Gene GL50803_17510 (G.lamblia)

GL50803_17510

Species: G.lamblia
Alias: GK107, GL50803_17510
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17510.AA Protein None 685 None Fasta, JSON
GL50803_17510.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of GL50803_17510.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_17510.AA S_TKc 28-291 22 5.9e-16 57.09 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-291
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

HCLSEILGRGASGILYALEGYP---ALAVREIQLDSFTEDIIKDIQCNLLVHTRLSHPHVLRCYQVLCDGEFIYVVVDCYRE---TIESMINRHKR--AR
  . ...|.|| |  |           |. .|      |.|.. ||.         ||.. ..| |  | ...|.| ..      .  ..| ...|   |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QPVSEQDIFLILEQVASGLAYLYDSGKIAANGKPLPVIIHGGLTPTSILASDNGKHFVLTDYGLPRELLQNGVSASIFSYSAPEEVIYSKHSP-ASDVWA
.| .| ..  .. |....|.|. . |           |||  | |  || ..   |  ..| || |.|           | ||| .   .... ..|.|.
FPFPE-HARFYMYQICCALEYCHSHG-----------IIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCIIYELATLSRPSFANSDDSQSAFTNDWKPNLTSVQSPLLRELLRYILVLDPEARLSAKELVS---LARDQTLI
.|||.||...  .| |      . .  .  .       || .....| .|. ||| |..| |.     ...    .
CGCILYEMLC-GYPPFP----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17510.AA Pkinase 199-282 20 1.9e-14 52.18 Pfam 177-288 (293) Show / Hide 
Range on Protein: 199-282
Range on HMM: 177-288/293
Sequence Identity: 20% (23 aa)

YSAPEEVI-YSKHSPASDVWALGCIIYELATLSRPSFANS-----DDSQSAFTNDWKPNLTSVQS-----------------------PLLRELLRYILV
| ||| .  .....|..|.|..|||.||...  || | ..     .| .  . .. .| | .  .                       . ........| 
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

LDPEARLSAKELV
.||. |..|....
KDPKKRPTAEQIL
Kinase GL50803_17510.AA Ciliate-E2 78-281 16 3.5e-11 34.62 In-house 88-359 (365) Show / Hide 
Range on Protein: 78-281
Range on HMM: 88-359/365
Sequence Identity: 16% (48 aa)

RLSHPHVLRCYQVLC--DGEFIYVVVDCYRE-TIESMIN--RHKR------ARQPVSEQDIFLILEQVAS---------------GLAYLYDSGKIAANG
.|.||.....| .    | . || | . .   . .. |.  ..||      . .. .|. |  | .|...               .| ||   ..|    
QLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI----

KPLPVIIHGGLTPTSILASDNGKHFVLTDYGL----------------PRELLQNG----VSASIF----------------SYSAPEEVIYSK------
      ||  . |  ||         ..| ||                  .... .    .. ...                 | ||| . . |      
------IHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

---HSPASDVWALGCIIYELATLSRPSFANSDDSQSAFTN-DWKPN----------------LTSVQSPLLRELLRY----ILVLDPEARLS-AKEL
   .. ..|.|.||.|.||. .  .|        |    . ... .                 .   |.    |..     .|. ||| |.. ....
QKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GL50803_17510.AA Ciliate-E2-Unclassified 79-281 16 4.1e-11 34.8 In-house 78-346 (352) Show / Hide 
Range on Protein: 79-281
Range on HMM: 78-346/352
Sequence Identity: 16% (46 aa)

LSHPHVLRCYQVLCDGEFIYVVVDCY-----RETIESMIN---------RHKRARQPVSEQDIF-----LILEQVASGLAYLYDSGKIAANGKPLPVIIH
. ||...... .  | . || | .       .. |... .         .... |. ..|| .       .. |. .|| ||  ...          |||
HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN----------IIH

GGLTPTSILASDNGK--HFVLTDYGL----------------------PRELLQNGVSASIFS-YSAPEEVIYS-KHS----PASDVWALGCIIYELATL
  ..|  || ..|||  .  ..|.|.                      . .. ..  . .  . | || ||. . ...     ..|.|.||.|.||. . 
RDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP-EVLQGQNYDHSKAYKCDIWSLGVILYEMLFG

SRPSFANSDDS-------------QSAFTNDWK---------------PNLTSVQSPLLRELLRYILVLDPEARLSAKEL
 .| ..|....              . . .. |                ..   .  ....||. .|. .|. |......
YYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI
Kinase GL50803_17510.AA NEK8 214-231 61 1.6e-10 26.1 In-house 203-220 (278) Show / Hide 
Range on Protein: 214-231
Range on HMM: 203-220/278
Sequence Identity: 61% (11 aa)

SDVWALGCIIYELATLSR
||.|||||..||...| |
SDMWALGCVLYEMCCLKR
Kinase GL50803_17510.AA AGC 204-280 21 2.6e-10 21.35 In-house 277-378 (395) Show / Hide 
Range on Protein: 204-280
Range on HMM: 277-378/395
Sequence Identity: 21% (23 aa)

