Gene GL50803_5346 (G.lamblia)

GL50803_5346

Species: G.lamblia
Alias: GK205, GL50803_5346
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5346.AA Protein None 493 None Fasta, JSON
GL50803_5346.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_5346.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_5346.AA S_TKc 17-283 27 1.1e-73 251.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLCCKKIMYSCLSSKAKELVTNEIDITMKLDHPNIVKYYEVFDDVDENSYSIIMDYYKN--GDMLKFLTDHKKHG
|.| |..| |..|||| ..    ...  .|.|          | . .||.| .| .||||||.|.||.|   ... ..|.|  .  ||..... ....||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KK--IDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDDMQVKLADFGVCRLYENAQEHMAMTIVGTPIYMPPESFESRTYTT-SFDIW
..  ..|   . .| |...|| ||||      . .||||.||.|.|. .  ..|..|||..|..        .|..||| ||.|| .    |.. . |.|
LRFPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGCTMYELAAQKYLITGPTDRDRLERARKVSSSQLSIPGYSTEFVRIISAMIKYHPDDRPSASDIIK-------SPEV
|.||..||... . .    ..   ... .            | |.  .|. . .. |..||.| .. .        | .
SCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_5346.AA NEK 17-224 37 2e-61 210.38 In-house 1-223 (286) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-223/286
Sequence Identity: 37% (84 aa)

YTIDRVVGTGSYGKVYAVTSA--QKD---KLLCCKKIMYSCLSSKAKELVT-NEIDITMKLDHPNIVKYYEVFDDVDENSYSIIMDYYK-NGDMLKF---
|.| ...| ||.|||| | .   .|    ||.. ||| ....|.| |.    ||. |  .|.||||||||. | . . |.  |.|.|   .||. ..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LTDHKKHGKKIDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIG-DDMQ---VKLADFGVCRLYENAQEHMAMT-IVGTPIYMPPESFES
.  .|. || ..|.  | ..|| .||| |.|.      . ..||||||.|. .  ....   ||. |||. .. .. .. || |  |||| || || ...
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTD-MAYTTQVGTPYYMSPEVCQN

RTYTTSFDIWSLGCTMYELAAQ--K
. |.   |||||||  ||....  |
KPYNNKSDIWSLGCVLYEMCTLKPK
Pkinase GL50803_5346.AA Pkinase 17-283 25 3.3e-61 214.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLCCKKIMYSCLSSKAKELVTN--EIDITMKLDHPNIVKYYEVFDDVDENSYSIIMDYYKNG----DMLKFLTDH
|.| |..| ||.|.||  .     |. ..|.| ..  .|. ..  ..  || |  .|.|||||..|..| |  .... ..|.|  .|    |   ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KKHGKKI--DEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDDMQV----KLADFGVCRLY-ENAQEHMAMTIVGTPIYMPPESFE-SR
 . ....  .|. .  .| |.| .| ||||        .||||.||.|.|| .....    |..|||..... .  ..  ..|..||| ||.||    ..
-WRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQ

TYTTSFDIWSLGCTMYELAAQKYLITGP----TDRDRLERARKVSSSQLSIPGY----------------------STEFVRIISAMIKYHPDDRPSASD
 |... |.||.||..||..  . .  |     . .| ... ... . .|. . .                      | |.  .|. .... | .||.| .
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

IIKSPEV
| ..| .
ILQHPWF
Kinase GL50803_5346.AA Ciliate-E2 17-283 21 1.7e-56 192.41 In-house 1-365 (365) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-365/365
Sequence Identity: 21% (84 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLC----------------CKKIMYSCLSS--KAKELVTNEIDITM----------------KLDHPNIVKYYEV
| . .. |.|..|.|| ..  ...|.                  .|. .|   .   . .| . .||.| .                .|.||||.|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FDDVDENSYSIIMDYYKNGDMLKFLTDH-KKHGKK------IDEDLLWAIMIQVLL---------------ALSYCHSPFNATGKA-VIHRDIKPANLLI
| . |.|.. ..|.|.. ||..... .. ||....      ..|     || |.|                || |.||      |  .||||||| |.|.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS------KNNIIHRDIKPENILF

GDDMQVKLADFGVCR----------------LYENAQ---------------EHMAMTIVGTPIYMPPESFESRT---------YTTSFDIWSLGCTMYE
     .|..||| ..                .| . .               ..|. ||.||| ||.|| ...           |... ||||||...||
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LAAQKYLITGPTDRDRLERARKVSSSQLSIP-------------------GYSTEFVRIISA----MIKYHPDDRPS-ASDIIKSPEV
.   |.              ..    ....|                     | |   .|.     |... |. |.. ...|.. |  
MLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_5346.AA STE 17-283 22 3.4e-54 186.38 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-359/359
Sequence Identity: 22% (85 aa)

