Gene GL50803_17578 (G.lamblia)
GL50803_17578
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_17578.AA | Protein | None | 1030 | None | Fasta, JSON |
| GL50803_17578.kin_dom | Protein Kinase Domain | None | 266 | None | Fasta, JSON |
Protein domains of GL50803_17578.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_17578.AA | ULK | 185-278 | 25 | 2.2e-15 | 50.23 | In-house | 214-329 (329) | Show / Hide |
Range on Protein: 185-278 Range on HMM: 214-329/329 Sequence Identity: 25% (30 aa) TSLYAAPETVL----RKEFT-SKSDAWSLGCILYELCCLDPAINLSVDDDAAKYFATDPKVTLDTSR------------------YSDELVTVIRKLLVV | || ||. . .|... .|.| ||||||.||. | . . | ... .. . .... |.|. ||..|.. TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQY CPEKRISISELVLHPRI ...|||. || || . DEKDRISWEELFNHPWF |
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| Kinase | GL50803_17578.AA | ULK | 185-278 | 24 | 2.9e-14 | 47.07 | In-house | 210-324 (324) | Show / Hide |
Range on Protein: 185-278 Range on HMM: 210-324/324 Sequence Identity: 24% (28 aa) TSLYAAPETVL----RKEFT-SKSDAWSLGCILYELCCLDPAINLSVDDDAA-------------KYFATDPKVTLDT----SRYSDELVTVIRKLLVVC | || ||. . .|... .|.| ||||||.||. . . . | ... . .. . |.|. ||..|.. TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYD PEKRISISELVLHPRI ...|||. |. || . EKDRISWEEIFNHPWF |
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| Kinase | GL50803_17578.AA | Ciliate-E2 | 185-278 | 23 | 1.1e-13 | 43.35 | In-house | 250-365 (365) | Show / Hide |
Range on Protein: 185-278 Range on HMM: 250-365/365 Sequence Identity: 23% (30 aa) TSLYAAPETVLRKE---------FTSKSDAWSLGCILYELCCLDPAINLSVDDDAAKYFA--TDPKVTLD-----------------TSRYSDELVTVIR | | ||| . .|. . |.| ||||.||||... | . . |. .. . |.| |. TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK K----LLVVCPEKRIS-ISELVLHPRI | .|.. |||||. .... || . KFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_17578.AA | NEK6 | 66-218 | 29 | 4.2e-13 | 39.23 | In-house | 53-199 (252) | Show / Hide |
Range on Protein: 66-218 Range on HMM: 53-199/252 Sequence Identity: 29% (46 aa) LMRINNQHILRLYDVYTEIPNKIFVTHEYARNGRLIDYLDHCYDMHKHPEEDTVWKVAAVVANALTSSNLKKKNDTSEFIHGHLCPAALFITHEGQVKLG | ..| ..... |. . | |.. . | | | . . | . | |.|| .. || |. .| . || ||| .| |||| LKQLNHPNVIKYYASFIEN-NELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKR------VMHRDIKPANVFITANGIVKLG HLEYFRLI-GKASCTLPIENTSLYAAPETVLRKEFTSKSDAWSLGCILYELCCL | | | . | | .|| . . . ||| |||||.|||. | DLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAAL |
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| Kinase | GL50803_17578.AA | NEK | 188-221 | 47 | 6.1e-11 | 35.15 | In-house | 190-225 (286) | Show / Hide |
Range on Protein: 188-221 Range on HMM: 190-225/286 Sequence Identity: 47% (17 aa) YAAPETVLRKEFTSKSDAWSLGCILYELCCL--DPA |..|| . | ..||| |||||.|||.|.| .. YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHP |
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| S_TKc | GL50803_17578.AA | S_TKc | 13-278 | 20 | 1.6e-10 | -22.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-278 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) YDDLIHVYGDNYCNLYDALDTASSKRKRKFLLEIFLSRVDPEIKQSISPTATALMRINNQHILRLYDVYTEIPNKIFVTHEYARN--GRLIDYLDHCYDM |. | .. . | . .. .|.. . | ..| |.. . .| .||||. . ..... ||. . | | ||.... YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH HKH--PEEDTVWKVAAVVANALTSSNLKKKNDTSEFIHGHLCPAALFITHEGQVKLGHLEYFRLIGKASCTLPIENTSLYAAPETVLRKEFTS-KSDAWS .. | ....... ...|| .. .|| | |. ..... ..|.. |.. . | | ||| . .. |.| || GLRFPFPE-HARFYMYQICCALEYCHSHG------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS LGCILYELCCLDPAINLSVDDDAAKYFATDPKVTLDTSRYSDELVTVIRKLLVVCPEKRISISELVL-------HPRI .||||||..| | .. | |.|. |||.|.. ||||... |. || . CGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_17578.AA | NEK2 | 188-220 | 45 | 4.8e-10 | 29.89 | In-house | 230-262 (319) | Show / Hide |
Range on Protein: 188-220 Range on HMM: 230-262/319 Sequence Identity: 45% (15 aa) YAAPETVLRKEFTSKSDAWSLGCILYELCCLDP | || . . ||| ||.||..||.| | | YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP |
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| Kinase | GL50803_17578.AA | Pkinase | 185-217 | 47 | 1.8e-09 | 34.6 | Pfam | 234-267 (293) | Show / Hide |
Range on Protein: 185-217 Range on HMM: 234-267/293 Sequence Identity: 47% (16 aa) TSLYAAPETVL-RKEFTSKSDAWSLGCILYELCC |. |.||| .. ... ..|.| ||.||||||..| TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | GL50803_17578.AA | NEK | 245-278 | 33 | 7.9e-09 | 27.63 | In-house | 251-286 (286) | Show / Hide |
Range on Protein: 245-278 Range on HMM: 251-286/286 Sequence Identity: 33% (12 aa) SR--YSDELVTVIRKLLVVCPEKRISISELVLHPRI |. ||..| .|...| . ||.| |.... .| | SHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_17578.AA | CAMKL | 248-278 | 41 | 9.9e-08 | 20.59 | In-house | 268-297 (297) | Show / Hide |
Range on Protein: 248-278 Range on HMM: 268-297/297 Sequence Identity: 41% (13 aa) SDELVTVIRKLLVVCPEKRISISELVLHPRI | .. |||.|.|.||||..| ... || S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | GL50803_17578.AA | Ciliate-E2-Unclassified | 188-216 | 42 | 2.3e-07 | 21.62 | In-house | 232-264 (352) | Show / Hide |
Range on Protein: 188-216 Range on HMM: 232-264/352 Sequence Identity: 42% (14 aa) YAAPETVLRKEFT----SKSDAWSLGCILYELC |.||| ... |.| ||||.||||.. YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML |
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| Kinase | GL50803_17578.AA | CAMK | 245-278 | 35 | 4e-07 | 18.23 | In-house | 384-425 (425) | Show / Hide |
Range on Protein: 245-278 Range on HMM: 384-425/425 Sequence Identity: 35% (15 aa) SRYSDE--------LVTVIRKLLVVCPEKRISISELVLHPRI .. ||| |||.|.| ||||..|.. || . DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | GL50803_17578.AA | AMPK | 72-103 | 46 | 4e-06 | 14.14 | In-house | 59-90 (254) | Show / Hide |
Range on Protein: 72-103 Range on HMM: 59-90/254 Sequence Identity: 46% (15 aa) QHILRLYDVYTEIPNKIFVTHEYARNGRLIDY .|| .||.| | | ||. ||. .| | || PHIIQLYEVIIETPTDIFMVMEYVSGGELFDY |
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| Kinase | GL50803_17578.AA | Ciliate-E2-Unclassified | 255-278 | 33 | 8e-06 | 16.23 | In-house | 329-352 (352) | Show / Hide |
Range on Protein: 255-278 Range on HMM: 329-352/352 Sequence Identity: 33% (8 aa) IRKLLVVCPEKRISISELVLHPRI ..|.|...|.|||..... || . LQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_17578.AA | NEK2 | 245-278 | 35 | 1.6e-05 | 14.39 | In-house | 286-319 (319) | Show / Hide |
Range on Protein: 245-278 Range on HMM: 286-319/319 Sequence Identity: 35% (12 aa) SRYSDELVTVIRKLLVVCPEKRISISELVLHPRI ..||..| .| . | ...| || |. ||.| YQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | GL50803_17578.AA | CAMK | 188-213 | 31 | 1.7e-05 | 12.9 | In-house | 285-325 (425) | Show / Hide |
Range on Protein: 188-213 Range on HMM: 285-325/425 Sequence Identity: 31% (13 aa) YAA-PETVLR-------------KEF-TSKSDAWSLGCILY |.| || ... |. . |.| ||.|.||| YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY |
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| Kinase | GL50803_17578.AA | AMPK | 248-278 | 38 | 2.2e-05 | 11.98 | In-house | 224-254 (254) | Show / Hide |
Range on Protein: 248-278 Range on HMM: 224-254/254 Sequence Identity: 38% (12 aa) SDELVTVIRKLLVVCPEKRISISELVLHPRI |.| |...| | |.|||.|.... || SPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| TyrKc | GL50803_17578.AA | TyrKc | 14-278 | 15 | 3e-05 | -137.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-278
Range on HMM: 1-280/280
Sequence Identity: 15% (51 aa)
DDLIHVYGD-NYCNLYDALDTASSKRKRKFLLEIF--LSRVDPEIKQSISPTATALMRI--NNQHILRLYDVYTEI-------PNKIFVTHEYARNGRLI
|... | ... | . . .. . | .. . | .... ....|.||| | |. . |. ||. .| |
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM-EYMPHGDLK
DYL-DHCYDMHKHPEEDTVWKVAAVVANALTSSNLKKKNDTSEFIHGHLCPAALF-----------------------------ITHEGQVK--------
||| .| . ||.. | ......||
DYLRKHRPK---------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR
-LGHL-------EYFRLIGKASCT--LPIENTSLYAAPETVLRKEFTSKSDAWSLGCILYELC--CLDPAIN-LS--VDDDAAKYFATDPKVTLDTSR--
... .| | .. .. ||| |||. ..||.||| || | ..|.. . | . .... . . . .
DIYDDDQQGESKDYYRKKEHKGGKTMLPIR----WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY
------YSDELVTVIRKLLVVCPEKRISISELVLHPRI
.||. ..... ||.| . ||. | ..
PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | GL50803_17578.AA | CAMKL | 188-213 | 44 | 0.000107 | 10.75 | In-house | 199-227 (297) | Show / Hide |
Range on Protein: 188-213 Range on HMM: 199-227/297 Sequence Identity: 44% (13 aa) YAAPETVLR--KEFT-SKSDAWSLGCILY |.||| ... |.. | | ||.| ||| YMAPEIFQGNNKPYDGPKVDIWSCGVILY |
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| Kinase | GL50803_17578.AA | Pkinase_Tyr | 190-218 | 41 | 0.000347 | 14.8 | Pfam | 182-210 (270) | Show / Hide |
Range on Protein: 190-218 Range on HMM: 182-210/270 Sequence Identity: 41% (12 aa) APETVLRKEFTSKSDAWSLGCILYELCCL ||| ..||.||| || | ..|.. . APECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_17578.AA | Ciliate-E2 | 66-104 | 32 | 0.000772 | 9.04 | In-house | 86-125 (365) | Show / Hide |
Range on Protein: 66-104 Range on HMM: 86-125/365 Sequence Identity: 32% (13 aa) LMRINNQHILRLYDVYTE-IPNKIFVTHEYARNGRLIDYL | ..|. .|...|... | |.|. ||. | | ||. LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYI |
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| Kinase | GL50803_17578.AA | CAMKL | 66-105 | 27 | 0.001067 | 7.51 | In-house | 66-115 (297) | Show / Hide |
Range on Protein: 66-105 Range on HMM: 66-115/297 Sequence Identity: 27% (14 aa) LMRIN---NQHILRLYDVYT------EIPNKIFVTHEYARNGR--LIDYLD ....| ..| .||.|.. | .||. ||. .| | ||.. MKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIV |
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| Kinase | GL50803_17578.AA | AMPK | 188-217 | 45 | 0.001589 | 6.4 | In-house | 165-195 (254) | Show / Hide |
Range on Protein: 188-217 Range on HMM: 165-195/254 Sequence Identity: 45% (14 aa) YAAPETVLRKEFTSKS-DAWSLGCILYELCC |||||.. | . | || | ||| . | YAAPEMISGKLYCGPEVDIWSCGVILYAMLC |
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| Kinase | GL50803_17578.AA | Pkinase | 248-278 | 29 | 0.002328 | 12.96 | Pfam | 263-293 (293) | Show / Hide |
Range on Protein: 248-278 Range on HMM: 263-293/293 Sequence Identity: 29% (9 aa) SDELVTVIRKLLVVCPEKRISISELVLHPRI |.|. .|...| ..|.||... ... || . SEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_17578.AA | CAMK | 66-104 | 16 | 0.006117 | 4.51 | In-house | 85-155 (425) | Show / Hide |
Range on Protein: 66-104 Range on HMM: 85-155/425 Sequence Identity: 16% (12 aa) LMR-------INNQHILRLYDVYTE-----------IPNK--------IFVTH---EYARNG----RLIDYL ... .. .|..||.|| .| .. ||. .| .| ||. MKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYI |
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| Kinase | GL50803_17578.AA | Ciliate-E2-Unclassified | 66-107 | 21 | 0.068516 | 2.37 | In-house | 70-115 (352) | Show / Hide |
Range on Protein: 66-107 Range on HMM: 70-115/352 Sequence Identity: 21% (10 aa) LMR---INNQHILRLYDVYTE-IPNKIFVTHEYARNGRLIDYLDHC .| .|..|.......|.. ..|. ||...| |..|. .. IMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKR |
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| Ank | GL50803_17578.AA | Ank | 492-512 | 42 | 0.005744 | 14.96 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 492-512 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) EGITALMLAAERGLTDFMKIL .| |.|.||...| |. .| | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_17578.AA | Ank | 565-588 | 20 | 0.010534 | 14.01 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 565-588 Range on HMM: 1-24/33 Sequence Identity: 20% (5 aa) HGYNALMVAAMANSLDCVPLLVEK .|. .|..|.. .....| .|... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_17578.AA | Ank | 534-564 | 24 | 0.028702 | 12.44 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 534-564 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) AGASALHFAAHGNQKAVIGMLID--VEADMCTD | ..|| |.. ... |. ||.. . .. .| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_17578.AA | Ank | 600-622 | 39 | 2.9e-05 | 23.24 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 600-622 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) KGKTALMIAAESGHAQVCQLLLK | |.|..|...||..|...||. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17578.AA | Ank | 632-664 | 30 | 0.001419 | 17.15 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 632-664 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) DNKTALMYAAENGHVAAVKILKRREVRLTLNDN | |.|..|...||. || | . . . |. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_17578.AA | Ank | 668-691 | 25 | 9.327171 | 3.38 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 668-691 Range on HMM: 1-24/33 Sequence Identity: 25% (6 aa) PGGSAMMLAVLTRNDDVVSILVEN | .. .||.. . .||. |... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_17578.AA | Ank | 867-892 | 26 | 0.010807 | 13.97 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 867-892 Range on HMM: 1-26/33 Sequence Identity: 26% (7 aa) RGKTALMAAAEKGHLSCASLVINKEA | |.|. |...||...... ... | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_17578.AA | Ank | 898-920 | 39 | 0.001675 | 16.89 | Pfam | 1-23 (33) | Show / Hide |
Range on Protein: 898-920 Range on HMM: 1-23/33 Sequence Identity: 39% (9 aa) SGWTALMIASMFGKVEVAKHLVS |.|.|..|.. | .||.| |.. DGFTPLHLACRCGHTEVVKMLLQ |
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| Ank | GL50803_17578.AA | Ank | 929-963 | 34 | 0.000335 | 19.41 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 929-963 Range on HMM: 1-33/33 Sequence Identity: 34% (12 aa) DGWTALMGAAYSNSPELVQLLLKEEAGKATNAMYY ||.|.|. |......| |..||. .| || DGFTPLHLACRCGHTEVVKMLLQ--HGADVNAQDD |
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| Ank | GL50803_17578.AA | Ank | 966-989 | 45 | 1.2e-05 | 24.59 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 966-989 Range on HMM: 1-24/33 Sequence Identity: 45% (11 aa) AGWTALLLAAKRNNLECVKFLIQH |.|.| ||......|.||.|.|| DGFTPLHLACRCGHTEVVKMLLQH |
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