Gene GL50803_24400 (G.lamblia)
GL50803_24400
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_24400.AA | Protein | None | 572 | None | Fasta, JSON |
| GL50803_24400.kin_dom | Protein Kinase Domain | None | 258 | None | Fasta, JSON |
Protein domains of GL50803_24400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_24400.AA | Pkinase | 233-327 | 24 | 6.1e-17 | 60.99 | Pfam | 178-293 (293) | Show / Hide |
Range on Protein: 233-327 Range on HMM: 178-293/293 Sequence Identity: 24% (29 aa) MAPEVIVDPMHMTSASDIWSVGAVFYELLT-LHPFAGDYPATDIDGLLQRLYERLG--VIPPELPGYS-------------------EDITHLIRCMLHM |||||| . . ....|.||.| ..||.|. || |. .| . .|......| . .. .| |. ..|...|.. MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DPRRRPSIEELLTNKHM || .||..|..| . . DPKKRPTAEQILQHPWF |
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| Kinase | GL50803_24400.AA | NEK1 | 248-327 | 38 | 9.5e-15 | 47.74 | In-house | 202-276 (276) | Show / Hide |
Range on Protein: 248-327 Range on HMM: 202-276/276 Sequence Identity: 38% (31 aa) SDIWSVGAVFYELLTL-HPFAGDYPATDIDGLLQRLYERLGVIPPELPGYSEDITHLIRCMLHMDPRRRPSIEELLTNKHM ||||| | | |||.|| ||| | | . . | .|| | ||... |. |. .|| |||. .|. . SDIWSLGCVLYELCTLKHPFE----ANNWKNLVLKICQ--GTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| S_TKc | GL50803_24400.AA | S_TKc | 70-330 | 20 | 1.4e-13 | 22.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 70-330 Range on HMM: 1-231/231 Sequence Identity: 20% (59 aa) PRYIKYIAKGAIGKVF--VHEA-------KVVNLVTNARPSWLKTMRTLLNLKHCNVSSYLAVEKRGACIYVA-ECCAE-LKTVRTLIESARTIK--RYV . .. | ||| |||. .| |... . .. .. | . .| |. .. | ..|. |.| | .....|.. .. . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF KESVVWEILYHVLSGLAYLHMYARNTIPWAETIVHGAITPDNILLLDDEVAVLS----SCALWELFPVTWFDINNPSTYL-----MAPEVIVDPMHMTSA | ... ..| ....|.|.| |.| . |.|||| . . .. .. | .|. |||||. . . . PE-HARFYMYQICCALEYCH---------SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCK SDIWSVGAVFYELLT-LHPFAGDYPATDIDGLLQRLYERLGVIPPELPGYSEDITHLIRCMLHMDPRRRPSIEELLT----NKHMLYT .|.||.| ..||.|. || .|......| |.. ..|| .|..||..||.. |.|. | . . CDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_24400.AA | ULK | 233-327 | 26 | 1.1e-12 | 40.64 | In-house | 218-329 (329) | Show / Hide |
Range on Protein: 233-327 Range on HMM: 218-329/329 Sequence Identity: 26% (30 aa) MAPEVIVDP----MHMTSASDIWSVGAVFYELLTLH-PFAGDYPATDIDGLLQRLYER-------LGVIPPELPG------YSEDITHLIRCMLHMDPRR |||... . . .. .||||.| .|||.|. || . . .... .|.|.. .|.. | |... |||.|| |.. MAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKD RPSIEELLTNKHM | |.|||. .. . RISWEELFNHPWF |
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| Kinase | GL50803_24400.AA | ULK | 233-327 | 25 | 2.3e-12 | 40.23 | In-house | 214-324 (324) | Show / Hide |
Range on Protein: 233-327 Range on HMM: 214-324/324 Sequence Identity: 25% (28 aa) MAPEVIVDP----MHMTSASDIWSVGAVFYELLTLH-PFAGDYPATDID---GLLQR-------LYERLGVIPP--ELPGYSEDITHLIRCMLHMDPRRR |||... . . .. .||||.| .|||.|. || .. . .... |.. . . .|. . | |... |||.|| |.. | MAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR PSIEELLTNKHM |.||.. .. . ISWEEIFNHPWF |
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| Kinase | GL50803_24400.AA | STE | 233-329 | 22 | 2.8e-11 | 36.19 | In-house | 229-359 (359) | Show / Hide |
Range on Protein: 233-329 Range on HMM: 229-359/359 Sequence Identity: 22% (30 aa) MAPEVIVDPM-----HMTSASDIWSVGAVFYELLTLHPFAGDYPATDIDGLLQRLYERLG---------VIPPELPG--------------------YSE |||||| . . .||||.| . |..| .| |.. . . .. | || || .|. MAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSP DITHLIRCMLHMDPRRRPSIEELLTNKHMLY . . |. | .||. ||. ..|| . | EFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_24400.AA | NEK4 | 248-327 | 37 | 3.2e-11 | 36.71 | In-house | 183-257 (257) | Show / Hide |