YTIDRVVGTGSYGKVYAVTSA------QKDKL---------LCCKKIMYSCLSS---------------KAKELVTNEIDITMKLD--HPNIVKYYEVFD
... ...| |..|.||           .....            |.. ..  ..               . .. . .||.| .|..  ||||||||  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DVDENSYSIIMDYYKNGDMLKFLTDHKKHGK----------KIDEDLLWAIMIQVLLA-LSYCHSPFNATGKAVIHRDIKPANLLIGDDMQVKLA
     . ....  |.| |  .|   ...   ...||          ...|... .|  |.| . |.| ||      . .||||||||| |.     |||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS------HHIIHRDIKPANILL-----VKLC

DFGVCRLYEN---------------AQEHMAMTIVGTPIYMPPESFES------RTYTTSFDIWSLGCTMYELAAQKYLI-TGPTDRDRLERARKVSSSQ
|||||   ..                .  .  |.|||| .| ||  .         |.|. ||||||||. |.|  |.   ...  |  .. ...  ..|
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

------------LSIPG--------------------YSTEFVRIISAMIKYHPDDRPSASDIIK--SPEV
             ..|                     .| ||   |.   .. |..||.||. .|   | .
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_5346.AA Ciliate-E2-Unclassified 17-283 20 4.6e-52 178.89 In-house 1-352 (352) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-352/352
Sequence Identity: 20% (73 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLL-----CCKKIMYSCLSSKAKELVTNEIDITMK------------------LDHPNIVKYYEVFDDVDENSYSI
|.| .. |.|..|||| .   ... ..      .|...|. .. . |.   . . ..|.                  |.||......... . |..   |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMDYYKNGDMLKFLTD-------------HKKHGKKIDEDLLW-----AIMIQVLLALSYCHSPFNATGKA-VIHRDIKPANLLIGDDM---QVKLADFG
.|.| ..||.......             ..|..|...|          .. |.|..|.|.|.      |  .||||||| |.|. ...   ..|..|||
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH------KNNIIHRDIKPENILFDNNGKNYYIKIIDFG

VCRLYENA--------------QEHMAMTIVGTPIYM----PPESFESRTYTTS----FDIWSLGCTMYELAAQKYLITGPTDRD-------------RL
 .. |..               ...|. |..|||.||    .|| ...  | .|     ||||||. .||.  ..|   .... .             |.
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRK

ERARKVSSSQLSIPGYST------------EFVR-IISAMIKYHPDDRPSASDIIKSPEV
.  ..    ....| ..             .|.. ... |.|. |. |.....|.. |  
QLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_5346.AA ULK 17-283 27 3.4e-51 176.41 In-house 1-329 (329) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-329/329
Sequence Identity: 27% (92 aa)

YTIDRVVGTGSYGKVYAVTSAQK----DKLLCCKKIMYSCLSSKAKE--------LVTNEIDITMKLD--------HPNIVKYYEVFDDVDENSYSIIMD
| .... | ||.||||  .  ..    ...  ||.|  . .. | .|        |..|||.|  ||.        ||||||.|..| . ..| . |||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YYKNGDMLKFLTDHKK------HGKKIDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDD------------MQVKLADFGVCRLYEN
|   ||  ...  .||       .|.. |.    ...| | .. . |.      . .|||||||.| || ..            ...|.|||| ..  .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

A--QEHMAMTIV------GTPIYMPPESFESR----TYTTS-FDIWSLGCTMYELAAQK--YLITGPTDRD-----RLERARKVS-----SSQLSIPG--
   .. |.|| |      |||.|| |. ....     |...  ||||||| .||.   |  .    ..| .     .| . ....     . .| .|   
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG

----YSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
     | |.  .|. |..| ..|| |  .... | .
NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_5346.AA CAMK 22-281 18 2.4e-49 156.74 In-house 1-423 (425) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-423/425
Sequence Identity: 18% (78 aa)

VVGTGSYGKVYAVTSAQKD------------KLLCCKKIMYSCLS--------------------------SKAKELVTNEIDITMK-------LDHPNI
. |.||.|||. ..  .              .   .| |  . |.                           | .. | .||.| .|       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYYEVFDDVD-----------------ENSYSIIM---DYYKNG----DMLKFLTDHKKHG-----------KKIDEDLLWAIMIQVLLALSYCHSPFN
.| |||..| .                 .. . ..|   .|  .|    |.. ....|.. |           ....|.    .. |.. |. ||||   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

