GL50803_21924

Species: G.lamblia
Alias: GL50803_21924, GK110
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GL50803_21924.AA Protein None 671 None Fasta, JSON
GL50803_21924.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of GL50803_21924.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_21924.AA TKL 128-278 18 3.6e-18 62.02 In-house 138-364 (364) Show / Hide
Range on Protein: 128-278
Range on HMM: 138-364/364
Sequence Identity: 18% (43 aa)

IRQIATALAYLHSVK----RADAEGLVHRDLRSTNISISADGEH-------------FIIAGLELCRNILWSGS-------------------TLIGIG-
...|| ...|||| .    .    ...|||| | || .  ....               |. . |.|.. .||.                   |.. .. 
ALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG

--AHTAPEVLLHN----------------EPSPASDVWSLGVIIYELVTLRMLDFLEDREP------------EDVFVDGWRPDLS------------GV
  .. |||||  .                | |...||.| |....|..| .   . .. ..            . | ..| || .               
TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPD

TDGFMQNVLERIFVLDPGRRPTARELHEML
..  | . ...    ||  ||.. |. . |
CPPSMKKLMQDCWDHDPEKRPSFQEILKRL

S_TKc GL50803_21924.AA S_TKc 25-278 19 2.9e-15 46.98 SMART 1-231 (231) Show / Hide
Range on Protein: 25-278
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

ERLGDILSKDITGIVYSLKDYP---SLVVKVAPLGCLEKDNTDAVRLELAALPELSHPGVLRYHQVIEHMNFVYFITDRYNK---TLGRLLIEHMQMK--
 ...... |   | ||  ..        .|. .         . .| |.. | .  || . ... |... ...|....  .    .| ... ..   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SPVPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNISISADGEHFIIAGLELCRNILWSGSTLIGIGAHTAPEVLLHNEPSP-ASDVWSLGVI
.| |  .. . ..||. ||.|.||       | .||||   || ..    |  |.   |.| .    .|..|     |||||     .. ..|.||.|.|
FPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IYELVTLRMLDFLEDREPEDVFVDGWRPDLSGVTDGFMQNVLERIFVLDPGRRPTARELHE---------ML
.||... . .   .. .  .. .          .. . .  ...... || .|||| |. .          .
LYEMLCGYPPFP-QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_21924.AA Ciliate-E2 69-221 17 2.9e-14 45.36 In-house 82-291 (365) Show / Hide
Range on Protein: 69-221
Range on HMM: 82-291/365
Sequence Identity: 17% (38 aa)

ELAALPELSHPGVLRYHQVIE--HMNFVYFITDRYNK-TLGRLLIEHMQMKSPVPT-------RVILSAIRQIAT---------------ALAYLHSVKR
|.  | .|.|| ..... . .    | .|.... ..  .|  ..... . .   ..       . |.  ..||.                || ||||   
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---

ADAEG-LVHRDLRSTNISISADGEHFIIAGLELCRNI--------------LWSGST---------------------LIGIGAHTAPEVLL--------
   ..  .|||.   || .        |. . |....              ..                         ..|     |||.|         
---KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

-HNEPSPASDVWSLGVIIYELVT
 ... . ..|.||||||.||...
KQKGYDYKCDIWSLGVILYEMLF

Kinase GL50803_21924.AA TK 193-278 20 5.1e-14 42.64 In-house 352-486 (486) Show / Hide
Range on Protein: 193-278
Range on HMM: 352-486/486
Sequence Identity: 20% (27 aa)

TAPEVLLHNE---------PSPASDVWSLGVIIYELVTLRMLDFLEDREPEDVFVD---------------------------GWRPDLSGVTD------
.|||.|....          ...|||||.|| ..|..|.    . ..   .|| .|                             .|   . .|      
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM

-------GFMQNVLERIFVLDPGRRPTARELHEML
        ... .. . . .|| .||| ..|||.|
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase GL50803_21924.AA Ciliate-E2-Unclassified 106-221 21 8.1e-13 40.81 In-house 122-265 (352) Show / Hide
Range on Protein: 106-221
Range on HMM: 122-265/352
Sequence Identity: 21% (32 aa)

GRLLIEHMQMKSPVPTRVIL-----SAIRQIATALAYLHSVKRADAEG-LVHRDLRSTNISISADGE--HFIIAGLELCRNILWS---------------
| .| ..|. .  .. . ..       ..||  .| |||.      ..  .|||.   || .. .|.  .  |... .....  .               
GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH------KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWK

---GSTLIGIGAHT----APEVLLHNEPS----PASDVWSLGVIIYELVT
    .| .|         |||||  ....     ..|.||||||.||...
QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF

TyrKc GL50803_21924.AA TyrKc 31-278 19 8.4e-12 -31.88 SMART 1-280 (280) Show / Hide
Range on Protein: 31-278
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

LSKDIT------GIVYS--LKDYPSLVVKVAPLGCLEKDNTDAVRLELAALPEL--SHPGVLRYHQVIEHM-------NFVYFITDRYNKTLGRLLIEHM
.... .      |.||   .|      ||.   ..       . . |.  . .|  .|| ..| . |. .          .. ..    .  | |. .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLK-DYL

QMKSP-VPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNISISADGEHFIIAGLELCRNILWS------GSTLI---GIGAH-------TAPE
. . | ....  ||   |||   .||||       ...||||   |. ..... .  |.   |.|.|         ...     . |..       .|||
RKHRPKLCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLLHNEPSPASDVWSLGVIIYELVTLRMLDFLED----REPEDVF---VDGWRPDLSGV--------TDGFMQNVLERIFVLDPGRRPTARELHEML
.. ... ...||||| || ..|. |. .    ..     ....|.    .| |..                | .. ..    ||  ||| .|.|| .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase GL50803_21924.AA TK-Unique 194-222 46 3.2e-11 35.04 In-house 204-235 (294) Show / Hide
Range on Protein: 194-222
Range on HMM: 204-235/294
Sequence Identity: 46% (15 aa)

APEVLL--HNEP-SPASDVWSLGVIIYELVTL
|||.|.  |.   .. |||||.||...|..||
APESLKCYHGMYHTTKSDVWSFGVLMWEIFTL

Kinase GL50803_21924.AA AGC 194-221 43 3.3e-11 23.72 In-house 275-300 (395) Show / Hide
Range on Protein: 194-221
Range on HMM: 275-300/395
Sequence Identity: 43% (13 aa)

APEVLLHNEPSPASDVWS--LGVIIYELVT
|||.|     ..| | ||  ||...||..|
APEIL----YGKACDWWSFGLGCLMYEMLT

Kinase GL50803_21924.AA UTK 129-221 26 7.5e-11 33.35 In-house 125-235 (296) Show / Hide
Range on Protein: 129-221
Range on HMM: 125-235/296
Sequence Identity: 26% (31 aa)

RQIATALAYLHSVKRADAEGLVHRDLRSTNISISADG------EHFIIAGLE---LCRNIL------WSGSTLIGIGAH--------TAPEVLLHN-EPS
..|| ...||||       |.|||||   |. . ...      . . ||..    ..|..        .....    .|        .|||.| |.  ..
WDIARGMQYLHSC------GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFT

PASDVWSLGVIIYELVT
 .|||||.||  .|..|
TKSDVWSFGVVCWEIWT

Kinase GL50803_21924.AA Fer 193-279 23 1.4e-09 28.86 In-house 185-283 (283) Show / Hide
Range on Protein: 193-279
Range on HMM: 185-283/283
Sequence Identity: 23% (23 aa)