Range on Protein: 248-327 Range on HMM: 183-257/257 Sequence Identity: 37% (30 aa) SDIWSVGAVFYELLTL-HPFAGDYPATDIDGLLQRLYERLGVIPPELPGYSEDITHLIRCMLHMDPRRRPSIEELLTNKHM ||||| | ||. || | | | |.. |. .. . | || | ||.|. |.. || | .|||| ... . SDIWSLGCCVYEMITLKHAFD----AKDMNSLIYQIIQ--GQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | GL50803_24400.AA | CMGC | 234-327 | 13 | 3.4e-11 | 32.11 | In-house | 293-513 (513) | Show / Hide |
Range on Protein: 234-327
Range on HMM: 293-513/513
Sequence Identity: 13% (29 aa)
APEVIVDP---------MHMTSASDIWSVGAVFYELLT---------LHPFAGDYP-------ATDIDGLLQRLYERLGVIP---------------PE-
|||... || |.. |.|||| .|.|..| | |. .. |.. . || .. .|
APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEE
---------------------------------------LPGYS-----------------------------------------------EDITHLIRC
.| . .. .|.
WPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKK
MLHMDPRRRPSIEELLTNKHM
||..|| .|...|. |
MLQYDPDKRITAEQALQHPYF
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| Kinase | GL50803_24400.AA | NEK | 248-327 | 34 | 4.7e-11 | 35.55 | In-house | 205-286 (286) | Show / Hide |
Range on Protein: 248-327 Range on HMM: 205-286/286 Sequence Identity: 34% (31 aa) SDIWSVGAVFYELLTL---HPFAGDYPATDIDGL-LQRLYERLGVI-PPE-LP-G--YSEDITHLIRCMLHMDPRRRPSIEELLTNKHM |||||.| | ||. || ||| .. | . . || . .. .| ||.| ||. ||. || |||....| . . SDIWSLGCVLYEMCTLKPKHPFEAW------D-MNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_24400.AA | TKL | 233-322 | 22 | 1.7e-10 | 34.0 | In-house | 240-361 (364) | Show / Hide |
Range on Protein: 233-322 Range on HMM: 240-361/364 Sequence Identity: 22% (27 aa) MAPEVIVDPMHMTSAS---------------DIWSVGAVFYELLTL-HPFAGDYPATDIDG-------LLQRLYERLGVIP---------PELPGYSEDI |||||. . | |... |..| | |..|.|| .|.... . . | . . . . || . | ... MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSM THLIRCMLHMDPRRRPSIEELL |. . ..||. ||| .|.| KKLMQDCWDHDPEKRPSFQEIL |
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| Kinase | GL50803_24400.AA | WEE | 293-327 | 31 | 6.8e-10 | 29.44 | In-house | 263-297 (297) | Show / Hide |
Range on Protein: 293-327 Range on HMM: 263-297/297 Sequence Identity: 31% (11 aa) LPGYSEDITHLIRCMLHMDPRRRPSIEELLTNKHM . ..|.. . ||. |.| ||..||....|| . . DNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | GL50803_24400.AA | NEK2 | 296-327 | 37 | 1.2e-08 | 25.14 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 296-327 Range on HMM: 288-319/319 Sequence Identity: 37% (12 aa) YSEDITHLIRCMLHMDPRRRPSIEELLTNKHM ||.. .| |. |.. ||||||.| . YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| TyrKc | GL50803_24400.AA | TyrKc | 70-328 | 14 | 6.6e-07 | -110.99 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 70-328
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)
PRYIKYIAKGAIGKVFVHEA------KVVNLVTNARPSWLKTMRTLLNL--KHCNVSSYLAVEKR--------GACIYVAECCAELKTVRTLIESARTIK
. .| . || |.|. .. |... . | .. .| . .| .| |. ..| . | | .. | .. ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
RYVKESVVWEILYHVLSGLAYLHMYARNTIPWAETIVHGAITPDNILLLDDE----------VAVLSS----------CA-----LWELFPVTWFDINNP
.. . .. . . .| .||| ..| . |.|. .. .. . . ..|. |
--LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW------
STYLMAPEVIVDPMHM--TSASDIWSVGAVFYELLTL--HPFAG---DYPATDIDGLLQRLYERLGVIPPEL------PGYSEDITHLIRCMLHMDPRRR
||||.| .. |..||.|| | . .|..|. | | . . ..... .. .|. .. .... .... | || |
----MAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR
PSIEELLTNKHML
|. .|. .. .
