  .  ...|| .|||||  | |  .|   .. ...
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FTEEECWYYICQILLGVASIHA---------------------LKIIHRDIKSLNIFLAENSE-------------------------------PMKDKP
. ||  |    |...    .|                        |.|||||  |||| ..                                 ||    
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMD---

YTKYLVKLGDMGVSKELQETQGLAQTLVGSPYYLSPEICRSEKYNQKSDIWALGVTFYELMNMGKHPFLAKNQASLIVKILKGKYEDLPDDCYSQALRDL
| .  ||||| |  . |.  .  |.| || ||| |||     ||| |||||..|   ||.    . || |.||| | .|| .|... .|   ||. | ..
YSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCAL-HPPFQATNQAQLQEKIKQGHFRRIP-YQYSRHLNEI

VYWCLRMNATGRPDVFTLLALPIV
.   .  .   || .. .|. | .
IHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_17069.AA Ciliate-E2 9-239 22 7.3e-56 190.23 In-house 1-306 (365) Show / Hide 
Range on Protein: 9-239
Range on HMM: 1-306/365
Sequence Identity: 22% (76 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVY------------------VLKEIRLAGATKKEIESAVSECHIL----------------ARIDSDYVVRYFDS
.... .||.|..|.|||||.... . .                    |.. .    |..||.  .| ||.                 .............
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FVESETETLWMVMEYCGSGTLRNLITSTKT----------RFTEEECW---------------YYICQILLGVASIHALK-IIHRDIKSLNIFLAENSEP
| |  .... .|||||  |.|. .| . |.          .|||.|.                .||..|.|.. ..|  . |||||||  ||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

MKDKPYTKYLVKLGDMGVSKELQE----------------------TQG---------LAQTLVGSPYYLSPEICRSEK---------YNQKSDIWALGV
          .|. |.| ||....                      |.|         ...|..|.|.|..||| ...|         |. |.|||.|||
----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TFYELMNMGKHPFLAKNQASLIVKILKGKYE
..||.. .||.||        . .|...|..
ILYEML-FGKPPF--------QQQIKQCKID
Kinase GL50803_17069.AA CAMK 14-266 18 1.2e-54 174.18 In-house 1-414 (425) Show / Hide 
Range on Protein: 14-266
Range on HMM: 1-414/425
Sequence Identity: 18% (77 aa)

QIGKGSYGVVYKCKRKLDS------------RVYVLKEIRLAGATKKE--------------------------IESAVSECHILAR-------IDSDYV
..|.||.|.|..|..|..             . .  | |    ...|.                           ..  .| .|. .       .|   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYFDSFVESE---------TET---------LWMVM---EYCGSG----TLRNLITST--------------KTRFTEEECWYYICQILLGVASIHALK
.. .. .  ..         | .         ..|||   |||  |     | . |..               . ||||.|. .|. ||. .|. .| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKSLNIFLAENSE-----------PMKDKPYTKYLVKLGDMGVSKELQETQG-----------------------LAQTLVGSPYYLS-PEICRS
|.|||.|  || | .|..           .       .. .|. | | ...... ..                       . .| .|.|.| . ||. ..
IVHRDLKPENILLDDNNDDSDPVEHDEIFD-----WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------------EKYNQKSDIWALGVTFYELMNMGKHPFLAK-------------NQASLIVKILKGKYE-DLP-------------DDCYSQA----
              . |..|.|.|..||  |  |  |. || ..             |.  |  ||.||||. . |             .|. |.     
KGHCNMQNATDEEKPYYGPKCDMWSCGVILY-IMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

----LRDLVYWCLRMNATGRP
     .||. ..|. . . |.
VSQECKDLIRKMLQVDPEKRM
Kinase GL50803_17069.AA Ciliate-E2-Unclassified 9-239 24 2.4e-54 186.85 In-house 1-304 (352) Show / Hide 
Range on Protein: 9-239
Range on HMM: 1-304/352
Sequence Identity: 24% (76 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVLKEIRLAGATKKEIESAV---------SECH--------------ILARIDSDYVVRYFDSFVESETETLWM
..|. |||.|..|.||||..| .  .|..|..  .   |. .   .          ...              ||  ... ..|..|  ...  .... .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF--YCFQDKQNIYI

VMEYCGSGTLRNLITSTKT----------------RFTEEECW-----YYICQILLGVASIHALK-IIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGD
|||||  |.|.. |.. |.                .|||...      .|. |||.|  ..|  . |||||||  ||.. .| .        .| .|. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--------NYYIKIID

MGVSKELQET---------------QGLAQTLVGSPYYL----SPEICRSEKYN----QKSDIWALGVTFYELMNMGKHPFLAKNQAS------------
 | ||..|.                | ...| .|.|.|.    .||. ....|.     |.|||.||| .||.. .|..|| ..|. .            
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML-FGYYPFYDNNCEQHQQLITQWINNA

----LIVKILKGKYE
    |. .|......
YRKQLYQNIKQKNIQ
Kinase GL50803_17069.AA STE20 9-277 29 8.9e-52 178.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 9-277
Range on HMM: 1-288/288
Sequence Identity: 29% (89 aa)

FEILGQIGKGSYGVVYKCKRKLDSRV----YVLKEIRLAGATK--KEIESAVSECHILARIDSDYVVRYFDSFVESET--ETLWMVMEYCGSGTLRNLIT
.|.| .||.||||.|||.  |   ..    .  | . |  .    .|.|. . |  |... .. ..|.|..|.. . |  . ||.|||||| |.|. ...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---STKT-----RFTEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKELQE----TQG-LAQTLVGSPYYL
   ...      ...||.  |   ..| | . .|. .|||||||. || | |. |           ||| | ||.  |..    |..   .|.||.||..
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGE-----------VKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWM

SPEICRS-----EKYNQKSDIWALGVTFYELMNMGKHPFLAKNQASLIVKILKG---KYEDLPDDC---YSQALRDLVYWCLRMNATGRPDVFTLLALPI
.||. .       .|..|.|||.|| |  |. . |. |..  .  . . .|.|.   . ..  | .   .|. ..|.|  || ..   || .  ||  | 
APEVIQCMEGPDKGYDYKCDIWSLGITAIEMAE-GEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPF

V
.
I
Kinase GL50803_17069.AA TyrKc 9-281 19 3.7e-16 38.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-281
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

FEILGQIGKGSYGVVYKCKRKLDSRVYVL-KEIRLAGATKKEIESAVSECHILARI--DSDYVVRYFDSFVES-----ETETLWMVMEYCGSGTLRNLIT
 . . ..| | .|.|||.. |    . |  | ..        .|   .|  |. ..  . . .|| .   ...     . | |..||||.  | |.. . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

STKTRFTEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKELQET--------QGLAQTLVGSP-----YYL
... ... ..  ..  ||  | . .|  ..||||.   |. ..||             || .| | |... .            ...  |.        .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

SPEICRSEKYNQKSDIWALGVTFYELMNMGKHPFLA-----KNQASLIVKILKGKYEDLPDD-------CYSQALRDLVYWCLRMNATGRPDVFTLLALP
.||  .  |.. |||.|. ||. .|..  |. |        .. . .| .. .|.. . |..       | .... ..  .| . ..  ||  |. .   
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT-FSEI---

IVKDKL
  ....
--HECF
Kinase GL50803_17069.AA Pkinase_Tyr 9-221 21 1.8e-09 32.67 Pfam 1-216 (270) Show / Hide 
Range on Protein: 9-221
Range on HMM: 1-216/270
Sequence Identity: 21% (49 aa)

FEILGQIGKGSYGVVYKCKRK----LDSRVYVLKEIRLAGATKKE--IESAVSECHILARI-DSDYVVRYFDSFVESETET--LWMVMEYCGSGTLRNLI
 ... ..|.|..|.|||.. |     .      | .   ||....  .|.  .|  |.  . . . .||.    . .. |   ...||||.  | |..  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY-GVCTDQGEPNQIYIVMEYMPHGDLLDYL

TST---KTRFTEEECWYYICQILLGVASIHALKIIHRDIKSLNIFLAENSEPMKDKPYTKYLVKLGDMGVSKEL--QETQ-GLAQTLVGSPYYLSPEICR
 .    | ..| ..   .  ||  | .  .. ..||||.   |. ..|           .  || .| | .. .   ..    ..        ..||  .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

SEKYNQKSDIWALGVTFYELMNMGKHP-F
  |.. |||.|. ||. .|..  |. | .
YGKFTTKSDVWSFGVLMWEIFTYGEQPTY