Gene GL50803_4322 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_4322.AA | Protein | None | 1003 | None | Fasta, JSON |
| GL50803_4322.kin_dom | Protein Kinase Domain | None | 302 | None | Fasta, JSON |
Protein domains of GL50803_4322.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_4322.AA | AGC | 207-250 | 32 | 4.3e-11 | 23.41 | In-house | 275-300 (395) | Show / Hide |
Range on Protein: 207-250 Range on HMM: 275-300/395 Sequence Identity: 32% (15 aa) APEILNALATPTPPGISAYDANTACCGAAPDLWS--LGIILYEMMA ||||| .| | | || ||...|||.. APEIL--------------------YGKACDWWSFGLGCLMYEMLT |
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| S_TKc | GL50803_4322.AA | S_TKc | 12-316 | 16 | 5.5e-11 | -15.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-316 Range on HMM: 1-231/231 Sequence Identity: 16% (52 aa) FYSSTILSRRKYVTVLLGTTYTTPEPHVAKLYNMKEIRESSLLQFVNDPHCLQYIQHPRLLRCYGCRVNPRRDTVTLFEEFGQV---SLQKLILEHRKTG . .. . . .| ... ... .|.|. .. . .|. .|| . ..|.. .. | . .. |. .| ..| .... | YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG KC--FSESALWSIAAAVASLLQYLHQHDNKTFYNAVSNNTINMGSMVHGNLKPSNVYITHQKDISSFGLSDVKITHPAIYRNFGTSRNSAGKQIDELI-- .. |.| ..... ... |.|.|.| .| |||.|. ... .||. || .| . .. LRFPFPE-HARFYMYQICCALEYCHSHG-----------------IIHRDLKPENILLDE----------HIKIC------DFGLARQL-----TTFCGT --YHAPEILNALATPTPPGISAYDANTACCGA-APDLWSLGIILYEMMALAKPSHTNQTVLSRLDNHNPGTITAMPDLDLSDTYSTDLLNVITQLLSPDP | |||.| | . | ||.|.|||||.. | . .. .. .. | .... | ..| || PWYMAPEVL-------------------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------------SPEAKDFIRKCLQKDP LQRPRIQSLLL-------TGPI .|| . .| . EKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_4322.AA | NEK | 281-316 | 39 | 1.6e-07 | 23.01 | In-house | 249-286 (286) | Show / Hide |
Range on Protein: 281-316 Range on HMM: 249-286/286 Sequence Identity: 39% (15 aa) LSDT--YSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI .... ||.|| |.|.|.| .|| ||| ....| . | IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| TyrKc | GL50803_4322.AA | TyrKc | 18-320 | 15 | 5e-07 | -108.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 18-320
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)
LSRRKYV------TVLLGTTYTTPEPHVAKLYN--MKEIRESSLLQFVNDPHCLQYI--QHPRLLRCYGCRVNPR------RDTVTLFEEFGQVSLQKLI
.. | .| .|| . .. | ..|... | . . . .|| ..|.||. . . ..| .|.. .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL
LEHRKTGKCFSESALWSIAAAVASLLQYLHQHDNKTFYNAVSNNTINMGSMVHGNLKPSNVYITHQKDISSFGLSDVKITHPAIYRNFGTSRNSAGK---
.||.. .. . | |.. .|. .|||.. .| | |. ..... |||. || ||. .
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------------NCIHRDLAARNCLVGENH--------TVKIS------DFGLSRDIYDDDQQ
-----QI-------DE--LIYH--APEILNALATPTPPGISAYDANTACCGAAPDLWSLGIILYEMMALAKPSH--------TNQTVLSRLDNHNPGTIT
. | . ||| . |. .. . | || |. ..|.. . .. . .|| |. .... |
GESKDYYRKKEHKGGKTMLPIRWMAPECI----------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ---GYRM
AMPDLDLSD----TYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPIMSIL
|. |. . .... ....| || .||. . . ...
PQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
|
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| Kinase | GL50803_4322.AA | NEK6 | 237-307 | 36 | 6.4e-07 | 18.54 | In-house | 185-252 (252) | Show / Hide |
Range on Protein: 237-307 Range on HMM: 185-252/252 Sequence Identity: 36% (26 aa) DLWSLGIILYEMMALAKPSHTNQTVLSRLDNHNPGTITAMPDLDLSDTYSTDLLNVITQLLSPDPLQRPRI |.|||| .|||| || | . | | | | .| ||..| . .. . ||| .|| | DIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKI--EQCDYPPLP-ADHYSEQLRQLVCMCIHPDPEWRPDI |
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| Kinase | GL50803_4322.AA | NEK1 | 281-316 | 25 | 2e-06 | 18.39 | In-house | 241-276 (276) | Show / Hide |
Range on Protein: 281-316 Range on HMM: 241-276/276 Sequence Identity: 25% (9 aa) LSDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI .. .||..| . ..|... .| || ....| . | IPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | GL50803_4322.AA | STE-Unique | 237-316 | 18 | 1.3e-05 | 15.28 | In-house | 535-616 (616) | Show / Hide |
Range on Protein: 237-316 Range on HMM: 535-616/616 Sequence Identity: 18% (15 aa) DLWSLGIILYEMMALAKPSHTNQTVLSR-LDNHNPGTITAM--PDLDLSDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI | ||||... .| . | ........ . .... . |. . . .. .. | .|...| .||.. || . DIWSLGCMCFHMCCGCPP-WHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL |
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| Kinase | GL50803_4322.AA | NEK8 | 280-317 | 31 | 1.5e-05 | 11.65 | In-house | 242-278 (278) | Show / Hide |
Range on Protein: 280-317 Range on HMM: 242-278/278 Sequence Identity: 31% (12 aa) DLSDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPIM ..|| || .. .....|. || ||| | .. | PISDHYSNEMRMLVHNCLQQDPEQRPSA-SQIMAMPLC |
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| Kinase | GL50803_4322.AA | KIS | 198-248 | 32 | 1.9e-05 | 11.78 | In-house | 330-387 (473) | Show / Hide |
Range on Protein: 198-248 Range on HMM: 330-387/473 Sequence Identity: 32% (19 aa) KQIDELIYHAPE--ILNALATPT-----PPGISAYDANTACCGAAPDLWSLGIILYEM |.| . | ||| . |... .|| | | | |.||||.|. .| KYIQTDCYQAPEAKVWNCFVQAGGNQKVVHKMSAVDQSDTECTHAVDIWSLGCIIVRM |
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| Kinase | GL50803_4322.AA | WEE | 277-316 | 32 | 2.3e-05 | 14.06 | In-house | 258-297 (297) | Show / Hide |
Range on Protein: 277-316 Range on HMM: 258-297/297 Sequence Identity: 32% (13 aa) PDLDLSDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI |...... .|..| ..| . . ||| ||| .|.|| . . PFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | GL50803_4322.AA | NEK4 | 281-316 | 33 | 2.6e-05 | 15.22 | In-house | 222-257 (257) | Show / Hide |
Range on Protein: 281-316 Range on HMM: 222-257/257 Sequence Identity: 33% (12 aa) LSDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI .. ||.|| | . |.|. | .|| | ... | MPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | GL50803_4322.AA | NEK | 237-254 | 55 | 2.7e-05 | 15.07 | In-house | 206-225 (286) | Show / Hide |
Range on Protein: 237-254 Range on HMM: 206-225/286 Sequence Identity: 55% (11 aa) DLWSLGIILYEMMAL--AKP | |||| .||||..| .| DIWSLGCVLYEMCTLKPKHP |
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| Kinase | GL50803_4322.AA | NEK1 | 237-254 | 55 | 2.8e-05 | 14.47 | In-house | 203-220 (276) | Show / Hide |
Range on Protein: 237-254 Range on HMM: 203-220/276 Sequence Identity: 55% (10 aa) DLWSLGIILYEMMALAKP | |||| .||| ..| | DIWSLGCVLYELCTLKHP |
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| Kinase | GL50803_4322.AA | NEK-Unclassified | 282-316 | 40 | 7e-05 | 11.76 | In-house | 224-258 (258) | Show / Hide |
Range on Protein: 282-316 Range on HMM: 224-258/258 Sequence Identity: 40% (14 aa) SDTYSTDLLNVITQLLSPDPLQRPRIQSLLLTGPI | |||||| .||. .| .. ||| .. | SKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | GL50803_4322.AA | WEE | 96-168 | 21 | 0.000196 | 10.87 | In-house | 91-149 (297) | Show / Hide |