TAPEVLLHNEPSPASDVWSLGVIIYELVTLRMLDFLE-----------DREPEDVFVDGWRPDLS-GVTDGFMQNVLERIFVLDPGRRPTARELHEMLD
.|||..   . ||..|||| || ..|  |    ....           ..  . . ..| .. .  .. . .|| ....... ||  |||. |....| 
LAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase GL50803_21924.AA LRTK 194-222 55 4.4e-09 27.49 In-house 221-249 (311) Show / Hide
Range on Protein: 194-222
Range on HMM: 221-249/311
Sequence Identity: 55% (16 aa)

APEVLLHNEPSPASDVWSLGVIIYELVTL
.||||     |||||.||.||  ||. |.
PPEVLREQRFSPASDMWSYGVLLYEMWTM

Kinase GL50803_21924.AA Ryk 194-222 55 7.6e-09 23.85 In-house 206-234 (292) Show / Hide
Range on Protein: 194-222
Range on HMM: 206-234/292
Sequence Identity: 55% (16 aa)

APEVLLHNEPSPASDVWSLGVIIYELVTL
..| | |.. | ||||||.||   ||.||
SLESLQHKHYSHASDVWSFGVTMWELMTL

Pkinase GL50803_21924.AA Pkinase 67-154 20 1.3e-08 31.55 Pfam 46-134 (293) Show / Hide
Range on Protein: 67-154
Range on HMM: 46-134/293
Sequence Identity: 20% (20 aa)

RL--ELAALPELSHPGVLRYHQVIEHMNFVYFITDRYNKTLGRLLIEHM-----QMKSPV--PTRVILSAIRQIATALAYLHSVKRADAEGLVHRDL
|.  |.. . .|.|| ..|.. . |  . .|....  ...|   ... .     ... ..  . ... . ..||. .|.|.||       | .||||
RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDL

Kinase GL50803_21924.AA Pkinase 194-221 41 1.9e-08 30.97 Pfam 179-207 (293) Show / Hide
Range on Protein: 194-221
Range on HMM: 179-207/293
Sequence Identity: 41% (12 aa)

APEVLL-HNEPSPASDVWSLGVIIYELVT
||||.. ... .|..|.||.|.|.||...
APEVIRGGQYYGPKVDMWSCGCILYEMLC

Kinase GL50803_21924.AA Pkinase_Tyr 193-222 40 7e-06 20.63 Pfam 181-210 (270) Show / Hide
Range on Protein: 193-222
Range on HMM: 181-210/270
Sequence Identity: 40% (12 aa)

TAPEVLLHNEPSPASDVWSLGVIIYELVTL
.|||.. ... . .||||| || ..|..|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY

Kinase GL50803_21924.AA TK 115-154 34 0.000758 7.93 In-house 228-266 (486) Show / Hide
Range on Protein: 115-154
Range on HMM: 228-266/486
Sequence Identity: 34% (14 aa)

MKSPVPTRVILSAIRQIATALAYLHSVKRADAE-GLVHRDL
.|......  |   .||| ...|||| .    . ..|||||
CKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDL

Kinase GL50803_21924.AA TK-Unique 114-166 27 0.009319 5.48 In-house 123-171 (294) Show / Hide
Range on Protein: 114-166
Range on HMM: 123-171/294
Sequence Identity: 27% (15 aa)

QMKSPVPTRVILSAIRQIATALAYLHS--VKRADAEGLVHRDLRSTNISISADGE
....|.  .  .. . ||| ...||.|   |       ||||| . |. .. |..
PRTEPISPKDLYHFAWQIACGMEYLASQRKKI------VHRDLCARNVLLTEDKV

Kinase GL50803_21924.AA LRTK 125-153 43 0.027626 3.7 In-house 107-130 (311) Show / Hide
Range on Protein: 125-153
Range on HMM: 107-130/311
Sequence Identity: 43% (13 aa)

LSAIR-QIATALAYLHSVKRADAEGLVHRD
. ||  |.| ||..||.       |.||||
MQAIYCQLASALQHLHHC------GIVHRD

Kinase GL50803_21924.AA Ryk 130-154 28 0.032019 2.56 In-house 141-159 (292) Show / Hide
Range on Protein: 130-154
Range on HMM: 141-159/292
Sequence Identity: 28% (7 aa)

QIATALAYLHSVKRADAEGLVHRDL
||. ....||.       ..||.|.
QITMGMMHLHK------HRIVHKDI

Kinase GL50803_21924.AA Pkinase_Tyr 264-278 60 0.052441 7.42 Pfam 256-270 (270) Show / Hide
Range on Protein: 264-278
Range on HMM: 256-270/270
Sequence Identity: 60% (9 aa)

DPGRRPTARELHEML
|| .||| .|.||.|
DPEDRPTFSEIHEQL

Kinase GL50803_21924.AA Pkinase_Tyr 116-159 31 0.155631 5.82 Pfam 105-142 (270) Show / Hide
Range on Protein: 116-159
Range on HMM: 105-142/270
Sequence Identity: 31% (14 aa)

KSPVPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNI
| |...  .|.  .||| ...||.| .      ..||||.  |.
KQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNC

Kinase GL50803_21924.AA Pkinase 253-278 21 0.28833 5.56 Pfam 266-293 (293) Show / Hide
Range on Protein: 253-278
Range on HMM: 266-293/293
Sequence Identity: 21% (6 aa)

MQNVLERIFVLDPGRRPTARELHEM--L
.. ...... .|| .||||... .   .
CKDFIKWCLCKDPKKRPTAEQILQHPWF

Ank GL50803_21924.AA Ank 457-477 42 0.000111 21.14 Pfam 1-21 (33) Show / Hide
Range on Protein: 457-477
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

NGWTALMHAAHCNHPEAVEIL
.|.|.|. |..|.|.| |. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_21924.AA Ank 426-456 27 0.019075 13.08 Pfam 1-33 (33) Show / Hide
Range on Protein: 426-456
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

KKMTALMHAAQQGHTGPIELLVK--EERGLQDK
  .|.|. |.. |||  ...|..   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_21924.AA Ank 401-425 36 4.622174 4.48 Pfam 9-33 (33) Show / Hide
Range on Protein: 401-425
Range on HMM: 9-33/33
Sequence Identity: 36% (9 aa)

AARTNETETVRMLVNEGVYIGQRDE
|.| . || |.||.. |  .  .| 
ACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_21924.AA Ank 488-508 28 0.084969 10.74 Pfam 1-21 (33) Show / Hide
Range on Protein: 488-508
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

NSRTALMVAAENGSAEAASIL
. .|.|..|...|..| .. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_21924.AA Ank 519-539 38 0.025915 12.6 Pfam 1-21 (33) Show / Hide
Range on Protein: 519-539
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

EGNTALMIAEKAGHKLVAEIL
.|.|.|..| . ||. |.. |
DGFTPLHLACRCGHTEVVKML

Ank GL50803_21924.AA Ank 545-568 41 2.4e-05 23.57 Pfam 1-24 (33) Show / Hide
Range on Protein: 545-568
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

DGCTALMQAAKCGRIDAVKLLIKN
||.|.|. |..||... ||.|...
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_21924.AA Ank 576-599 45 2.9e-05 23.26 Pfam 1-24 (33) Show / Hide
Range on Protein: 576-599
Range on HMM: 1-24/33
Sequence Identity: 45% (11 aa)

LGTTALMEAASWGHSEIVKLLIDH
 | |.|. |...|| |.||.|..|
DGFTPLHLACRCGHTEVVKMLLQH

Ank GL50803_21924.AA Ank 607-637 27 0.006084 14.87 Pfam 1-33 (33) Show / Hide
Range on Protein: 607-637
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

FGATALITAIRNNQLECAKLLVE--RERDIKDK
 | |.|  |.|....|..|.|..   . ...|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD