Gene GL50803_17073 (G.lamblia)

GL50803_17073

Species: G.lamblia
Alias: GK061, GL50803_17073
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17073.AA Protein None 799 None Fasta, JSON
GL50803_17073.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of GL50803_17073.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_17073.AA Pkinase 30-238 20 2.6e-20 72.88 Pfam 1-192 (293) Show / Hide 
Range on Protein: 30-238
Range on HMM: 1-192/293
Sequence Identity: 20% (46 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQIRFQRFTNPLSE----LSGGKEAAPCQREMHASTNTEVCALRHLNTRPHSSIPMFHHAFNVDESLYIVM
|... .|||| .| |. ...   .. .|.|.|. ..      .    |                  .|.. ...||   |  |  ....|  . ..|.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------------------SEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVM

EFSSGS----PLTDVLTRYRSLNSGAFPAIPYYYLKLLVRRLLRAIHHCHQSGVAHLDIKPDNIHIESPTRL----TLVDYGQSYTIHEGVSDDPWLDSR
|.  |      | |....    ..|.|   ..  .|  .. .||.. .||. |. | |.||.|| | .   .     . | | .  .      .. ....
EYCEGGLYVMDLFDYIST---WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTF

IGAMAFLPPEVLTSSTLYTTS
 |   ...|||. ... |...
CGTPWYMAPEVIRGGQYYGPK
S_TKc GL50803_17073.AA S_TKc 30-616 8 5.4e-16 57.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-616
Range on HMM: 1-231/231
Sequence Identity: 8% (54 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQIRFQRFTNPLSELSGGKEAAPCQREMHASTNTEVCALRHLNTRPHSSIPMFHHAFNVDESLYIVMEFSS
|..|  ||.| .| |. ....     .|.|.|.                          ..  |.  |..     |  |  .. .|   ..||.|||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCD

G--SPLTDVLTRYRS--LNSGAFPAIPYYYLKLLVRRLLRAIHHCHQSGVAHLDIKPDNIHIESPTRLTLVDYGQSYTIHEGVSDDPWLDSRIGAMAFLP
|    | |.. ....  |...    .|    . ... ...|. .||. |. | |.||.|| . .  .. . | | .  .          .. .|   ...
GDLGDLFDYIKKRGRHGLRFP----FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMA

PEVLTSSTLYTT-------------SYLNLKNLVSSFSLDPSLTPNCQSAQSQQALRTPRRTPTLTDVKEQNLPQHKSPHVKSKGSKQVSQSRDSSSSDS
||||     |..               |  . . .               | |. ..  .                                        
PEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG----------------------------------------

KKSTSAPTRSASVSVSYTPMHHISTLFLKDCTLYHDKGRVQATGARFRLWMDAILRMRMFTKFDRPQTPPFCVSFENGSVKLNAIDIRDIIEISEALNDS
                                                                                                    
----------------------------------------------------------------------------------------------------

VAKYNIVDPKAAVTDSSANTFPLASDLLEIGIKLGIPDLKGTTLHVFNSKLAIDSWAAGLVLLICIIGDYPFRDVSTFEIVPSVQLMAEAIRQQLDSTLE
                                                                                                    
----------------------------------------------------------------------------------------------------

VISQGNFEKYRLYLRTLNDKASCDLCGKCALCLMEKSFCNQQLRRNITKFCRKPVPLPDSFTVSPNGPLSSDLHLDLFLLIAGLLHPNPKARMSISEAME
                                                                           ..  .| ..|. .|. |... ||..
-------------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------CPWL
        ||.
DEWDIKCHPWF
Kinase GL50803_17073.AA CAMK 35-229 14 7e-15 43.68 In-house 1-292 (425) Show / Hide 
Range on Protein: 35-229
Range on HMM: 1-292/425
Sequence Identity: 14% (41 aa)

CIGSGCYGAVFVAIDN-TRS-----------CFYALKQIRFQRFTNP----------LSELSGGKEAAPCQREMHASTNTEVCALRHLNTRP----HSSI
 .|.| .| |. .|.  |               .| | |  .. ..           ..   ... .   . .. ..   |.. ...|.       |  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PMFHHAFNV-------------------DESLYIVM---EFSSGSPL-TDVLTRYRSLNSGAF----------PAIPYYYLKLLVRRLLRAIHHCHQSGV
  .....                     |. .|.||   |. ||  |  |.. . ..  .. .            ..    . ..| .. |.|.||. ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHLDIKPDNIHIESPT-----------------RLTLVDYGQS--YTIHEGVS------------------DDPWLDSRIGAMAFLP-PEVL
.|.|.||.|| . .                    . ..| | .  ..  |.                    ... .  . |  .. . ||||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL
Kinase GL50803_17073.AA CMGC 30-185 14 1.5e-14 43.33 In-house 1-215 (513) Show / Hide 
Range on Protein: 30-185
Range on HMM: 1-215/513
Sequence Identity: 14% (35 aa)

YTLLHCIGSGCYGAVFVAIDNTRS--------------CFYALKQIR---FQRFTNPLSELSGGKEAAPCQREMHA--------STNTEVCALRHLNTR-
|. .  ||.| || |. ..|. .                ..|.| |.   ...   .                  .        ... |.  |.||| . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKS------------------TIEKDGFPIRALREIKILKHLNKNH

------------PHSS-IPMFHHAFNVDE-----------------SLYIVMEFSSGSPLTDVLTRYR---------SLNSGA------------FPAIP
            .|   |   .  |  ..                 .||.|.|.  .  | ... ...          |.                  ..
DPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEY-MDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFM

YYYLKLLVRRLLRAIH--HCHQSG--VAHLDIKPDNI
  . .   . .||...  .||. .  . | |.|| ||
I-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENI
Kinase GL50803_17073.AA STE 30-185 18 7.8e-13 41.76 In-house 1-183 (359) Show / Hide 
Range on Protein: 30-185
Range on HMM: 1-183/359
Sequence Identity: 18% (36 aa)

YTLLHCIGSGCYGAVFVAIDNT---------------RSCFYALKQIRFQRFTNPLSELSGGKEAAPCQ-----REMHASTNTEVCALRHLN-TRPHSSI
.... .||.| .| |. |...                  ...| ||..... .|   |.    |.   .      | . .   |.  ....| .  |  |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-EN--Q-EN-Q-ELENKNHEEMQQILKEIKIMKKCNHM--HPNI

PMFHHAFNVD-------ESLYIVMEFSSGSPLTDVLT-RYRSLNS------GAFPAIPYYYLKLLVRRLLRA-IHHCHQSGVAHLDIKPDNI
  .. .. ..       ..|.|.||. .|  |.|..  .|  ...      . .  .|   ..  .| .|..  .. |. .. | ||||.||
VKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANI
Kinase GL50803_17073.AA Trio 160-199 29 5.3e-12 26.39 In-house 101-144 (258) Show / Hide 
Range on Protein: 160-199
Range on HMM: 101-144/258
Sequence Identity: 29% (13 aa)

VRRLLRAIHHCHQSGVAHLDIKPDNIHIESPTR----LTLVDYG
.. .| |.|  |.....||||||.|. .. . .    . ..| |
MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFG
Kinase GL50803_17073.AA Ciliate-E2 105-238 15 6.5e-11 33.68 In-house 91-276 (365) Show / Hide 
Range on Protein: 105-238
Range on HMM: 91-276/365
Sequence Identity: 15% (31 aa)

HSSIPMFHHAFN--VDESLYIVMEFSSGSPLTDVLT-----RYRSLNSGAFPAIPYYYLKLLVRRLLR---------------AIHHCHQSG-VAHLDIK
|  |  .. .|    |...|.|||. .|  | | .      |   ... .   .  .  | . . .|.               |....|. . . | |||
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK

PDNIHIESPTRLTLVDYG--------QSYTIHEGVSDDPWLDSR----------------------IGAMAFLPPEVLTS--------STLYTTS
|.|| .     . ..| |        . ...| ..    ... .                      .|   ...||.| .        .. |...
PENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYK
Kinase GL50803_17073.AA CAMK 592-616 36 5e-09 24.47 In-house 401-425 (425) Show / Hide 
Range on Protein: 592-616
Range on HMM: 401-425/425
Sequence Identity: 36% (9 aa)