Range on Protein: 96-168 Range on HMM: 91-149/297 Sequence Identity: 21% (16 aa) S--LQKLILEHRKTGKCFSESALWSIAAAVASLLQYLHQH-DNKTFYNAVSNNTINMGSMVHGNLKPSNVYITHQK | ||..| .. . .....|. .| | .. |...|.. . ||| .||.|..|.... SNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCG-----------------MVHMDIKPENIFISKKM |
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| Kinase | GL50803_4322.AA | Pkinase | 237-314 | 19 | 0.00075 | 14.7 | Pfam | 194-293 (293) | Show / Hide |
Range on Protein: 237-314 Range on HMM: 194-293/293 Sequence Identity: 19% (20 aa) DLWSLGIILYEMMA--LAKPSH----TNQTVLSRLDNHNPGTITAMPDLDLSDTYS---------------TDLLNVITQLLSPDPLQRPRIQSLLLT-- | ||.|.|||||. . |.| . . . .... .. . . . | |. ... .|. .| .|| .|| .. .| DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW G F |
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| Kinase | GL50803_4322.AA | NEK-Unclassified | 237-250 | 64 | 0.020459 | 3.46 | In-house | 179-192 (258) | Show / Hide |
Range on Protein: 237-250 Range on HMM: 179-192/258 Sequence Identity: 64% (9 aa) DLWSLGIILYEMMA | |||| |.||| . DVWSLGCIIYEMCT |
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| Kinase | GL50803_4322.AA | NEK4 | 237-251 | 60 | 0.049512 | 3.31 | In-house | 184-198 (257) | Show / Hide |
Range on Protein: 237-251 Range on HMM: 184-198/257 Sequence Identity: 60% (9 aa) DLWSLGIILYEMMAL |.|||| .|||. | DIWSLGCCVYEMITL |
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| Kinase | GL50803_4322.AA | NEK8 | 237-251 | 60 | 0.059101 | 1.23 | In-house | 204-218 (278) | Show / Hide |
Range on Protein: 237-251 Range on HMM: 204-218/278 Sequence Identity: 60% (9 aa) DLWSLGIILYEMMAL | |.|| .|||| | DMWALGCVLYEMCCL |
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| Ank | GL50803_4322.AA | Ank | 720-737 | 33 | 6.239222 | 4.01 | Pfam | 1-18 (33) | Show / Hide |
Range on Protein: 720-737 Range on HMM: 1-18/33 Sequence Identity: 33% (6 aa) KGNTQLMLAALSNNLKAV |.| |.||....... | DGFTPLHLACRCGHTEVV |
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| Ank | GL50803_4322.AA | Ank | 750-773 | 37 | 0.000735 | 18.18 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 750-773 Range on HMM: 1-24/33 Sequence Identity: 37% (9 aa) FGFTAMMIAAKRGFVEIVKILMNQ |||. ..|...| .|.|| |... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_4322.AA | Ank | 848-880 | 24 | 2e-05 | 23.8 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 848-880 Range on HMM: 1-33/33 Sequence Identity: 24% (8 aa) HGCTALLMATEYNRLDIIKLLIDQEAQMSTTDG .|.|.| .| ........|.|... | .| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_4322.AA | Ank | 817-847 | 30 | 0.000731 | 18.19 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 817-847 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) SGMTALMHAAMRGYTDIVLILRS--AEARKRDF |.|.|. |...|.|..| | . |. .| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_4322.AA | Ank | 789-816 | 36 | 0.368945 | 8.44 | Pfam | 4-33 (33) | Show / Hide |
Range on Protein: 789-816 Range on HMM: 4-33/33 Sequence Identity: 36% (11 aa) TALILAAMCGQAEIVYLLHE--KERGIQDK |.| ||..||..|.| .| . . .||. TPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_4322.AA | Ank | 885-911 | 37 | 0.00034 | 19.39 | Pfam | 1-27 (33) | Show / Hide |
Range on Protein: 885-911 Range on HMM: 1-27/33 Sequence Identity: 37% (10 aa) SGFTALMCAARLGFVQAVELLVKKEAN |||.|..|.| | .. |..|... |. DGFTPLHLACRCGHTEVVKMLLQHGAD |
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| Ank | GL50803_4322.AA | Ank | 922-942 | 47 | 0.008866 | 14.28 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 922-942 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) GGFTALVWAAREGHLACIKVL |||.| .|.| ||. ..| | DGFTPLHLACRCGHTEVVKML |
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