Gene GL50803_2082 (G.lamblia)

GL50803_2082

Species: G.lamblia
Alias: GL50803_2082, GK199
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_2082.AA Protein None 286 None Fasta, JSON
GL50803_2082.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_2082.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_2082.AA S_TKc 9-275 23 4.6e-32 113.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-275
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKEVVYGGPDQECSSEALLAMLRKEANLFSRLAHRCLPKTVSVYNNPLTSTWHTVIELFDN--GDLATMISE
|... .||.| |.||..|.  ..| ..|.|..                ..|.| .. ..  |  . |   |. .   .  . | |. |.  ||| ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKK

YSQANVR--IPEERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILLKLNGLI-----GLATLRLAEEQELPRRHMDRLAPSPYLAPEALAG
.     |  .|| ..  .. |. . |.|.|.         |.|.|| | ||||||     |     |||..            .       |.||| |  
RGRHGLRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--

EPYGA-MADAWSLGCIISEMCTLERLFDASGPAPGKLPVNLTGLGYSKTLEVLVNALLQENVNVRCSVVDMRH-------NPVL
 .||   .| ||.|||. ||.. . .|.       ..  .. |   |. .  ... .|| . . | .. .  .        | .
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_2082.AA Pkinase 9-220 25 1.1e-22 81.24 Pfam 1-207 (293) Show / Hide 
Range on Protein: 9-220
Range on HMM: 1-207/293
Sequence Identity: 25% (58 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKEVVYGGPDQECSSEALLAMLRKEANLFSRLAHRCLPKTVSVYNNPLTSTWHTVIELFDNG----DLATMI
|..|  ||.| |..|..|.  ..|...|||.. . . . ..  .....    |. .  || | .  ..  .. .   .  . | |. ..|    ||...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYI

SEYSQANVRI--PEERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILLKLNGLI---------GLAT-LRLAEEQELPRRHMDRLAPSPYL
|   ... ..  .|. .  .. |.   |.|.|.           |.|| | |||||.. || |         |||  ..        .  ...   ..|.
ST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYM

APEALA-GEPYGAMADAWSLGCIISEMCT
||| .  |..||  .| ||.|||. ||..
APEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase GL50803_2082.AA CAMK 14-159 18 1.2e-16 49.47 In-house 1-212 (425) Show / Hide 
Range on Protein: 14-159
Range on HMM: 1-212/425
Sequence Identity: 18% (42 aa)

LIGEGRFAKVFLCIPPDSG------------DLYAVKEVVY---------------------GGPDQECSSEALLAMLRKEANLFSRLA-------HRCL
 .|.|.|.||.|||   ..              .|.| .                       .. ...  ..  ....|.| .. ..|        |...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PKTVSVYNNPL---------TST---------WHTVI---ELFDNGDLATMISEYSQAN---------------VRIPEERVLEIFGQLTDVLAYLHETY
 |   || .|          | .          . |    |. ..|.|   . .| ...                |..|. .  .| |. . ..|.|.  
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--

KTDSAEVHQIVHRNLRPENILL
       | |||| | ||||||
-------HNIVHRDLKPENILL
Kinase GL50803_2082.AA Ciliate-E2 91-225 20 7.5e-14 43.91 In-house 112-296 (365) Show / Hide 
Range on Protein: 91-225
Range on HMM: 112-296/365
Sequence Identity: 20% (41 aa)

VIELFDNGDLATMISEY---------SQANVRIPEERVLEIFGQLTD---------------VLAYLHETYKTDSAEVHQ-IVHRNLRPENILLKLNGLI
| |... |||   | .          . .  .. |. ...|. |...                | |||.            |.||.. |||||.     |
VMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---------KNNIIHRDIKPENILF-----I

GLATLRLAEEQELP---RRHMDRLA------------------------------PSPYLAPEALAGEP---------YGAMADAWSLGCIISEMCTLER
 .. . |. ..  .   |.|  ...                                .|.||| | |..         |. ..| ||||.|. ||.. ..
KIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

LF
 |
PF
Kinase GL50803_2082.AA Ciliate-E2-Unclassified 91-220 23 3e-13 42.32 In-house 99-265 (352) Show / Hide 
Range on Protein: 91-220
Range on HMM: 99-265/352
Sequence Identity: 23% (41 aa)

VIELFDNGDLATMISEYSQ-------------ANVRIPEERVL-----EIFGQLTDVLAYLHETYKTDSAEVHQ--IVHRNLRPENILLKLNG---LIGL
| |....|||  .|.....              . ...|. ..      .| |. . | |||          |.  |.||.. |||||.. ||    | .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH----------HKNNIIHRDIKPENILFDNNGKNYYIKI

ATLRLA-EEQEL---------------PRRHMDRLAPSPYL----APEALAGEPYG----AMADAWSLGCIISEMCT
. . .. . |.                . .  ..     |.    ||| | |. |.     ..| ||||.|. ||..
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase GL50803_2082.AA NEK-Unclassified 191-227 51 2.7e-12 36.72 In-house 163-199 (258) Show / Hide 
Range on Protein: 191-227
Range on HMM: 163-199/258
Sequence Identity: 51% (19 aa)

YLAPEALAGEPYGAMADAWSLGCIISEMCTLERLFDA
...|| .   ||    | ||||||| |||| |  ||.
WMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDT
Kinase GL50803_2082.AA CAMK-Unique 9-163 18 1.2e-11 34.46 In-house 1-194 (363) Show / Hide 
Range on Protein: 9-163
Range on HMM: 1-194/363
Sequence Identity: 18% (39 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKEVVYGGPDQECSSEALLA-----------------MLRKEANLFSRLAHRCLPKTVSVYNNPL--TST--
|... .||.| | .|. |.    |...|.| |      |  .......                  |..|...  .. | .. | . . |||.  ...  
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKK----QTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDW-NNPIFCDRKYP

--------------WHTVIELFDNGDLATMISEYSQ----------------ANVRIPE--ERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPE
               ..| |. . |||   | . .                  . .  |    .. |. .|. ..||.|.          .||||.| .|
LCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHS---------QDIVHRDLKLE

NILLKLNG
||... ..
NIMVCYSF
Kinase GL50803_2082.AA NEK10 191-225 48 6.3e-10 28.67 In-house 186-220 (279) Show / Hide 
Range on Protein: 191-225
Range on HMM: 186-220/279
Sequence Identity: 48% (17 aa)

YLAPEALAGEPYGAMADAWSLGCIISEMCTLERLF
|  || .  ||||  || |. ||.. .||||.  |
YSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQPPF
Kinase GL50803_2082.AA STE11 9-70 28 7.3e-10 32.13 In-house 1-69 (303) Show / Hide 
Range on Protein: 9-70
Range on HMM: 1-69/303
Sequence Identity: 28% (20 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKEVVYGGPDQ--ECSSEALLA-----MLRKEANLFSRLAH
..||..||.| | .|..|.  | | |.|||.. ... .|  |  .. . .      ...| .|.. | |
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNH
Kinase GL50803_2082.AA NEK 191-228 45 1.1e-09 30.74 In-house 190-229 (286) Show / Hide 
Range on Protein: 191-228
Range on HMM: 190-229/286
Sequence Identity: 45% (18 aa)

YLAPEALAGEPYGAMADAWSLGCIISEMCTL--ERLFDAS
|..|| . ..||.  .| |||||.. |||||  .. |.|.
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAW
Kinase GL50803_2082.AA NEK 96-165 25 8.5e-09 27.52 In-house 89-162 (286) Show / Hide 
Range on Protein: 96-165
Range on HMM: 89-162/286
Sequence Identity: 25% (20 aa)

D-NGDLATM---ISEYSQANVRIPEERVLEIFGQLTDVLAYLHET--YKTDSAEVHQIVHRNLRPENILLKLNGL----I
. .|||. .   | .. |..  ..|| ....| |.   | |.|.           . |.|| . | || |  |.     .
EGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGP------QRKILHRDIKPQNIFLTKNNNDYHNV
Kinase GL50803_2082.AA NEK2 191-221 48 4e-08 23.33 In-house 230-260 (319) Show / Hide 
Range on Protein: 191-221
Range on HMM: 230-260/319
Sequence Identity: 48% (15 aa)

YLAPEALAGEPYGAMADAWSLGCIISEMCTL
|  || . | .|    | ||.||.| |||.|
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCAL
Kinase GL50803_2082.AA TyrKc 9-273 15 2.1e-07 -102.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKEVVYGGPDQECSSEALLAMLRKEANLFSRL--AHRCLPKTVSVYNNPLT-----STWHTVIELFDNGDLA
 |.|  .||| | .|....        ||| .  .           ......||.. ..|   | .. . . |   .            | |. ..||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

TMISEYSQANVRIPEERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILLKLNGLI-----GLATLRLAE------EQELPRR---HMDRLA
  . ..      .. .  |..  |  .  .|||.          ...|| |   |.|.. |. .     ||.     .      ..    .   . . . 
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PSPYLAPEALAGEPYGAMADAWSLGCIISEMCTLERLFDAS---GPAPGKLPVNLTGLG-------Y---------SKTLEVLVNALLQENVNVRCSVVD
|   .|||..    .    | || |  . |..|.           . . .  ...   |       .         .. .  .     .|. . |..  .
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

MRHNP
 ..  
IHECF
Kinase GL50803_2082.AA STE11 193-220 51 2.1e-07 23.12 In-house 203-233 (303) Show / Hide 
Range on Protein: 193-220
Range on HMM: 203-233/303
Sequence Identity: 51% (16 aa)

