Gene GL50803_17417 (G.lamblia)

GL50803_17417

Species: G.lamblia
Alias: GL50803_17417, GK034
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17417.AA Protein None 695 None Fasta, JSON
GL50803_17417.kin_dom Protein Kinase Domain None 334 None Fasta, JSON

Protein domain

Protein domains of GL50803_17417.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17417.AA DYRK 315-648 44 3.5e-140 472.02 In-house 1-320 (320) Show / Hide 
Range on Protein: 315-648
Range on HMM: 1-320/320
Sequence Identity: 44% (152 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLTKKDLKGL-
|| .. .|.||||.| |. ||| .. ||.|||.|.|||.||.. |.||||.|...||.    ||. . .||.| |||| |||||.||||.| .   .|. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLSLVRKFSLQLLIAFAYARKL-RIIHADVKPENILLREP-DKSSIKVIDWGSGAMVSETIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTG
||.|||||  |.| .  .  |. .|||.| |||||.|..| .|| ||||| ||   ....||.|||||||||||||||.||. .||.|| ||.| ||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

LPIFPGDDERDQLGKICELLGMPPNDMIFKS--PRKNDFFVNIGTGMGVAGVSEGGNPIFSGNLQQLSSVNEYLQATGRGAGGSEVPGIRLRTTHKVNSK
 |.|||..| ||| .|.|.|||||..|| |.  .||. || .                      ... .. .    | .  . . .|  |  .    ...
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRR

TLSGVLNAPDD-FISFISLFLQWDPQRRCTPEVAMSHPWI
 .  .... |. |. ||   |||||..| ||. |. |||.
NWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase GL50803_17417.AA DYRK2 315-549 50 3.5e-124 405.86 In-house 1-241 (318) Show / Hide 
Range on Protein: 315-549
Range on HMM: 1-241/318
Sequence Identity: 50% (121 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLTKKDLKGLS
||... .|.|||| | |..||| .|.||.|.| |.||| .| ..|..||. .| .|...   ||. | .|||| |.||.|||||.||||.. |.  .|.|
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSE-TIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLP
|.|||.|  ..| .    .| .|||.| |||||||... .|.||||| ||   . .  || |||||||||||||||..|| .||.|| ||.. ||||| |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

IFPGDDERDQLGKICELLGMPPNDMIFKS-----PRKNDFF
.|||..| ||.. . |.||||| ... ..      |.. ||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF
Kinase GL50803_17417.AA DYRK1 315-549 51 9.2e-97 327.77 In-house 1-237 (321) Show / Hide 
Range on Protein: 315-549
Range on HMM: 1-237/321
Sequence Identity: 51% (121 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLTKKDLKGLS
||  | .| ||||.| || ||.||..||.|||||.| |  | ..|...|||.  .|..     |..   | || |||. ||||| |||.||   . .| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LSLVRKFSLQLLIA--FAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSETIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGL
| |.|||  |.. |  |  .  | ||| |.|||||||. | .| ||.||.||   . . || ||||||||.|||.||..|  .||.||.||.| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PIFPGDDERDQLGKICELLGMPPNDMIFKSPRKNDFF
|.| | .| ||. || | |||||..|| ..|.   .|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF
Kinase GL50803_17417.AA CMGC 315-553 22 5.3e-91 299.21 In-house 1-398 (513) Show / Hide 
Range on Protein: 315-553
Range on HMM: 1-398/513
Sequence Identity: 22% (90 aa)

YELVSKLGSGSFGKVYKALD--------------HKEQQFVALKIIKNRKRFQRQGL-------------VEVKILELLR-----------DNDPNGDQC
|| ..|.|.|..|.|||. |              |. ...||.|.|||.. ...|..              |.|||. |.           | | . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVKVLSSFYFRS-----------------HLCIAFELLSINLYELLTKKD--------------------------LKGLSLSLVRKFSLQLLIAFA--Y
.|| . .||..                  ||.. ||..  .||... ..                            | ... ..| .. |.| . .  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

ARKLR--IIHADVKPENILLREPDKS------------------SIKVIDWGSGAMVSET------------------------IYSYIQSRFYRAPEVI
  . .  ||| | ||||||. .  ..                   .|..|.|.   ...                         ...|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLP----------YGQEIDIWSIGCVLCELYTG--------LPIFPGDDE-----------RDQLGKICELLGMPPNDMIFK-------SPRKNDFFVN
|| .          |...||.||.||.. |.|||         |.|||..|            ||| ||...||.|.  || |       ........  
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

IG
|.
IK
Kinase GL50803_17417.AA YAK 315-549 40 2.3e-81 276.15 In-house 1-239 (347) Show / Hide 
Range on Protein: 315-549
Range on HMM: 1-239/347
Sequence Identity: 40% (96 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRD-NDPNGDQ---CCVKVLSSFYFRSHLCIAFELLSINLYELLTKKDL
|     || | || | |         .| |.||||  .  |.  |..||..| .  |||.       .. . .| .. |.|. ||.||.||||.|     
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSETIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYT
.|.| .|.| .  | | .   .   .||| | |||||.|. |.|  ||.|| ||      ..| |||.|.||.||.|.. .|   || || ||.. ||. 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GLPIFPGDDERDQLGKICELLGMPPNDMIFKSPRKNDFF
|||||||  | .|.  | . || ||..|| .   || .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase GL50803_17417.AA S_TKc 315-648 23 2.5e-77 264.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 315-648
Range on HMM: 1-231/231
Sequence Identity: 23% (82 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSI---NLYELLTKKDLK
||.. |.|.|.||||||. ..| .. ||.||||      .. . |..||.        .    || . .|.  .||.. .|...    .|.... |.  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----LSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSETIYSYIQSRFYRAPEVILGLPYGQ-EIDIWSIGCVLC
|    ..   .|..  |.. | .|  ...||| |.||||||| |     ||..| |. . .    .... ...|.||||.   .||  ..|.||.||.| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELYTGLPIFPGDDERDQLGKICELLGMPPNDMIFKSPRKNDFFVNIGTGMGVAGVSEGGNPIFSGNLQQLSSVNEYLQATGRGAGGSEVPGIRLRTTHKV
|...| | ||      |. .. ...|                                                                          
EMLCGYPPFP------QMQMMFKKIG--------------------------------------------------------------------------

NSKTLSGVLNAPDDFISFISLFLQWDPQRRCTPEVAMS-------HPWI
           ......||.  ||.||..| |   |.        |||.
-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17417.AA HIPK 315-549 39 8.3e-70 218.88 In-house 1-237 (329) Show / Hide 
Range on Protein: 315-549
Range on HMM: 1-237/329
Sequence Identity: 39% (95 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLTKKDLKGLS
|| .  || | ||.| |.  .  .  ||.||.||   . ||| .||.||. |.. ... .   |. .  |  ..| |. ||.|  |||. . .     | 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSS--IKVIDWGSGAMVSETIYS-YIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTG
|  .|   .| | | .  ..| .|||| |||||.| .| .    .||||.||  .||... . |.|||.|||||.|||||. ...|.|| |||. ||. |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

LPIFPGDDERDQLGKICELLGMPPNDMIFKSPRKNDFF
 | .|| || ||   ||.  . |   ....  .|. ||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFF
Kinase GL50803_17417.AA PRP4 315-517 43 2.8e-63 216.56 In-house 1-207 (320) Show / Hide 
Range on Protein: 315-517
Range on HMM: 1-207/320
Sequence Identity: 43% (91 aa)

YELVSKLGSGSFGKVYKALDHKEQQ-FVALKIIKNRKRFQRQGLVEVKILELLRDN--DPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLTK--KD
|. ... |.| |. | .. |    .  || ||| |.   .. || |. ||  | |.  |.|    ||.   .|..| |.|. || .| || |.| |  ||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

LKGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSET-IYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCEL
 .||.|  || .. ||..|     |. |.|||.|| |||  | .|. .| .| ||   ..|  |  | .||||||||.|.| ||   ||.||.|| | ||
-VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE-SKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYEL

YTGLPIFPG
|||  .|||
YTGKIMFPG
Kinase GL50803_17417.AA Pkinase 315-648 24 3.5e-63 221.0 Pfam 1-293 (293) Show / Hide 
Range on Protein: 315-648
Range on HMM: 1-293/293
Sequence Identity: 24% (87 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQ--RQGLV---EVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSI-----NLYEL
|....|.||||||.|||. ...... ||.|||| |..    .| ..   |..|.  |.   ||     |. . .|. ..|... .|..        |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNI----VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LTKKDLKGL--SLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLR-EPDK-SSIKVIDWGSG----AMVSETIYSYIQSRFYRAPEVIL-GLPYGQE
.. .. ...  |   .... .|.| . .|  . .||| |.||||||.  ...  ...|..|.|.        ..  ...  ...|.|||||. | .||..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDIWSIGCVLCELYTGLPIFPGD----DERDQLGKICELLGMPPNDMIFKSPRKNDFFVNIGTGMGVAGVSEGGNPIFSGNLQQLSSVNEYLQATGRGAG
.|.||.||.| |...| |.|||.    . .||. .||. .| |.   .... .. .||... .                                     
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-----------------------------------

GSEVPGIRLRTTHKVNSKTLSGVLNAPDDFISFISLFLQWDPQRRCTPEVAMSHPWI
                 . .. . |.......||.  |..||..|.|.| .. |||.
-----------------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17417.AA DyrkP 315-551 35 1.8e-52 170.75 In-house 1-241 (323) Show / Hide 
Range on Protein: 315-551
Range on HMM: 1-241/323
Sequence Identity: 35% (86 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFRSHLCIAFELLSINLYELLT----KKDL
| ..  |||  | |  . .| .  | . .||| | | .  | . |.|.|  .  |    ..  ...   || . || |  |||  ||||           
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

KGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKVIDWGSGAMVSETIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYT
.   .  . |   |.|||  |   ||.|| |.||||||..   |  .|.||.||   . . . ||.||| |||||||.|  |   ||.||.||.| ||.|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GLPIFPGDDERDQLGKICELLGMPPNDMIFKSPRKNDFFVN
|  .|  |     | ..  ..|  |  |.      . || .
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTR
Kinase GL50803_17417.AA CLK 315-449 31 5.1e-47 138.58 In-house 1-147 (350) Show / Hide 
Range on Protein: 315-449
Range on HMM: 1-147/350
Sequence Identity: 31% (47 aa)

YELVSKLGSGSFGKVYKALDHKE-QQFVALKIIKNRKRFQRQGLVEVK-ILELLRDN-DPNGDQC--CVKVLSSFYF-RSHLCIAFELLSINLYELLTKK
|| |..||.| ||||..  |||   ..||||||.| ...  .  ||.. |.. .  . |||..    |.| ...| .   | || |||.  ..|... . 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

D------LKGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILL
        ... .. .|... ||. |     .....| | |||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase GL50803_17417.AA CDK 315-648 22 1.9e-46 146.55 In-house 1-284 (284) Show / Hide 
Range on Protein: 315-648
Range on HMM: 1-284/284
Sequence Identity: 22% (84 aa)

YELVSKLGSGSFGKVYKALDHKEQ-----QFVALKIIK---N-----RKRFQRQGLVEVKILELLRDNDPNGDQCCVKVLSSFYFR-----------SHL
|| . |.| |..|.|||| |.. .     |.|||| |.   .     .  |    . |...|  |    ||     ||..  ..             . |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HPN----IVKLHDVCHTKNMDRNNKDKHENKL

CIAFELLSINLYELLTKKDLKGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSS---IKVIDWGSGAMVSE--------TIYS-YIQS
 . || .   |....            .. . .||| . .|  . .|.| | || |||. .  .     .|. | |     .           |.  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEVIL-GLPYG--QEIDIWSIGCVLCELYT---GLPIFPGDDERDQLGKICELLGMPPNDM---IFKSPRKNDFFVNIGTGMGVAGVSEGGNPIF
. |||||. |    |.   .||.||.||.. |..|   . |.|||| | ||| ||....| |  |.   . | |                          
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

SGNLQQLSSVNEYLQATGRGAGGSEVPGIRLRTTHKVNSKTLSGVLNAPDDFISFISLFLQWDPQRRCTPEVAMSHPWI
                                                      ... .|. ||..|.. | |..||. 
-----------------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_17417.AA CLK 457-539 47 2.6e-26 75.28 In-house 186-272 (350) Show / Hide 
Range on Protein: 457-539
Range on HMM: 186-272/350
Sequence Identity: 47% (41 aa)

IKVIDWGSGA---MVSETIYSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLPIFPGDDERDQLGKICELLGMP-PNDMI
|.||| ||        |  .  ...| ||||||||||.. |  |.|||||.| |||||   |.. |.|. |  . ...||| |. ||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMI
Kinase GL50803_17417.AA DYRK2 607-648 43 3e-11 32.51 In-house 275-318 (318) Show / Hide 
Range on Protein: 607-648
Range on HMM: 275-318/318
Sequence Identity: 43% (19 aa)

NSKTLSGVLN--APDDFISFISLFLQWDPQRRCTPEVAMSHPWI
.|| .. ||     ..|| ||.  ..|||. | ||. |  ||||
GSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase GL50803_17417.AA CMGC 597-648 16 4.7e-11 31.62 In-house 429-513 (513) Show / Hide 
Range on Protein: 597-648
Range on HMM: 429-513/513
Sequence Identity: 16% (14 aa)

GIRLRTTHKVNSKTLSGVLN---------------------------------APDDFISFISLFLQWDPQRRCTPEVAMSHPWI
..|. . .. . | |   ..                                 .....| ...  ||.||..| |.| |..||..
NNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17417.AA TyrKc 315-648 16 6.7e-09 -78.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 315-648
Range on HMM: 1-280/280
Sequence Identity: 16% (62 aa)

YELVSKLGSGSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELL--RDNDPNGDQCCVKVLSSFYFR-------SHLCIAFELLS-INLYEL
 .|  |||.| ||.|||.      . || | .|. .  ..  . | .|.  |  .       .. |. .               |.| .|. .  .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LTKKDLKGLSLSLVRKFSLQLLIAFAYARKLRIIHADVKPENILLREPDKSSIKV------IDWGSG---AMVSETIYSY---IQSR-----FYRAPEVI
| |.  | |...   .|..|     .|  . ..|| |    |.|. |.    .|.       |....     .|.  |.     ...        |||.|
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPYGQEIDIWSIGCVLCELYT-GLPIFPG-----DDERDQLGKI--CELLGMPPN----DMIFKSPRKNDFFVNIGTGMGVAGVSEGGNPIFSGNLQQ
    .  . |.|| | .. |..| | .  ||      . .. . ..   . .  |||                                           
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

LSSVNEYLQATGRGAGGSEVPGIRLRTTHKVNSKTLSGVLNAPDDFISFISLFLQWDPQRRCTPEVAMSHPWI
                                    .    .||.  . ..   . ||  |.| .    |  .
------------------------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_17417.AA YAK 621-648 50 3.4e-07 20.06 In-house 320-347 (347) Show / Hide 
Range on Protein: 621-648
Range on HMM: 320-347/347
Sequence Identity: 50% (14 aa)

FISFISLFLQWDPQRRCTPEVAMSHPWI
|| ||   || .|  | .|  || || |
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase GL50803_17417.AA DyrkP 621-648 46 4e-06 15.5 In-house 296-323 (323) Show / Hide 
Range on Protein: 621-648
Range on HMM: 296-323/323
Sequence Identity: 46% (13 aa)

FISFISLFLQWDPQRRCTPEVAMSHPWI
|| |.   || |  || |   |..|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase GL50803_17417.AA Pkinase_Tyr 315-348 34 0.000165 15.89 Pfam 1-38 (270) Show / Hide 
Range on Protein: 315-348
Range on HMM: 1-38/270
Sequence Identity: 34% (13 aa)

YELVSKLGSGSFGKVYKALDH----KEQQFVALKIIKN
 ..  |||.|.||.|||.  .    .... || |..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase GL50803_17417.AA PRP4 629-648 45 0.000649 10.31 In-house 301-320 (320) Show / Hide 
Range on Protein: 629-648
Range on HMM: 301-320/320
Sequence Identity: 45% (9 aa)

LQWDPQRRCTPEVAMSHPWI
|. ||..| |.. |  || |
LMLDPKKRITCNEALKHPFI
Kinase GL50803_17417.AA DYRK1 621-648 39 0.001116 8.23 In-house 294-321 (321) Show / Hide 
Range on Protein: 621-648
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FISFISLFLQWDPQRRCTPEVAMSHPWI
|   |   ||.||..| ||  |. |...
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase GL50803_17417.AA HIPK 629-648 40 0.006632 4.43 In-house 310-329 (329) Show / Hide 
Range on Protein: 629-648
Range on HMM: 310-329/329
Sequence Identity: 40% (8 aa)

LQWDPQRRCTPEVAMSHPWI
. ||...| ||  |. ||..
CTWDAHKRITPCEALNHPFV
Kinase GL50803_17417.AA CLK 619-648 30 0.023145 2.08 In-house 321-350 (350) Show / Hide 
Range on Protein: 619-648
Range on HMM: 321-350/350
Sequence Identity: 30% (9 aa)

DDFISFISLFLQWDPQRRCTPEVAMSHPWI
. ..  |.  |  || .| |   | .||. 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF