Gene GL50803_17558 (G.lamblia)

GL50803_17558

Species: G.lamblia
Alias: GK033, GL50803_17558
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_17558.AA Protein None 1234 None Fasta, JSON
GL50803_17558.kin_dom Protein Kinase Domain None 317 None Fasta, JSON

Protein domain

Protein domains of GL50803_17558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_17558.AA DYRK 911-1227 32 1.2e-82 280.93 In-house 1-320 (320) Show / Hide 
Range on Protein: 911-1227
Range on HMM: 1-320/320
Sequence Identity: 32% (111 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNRREKKGQP
|. |.. |. .|..|. | | | |   ..|||. .|.|..||..|...||.|.. ||... ..... ||||.|.|| . | ||  .||    .. ..|  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF-

NDYTIPVIRDMARQVLKALDYIHRL-GITHLDLKPENLLHGDKNFIGGVNEP----SVTLVDFGSSSFIFDKMHSYIQSRSYRAPEVILATPYDSRADIW
   .. ..| .|.|.|..|...|..  | | |||||| .         ...|     . ..|||||.|. .....||||| |||||||| .||.   |.|
--FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM---------LKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMW

SFGCVVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMIMSG----------RMGQRVLTFGLVPYEHDEKNRQHF----YFT----PQQGLLEYWLFG
|.||.. ||.|| .|||. .    | .|. ..|..|..|| .|          .         . ..|.||.  | .    |.|    |  .  .. . |
SLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPG

ER--CANLTDEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI
 |   . .. .  .| || .. |. || ||.|..  |.||..
RRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase GL50803_17558.AA DyrkP 911-1156 42 1.1e-75 248.59 In-house 1-240 (323) Show / Hide 
Range on Protein: 911-1156
Range on HMM: 1-240/323
Sequence Identity: 42% (104 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGEDLYTHFN-RREKKGQ
|...  .||| ||    |.|.. |   |.|||   |..|||.|||. ||  .         |.....|||| .||| .   || . ||  .   ||   |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

PNDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDKMHSYIQSRSYRAPEVILATPYDSRADIWSFGC
.  .|.  .  .  |.| |||||| | . | ||||||.|      .       | ..||||| || | . ||.|||||||||||.   || | |.|| ||
RY-FTVGRLQKITQQILIALDYIHSLRLIHCDLKPENIL------MKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGC

VVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMIMSGRMGQRVLT
.. || || ||| |  .  .| |.  .|||.|  |.  ||. |   |
ILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFT
Kinase GL50803_17558.AA CMGC 911-1227 17 2.1e-70 230.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 911-1227
Range on HMM: 1-513/513
Sequence Identity: 17% (92 aa)

YKLLKMVGSATFSNVFSCLD--------------LKDNVTYCLKIIKQEKEFFDQAI-------------DEVHLLELLK-----------DIDPNNNIN
|. .| .|. |...|..| |               ..|  . .|.||... . .||              .|. .|. |.           | | ..  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKIHDYFYFRE-----------------HLLLKFTLLGEDLYTHFNR--------REKKGQPND---------------YTIPVIRDMARQVLKALD--
|.|..|.||...                 || | | ... |||    .        | ..  .                 ..|  || ...|.|..|.  
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YIHRLG--ITHLDLKPENLLHGDK--------------NFIGGVNEPSVTLVDFGSSSFIFDK------------------------MHSYIQSRSYRAP
|.|. .  | | ||||||.|  ..              |    .    . . |||.. .. .                         . .|...| ||||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP

EVILATP----------YDSRADIWSFGCVVCELLTG--------RVLFPNYSV-----------ATILSRICSLIGPIPRDMIMSGRMGQRVLTFGLVP
|..|  .          |..  |.||.||.  |..||        . |||  |               | .|. ..|...  || .|.  .         
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RH-F-------

YEHDEKNRQHFYFTPQQGL-----------------------------LEYWL---FGERCANLTD--------------------------------EE
. .... .. ..... ..                              .  |    . . . .. .                                . 
N-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCD

VLFSDFCRQALIVDPIKRPTAAMLLEHPFI
 .. |.  . |. || ||.||.  |.||..
PQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_17558.AA DYRK2 911-1122 37 5.3e-68 220.12 In-house 1-203 (318) Show / Hide 
Range on Protein: 911-1122
Range on HMM: 1-203/318
Sequence Identity: 37% (80 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNRREKKGQP
| .|.. |.  |  |. |.| | .   ..|.|  .| |  ||  |.  |. .. .|..|. |.... |||||| |. . | ||. .||    .....|  
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQG--

NDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFD-KMHSYIQSRSYRAPEVILATPYDSRADIWSFGC
  ..   .| .|...|..|.  |.  | | |||||| |          |  .. ..||||| |    ... ||||| |||||||| ..|.   |.|||||
--FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL------LKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGC

VVCELLTGRVLFP
.. ||.||  |||
IMAELYTGYPLFP
Kinase GL50803_17558.AA S_TKc 911-1227 22 5.8e-62 213.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 911-1227
Range on HMM: 1-231/231
Sequence Identity: 22% (74 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGE---DLYTHFNRREKK
|..|. .|. .|. |. | . |..  . .||||      .... |. .|.        .  ||.|..|.|.  .|| . . ...    ||...  .| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

GQPNDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDKMHSYIQSRSYRAPEVILATPYDS-RADIWS
| .  ..  ..| ...|...||.|.|..|| | ||||||.|  .           . . |||.. ..    .... .. |.||||.   .|.  ..|.||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGCVVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMIMSGRMGQRVLTFGLVPYEHDEKNRQHFYFTPQQGLLEYWLFGERCANLTDEEVLFSDFCRQ
.||.. |.|.|. .||   ..... .|.                                                                 . || |.
CGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------------------------------SPEAKDFIRK

ALIVDPIKRPTAAMLLE-------HPFI
 | .|| |||||  .|.       ||..
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_17558.AA DYRK1 911-1145 33 1.2e-44 154.6 In-house 1-227 (321) Show / Hide 
Range on Protein: 911-1145
Range on HMM: 1-227/321
Sequence Identity: 33% (80 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNRREKKGQP
|.   ..|   |  |    | ..     .||||  | |..||  |..||||.   |...  .|...   | ||.|| | | ||   ||      . .|  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG--

NDYTIPVIRDMARQVLKALDYIH--RLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDKMHSYIQSRSYRAPEVILATPYDSRADIWSFG
    . ..| .|.|...|| ..    | | | ||||||.|      .       . ..|||||    ...  ||||| ||.|||.| ..||   |.|| |
--VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENIL------LCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLG

CVVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMI
|.. |. ||  ||   .    ...|   .|  |..||
CILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMI
Kinase GL50803_17558.AA Pkinase 911-1142 25 1.2e-37 134.17 Pfam 1-236 (293) Show / Hide 
Range on Protein: 911-1142
Range on HMM: 1-236/293
Sequence Identity: 25% (64 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAID-----EVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGE-----DLYTH
|.... .|| .|. |. | . ... ....|||| ..|  .. .      |....  |.        ||....|.|. . |. . . ...      ||...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

FN-RREKKGQPNDY--TIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSS---FIFDKMHSYIQSRSYRAPEVIL
   .|...     .  .  .......|.|..|.|.|. || | ||||||.|  ... |.     .| . |||..       . |...  .. |.|||||.
ISTWRHGC-----FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR

-ATPYDSRADIWSFGCVVCELLTGRVLFPNY----SVATILSRICSLIGPIPR
 ...|....|.||.||.. |.|.|| .||.     . .. . .||   ||...
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH
Kinase GL50803_17558.AA HIPK 911-1123 33 1.1e-35 109.51 In-house 1-205 (329) Show / Hide 
Range on Protein: 911-1123
Range on HMM: 1-205/329
Sequence Identity: 33% (72 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNNNINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNRREKKGQP
|  | . |  ||  |  |     |    .||.|..  .  |   || .|. |.. .. .. ....  ..|  ..|  | | .|   ||     .. |  |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENA-DEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQ--KQNKFMP

NDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEP-SVTLVDFGSSSFIFDKMHS-YIQSRSYRAPEVILATPYDSRADIWSFG
    . .|| .  |||.||  .  ||. | ||||||..  |.     .  |  |  .|||| | . .   . |.||| |||||.||. |.    |.|| |
--LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDP-----TRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLG

CVVCELLTGRVLFPN
||. ||  |. |.|.
CVIAELFLGWPLYPG
Kinase GL50803_17558.AA YAK 911-1149 33 7.6e-35 115.55 In-house 1-233 (347) Show / Hide 
Range on Protein: 911-1149
Range on HMM: 1-233/347
Sequence Identity: 33% (81 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELL-KDIDPNNNI---NIIKIHDYFYFREHLLLKFTLLGEDLYTHFNRREK
|. | | |  ||  |  |  .  |     |.||   ..| ||. |. .|..| . .||||      |... |.| .. |. | | .|   ||        
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KGQPNDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDKMHSYIQSRSYRAPEVILATPYDSRADIWS
.|      . .||    |.| ..       | | |||||| .         .| | . ..|||||      .  |||.| ||.||.|. ..|    | ||
CG----FSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIM------LCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWS

FGCVVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMIMSGR
 ||.| ||  |  .||  |    ..||    |  | .||  ||
LGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGR
Kinase GL50803_17558.AA Ciliate-E2 911-1227 16 1.4e-34 116.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 911-1227
Range on HMM: 1-365/365
Sequence Identity: 16% (73 aa)

YKLLKMVGSATFSNVFSCLDLKDNV-----------------------TYCLKII-KQEKEFFDQAIDEVHLLE----------LLKDIDPNNNINIIKI
||..|. |. .|. |. | . |..                         | .||. |...|.. | |..   ..          .|. .   |. ||||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL---NHPNIIKM

HDYFY--FREHLLLKFTLLGE-DLYTHFNRREKKG------QPNDYTIPVIRDMARQVLK---------------ALDYIHRLG-ITHLDLKPENLLHGD
...|.   .... | . ..   ||. . . . ||       . . .|.  |... .|.|.               || |.|  . | | |.||||.|   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

KNFIGGVNEPSVTLVDFGSSSF----------------------------------IFDKMHSYIQSRSYRAPEVILATP---------YDSRADIWSFG
           . ..||| | .                                  ...  .... .  | |||..   .         ||  .||||.|
-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

CVVCELLTGRVLFPNYSVATILSRICSLIGPIPRDMIMSGRMGQRVLTFGLVPYEHDEKNRQHFYFTPQQGLLEYWLFGERCANLTDEEVLFS-------
..  |.|.|.  |                                                                      .  . .. |.       
VILYEMLFGKPPF--------------------------------------------------------------------QQQIKQCKIDFPCPEWQKD

-------------------DFCRQ----ALIVDPIKRPT-AAMLLEHPFI
                   |....     | .|| ||.| .  .|.||..
TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_17558.AA STE 1016-1142 25 1.1e-30 105.62 In-house 151-302 (359) Show / Hide 
Range on Protein: 1016-1142
Range on HMM: 151-302/359
Sequence Identity: 25% (42 aa)

PVIRDMARQVLKA-LDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFD-------------------KMHSYIQSRSYRAPEVILA
..|. ..||.||. |.|.|...| | |.|| | |              | |.||| .. . |                   |  . . .  . |||||. 
SQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQ

------TPYDSRADIWSFGCVVCELLTGRVLFPNYSVATILSRICSLI-------------GPIPR
       .|| ..||||.||...|..||.. . ...    . .|   .             ||.|.
NGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPP
Kinase GL50803_17558.AA CLK 911-1048 30 1.6e-27 78.95 In-house 1-146 (350) Show / Hide 
Range on Protein: 911-1048
Range on HMM: 1-146/350
Sequence Identity: 30% (45 aa)

YKLLKMVGSATFSNVFSCLDLKD-NVTYCLKIIKQEKEFFDQAIDEVH-LLELLKDI-DPNNNIN--IIKIHDYFYF-REHLLLKFTLLGEDLYTHFNRR
|. .. .|. ||. |. | | |  .  . ||||.  ... ..|  |.   .. .. . ||||     ..|. |.| .   |  . | |.|  .|      
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

E----KKGQPNDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLL
      | .|  | |  || ||.| ..|.   | ...||.|||||| .
NSKMPNKYIP--YPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENIC
Kinase GL50803_17558.AA CLK 1058-1122 41 3.2e-22 62.79 In-house 181-248 (350) Show / Hide 
Range on Protein: 1058-1122
Range on HMM: 181-248/350
Sequence Identity: 41% (28 aa)

VNEPSVTLVDFGSSS-FIFDKMHSY--IQSRSYRAPEVILATPYDSRADIWSFGCVVCELLTGRVLFP
| .. . ..||||     ||. |..  ...| ||||||||. ..  . |.||.||.  || ||  ||.
VKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQ
Kinase GL50803_17558.AA STE 1200-1227 56 6e-10 31.45 In-house 330-359 (359) Show / Hide 
Range on Protein: 1200-1227
Range on HMM: 330-359/359
Sequence Identity: 56% (17 aa)

FSDFCRQALIVDPIKRPTAAMLLE--HPFI
| || .. |. || |||||  ||.  ||||
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_17558.AA DyrkP 1191-1227 43 6.7e-08 21.39 In-house 287-323 (323) Show / Hide 
Range on Protein: 1191-1227
Range on HMM: 287-323/323
Sequence Identity: 43% (16 aa)

ANLTDEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI
| |  .. .| || || | .|  .||||   |.||..
ARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase GL50803_17558.AA TyrKc 911-1227 16 2e-07 -102.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 911-1227
Range on HMM: 1-280/280
Sequence Identity: 16% (57 aa)

YKLLKMVGSATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELL-KDIDPNNNINIIKIHDYFYFR-------EHLLLKFTLL-GEDLYTHF
 .|.|. |.  |  |. .      ..   | .| ..      ..|  ..  | .     .. ||.... .           | |.. . .  . ||  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

NRREKKGQPNDYTIPVIRDMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDK-----MHSYIQSR---SYR-----
 ....|      . .   ... |. .  .|.|. .. | ||   | | |...         |   ||| | .| |.      ..|. ..   . .     
RKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

---APEVILATPYDSRADIWSFGCVVCELLT-GRVLFPN-----YSVATILSRICSLIGPIPRDMI--MSGRMGQRVLTFGLVPYEHDEKNRQHFYFTPQ
   |||.|    . .  |.|||| .  |..| |    |.      | . .. .. .   . . . .  ||                              
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------

QGLLEYWLFGERCANLTDEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI
        |       .  . ...   .|    || .||| . .  | ..
--------F------VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_17558.AA Pkinase 1202-1227 50 8.6e-07 25.09 Pfam 268-293 (293) Show / Hide 
Range on Protein: 1202-1227
Range on HMM: 268-293/293
Sequence Identity: 50% (13 aa)

DFCRQALIVDPIKRPTAAMLLEHPFI
||..  | .|| |||||. .|.||..
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_17558.AA CLK 1195-1227 39 2e-06 14.68 In-house 318-350 (350) Show / Hide 
Range on Protein: 1195-1227
Range on HMM: 318-350/350
Sequence Identity: 39% (13 aa)

DEEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI
.| . . |  |. |..|| ||.|..  | ||| 
PEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase GL50803_17558.AA YAK 1199-1227 37 6.4e-05 12.22 In-house 319-347 (347) Show / Hide 
Range on Protein: 1199-1227
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

LFSDFCRQALIVDPIKRPTAAMLLEHPFI
.| ||  | |  .| .| ..    .||||
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase GL50803_17558.AA DYRK2 1199-1227 37 0.000878 7.81 In-house 290-318 (318) Show / Hide 
Range on Protein: 1199-1227
Range on HMM: 290-318/318
Sequence Identity: 37% (11 aa)

LFSDFCRQALIVDPIKRPTAAMLLEHPFI
.| || .. .  || .| |..  |.||.|
NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase GL50803_17558.AA STE 911-981 10 0.009697 5.65 In-house 1-100 (359) Show / Hide 
Range on Protein: 911-981
Range on HMM: 1-100/359
Sequence Identity: 10% (11 aa)

YKLLKMVGSATFSNVFSCLDLK---------------DNVTYCLKIIK---QEK---------------EFFDQAIDEVHLLELLKDIDPNNNINIIKIH
.......|. .|  |. ... |                .. .  |...   ...               | ..| . |. ..  ...       ||.| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH---M-HPNIVKYY

DYFY
....
GCYF
Kinase GL50803_17558.AA HIPK 1200-1227 32 0.017618 3.07 In-house 302-329 (329) Show / Hide 
Range on Protein: 1200-1227
Range on HMM: 302-329/329
Sequence Identity: 32% (9 aa)

FSDFCRQALIVDPIKRPTAAMLLEHPFI
|..  .. . .|. || | .  |.|||.
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase GL50803_17558.AA DYRK1 1200-1227 35 0.022376 3.58 In-house 294-321 (321) Show / Hide 
Range on Protein: 1200-1227
Range on HMM: 294-321/321
Sequence Identity: 35% (10 aa)

FSDFCRQALIVDPIKRPTAAMLLEHPFI
| |  .. |. || .| |    |.|.|.
FKDLIKRMLQYDPKQRITPYYALQHSFF