Gene GL50803_42328 (G.lamblia)

GL50803_42328

Species: G.lamblia
Alias: GK221, GL50803_42328
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_42328.AA Protein None 536 None Fasta, JSON
GL50803_42328.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of GL50803_42328.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_42328.AA Ciliate-E2 85-267 19 3.4e-13 41.61 In-house 113-365 (365) Show / Hide 
Range on Protein: 85-267
Range on HMM: 113-365/365
Sequence Identity: 19% (51 aa)

TEYLQGENLSALLDRHIKQQNPV-------EEEEIWSIARSVAD---------------ALAHLHSKFNPMGPLVYKALRPENILIAGIGVYKLCDCWCG
.||.|| .|  ..  . |..|          |.||  | . ...               || .||||    .. ..  . |||||.      |..|    
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK----NNIIHRDIKPENILF-----IKIIDF---

GISMSATIDETN-------QDWIYSA------------------------GNLYRAPEQMSSKT---------HTTKTDIWSFGSLLLHLCKPDL--LIN
|.|  ...|. |       . ...                             | |||  ..|          ...| ||||.| .|  ..   .  ...
GLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQ

QQNESLDFQHV--------------NLSEYSINLTNMIGK----CLLSDPQSRPS-AAELLLHIQY
...  .||.                .  . | .  ..| |    .|  ||. |.. . ..| |   
IKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_42328.AA Ciliate-E2-Unclassified 85-267 16 5.7e-13 41.36 In-house 100-352 (352) Show / Hide 
Range on Protein: 85-267
Range on HMM: 100-352/352
Sequence Identity: 16% (42 aa)

TEYLQGENLSALLD-------------RHIKQQNPVEEEEIW-----SIARSVADALAHLHSKFNPMGPLVYKALRPENILIAGIG---VYKLCDCWCGG
.||..| .|.  .              ...||.. ..|...       ... . ..| .||.|    .  ..  . |||||.   |     |..|    |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK----NNIIHRDIKPENILFDNNGKNYYIKIIDF---G

ISMSAT----------------IDETNQDWIYSAGNL--YRAPEQMSSKTHT----TKTDIWSFGSLLLHLCKPDLLINQQN------------------
||.                   ...  .. . . . .  | ||| . .. .      | ||||.| .|  ..   .  ...|                  
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

ESLDFQH---------------VNLSEYSINLTN-MIGKCLLSDPQSRPSAAELLLHIQY
. .. ..                ..|.  ... | .. |.|  .| .|... ..| |   
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
S_TKc GL50803_42328.AA S_TKc 21-267 20 2.5e-12 3.91 SMART 14-231 (231) Show / Hide 
Range on Protein: 21-267
Range on HMM: 14-231/231
Sequence Identity: 20% (55 aa)

TVYIARRLVDDTFVLVKDIDLHELDSVDRTEILAFYDRFSSLDTESVVKIHRIWPRKEDRLLVETEYLQG--ENLSALLDRHIKQQNP--VEEEEIWSIA
.|| .|   ..  | .| |.        | ||          . . .||.. ..    |.| . .||. |   .|  ..... .. ..    | ......
KVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

RSVADALAHLHSKFNPMGPLVYKALRPENILIAGIGVYKLCD---CWCGGISMSATIDETNQDWIYSAGNLYRAPEQMSSKTHTT-KTDIWSFGSLLLHL
. ...||...||. .     ..  | |||||.    . |.||   .                   .     |.||| .    ... | |.||.| .|  .
YQICCALEYCHSH-G----IIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CKPDLLINQQNESLDFQHVNLSEYSINLTNMIGKCLLSDPQSRPSAAELLL-------HIQY
.    .    .. . |...     |  . ..| |||  ||. ||.| |.|        |   
LCGYPPFP--QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_42328.AA NRBP 52-268 25 3.3e-12 38.94 In-house 42-261 (261) Show / Hide 
Range on Protein: 52-268
Range on HMM: 42-261/261
Sequence Identity: 25% (57 aa)

ILAFYDRFSSLDTESVVKIHRIW---PRKEDRLLVETEYLQGENLSALLDRHIKQQNPVEEEEIWSIARSVADALAHLHSKFNPMGPLVYKALRPENILI
| . .|.   || . .||.|. |    ... |..  |||.    ... | .  |..  ..|.     .  .  ||..|||  .|  |..   |  . | |
IRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNMNEKAWKRWCTQILSALSYLHS-CDP--PIIHGNLTCDTIFI

AGIGVYKLCDCWCGGISMSATIDETNQDWIYSAGNLYRAPEQM--SSKTHTTKTDIWSFGSLLLHLCKPDLL---INQQNESLDFQHVNLSEYSI---NL
   |. |.   |   |  .      ..  ..     . |||      .  ||  ||.|||   | .   . .    | . | .  . .. .  |.   . 
QHNGLIKIGCVWPDAIHHHVRTCREEMRNMH-----FFAPEYGILEVTDLTTAVDIYSFGMCALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQ

TNMIGKCLLSDPQSRPSAAELLLHIQYL
 ..| ||| .||. |||| ||| |   .
RDFIRKCLQKDPARRPSARELLFHQILF
Kinase GL50803_42328.AA TKL 85-265 14 1.3e-11 38.06 In-house 117-364 (364) Show / Hide 
Range on Protein: 85-265
Range on HMM: 117-364/364
Sequence Identity: 14% (39 aa)

TEYLQGEN-LSALLDRHIKQQNPVEEEEIWSIARSVADALAHLHS------KFNPMGP--LVYKALRPENILIAGIGV--------------YKLCDCWC
.|| .| . |. |.            . . ..|...| ....|||      .     .  ...  | ..|||.   .                |.||   
MEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF--

GGISMSATIDETNQDWIYSAGN------------------LYRAPEQMSSK----------------THTTKTDIWSFGSLLLHLCK---PDL-LINQ--
 |.| . . .. ..|. .. ..                   . ||| .  .                . ..|.|..||| .|  ..    |   . .   
-GLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM

----------QNESLDFQHVNLSEYSIN-------------LTNMIGKCLLSDPQSRPSAAELLLHI
             ......  . .   |             . . . .|  .||..|||. |.| ..
IFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_42328.AA STE 187-264 20 3.1e-10 32.46 In-house 230-356 (359) Show / Hide 
Range on Protein: 187-264
Range on HMM: 230-356/359
Sequence Identity: 20% (26 aa)

APEQMSS------KTHTTKTDIWSFGSLL-------LHLCK-PDL----LINQQNESLD---------FQHVNLSE--------------------YSIN
||| ..       | ..|| ||||.| ..         ... ...    .|.. . . .         ...  | .                    .| .
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LTNMIGKCLLSDPQSRPSAAELLL--H
. . | |||  ||. ||.| .||   |
FKDFINKCLQKDPNKRPTASQLLKSEH
Kinase GL50803_42328.AA Pkinase 185-265 19 4.4e-08 29.65 Pfam 177-293 (293) Show / Hide 
Range on Protein: 185-265
Range on HMM: 177-293/293
Sequence Identity: 19% (23 aa)

YRAPEQMS-SKTHTTKTDIWSFGSLLLHLCK------PD----------LLINQQNESLDFQHVNLSEYS-----------------INLTNMIGKCLLS
|.|||    .. ...| |.||.| .|  ..        .          .. .     |.|.  .... |                  ..   | .||  
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPQSRPSAAELLLH--I
||..||.|...| |  .
DPKKRPTAEQILQHPWF
TyrKc GL50803_42328.AA TyrKc 21-265 16 3e-07 -105.44 SMART 14-280 (280) Show / Hide 
Range on Protein: 21-265
Range on HMM: 14-280/280
Sequence Identity: 16% (49 aa)

TVYIARRLVDDTFVLVKDIDLHELDSVDRTEILAFYDRFSSL--DTESVVKIHRIWPRKE------DRLLVETEYLQGENLSALLDRHIKQQNPVEEEEI
.|| ..     . | || .  .      | ...      ..|  . . .|... .   ..      . |.. .||  . .|   | .| ..   .  .. 
EVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDL

WSIARSVADALAHLHSKFNPMGPLVYKALRPENILIAGIGVYKLCDCWCGGISMSATIDET-----NQDWIYS----AGN--L---YRAPEQMSSKTHTT
 |..  .|.  ..||||     ...   |   |.|..  .. | .|       .|  |..      ..| . .     |.  |     ||| .  .. ||
LSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISD-----FGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDIWSFGSLL-----------LHL----CKPDLLIN--QQNESLDFQHVNLSE-----YSINLTNMIGKCLLSDPQSRPSAAELLLHI
|.|.|||| ..                  .... .|.  .| . ..  . .. .      .  . ... .|   || .||. .|.   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_42328.AA GCN2 86-129 27 8e-06 15.95 In-house 287-327 (511) Show / Hide 
Range on Protein: 86-129
Range on HMM: 287-327/511
Sequence Identity: 27% (12 aa)

EYLQGENLSALLDRHIKQQNPVEEEEIWSIARSVADALAHLHSK
||..| .|. ..| |  .. ..   |.|...| . ..|...||.
EYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQ
Kinase GL50803_42328.AA STE20 234-264 38 2e-05 16.11 In-house 255-285 (288) Show / Hide 
Range on Protein: 234-264
Range on HMM: 255-285/288
Sequence Identity: 38% (12 aa)

SEYSINLTNMIGKCLLSDPQSRPSAAELLLH
. .| .. ... |||  ||. ||.| .|| |
HKWSPEFHDFVDKCLQKDPEKRPTASQLLKH
Kinase GL50803_42328.AA PEK 85-129 12 2.3e-05 13.83 In-house 362-446 (655) Show / Hide 
Range on Protein: 85-129
Range on HMM: 362-446/655
Sequence Identity: 12% (11 aa)

TEYLQGENLSALLDRH-------------------IKQQN---------------------PVEEEEIWSIARSVADALAHLHSK
.|| ....|. ..|..                   ... |                      ......|.|.| ....|...||.
MEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQ
Kinase GL50803_42328.AA BIKE 185-213 53 2.5e-05 15.01 In-house 182-213 (267) Show / Hide 
Range on Protein: 185-213
Range on HMM: 182-213/267
Sequence Identity: 53% (17 aa)

YRAPEQM---SSKTHTTKTDIWSFGSLLLHLC
|||||     | |. ||| |||  | .|  ||
YRAPEMIDLYSGKEITTKADIWALGCMLYKLC
Kinase GL50803_42328.AA NEK 234-267 36 7.1e-05 13.54 In-house 251-286 (286) Show / Hide 
Range on Protein: 234-267
Range on HMM: 251-286/286
Sequence Identity: 36% (13 aa)

SE--YSINLTNMIGKCLLSDPQSRPSAAELLLHIQY
|   ||  | |.| ..|  ||..|||. ..| . . 
SHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_42328.AA BIKE 82-158 26 8.2e-05 13.11 In-house 77-151 (267) Show / Hide 
Range on Protein: 82-158
Range on HMM: 77-151/267
Sequence Identity: 26% (21 aa)

LVETEYLQGENLSALLDRHIKQQNPVEEEEIWSIARSVADALAHLHSKFNPMGPLVYKALRPENILIAGIG--VYKLCD
.. .|| .. .. ... . ..|     |.|. .|   |. | . ||   .   | .   |. ||||.   |   | |||
MILMEYCRH-QVVNMMNQRLQQGQYFTEQEVLQIFCDVCEAVSRLH---HCQTPIIHRDLKVENILLHDHGPPHYVLCD
Kinase GL50803_42328.AA Pkinase 67-158 22 0.000205 16.69 Pfam 62-155 (293) Show / Hide 
Range on Protein: 67-158
Range on HMM: 62-155/293
Sequence Identity: 22% (23 aa)

VVKIHRIWPRKEDRLLVETEYLQG-ENLSALLDRHIK--QQNPV--EEEEIWSIARSVADALAHLHSKFNPMGPLVYKALRPENILIAGIGVY----KLC
.|...... . .|.. . .||..| .   . | ..|.  .....  .|.|. .... .. .|...||.       ..  | ||||||   |.     |.|
IVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKIC

D
|
D
Kinase GL50803_42328.AA GCN2 239-267 48 0.000262 10.51 In-house 483-511 (511) Show / Hide 
Range on Protein: 239-267
Range on HMM: 483-511/511
Sequence Identity: 48% (14 aa)

NLTNMIGKCLLSDPQSRPSAAELLLHIQY
. . || .||  |||.|||| .|| |  .
DQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase GL50803_42328.AA PEK 184-206 35 0.000272 10.0 In-house 554-581 (655) Show / Hide 
Range on Protein: 184-206
Range on HMM: 554-581/655
Sequence Identity: 35% (10 aa)

LYRAPEQMSSK-----THTTKTDIWSFG
||..||| | .      ...|.|..| |
LYMSPEQLSGQHYQKSHYNHKVDMYSLG
Kinase GL50803_42328.AA STE20 187-206 40 0.000318 11.68 In-house 190-214 (288) Show / Hide 
Range on Protein: 187-206
Range on HMM: 190-214/288
Sequence Identity: 40% (10 aa)

APEQMSS-----KTHTTKTDIWSFG
||| ..      | ...|.||||.|
APEVIQCMEGPDKGYDYKCDIWSLG
Kinase GL50803_42328.AA STE 86-129 21 0.00048 10.32 In-house 117-171 (359) Show / Hide 
Range on Protein: 86-129
Range on HMM: 117-171/359
Sequence Identity: 21% (12 aa)

EYLQGENLSALLD-RHIKQQN---------PVEEEEIWSIARSVADA-LAHLHSK
||. |  |. ... .......         ...|..|  |.|..  . |..|||.
EYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH
Kinase GL50803_42328.AA GCN2 184-213 25 0.0009 8.6 In-house 418-447 (511) Show / Hide 
Range on Protein: 184-213
Range on HMM: 418-447/511
Sequence Identity: 25% (8 aa)

LYRAPEQMSSKTHTTKTDIWSF-GSLLLHLC
.|..|||  .. ...| |..|  | ... ..
FYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMW
Kinase GL50803_42328.AA NEK 185-213 41 0.007638 6.31 In-house 190-218 (286) Show / Hide 
Range on Protein: 185-213
Range on HMM: 190-218/286
Sequence Identity: 41% (12 aa)

YRAPEQMSSKTHTTKTDIWSFGSLLLHLC
| .||....|  . | ||||.| .| ..|
YMSPEVCQNKPYNNKSDIWSLGCVLYEMC
Kinase GL50803_42328.AA PEK 239-267 37 0.010136 4.43 In-house 627-655 (655) Show / Hide 
Range on Protein: 239-267
Range on HMM: 627-655/655
Sequence Identity: 37% (11 aa)

NLTNMIGKCLLSDPQSRPSAAELLLHIQY
.. ..| ..|  ||| |||| ..| |  .
KQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase GL50803_42328.AA NEK 97-129 30 0.024134 4.53 In-house 94-133 (286) Show / Hide 
Range on Protein: 97-129
Range on HMM: 94-133/286
Sequence Identity: 30% (12 aa)

LDRH---IKQQN----PVEEEEIWSIARSVADALAHLHSK
|...   ||.|     . |||.|| .    . || ..|..
LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDR
Kinase GL50803_42328.AA STE20 86-129 32 0.029804 4.39 In-house 88-136 (288) Show / Hide 
Range on Protein: 86-129
Range on HMM: 88-136/288
Sequence Identity: 32% (16 aa)

EYLQGENLSALLDRHIKQQN-----PVEEEEIWSIARSVADALAHLHSK
||..|  |. ......| ..     | .||.|  | | |  .|..|||.
EYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN
Ank GL50803_42328.AA Ank 321-333 46 2.305004 5.57 Pfam 4-16 (33) Show / Hide 
Range on Protein: 321-333
Range on HMM: 4-16/33
Sequence Identity: 46% (6 aa)

TPLMLAAEKGNVD
|||.||...|...
TPLHLACRCGHTE
Ank GL50803_42328.AA Ank 347-376 33 0.196099 9.43 Pfam 1-33 (33) Show / Hide 
Range on Protein: 347-376
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

WQGTALIKAARKGHVECVSALLS---ELGIQSR
   |.|  |.|.||.|.|. ||.   .. .| .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_42328.AA Ank 377-398 27 2.956599 5.18 Pfam 1-22 (33) Show / Hide 
Range on Protein: 377-398
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

RGWTALQDAAYSGQKACIPLLM
 |.|.|  |...|.. .. .|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_42328.AA Ank 407-427 52 0.000163 20.54 Pfam 1-21 (33) Show / Hide 
Range on Protein: 407-427
Range on HMM: 1-21/33
Sequence Identity: 52% (11 aa)

DGHTALMGAARNGHQDCVKLL
|| |.|. |.|.|| ..||.|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_42328.AA Ank 438-463 34 4e-06 26.5 Pfam 1-25 (33) Show / Hide 
Range on Protein: 438-463
Range on HMM: 1-25/33
Sequence Identity: 34% (9 aa)

SGRTALMYAAENNHPQCVRLLLDEAG
 |.|.|..|....|...|..||. .|
DGFTPLHLACRCGHTEVVKMLLQ-HG
Ank GL50803_42328.AA Ank 468-488 42 0.012201 13.78 Pfam 1-21 (33) Show / Hide 
Range on Protein: 468-488
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

SGNTALILATLEGNVECVALL
 |.|.| || . |..|.| .|
DGFTPLHLACRCGHTEVVKML