PTFSEI---HECF
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| Kinase | GL50803_24400.AA | NEK2 | 231-265 | 45 | 7e-06 | 15.59 | In-house | 229-262 (319) | Show / Hide |
Range on Protein: 231-265 Range on HMM: 229-262/319 Sequence Identity: 45% (16 aa) YLMAPEVIVDPMHMTSASDIWSVGAVFYELLTLHP | | ||.. . . ||||||| . ||. .||| YYMSPEQMHG-QKYNEKSDIWSVGCLIYEMCALHP |
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| Kinase | GL50803_24400.AA | WEE | 233-262 | 40 | 0.003666 | 6.54 | In-house | 200-231 (297) | Show / Hide |
Range on Protein: 233-262 Range on HMM: 200-231/297 Sequence Identity: 40% (13 aa) MAPEVIVDPMHMTSA--SDIWSVGAVFYELLT ||||.. . |.| . .|| | |...||| . MAPEILQGYYHYTHLYKADIFSLGITIYELAC |
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| Kinase | GL50803_24400.AA | TKL | 164-204 | 18 | 0.022257 | 4.39 | In-house | 137-176 (364) | Show / Hide |
Range on Protein: 164-204 Range on HMM: 137-176/364 Sequence Identity: 18% (9 aa) ILYHVLSGLAYLHM-----YARNTIPWAET--IVHGAITPDNILLLDD . . . .|..|||. . . |.| ....|||. .. WALDIARGMNYLHSMNPKWCT--------KPPIIHRDLKSKNILVDEN |
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| Kinase | GL50803_24400.AA | WEE | 153-176 | 29 | 0.029462 | 3.46 | In-house | 105-128 (297) | Show / Hide |
Range on Protein: 153-176 Range on HMM: 105-128/297 Sequence Identity: 29% (7 aa) KRYVKESVVWEILYHVLSGLAYLH ... |. .| || ... ||...| NHWLPEWMIWQILVDICQGLHHIH |
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| Kinase | GL50803_24400.AA | NEK | 145-176 | 20 | 0.048504 | 3.45 | In-house | 97-131 (286) | Show / Hide |
Range on Protein: 145-176 Range on HMM: 97-131/286 Sequence Identity: 20% (7 aa) L---IESARTIKRYVKESVVWEILYHVLSGLAYLH . |. . . | |...|..... ...| |.| KIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMH |
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| Kinase | GL50803_24400.AA | STE | 153-176 | 36 | 0.230044 | 0.73 | In-house | 145-169 (359) | Show / Hide |
Range on Protein: 153-176 Range on HMM: 145-169/359 Sequence Identity: 36% (9 aa) KRYVKESVVWEILYHVLSG-LAYLH . ...||.. |.. .| | |.||| QHRFPESQIAYICRQILKGLLYYLH |
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| Ank | GL50803_24400.AA | Ank | 422-447 | 26 | 0.000315 | 19.51 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 422-447 Range on HMM: 1-26/33 Sequence Identity: 26% (7 aa) DGMTALMYAALFNNSLAINYLIDKEA ||.|.|..|.. .. . .|... | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_24400.AA | Ank | 453-473 | 23 | 17.767721 | 2.37 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 453-473 Range on HMM: 1-21/33 Sequence Identity: 23% (5 aa) DGNSALIFAIHSNFRCCAELL ||...| |.... ....| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_24400.AA | Ank | 484-514 | 21 | 0.027448 | 12.51 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 484-514 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) VGETALMYATRRRYDNIIRTLVR--KETGIQNN |.|.|..| |. . .... |. . .|.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_24400.AA | Ank | 515-535 | 38 | 1.233029 | 6.55 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 515-535 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) SGDTALIIAIRANYKEGVRIL |.|.| .|.| ...| |. | DGFTPLHLACRCGHTEVVKML |
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