APEALAGEP---YGAMADAWSLGCIISEMCT
||| . .|.   ||. || |||||.. ||.|
APEVIKQEGRDGYGRKADIWSLGCTVIEMAT
Kinase GL50803_2082.AA SgK071 193-220 53 4.9e-07 20.47 In-house 190-216 (283) Show / Hide 
Range on Protein: 193-220
Range on HMM: 190-216/283
Sequence Identity: 53% (15 aa)

APEALAGEPYGAMADAWSLGCIISEMCT
|||.| . |..   | ||||||| .| |
APEVLEF-PFSQKSDIWSLGCIILDMTT
Kinase GL50803_2082.AA SgK071 91-159 27 1e-06 19.1 In-house 78-137 (283) Show / Hide 
Range on Protein: 91-159
Range on HMM: 78-137/283
Sequence Identity: 27% (19 aa)

VIELFDNGDLATMISEYSQANVRIPEERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILL
| . .  ||.  .. | . ..  . ||    . ||. . ..|||.          .|.||.| | || |
VMDYYKMGDFDRFMKEKRKKKKIMCEEWMQRWCGQMLHAIEYLHH---------RNIIHRDLKPSNIYL
Kinase GL50803_2082.AA NEK2 98-159 28 1.1e-05 15.05 In-house 85-158 (319) Show / Hide 
Range on Protein: 98-159
Range on HMM: 85-158/319
Sequence Identity: 28% (21 aa)

GDLATMISEYSQANVRIPEERVLEIFGQLTDVLAYLHE------------TYKTDSAEVHQIVHRNLRPENILL
|||. ||. . .   ...|| .. |. ||.  |   |               |  .   | | || . | || |
GDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFL
Kinase GL50803_2082.AA CAMK 190-214 32 0.000255 9.04 In-house 284-323 (425) Show / Hide 
Range on Protein: 190-214
Range on HMM: 284-323/425
Sequence Identity: 32% (13 aa)

PYLA-PEALAG--------------EPYGAMADAWSLGCI
.| | || | |              ..||  .| ||.|.|
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase GL50803_2082.AA Ciliate-E2-Unclassified 9-39 35 0.000474 9.97 In-house 1-31 (352) Show / Hide 
Range on Protein: 9-39
Range on HMM: 1-31/352
Sequence Identity: 35% (11 aa)

YTKGALIGEGRFAKVFLCIPPDSGDLYAVKE
|...  ||.| |.||..|.  . . .|| |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKY
Kinase GL50803_2082.AA NEK10 116-159 40 0.000547 8.78 In-house 118-153 (279) Show / Hide 
Range on Protein: 116-159
Range on HMM: 118-153/279
Sequence Identity: 40% (18 aa)

EERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILL
|||. ..| |.   | |||           ||||| |.| ||..
EERIWHMFIQMCLALRYLHKE--------KQIVHRDLTPNNIMM
Kinase GL50803_2082.AA NEK 9-70 22 0.001738 8.6 In-house 1-63 (286) Show / Hide 
Range on Protein: 9-70
Range on HMM: 1-63/286
Sequence Identity: 22% (15 aa)

YTKGALIGEGRFAKVFLCIPPDSGDL-----YAVKEVVYGGPDQECSSEALLAMLRKEANLFSRLAH
|..   ||.| | ||...     |.      |. |.. .|. ...   .|.    ..|... ..| |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQ----NNEVRILKQLKH
Kinase GL50803_2082.AA Ciliate-E2 9-26 38 0.003507 6.75 In-house 1-18 (365) Show / Hide 
Range on Protein: 9-26
Range on HMM: 1-18/365
Sequence Identity: 38% (7 aa)

YTKGALIGEGRFAKVFLC
| .  .||.| |..|..|
YKFIKKIGQGNFGSVYKC
Kinase GL50803_2082.AA CAMK-Unique 189-214 25 0.015714 3.94 In-house 239-282 (363) Show / Hide 
Range on Protein: 189-214
Range on HMM: 239-282/363
Sequence Identity: 25% (11 aa)

SPYLAP--------------EALAGEPYGAMA----DAWSLGCI
..|.||              | ... .|.       | |||| |
PCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVI
Kinase GL50803_2082.AA NEK-Unclassified 96-159 28 0.028414 2.98 In-house 76-130 (258) Show / Hide 
Range on Protein: 96-159
Range on HMM: 76-130/258
Sequence Identity: 28% (18 aa)

DNGDLATMISEYSQANVRIPEERVLEIFGQLTDVLAYLHETYKTDSAEVHQIVHRNLRPENILL
| |.|   |      |  . | |.   ..|.   ..| |            |.|| |.| || |
DGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQ---------RKIIHRDLKPQNIFL