ATGKAVIHRDIKPANLLIGDDM-----------------QVKLADFGVCRLYENAQ----------------------EHMAMTIVGTPIYMP-PESFES
   . ..|||.|| |.|. |..                 ..|..|||  . ..  .                       ..  | .||| ||. || ...
---HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------------RTYTTSFDIWSLGCTMYELAAQKYLITGPTDRDRLE----------RARKVSSSQLS-IPGY------------------------
              . |. . |.||.|. .| .   ..   |..| . .|            .|. . . . .| |                        
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

STEFVRIISAMIKYHPDDRPSASDIIKSP
|.|    |. | .. |..|...... . |
SQECKDLIRKMLQVDPEKRMTIEQCLNHP
Kinase GL50803_5346.AA ULK 17-283 26 4.6e-47 162.67 In-house 1-324 (324) Show / Hide 
Range on Protein: 17-283
Range on HMM: 1-324/324
Sequence Identity: 26% (88 aa)

YTIDRVVGTGSYG-KVYAVTSAQK---DKLLCCKKIMYSCLSSKAKE--------LVTNEIDITMKLD---HPN--IVKYYEVFDDVDENSYSIIMDYYK
| .... | ||.| |||  .  ..   ...  ||.|  . .. | .|        |  ||| |  ||.   |||  |||.|..| . ..| . |||.|  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDMLKFLTDHKK-----HGKKIDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDD------------MQVKLADFGVCRLYEN--AQ
 ||  ...  .||      .|.. |.    ...| . .. . |.      . .|||||||.|.|| ..             ..|.|||| ..  .|   .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME

EHMAMTIV------GTPIYMPPESFESR----TYTTS-FDIWSLGCTMYELAAQK-----YLITGPTDRDRLERARK-------VSSSQLSIP------G
. | .|.|      |||.|| |. ....     |...  ||||||| .||.   |     . ..   ..   .  ..       .   .. .|       
QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPK

YSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
 | |.  .|. |..| ..|| |  .|.. | .
ISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_5346.AA NEK1 17-220 32 1e-45 156.56 In-house 1-214 (276) Show / Hide 
Range on Protein: 17-220
Range on HMM: 1-214/276
Sequence Identity: 32% (73 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLCCKKIMYSCLSSKAKELVTNEIDITMKLDHPNIVKYYEVFDDVDENS--YSIIMDYYKNGDMLKFLTDHKKHG
|.. ...| ||.||.. |..    .... | |  .. ..| .| . ||  |  |..|||||||.| |  . . .  . |.|.|  .||. .     |  |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESF--EENGCGILYIVMEYCDGGDLMQKINRQKRKG

KKIDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIG---DDM--------------QVKLADFGVCRLYENAQEHMAMTIVGTPIYMPPE
| . ||      .|  ||| . |.      . ..|||||. |.      ..|               |||.|||. |.  .  |. | | .||| | .||
KLFSEDQIMHWFCQICLALNHIHD------RKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEY-ACTCIGTPYYLSPE

SFESRTYTTSFDIWSLGCTMYEL
  . . |.   |||||||  |||
ICQNKPYNNKSDIWSLGCVLYEL
Kinase GL50803_5346.AA NEK2 17-222 28 2.1e-43 143.94 In-house 1-259 (319) Show / Hide 
Range on Protein: 17-222
Range on HMM: 1-259/319
Sequence Identity: 28% (75 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLCCKKIMYSCLSSKAKELVTNEIDITMKLDHPNIVKYYEVFDDVDENSYSIIMDYYKNGDMLKFLTDHKKHGKK
| .  . |.||.|... |      |.|  | | |  . .| . .  .|. |  .| |||||.||    |  . .  |.| |   ||     .  .|  . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IDEDLLWAIMIQVLLALSYCHS---------------PFNATGKAVIHRDIKPANLLIGDDMQ-------------------------------------
..|   | || | ..||  ||                |    .....||||||||.    |                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLADFGVCRLYENAQEHMAMTIVGTPIYMPPESFESRTYTTSFDIWSLGCTMYELAA
  ||| |||  |  .  .   | | |||| || ||  . . |    ||||.||  ||..|
VVVKLGDFGLARMLNHDTSF-AHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCA
Kinase GL50803_5346.AA NEK4 17-224 33 4e-41 142.95 In-house 1-199 (257) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-199/257
Sequence Identity: 33% (69 aa)

YTIDRVVGTGSYGKVYAVTSAQKDKLLCCKKIMYSCLSSKAKELVTNEIDITMKLDHPNIVKYYEVFDDVDENSYSIIMDYYKNGDMLKFLTDHKKHGKK
| . .||| |||| |. | . .  |    ||.     |.. .     |. .  .| |||||.| | ..  .     |.| .   ||. . |   .. .. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQF

IDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDDMQVKLADFGVCRLYENAQEHMAMTIVGTPIYMPPESFESRTYTTSFDIWSLGCT
..|       .|. .|| | |       | ..||| |  |. .     .|. |||. |  .|  . || |..||| || || | .| |    ||||||| 
LEEYQVVEWFVQIAMALQYMHE------KHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCD-MAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCC

MYELAAQK
.||..  |
VYEMITLK
Kinase GL50803_5346.AA TyrKc 17-286 22 2.8e-16 40.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-286
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YTIDRVVGTGSYGKVY-AVTSAQKDKLLC-CKKIMYSCLSSKAKELVTNEIDITMKL--DHPNIVKYYEVFDDVDE-----NSYSIIMDYYKNGDMLKFL
 | ... | | .|.|| .. .     . .  |..  ..     .|   .|. | .||  .|||||. | |  .  .       . |.| | ..|| ...|
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

TDHKKHGKKIDEDLLWAIMIQVLLALSYCHSPFNATGKAVIHRDIKPANLLIGDDMQVKLADFGVCRLYENA-------QEHMAMT-IVGT---PI-YMP
 .|...   .  . |  ...|.    .| ||        .||||.   | |.|.. .|| .||| .|  ..        .  ....   |    ||  |.
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PESFESRTYTTSFDIWSLGCTMYE---LAAQKYL------ITGPTDRDRLERARKVSSSQL-----SIPGYSTEFVRIISAMIKYHPDDRPSASDIIKSP
||..  ...||  |.|| | .|.|   . .| |       ..    . .... .     .      . .. ..|  .|..   .. |.|||. |.|    
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEI----

EVQSI
 .. .
-HECF
Kinase GL50803_5346.AA Pkinase_Tyr 148-220 34 6.3e-10 34.24 Pfam 133-207 (270) Show / Hide 
Range on Protein: 148-220
Range on HMM: 133-207/270
Sequence Identity: 34% (26 aa)

IHRDIKPANLLIGDDMQVKLADFGVCRLYENAQEH-MAMTIVGTPI-YMPPESFESRTYTTSFDIWSLGCTMYEL
||||.   | |......|| .||| .|. .|  .   . .    ||  |.||..  . .||  |.|| | .|.|.
IHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase GL50803_5346.AA NEK 249-283 34 2.6e-08 25.8 In-house 249-286 (286) Show / Hide 
Range on Protein: 249-283
Range on HMM: 249-286/286
Sequence Identity: 34% (13 aa)

IP-G--YSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
||    ||..  ..|| |..  |..|||...|.. | .
IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_5346.AA NEK2 252-283 34 4e-06 16.46 In-house 288-319 (319) Show / Hide 
Range on Protein: 252-283
Range on HMM: 288-319/319
Sequence Identity: 34% (11 aa)

YSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
||..   ||. ||.  .  |||   |...| .
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_5346.AA NEK1 250-283 38 1e-05 16.07 In-house 243-276 (276) Show / Hide 
Range on Protein: 250-283
Range on HMM: 243-276/276
Sequence Identity: 38% (13 aa)

PGYSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
| ||.|    .| | |  | .|||. .| ..| .
PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_5346.AA NEK4 250-283 32 4.2e-05 14.49 In-house 224-257 (257) Show / Hide 
Range on Protein: 250-283
Range on HMM: 224-257/257
Sequence Identity: 32% (11 aa)

PGYSTEFVRIISAMIKYHPDDRPSASDIIKSPEV
| ||..   ..  |..  |..|||  ||.. | .
PNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_5346.AA Pkinase_Tyr 17-113 28 7.9e-05 16.98 Pfam 1-107 (270) Show / Hide 
Range on Protein: 17-113
Range on HMM: 1-107/270
Sequence Identity: 28% (31 aa)

YTIDRVVGTGSYGKVYAVTSA---QKDKLLCCKKIMYSCLSSKA--KELVTNEIDITMKL-DHPNIVKYYEVFDDVDEN-SYSIIMDYYKNGDMLKFLTD
 |.... | |..|.||  |     ...|. .  |..    ....  .|   .|. | ..| .|||||..| |  | .|  .. |.| | ..||.|..| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KKH
|   |..
HREDKQP
Ank GL50803_5346.AA Ank 412-434 34 0.006241 14.83 Pfam 1-23 (33) Show / Hide 
Range on Protein: 412-434
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

DGMTALMIAAVTNNVEAGRILLD
||.|.|..|.  ...|  . ||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_5346.AA Ank 443-466 29 0.46132 8.09 Pfam 1-24 (33) Show / Hide 
Range on Protein: 443-466
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

SGFTALLYAIENRNLEFARLMASH
 |||.| .|... ..| ...  .|
DGFTPLHLACRCGHTEVVKMLLQH