EVIYSKHSPASDVWA--LGCIIYELATLSRPSFANSDD--------SQSAFTN-D-------WKPNLT----------SVQSPLLRELLRYILVLDPEAR
|..   ...| | |.  |||..||. |   | ......            | .         ||. .           .  || .. |..  |. ||| |
EIL---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKR

LSAKE
| ...
LGCGG
Kinase GL50803_17510.AA NEK 214-232 52 2.3e-09 29.51 In-house 205-225 (286) Show / Hide 
Range on Protein: 214-232
Range on HMM: 205-225/286
Sequence Identity: 52% (11 aa)

SDVWALGCIIYELATL--SRP
||.|.|||..||..||   .|
SDIWSLGCVLYEMCTLKPKHP
Kinase GL50803_17510.AA NEK2 202-230 41 3.5e-09 26.95 In-house 233-261 (319) Show / Hide 
Range on Protein: 202-230
Range on HMM: 233-261/319
Sequence Identity: 41% (12 aa)

PEEVIYSKHSPASDVWALGCIIYELATLS
|| .   | .. ||.|..||.|||...|.
PEQMHGQKYNEKSDIWSVGCLIYEMCALH
Kinase GL50803_17510.AA STE 204-281 20 3.8e-09 28.59 In-house 232-351 (359) Show / Hide 
Range on Protein: 204-281
Range on HMM: 232-351/359
Sequence Identity: 20% (24 aa)

EVIY-------SKHSPASDVWALGCIIYELATLSRPS---FANSDDSQSAFTN-------------DWKPNLTS-------------------VQSPLLR
|||        ....  .|.| ||| | |.||   |       .   . .| .             .  | | .                     || ..
EVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFK

ELLRYILVLDPEARLSAKEL
. ..  |. ||. | .|..|
DFINKCLQKDPNKRPTASQL
Kinase GL50803_17510.AA TK 28-229 11 4.8e-09 25.66 In-house 1-390 (486) Show / Hide 
Range on Protein: 28-229
Range on HMM: 1-390/486
Sequence Identity: 11% (47 aa)

HCLSEILGRGASG---ILYAL----------------------------EGYPALAVREIQLD-SFTEDIIKD---------------IQCNLLVHT-RL
  | . ||.|. |     |                              .|    ||  . .. . ...  .|                .   . .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPHVLRCYQVLCDG------------EFIYVVVDCYRET-----IESMINRHKRARQP-----------------------------------------
 ||...|.| | ..|            | ...|. .           .   .... .|.                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSEQDIFLILEQVASGLAYLYDS---GKIAANGKPLPVI---IHGGLTPTSILASDNGK----------
                               .. ..   .  |.|.|..|| .    .           |   .|. |    .| ..|..          
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF-----------IQNFVHRDLAARNCLVGENNVCKWHFDGCGP

HFVLTDYGLP--------RELLQNGVSASIFSY------------------------------SAPEEVI---------YSKHSPASDVWALGCIIYELA
.  ..|.||         |.. ...   .  ||                               ||| .          | |....||||..|. ..|. 
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

TL
|.
TY
Kinase GL50803_17510.AA SAK 75-226 26 1.2e-08 25.24 In-house 52-193 (254) Show / Hide 
Range on Protein: 75-226
Range on HMM: 52-193/254
Sequence Identity: 26% (42 aa)

VHTRLSHPHVLRCYQVLCDGEFIYVVVDCYRETIESMINRHKRARQPVSEQDIFLILEQVASGLAYLYDSGKIAANGKPLPVIIHGGLTPTSILASDNGK
.|..| || .|  |.   |  ..|.|..  .     |    |.  .| .|..   ...|.  |. ||   |           |.|  || . || . .  
IHCQLKHPSILELYNYFEDNNYVYLVLEMCHNG--EMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHG-----------IMHRDLTLSNILLTRD-M

HFVLTDYGLPRELLQNGVSASIF----SYSAPEEVIYSKHSPASDVWALGCIIYEL
|  . |.||   |         .     | .|| .  . |   ||||.|||..| |
HCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTL
Kinase GL50803_17510.AA TyrKc 28-285 14 5.9e-08 -93.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-285
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

HCLSEILGRGA-----SGILYALEGYPALAVREIQLDSFTEDIIKDIQCNLLVHTRL--SHPHVLRCYQVLCDG-------EFIYVVVDCYRETIESMIN
  | ..||.||      |...        ||  .. |.     ..|.   . . ..|  .||...|.| |  ..       | ...|.        .  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKD

RHKRARQPVSEQDIFLILEQVASGLAYLYDSGKIAANGKPLPVIIHGGLTPTSILASDNGKHFV------------------LTDYGLPRELLQN---GV
. .. |  .. .|   .  |.|.| .|| .                               ...                   .| || |..      |.
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGE

SASIFSY----SAPE---------EVI-YSKHSPASDVWALGCIIYELATLSRPSFANS----DDSQSAFTNDWKPNLTSVQSP-----------LLREL
| .  .     ..           |.| |.| ...||||. |  ..|. |.  .   .      . | .. .  . .                   . ..
SKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQI

LRYILVLDPEARLSAKELVSLA
 .     ||| | . .|.... 
MKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_17510.AA STE 28-147 12 9.3e-08 23.6 In-house 1-174 (359) Show / Hide 
Range on Protein: 28-147
Range on HMM: 1-174/359
Sequence Identity: 12% (22 aa)

HCLSEILGRGASG-ILYALEGYPA-----------------LAVREIQLDSFT---------------EDIIKDIQCNLLVHTRLS--HPHVLRCYQVLC
  . |..|.||.|   .|.   .                   |. .. |.. .               ......|.  . .. ...  ||.. ..|    
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------EFIYVVVDCYR-ETIESMIN-RHKRAR---------QPVSEQDIFLILEQVASG-LAYLYDSGKI
..       . ....       .....|. .... .         ....|. |  |. |.  | |.|| . ..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII
Kinase GL50803_17510.AA Pkinase 75-143 21 5.6e-07 25.75 Pfam 53-126 (293) Show / Hide 
Range on Protein: 75-143
Range on HMM: 53-126/293
Sequence Identity: 21% (16 aa)

VHTRLSHPHVLRCYQVLCDGEFIYVVVDCYRETIESMINRH----KRARQPV--SEQDIFLILEQVASGLAYLYD
.. ||.||...|.| .  |.  ||.| .. . . .  .  .     ... ..  ||...  .. |...||.|...
IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase GL50803_17510.AA PLK1 75-143 26 2e-06 16.73 In-house 52-117 (253) Show / Hide 
Range on Protein: 75-143
Range on HMM: 52-117/253
Sequence Identity: 26% (18 aa)

VHTRLSHPHVLRCYQVLCDGEFIYVVVDCYRETIESMINRHKRARQPVSEQDIFLILEQVASGLAYLYD
.|  |.|.|. . ..   | ...|.|..  |    |..  ||| |... |..    . |.. |  || .
IHRQLHHRHIVKFHHFFEDKQNVYIVLELCRR--RSLMELHKR-RKAITEPECRYYMYQIVEGCQYLHN
Kinase GL50803_17510.AA PLK1 199-226 46 0.000314 9.51 In-house 165-192 (253) Show / Hide 
Range on Protein: 199-226
Range on HMM: 165-192/253
Sequence Identity: 46% (13 aa)

YSAPEEVIYSKHSPASDVWALGCIIYEL
| ||| .    ||   |.|..|||.| |
YIAPEVLNKKGHSFEVDIWSIGCIMYIL
Ank GL50803_17510.AA Ank 455-474 50 0.000476 18.86 Pfam 1-20 (33) Show / Hide 
Range on Protein: 455-474
Range on HMM: 1-20/33
Sequence Identity: 50% (10 aa)

DGDTALTLAARMGHKDIVEL
||.|.| ||.|.||...|..
DGFTPLHLACRCGHTEVVKM
Ank GL50803_17510.AA Ank 424-454 21 20.575529 2.14 Pfam 1-33 (33) Show / Hide 
Range on Protein: 424-454
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

SSWTPLMHAVVVGDARAAKKYID--NNRNKMNK
  .|||. |.  |... .|  ..   . |  ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17510.AA Ank 481-502 50 3.9e-05 22.76 Pfam 1-22 (33) Show / Hide 
Range on Protein: 481-502
Range on HMM: 1-22/33
Sequence Identity: 50% (11 aa)

DGVTALMRAADRGDVEVVKLLI
|| |.|. |. .|..||||.|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_17510.AA Ank 522-545 41 0.017004 13.26 Pfam 1-24 (33) Show / Hide 
Range on Protein: 522-545
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

CNRTALMGATIYGHTDAVKLLMEH
. .|.|. | ..|||. ||.|..|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_17510.AA Ank 553-583 33 0.000398 19.14 Pfam 1-33 (33) Show / Hide 
Range on Protein: 553-583
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

TGWTALMYAALTNHTELVGLLMN--VEEGAQNS
 |.|.|..|.. .||| | .|..   .  ||. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_17510.AA Ank 584-610 29 0.000552 18.63 Pfam 1-27 (33) Show / Hide 
Range on Protein: 584-610
Range on HMM: 1-27/33
Sequence Identity: 29% (8 aa)

EDRTALMYAAQSNNQNSVKLLLKKEAC
. .|.|..|..... . ||.||.. |.
DGFTPLHLACRCGHTEVVKMLLQHGAD
Ank GL50803_17510.AA Ank 615-647 24 0.000213 20.12 Pfam 1-33 (33) Show / Hide 
Range on Protein: 615-647
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

NGITALMRATCNNNLECVRLLASKEGDIKTTHN
.| |.|. | .....|.|..| ..  |.  . .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD