Gene GL50803_17084 (G.lamblia)

GL50803_17084

Species: G.lamblia
Alias: GL50803_17084, GK192
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17084.AA Protein None 1462 None Fasta, JSON
GL50803_17084.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of GL50803_17084.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17084.AA S_TKc 10-376 15 9.4e-15 39.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-376
Range on HMM: 1-231/231
Sequence Identity: 15% (62 aa)

YELMDHLGAGPHGSVFIAHSKVSDKLRAVKVFSLAKLDEDQRERLKDELSCAHRIENERLVRYYNVYEDQDCQTLSVVMDYLPL--GSLAAEMDRRTIH-
||.....| |  |.|. .. | .... |.|. .         |... |... ..   . .|..| |..|   . | .||.|..   |.|   ...|  | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

-HSPYTEQQIWAIIGQLCLALKAVYTALGSLQTSANKLTEISHGNLKPTNILLADSGLLSLTDYGLTHQAITEETIMDTIDAV-------PEAVLTNDIS
 ..|..| ... .. |.|.||.      |           | |  ||| |||| .   . ..| ||  |             .       || .     .
LRFPFPE-HARFYMYQICCALEYCHSH-G-----------IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----G

NTQ-RGDVWCLGRIAFELCCVGFPGFVGSGCPTPGLLTAAGVSVPSPLRPPSSSNVLVSSSPSLPPTPSERPQTSKLRIKEVNKRNSRTPISQRGRDQEQ
 .  . |.| .| | .|..| | | |      .. ..    .                                                          
YGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------------------------------------------------------

KEREEREREEREREERERLETEESAAPASQSAKTKAKTVLNPKLLNHVAGHLSPTLRQLIMSCLS-VGK---TDSENGN-------LPIT
                                                    || ....|. ||    .   |  |  .        |  
----------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17084.AA STE 10-127 16 2e-13 43.89 In-house 1-166 (359) Show / Hide 
Range on Protein: 10-127
Range on HMM: 1-166/359
Sequence Identity: 16% (27 aa)

YELMDHLGAGPHGSVFIAHSK------VSDKL---------RAVKVFSLAKLD---------------EDQRERLKDELSCAHRIE--NERLVRYYNVYE
.|... .| |  |.|. |  .       ....          |.|. .| . .               ........ |..  ..     .  |.||  |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DQDCQTLSVVMDYLPLGSLAAEMDRRTIHHSPYT----------EQQIWAIIGQLCLA-LK
     ......| ..| |.. |||   .... ..  | .          |.|| .|. |.. . |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLY
Kinase GL50803_17084.AA Pkinase 10-171 22 3.3e-10 37.19 Pfam 1-158 (293) Show / Hide 
Range on Protein: 10-171
Range on HMM: 1-158/293
Sequence Identity: 22% (40 aa)

YELMDHLGAGPHGSVFIAHSKVSDKLRAVKVFSLAKLDEDQRERLKD--ELSCAHRIENERLVRYYNVYEDQDCQTLSVVMDYLPLG----SLAAEMDRR
|..   .|.|  |.|...| | . |. |||.... . ........    |..  .|.  .  ||.| ..||   . . .||.|.. |    .|.     .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF-----D

TIH---HSPY--TEQQIWAIIGQLCLALKAVYTALGSLQTSANKLTEISHGNLKPTNILLADSGLL----SLTDYGL
 |.   | ..  .|...  .. |.. .|.  .               | |  ||| |||. . | .     ..| ||
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM------------GIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase GL50803_17084.AA CAMK 15-127 14 1.1e-09 26.67 In-house 1-193 (425) Show / Hide 
Range on Protein: 15-127
Range on HMM: 1-193/425
Sequence Identity: 14% (29 aa)

HLGAGPHGSVFIAHSKVSD------------KLRAVKVFSLAKLDEDQ--------------------------RERLKDELSCAHR-------IENERL
 || |  | |. .  | .             .  |.|. .  ||...|                          |.... |...  .       .  . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRYYNVYEDQ----------DCQT--------LSVVM---DYLPLGSLAAEMDRRTIHHSP---------------YTEQQIWAIIGQLCLALK
.. | ||||             ..        .  ||   .| . | |  ..  . . |..               .||..   .. |.| |..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVH
Kinase GL50803_17084.AA Ciliate-E2a 10-78 27 1.1e-08 21.66 In-house 1-70 (275) Show / Hide 
Range on Protein: 10-78
Range on HMM: 1-70/275
Sequence Identity: 27% (19 aa)

YELMDHLGAGPHGSVFIAHSKVSDKLRAVKVFSLAKLDED-QRERLKDELSCAHRIENERLVRYYNVYED
|.. . .| |  |||..|  |   | .|.|.|. .  ... ..| ...|..   .. .  . . | ||||
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYED
Kinase GL50803_17084.AA Ciliate-E2 10-217 15 2.4e-08 24.72 In-house 1-291 (365) Show / Hide 
Range on Protein: 10-217
Range on HMM: 1-291/365
Sequence Identity: 15% (50 aa)

YELMDHLGAGPHGSVFIA-HSKVSDKL-----------------RAVKVFSLAKLDEDQRERLKDELSCAHRIE------NER----------LVRYYNV
|..   .| | .|||. . . ||  .                   ..| . .  . ..| | .| |..   .|.      ||.          ....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YEDQDCQTLSVVMDYLPLGSLAAEMD-----RRTI---HHSPYTEQQIWAIIGQLCLALKAVYTALGSLQTSANKLT-------------------E-IS
....| ...  ||.|.  |.|   .      |  .      ..||..|  |. |.. . |                |                     | 
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFK----------------TKAEFYIACIILALEYLHSKNNII

HGNLKPTNILLADSGLLSLTDYGLTHQAITE----------ETIMDTI---------------------------DAVPEAVLTNDIS-------NTQRG
| ..|| |||.     . ..| ||  .. ..          . .|.                                || .   ...        .   
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC

DVWCLGRIAFELCC
|.|.|| | .|...
DIWSLGVILYEMLF
Kinase GL50803_17084.AA PAKA 10-127 21 3e-08 25.2 In-house 1-117 (260) Show / Hide 
Range on Protein: 10-127
Range on HMM: 1-117/260
Sequence Identity: 21% (26 aa)

YELMDHLGAGPHGSVFIAHSKVSDKL--RAVKVFSLAKLDEDQRERLKDELSCAHRIENERLVRYYNVYEDQDCQTLSVVMDYLPLGSLAAEMDRRT-IH
|. |. .| |  |.|..| ..   .    |.|.  .   .... | .. |..      .. .|.|.  |    .  | |||.|.  |.|    .    | 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNM--KNQPKKELIINEILVMKECKHKNIVNYIDSYLV--DDELWVVMEYMEGGCLTDVITQCCNIQ

HSPYTEQQIWAIIGQLCLALK
 .. .|.|| ... . . .|.
CNYMDEGQIAYVCRECLQGLE
Kinase GL50803_17084.AA KHS 10-96 31 3.7e-08 23.4 In-house 1-83 (258) Show / Hide 
Range on Protein: 10-96
Range on HMM: 1-83/258
Sequence Identity: 31% (27 aa)

YELMDHLGAGPHGSVFIAHSKVSDKLRAVKVFSLAKLDEDQRERLKDELSCAHRIENERLVRYYNVYEDQDCQTLSVVMDYLPLGSL
|||. ..|.|  | |. |. ..||.| ||||  .    .|. . .. |.   .  .   .| |.  |  .|   | ..|.|   |||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEP--GDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRD--KLWICMEYCGGGSL
Kinase GL50803_17084.AA NEK 10-129 23 1.3e-07 23.31 In-house 1-130 (286) Show / Hide 
Range on Protein: 10-129
Range on HMM: 1-130/286
Sequence Identity: 23% (30 aa)

YELMDHLGAGPHGSVFIAHSKVSDKL-----RAVKVFSLAKLDEDQRERLK-DELSCAHRIENERLVRYYNVYEDQDCQTLSVVMDYLP-LGSLAAE---
||.  ..| | .|.|. . .|   |       . |  .. ...| ... .   |     .. ..  |.||. ..... ..|  ||.|    | |.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

MDRRTIHHSPYTEQQIWAIIGQLCLALKAV
  ...  . .  | ||| .  |.||||| .
IKKQKQKGKYFEEEQIWDWFIQMCLALKYM
Kinase GL50803_17084.AA NAK 86-128 29 1.4e-07 21.26 In-house 91-134 (299) Show / Hide 
Range on Protein: 86-128
Range on HMM: 91-134/299
Sequence Identity: 29% (13 aa)

VVMDYLPLGSLAAEMDRRT-IHHSPYTEQQIWAIIGQLCLALKA
..| |.. |||. .|..|.    .. ||..|. |. . | ...|
LLMEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQA
Kinase GL50803_17084.AA CAMK1 10-59 21 1.9e-07 17.65 In-house 1-57 (276) Show / Hide 
Range on Protein: 10-59
Range on HMM: 1-57/276
Sequence Identity: 21% (12 aa)

YELMDHLGAGPHGSVFIAHSKVS---DKLRAVKVFS-LAKLDEDQR---ERLKDELS
||... .|.|  . |. .  | .   .|  |.|...    .... .   |.|. |..
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIE
Kinase GL50803_17084.AA NEK10 70-174 27 4e-06 15.8 In-house 76-169 (279) Show / Hide 
Range on Protein: 70-174
Range on HMM: 76-169/279
Sequence Identity: 27% (29 aa)

VRYYNVYEDQDCQTLSVVMDYLPLGSLAAEMDRRTIHHSPYTEQQIWAIIGQLCLALKAVYTALGSLQTSANKLTEISHGNLKPTNILLADSGLLSLTDY
|||| ..     . . .||.     .|   .      |  ..|..||... |.||||               |   | |  |.| ||.. |      ||.
VRYYRTFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLH-----------KEKQIVHRDLTPNNIMMGDKDRVTITDF

GLTHQ
||  |
GLAKQ
Kinase GL50803_17084.AA NEK10 10-25 56 3.5e-05 12.79 In-house 1-16 (279) Show / Hide 
Range on Protein: 10-25
Range on HMM: 1-16/279
Sequence Identity: 56% (9 aa)

YELMDHLGAGPHGSVF
||..||||.|  |.|.
YEVYDHLGTGAFGCVY
Kinase GL50803_17084.AA TyrKc 10-279 16 7.6e-05 -144.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-279
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

YELMDHLGAGPHGSVFIAHSKVSDKLRAVKVFSLAKLDEDQRERLKDELSCAHRI--ENERLVRYYNVYEDQ-----DCQTLSVVMDYLPLGSLAAEMDR
 .| . || |  | |. .. |      |||.    .     || . .|..  ...  ... .|| | |  .|       . | .|| | |.|.|     .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RTIHHSPYTEQQIWAIIGQLCLALKAVYTALGSLQTSANKLTEISHGNLKPTNILLADSGLLSLTDYGLTHQAITE-------ETIMD--TIDAV-----
.  .    . ..   .  | .                      . |  |   |.|... .    .| ||.     .       ....   . ..      
HRPK---LCMKDLLSFCWQIACGMEYLHSK------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

----PEAVLTNDISNTQRGDVWCLGRIAFELCCVGFPGFVG---SGCPTPGLLTAAGVSVPSPLRPPSS-----SNVLVSSSPSL--------PPTPSER
    ||.   |.   |   |||  |   .|..  | .   |      . .     . |     ...| .     .   |  .. .           |..|
RWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDR

PQTSKLRIKEV
|  | . ... 
PTFSEI-HECF
Kinase GL50803_17084.AA KHS 148-174 44 0.086896 1.64 In-house 119-145 (258) Show / Hide 
Range on Protein: 148-174
Range on HMM: 119-145/258
Sequence Identity: 44% (12 aa)

HGNLKPTNILLADSGLLSLTDYGLTHQ
|  .|  ||||.|.|   | |.|.. |
HRDIKGANILLTDQGDVKLADFGVSAQ
Kinase GL50803_17084.AA CAMK 146-171 27 0.106433 0.44 In-house 200-242 (425) Show / Hide 
Range on Protein: 146-171
Range on HMM: 200-242/425
Sequence Identity: 27% (12 aa)

ISHGNLKPTNILLADS-----------------GLLSLTDYGL
| |  ||| |||| |.                 . . ..| |.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF
Ank GL50803_17084.AA Ank 420-435 37 0.246768 9.07 Pfam 1-16 (33) Show / Hide 
Range on Protein: 420-435
Range on HMM: 1-16/33
Sequence Identity: 37% (6 aa)

QGNTPLHRAVLERNVQ
 |.|||| |..  ...
DGFTPLHLACRCGHTE
Ank GL50803_17084.AA Ank 450-470 33 21.37825 2.08 Pfam 1-21 (33) Show / Hide 
Range on Protein: 450-470
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

NGVTALILCAQTNFIEGAKIL
.| |.| | .. . .| .| |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_17084.AA Ank 547-567 28 4.281352 4.6 Pfam 1-21 (33) Show / Hide 
Range on Protein: 547-567
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

EGRTALIIAAEVDFFNAVRIL
.|.|.| .|.. .  . |. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_17084.AA Ank 578-599 18 9.629586 3.33 Pfam 1-22 (33) Show / Hide 
Range on Protein: 578-599
Range on HMM: 1-22/33
Sequence Identity: 18% (4 aa)

NGKAAIDIALDHNHLKIATFLI
.|  .  .|  ..|......|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_17084.AA Ank 612-625 28 27.944913 1.66 Pfam 1-14 (33) Show / Hide 
Range on Protein: 612-625
Range on HMM: 1-14/33
Sequence Identity: 28% (4 aa)

NGHTNLMRAAIKNN
.| | |. |.....
DGFTPLHLACRCGH
Ank GL50803_17084.AA Ank 643-664 45 0.000106 21.22 Pfam 1-22 (33) Show / Hide 
Range on Protein: 643-664
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

EGMTALMLAARHGSCDVLKYLI
.|.|.|.||.|.|. .|.|.|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_17084.AA Ank 674-706 18 0.026416 12.57 Pfam 1-33 (33) Show / Hide 
Range on Protein: 674-706
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

TNKTALMYAAEANMLNVIVELVAHEYCPDPKEY
   |.|..|.. . ..|. .|. |  ... .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 777-808 33 9.4e-05 21.4 Pfam 1-33 (33) Show / Hide 
Range on Protein: 777-808
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

DGMTALMYACQAKSKDCVDLLVS-EKDLQASDG
||.|.|..||.  ....| .|..   |. | | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 971-1000 45 4.7e-07 29.71 Pfam 1-33 (33) Show / Hide 
Range on Protein: 971-1000
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DGYTALMLAARAGHDSIVSLLLA---EVGLQDK
||.|.|.||.| || ..|..||    .| .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 1103-1135 30 0.125427 10.13 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1103-1135
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

LGETPLHTAVRNDDLLSIRKYLYRSGEVNTEGV
 |.|||| |.|....  ..  |..  .||    
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 1194-1223 24 0.201171 9.39 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1194-1223
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

RGHTAFMLAANQGHYDLADRLAE---EKDMVDN
 | |. .||.  ||.. .  | .   . ...|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 1277-1302 34 0.328893 8.62 Pfam 1-26 (33) Show / Hide 
Range on Protein: 1277-1302
Range on HMM: 1-26/33
Sequence Identity: 34% (9 aa)

AGWTALARAAENGFAEAVPLLIEKEA
 |.|.|  |...| .| | .|... |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_17084.AA Ank 1318-1346 37 0.003073 15.94 Pfam 1-28 (33) Show / Hide 
Range on Protein: 1318-1346
Range on HMM: 1-28/33
Sequence Identity: 37% (11 aa)

RGLLAIHIAALKGHATVVRLLLDTEGGSV
 |  . |.|...||. ||..||.  | .|
DGFTPLHLACRCGHTEVVKMLLQ-HGADV
Ank GL50803_17084.AA Ank 1350-1382 30 0.001592 16.97 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1350-1382
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

IGFTSLMISAYMGHALCVKELIAREAKMFERTG
 ||| |.. ...||. .||.|. . |    .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17084.AA Ank 1385-1402 44 0.025424 12.63 Pfam 4-21 (33) Show / Hide 
Range on Protein: 1385-1402
Range on HMM: 4-21/33
Sequence Identity: 44% (8 aa)

TALWYAAYCGHLDCVELL
|.| .|..|||...|..|
TPLHLACRCGHTEVVKML