Gene GL50803_17139 (G.lamblia)

GL50803_17139

Species: G.lamblia
Alias: GL50803_17139, GK029
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CMGC-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17139.AA Protein None 613 None Fasta, JSON
GL50803_17139.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of GL50803_17139.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_17139.AA S_TKc 24-537 13 2e-25 91.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-537
Range on HMM: 1-231/231
Sequence Identity: 13% (71 aa)

YINARPRAKGGYSYVYQGWHESDERIQLAFKLLLLHDRRGFLSRSQTRDIDNMVSLVDAMSRRPGATSNHPDLYVDFPFLPLLDIIDVSSSTKSNVHRLK
|   |.  ||... ||...| .    . | | .                                                .  |   ..    |. .|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------------------------------------------EHIRREIQILKK-HHPNIVKLY

EYESEANAELSLLLVFPFCEL---DLKTYLKHGSL----YSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQLLLCDFGMARCEVTFLR
..  .     .| .|. .|.    ||..|.|.       .   | .. ...|||..|.  .||.|  |||||||| |...  .. .||||.||       
DVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----

RFGVSYNYDYRGNSYTDTKMPIREYDERCAVAYDPLEGLDRTQQPGIVSRRLLPPAGATSICGTIWWRAPEQSFRKNVNCSGFIGDSWSLGCILIQLLFD
                                                          |..||| |..|||         ...  | ||.||||. .|  
----------------------------------------------------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCG

YPAFHSKDRDENTGSGEVLAYVNQLRPLAENEDFLEAIVSFNGVSRSFIDSFRAVTTKLNKARAADLQRILAMPREQVEAVLANARDSNAGREDSNLQEP
|| |.           .. .  ....                                                                          
YPPFP-----------QMQMMFKKIG--------------------------------------------------------------------------

PVKHSDDPLKQIPSHIKQLIILNRHAILSPYRDCDAIYSTSRYTLKQACFLMLVLRFAPLPKVVEMMDKPAISVQELTILLELSPTAICFYNMYSDLVSK
                                                                                               |...|
------------------------------------------------------------------------------------------SPEAKDFIRK

LMNPNPLRRLMPTEALT-------HPIF
... .| .|.   |||.       || |
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17139.AA CDK 132-209 34 2e-22 68.44 In-house 90-161 (284) Show / Hide 
Range on Protein: 132-209
Range on HMM: 90-161/284
Sequence Identity: 34% (29 aa)

ELSLLLVFPFCELDLKTYLKHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQ-----LLLCDFGMAR
| .| .||.... |||.|..           .    .|.||..  .|| .  |||||| | ||...|.     | . ||| ||
ENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase GL50803_17139.AA CDC2 134-209 37 2.8e-21 61.7 In-house 74-151 (301) Show / Hide 
Range on Protein: 134-209
Range on HMM: 74-151/301
Sequence Identity: 37% (29 aa)

SLLLVFPFCELDLKTYLK--HGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQLLLCDFGMAR
.| .|| ... ||| |..   .. ..  .. |   .||||..|   |. .  |||||| | ||...|.. . ||| ||
KLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLAR
Kinase GL50803_17139.AA Pkinase 134-210 38 8.8e-20 71.02 Pfam 74-161 (293) Show / Hide 
Range on Protein: 134-210
Range on HMM: 74-161/293
Sequence Identity: 38% (34 aa)

SLLLVFPFCEL-----DLKTYLK---HGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQL----LLCDFGMARC
.. .|...||      ||..|..   ||..|   |... ...|||||..  .|| |  |||||||| ||...|..     .|||| |..
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase GL50803_17139.AA CMGC 134-209 27 1.1e-19 60.46 In-house 129-252 (513) Show / Hide 
Range on Protein: 134-209
Range on HMM: 129-252/513
Sequence Identity: 27% (34 aa)

SLLLVFPFCELDLKTYLKHGS---------LYSAKE----------EDVLRVA------YQILRAVG--IMHSLG--WSHRDLKPENMLISRD-------
.| ||| ... ||. |.|. .           |  .          ...          |||||..    .|| .    |||||||| ||. .       
HLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM

-------------GQLLLCDFGMAR
             |.| .||||.||
MWKSEDWNPCQKNGRLKICDFGLAR
Kinase GL50803_17139.AA CDK5 135-209 41 5.1e-18 53.07 In-house 73-146 (287) Show / Hide 
Range on Protein: 135-209
Range on HMM: 73-146/287
Sequence Identity: 41% (31 aa)

LLLVFPFCELDLKTYLKHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQLLLCDFGMAR
| ||| ||  ||| |.          . .    || |. ... |.    |||||| |.||.. |.| | |||.||
LTLVFEFCDQDLKKYMDSCNG-EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLAR
Kinase GL50803_17139.AA CDK4 131-209 40 7.3e-17 54.18 In-house 80-158 (290) Show / Hide 
Range on Protein: 131-209
Range on HMM: 80-158/290
Sequence Identity: 40% (32 aa)

AELSLLLVFPFCELDLKTYLKHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQLLLCDFGMAR
||. ...||  |. ||.|||         .. . ..  |.||.|   ||    ||||||.|.|...||.. | ||| ||
AEMKITMVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR
Kinase GL50803_17139.AA GAK 163-208 52 1.1e-16 51.95 In-house 110-157 (277) Show / Hide 
Range on Protein: 163-208
Range on HMM: 110-157/277
Sequence Identity: 52% (25 aa)

VLRVAYQILRAVGIMHSLG--WSHRDLKPENMLISRDGQLLLCDFGMA
|||. ||  |||  ||| .    |||.| ||.||. .... ||||| |
VLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSA
Kinase GL50803_17139.AA CDKL 137-209 40 1.8e-16 52.83 In-house 75-147 (286) Show / Hide 
Range on Protein: 137-209
Range on HMM: 75-147/286
Sequence Identity: 40% (30 aa)

LVFPFCELDLKTYLKHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLIS-RDGQLLLCDFGMAR
||| .|.  .  .|..       |..|  . .|||.|.   |.    ||| |||| ||. ..||. ||||| ||
LVFEYCDHTVLHELEE-YPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR
Kinase GL50803_17139.AA Ciliate-E2-Unclassified 144-328 19 1.5e-14 46.93 In-house 106-278 (352) Show / Hide 
Range on Protein: 144-328
Range on HMM: 106-278/352
Sequence Identity: 19% (44 aa)

LDLKTYLKH------------GSLYSAK---EEDVL-----RVAYQILRAVGIMHSLG-WSHRDLKPENMLISRDG---QLLLCDFGMAR-------CEV
.||. |.|.             .... |   |. ..     . ..||| .   .|. .   |||.|||| |.. .|   .. ..||| ..       |. 
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-

TFLRRFGVSYNYDYRGNSYTDTKMPIREYDERCAVAYDPLEGLDRTQQPGIVSRRLLPPAGATSICGTIWWR----APEQSFRKNVNCSG-FIGDSWSLG
|.                                             |   . .  ...  ....|||.       |||   ..| . |  .  | ||||
TNQ--------------------------------------------Q---QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG

CILIQLLFDYPAFHSKDRDEN
.|| ..|| |. | .......
VILYEMLFGYYPFYDNNCEQH
Kinase GL50803_17139.AA ERK7 129-209 39 2e-13 41.96 In-house 70-148 (292) Show / Hide 
Range on Protein: 129-209
Range on HMM: 70-148/292
Sequence Identity: 39% (32 aa)

ANAELSLLLVFPFCELDLKTYLKHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLISRDGQLLLCDFGMAR
|. .. . ||| | | ||    ..|..   |.  .  . ||.|||.  |||    |||||| |.|.  .  . .||||.||
ADNDRDIYLVFEFMETDLHAVIRKGNIL--KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLAR
Kinase GL50803_17139.AA Ciliate-E2 145-320 20 9.2e-13 40.12 In-house 120-296 (365) Show / Hide 
Range on Protein: 145-320
Range on HMM: 120-296/365
Sequence Identity: 20% (45 aa)

DLKTYLKHGSLYSAKE---------EDVLRVAYQILR---------------AVGIMHSLG-WSHRDLKPENMLISRDGQLLLCDFGMAR----CEVTFL
||. |.|. .. . .|         . .... .|||.               |.  .|| .   |||.|||| |.     . ..|||...    ..   .
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRT

RRFGVSYNYDYRGN------SYTDTKMPIREYDERCAVAYDPLEGLDRTQQPGIVSRRLLPPAGATSICGTIWWRAPEQSFRKNVNC------SGFIGDS
  .  ...| . .|      .| |  .                                .    . .||||    |||   .|. .        ..  | 
H-KQQCKWYMF-KNDTSRTPGYMD--Q-------------------------------IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI

WSLGCILIQLLFDYPAF
||||.|| ..|| .| |
WSLGVILYEMLFGKPPF
Kinase GL50803_17139.AA Pkinase 264-327 28 4e-06 22.92 Pfam 158-218 (293) Show / Hide 
Range on Protein: 264-327
Range on HMM: 158-218/293
Sequence Identity: 28% (19 aa)

VSRR--LLPPAGATSICGTIWWRAPEQSFRKNVNCSGFIGDSWSLGCILIQLLFDYPAFHSKDRDE
...   . .   .|..|||.|..|||       .  |   | ||.||||...|. .| | ... ..
LAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WH
Kinase GL50803_17139.AA CDK5 512-537 42 6e-06 14.3 In-house 262-287 (287) Show / Hide 
Range on Protein: 512-537
Range on HMM: 262-287/287
Sequence Identity: 42% (11 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
|| .|..  ||  |.   .|| || |
DLLQKMLQCNPNQRISAKAALHHPYF
Kinase GL50803_17139.AA Ciliate-E2 512-537 29 3.1e-05 13.9 In-house 335-365 (365) Show / Hide 
Range on Protein: 512-537
Range on HMM: 335-365/365
Sequence Identity: 29% (9 aa)

DLVSK----LMNPNPLRRLM-PTEALTHPIF
|| .|    ... .|  |.  . ..| ||.|
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_17139.AA CMGC 512-537 38 6.7e-05 11.03 In-house 488-513 (513) Show / Hide 
Range on Protein: 512-537
Range on HMM: 488-513/513
Sequence Identity: 38% (10 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
||..|..  .| .|. . .|| || |
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17139.AA ERK7 512-537 42 0.000432 9.53 In-house 267-292 (292) Show / Hide 
Range on Protein: 512-537
Range on HMM: 267-292/292
Sequence Identity: 42% (11 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
||. .|.  || .||  ..|| ||  
DLLKRLLVFNPKKRLTAEQALQHPYV
TyrKc GL50803_17139.AA TyrKc 24-297 15 0.000608 -158.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-297
Range on HMM: 1-280/280
Sequence Identity: 15% (54 aa)

YINARPRAKGGYSYVYQGWHESDERIQLAFKLLLLHDRRGFLSRSQTRDIDNMVSLVDAMSRRPGATSNHPDLYVDFPFLPLLDIIDVSSSTKSNVHRLK
    .    | .  ||.|       || | | |  .                                                              ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------------------------------------------------------------RE

EYESEAN--AEL-------------------------SLLLVFPFCEL-DLKTYL-KHGSLYSAKEEDVLRVAYQILRAVGIMHSLGWSHRDLKPENMLI
.  .||.   .|                          |..|. .... ||| || ||.     . .| |  ..|| .     || .  ||||   | |.
DFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV

SRDGQLLLCDFGMARCEVTFLRRFGVSYNYDY-----RGNSYT-----DTK--MPIR-------EYD-------------------ERCAVAYDP-----
.....   .|||..|            . ||.     ..  |.     ..|  .|||        |                     ...  |       
GENHTVKISDFGLSR------------DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQM

LEG---LDRTQQPGIVSRRLL--------PPAGATSICGTIWWRAPEQ--SFRKNVNCS
..    . . .| .   .            |.   .|  . | . ||.  .|.  . | 
MSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_17139.AA CDC2 512-537 38 0.000661 7.31 In-house 276-301 (301) Show / Hide 
Range on Protein: 512-537
Range on HMM: 276-301/301
Sequence Identity: 38% (10 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
|| ...   .| .|.   ||| || |
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase GL50803_17139.AA CDKL 512-537 26 0.000802 8.95 In-house 261-286 (286) Show / Hide 
Range on Protein: 512-537
Range on HMM: 261-286/286
Sequence Identity: 26% (7 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
|.. |..  .| .|.  .... ||.|
DFMKKCLHMDPDERMTCEQLMHHPYF
Kinase GL50803_17139.AA ERK7 302-320 52 0.006415 5.46 In-house 189-207 (292) Show / Hide 
Range on Protein: 302-320
Range on HMM: 189-207/292
Sequence Identity: 52% (10 aa)

DSWSLGCILIQLLFDYPAF
| ||.|||| ..| . | |
DMWSIGCILGEMLRGKPMF
Kinase GL50803_17139.AA Ciliate-E2-Unclassified 512-537 30 0.012333 4.99 In-house 323-352 (352) Show / Hide 
Range on Protein: 512-537
Range on HMM: 323-352/352
Sequence Identity: 30% (9 aa)

DLVS----KLMNPNPLRRLMPTEALTHPIF
|...    |... ||  |. . ..| ||.|
DFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_17139.AA CDK 512-537 38 0.02125 3.3 In-house 259-284 (284) Show / Hide 
Range on Protein: 512-537
Range on HMM: 259-284/284
Sequence Identity: 38% (10 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
|| .|..  .| .|.  ..|| || |
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_17139.AA CDK4 512-537 34 0.059375 2.24 In-house 265-290 (290) Show / Hide 
Range on Protein: 512-537
Range on HMM: 265-290/290
Sequence Identity: 34% (9 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
||. |    |. .|.   ..| || |
DLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase GL50803_17139.AA Pkinase 512-537 26 0.060807 7.95 Pfam 268-293 (293) Show / Hide 
Range on Protein: 512-537
Range on HMM: 268-293/293
Sequence Identity: 26% (7 aa)

DLVSKLMNPNPLRRLMPTEALTHPIF
|..... ...| .|. ....| || |
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17139.AA CDK 304-321 33 0.126578 0.78 In-house 206-226 (284) Show / Hide 
Range on Protein: 304-321
Range on HMM: 206-226/284
Sequence Identity: 33% (7 aa)

WSLGCILIQLLF---DYPAFH
||.|||.. ..      | |.
WSVGCIFAEMFTDVTRKPLFP