LIAGLLHPNPKARMSISEAMECPWL
|| ..| ..|. ||.|..... ||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_17073.AA Ciliate-E2-Unclassified 104-231 16 3.1e-08 24.71 In-house 79-240 (352) Show / Hide 
Range on Protein: 104-231
Range on HMM: 79-240/352
Sequence Identity: 16% (30 aa)

PHSSIPMFHHAFNVDESLYIVMEFSSGSPLTDVLT---------------------------RYRSLNSGAFPAIPYYYLK---LLVRRLLRAIHHCHQS
||  |  ....|. .. .|||||.  |  | . ..                           .|                |    . . .| .. ..|..
PHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY----------------KKAKFYFAQILQGLEYLHHK

G-VAHLDIKPDNIHIESPT---RLTLVDYGQSY--------TIHEG-----VSDDPWLDSRIGAMAFL----PPEVLTS
. . | ||||.|| . .     .. . |.| |.        . ...     . ..  .....|   ..    .|||| .
NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG
Kinase GL50803_17073.AA CDC2 151-199 32 3.4e-08 20.75 In-house 100-148 (301) Show / Hide 
Range on Protein: 151-199
Range on HMM: 100-148/301
Sequence Identity: 32% (16 aa)

IPYYYLKLLVRRLLRAIHHCHQSGVAHLDIKPDNIHIESPTRLTLVDYG
.|  ..| .   .|...|.||| .. | |.||.|| | .  .. . | |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase GL50803_17073.AA MLCK 163-185 43 3.4e-08 17.17 In-house 106-128 (257) Show / Hide 
Range on Protein: 163-185
Range on HMM: 106-128/257
Sequence Identity: 43% (10 aa)

LLRAIHHCHQSGVAHLDIKPDNI
.. ..|| |. ...|||.||.||
ICEGVHHMHWQNIVHLDLKPENI
Kinase GL50803_17073.AA MLCK 593-616 37 2.1e-07 15.05 In-house 234-257 (257) Show / Hide 
Range on Protein: 593-616
Range on HMM: 234-257/257
Sequence Identity: 37% (9 aa)

IAGLLHPNPKARMSISEAMECPWL
|  ||  ... ||...|... |||
ISRLLVKDKEKRMTAHECLQHPWL
Kinase GL50803_17073.AA CDK-DD1 30-61 40 2.7e-07 17.95 In-house 1-32 (379) Show / Hide 
Range on Protein: 30-61
Range on HMM: 1-32/379
Sequence Identity: 40% (13 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQI
|  .  .|.| || || || .   |  ||| .
YQIISKCGQGIYGSVFKAIHKITHCMVALKNF
Kinase GL50803_17073.AA CDK 30-64 37 6.3e-07 18.03 In-house 1-40 (284) Show / Hide 
Range on Protein: 30-64
Range on HMM: 1-40/284
Sequence Identity: 37% (15 aa)

YTLLHCIGSGCYGAVFVAIDNTRS-----CFYALKQIRFQ
|  |  || | || |. |.|  .       ..|||.|| .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRME
Kinase GL50803_17073.AA CDK 157-185 44 9.4e-07 17.46 In-house 111-139 (284) Show / Hide 
Range on Protein: 157-185
Range on HMM: 111-139/284
Sequence Identity: 44% (13 aa)

KLLVRRLLRAIHHCHQSGVAHLDIKPDNI
| . . |||..|.||. .. | |.|| ||
KCYMWQLLRGLHYCHSNWIMHRDLKPQNI
Kinase GL50803_17073.AA CMGC 548-616 14 4e-06 15.02 In-house 419-513 (513) Show / Hide 
Range on Protein: 548-616
Range on HMM: 419-513/513
Sequence Identity: 14% (14 aa)

KSFCNQQLRRNITKFCRKPVPLPDSFTVSPN----------------GPLSSD----------LHLDLFLLIAGLLHPNPKARMSISEAMECPWL
..|  .....|...  ..| |. . |  .||                 .  |.          .. ... |. ..|. .|. |.....|.. |..
SEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17073.AA CDK 592-616 32 4e-06 15.49 In-house 260-284 (284) Show / Hide 
Range on Protein: 592-616
Range on HMM: 260-284/284
Sequence Identity: 32% (8 aa)

LIAGLLHPNPKARMSISEAMECPWL
|. ..|  .|| |.| ..|...|..
LLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_17073.AA Trio 593-616 33 6e-06 10.55 In-house 235-258 (258) Show / Hide 
Range on Protein: 593-616
Range on HMM: 235-258/258
Sequence Identity: 33% (8 aa)

IAGLLHPNPKARMSISEAMECPWL
| ..|.  | .| . ||. ..||.
ICKVLQEDPWKRPCASECLQHPWF
Kinase GL50803_17073.AA CDC2 30-62 39 1.7e-05 12.28 In-house 1-33 (301) Show / Hide 
Range on Protein: 30-62
Range on HMM: 1-33/301
Sequence Identity: 39% (13 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQIR
|. .  || | || |. ..|.      |||.||
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIR
Kinase GL50803_17073.AA Ciliate-E2 30-64 28 2e-05 14.54 In-house 1-34 (365) Show / Hide 
Range on Protein: 30-64
Range on HMM: 1-34/365
Sequence Identity: 28% (10 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQIRFQ
| .. .||.|..| |. . .    . .|.|.|. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-Q
Kinase GL50803_17073.AA CDK-DD1 592-616 40 4.8e-05 10.84 In-house 355-379 (379) Show / Hide 
Range on Protein: 592-616
Range on HMM: 355-379/379
Sequence Identity: 40% (10 aa)

LIAGLLHPNPKARMSISEAMECPWL
|| ..|  .|| |..  || . || 
LIERMLTLCPKKRINTKEALQHPWF
Kinase GL50803_17073.AA Ciliate-E2-Unclassified 30-61 28 6e-05 13.13 In-house 1-32 (352) Show / Hide 
Range on Protein: 30-61
Range on HMM: 1-32/352
Sequence Identity: 28% (9 aa)

YTLLHCIGSGCYGAVFVAIDNTRSCFYALKQI
|.....||.|..| |. ....    .||.|..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYM
Kinase GL50803_17073.AA CDK-DD1 157-201 37 0.000246 8.62 In-house 101-145 (379) Show / Hide 
Range on Protein: 157-201
Range on HMM: 101-145/379
Sequence Identity: 37% (17 aa)

KLLVRRLLRAIHHCHQSGVAHLDIKPDNIHIESPTRLTLVDYGQS
|  .. ||  |  ||  |. |.|||| |  |     | . | | .
KCFFHQLLEGINECHNQGIMHRDIKPANLLINNRGDLKITDFGFT
Kinase GL50803_17073.AA Pkinase 585-616 21 0.000504 15.31 Pfam 262-293 (293) Show / Hide 
Range on Protein: 585-616
Range on HMM: 262-293/293
Sequence Identity: 21% (7 aa)

LHLDLFLLIAGLLHPNPKARMSISEAMECPWL
.. ..  .| ..|...|| | .. .... ||.
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17073.AA CDC2 592-616 32 0.000628 7.38 In-house 277-301 (301) Show / Hide 
Range on Protein: 592-616
Range on HMM: 277-301/301
Sequence Identity: 32% (8 aa)

LIAGLLHPNPKARMSISEAMECPWL
|.  .|. .|  | |. ||.. |..
LLMQMLQYDPQKRISAKEALQHPYF
Kinase GL50803_17073.AA Ciliate-E2 592-616 23 0.001194 8.38 In-house 336-365 (365) Show / Hide 
Range on Protein: 592-616
Range on HMM: 336-365/365
Sequence Identity: 23% (7 aa)

LIAG----LLHPNPKARMS-ISEAMECPWL
||      .|  .|. |.. ...... ||.
LIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_17073.AA Ciliate-E2-Unclassified 592-616 28 0.003419 6.95 In-house 328-352 (352) Show / Hide 
Range on Protein: 592-616
Range on HMM: 328-352/352
Sequence Identity: 28% (7 aa)

LIAGLLHPNPKARMSISEAMECPWL
|.  .|  ||. |........ ||.
LLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_17073.AA STE 597-616 22 0.092246 2.15 In-house 338-359 (359) Show / Hide 
Range on Protein: 597-616
Range on HMM: 338-359/359
Sequence Identity: 22% (5 aa)

LHPNPKARMSISEAME--CPWL
|  .|. | . |. ..   |..
LQKDPNKRPTASQLLKSEHPFI