Gene GL50803_5554 (G.lamblia)

GL50803_5554

Species: G.lamblia
Alias: GL50803_5554, GK289
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_5554.AA Protein None 595 None Fasta, JSON
GL50803_5554.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of GL50803_5554.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_5554.AA S_TKc 22-290 18 2.3e-11 -10.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-290
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

YRQESEIFRGKYSHIFCMKDITSQRQFSCKKFPLAKLTSHQIELIRYEAALAQKSTFPGQMKYSSVVLDQKGGNLAALVDLHKY--GDLRTQLDTAIMDD
|.   .| .| ..  .. ... ..|.. .|. .         | || | .. .|   |   |.  |  |   ..|    ..     |||.. ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

FF--FSEDTIWMIATQL---IKFLADYSSQTATKDKVLLDLRPSCIYISEMGFVLVDTVRL-----ARFDIFPESADYETPCYNAPELLAGARPFHT--M
    |.| ... .. |.   .... .       .  .  || |. | ..|       .. .     ||.     .    || | |||.|    .. .   
LRFPFPE-HARFYMYQICCALEYCHS-------HGIIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKC

DIWSLGATLFELCMRRPYVTGWTRQQVLELSLAPPNITVELTTNPANTKFKYSRKLSDFITDLLNPRPERRPSTDDLIA-------RPPI
|.||.| .|.|.. ..|     . |..... .                    |. . |||  .|.  ||.||.  .. .        | .
DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_5554.AA Ciliate-E2 189-290 24 1.7e-10 32.19 In-house 250-365 (365) Show / Hide 
Range on Protein: 189-290
Range on HMM: 250-365/365
Sequence Identity: 24% (30 aa)

TPCYNAPELLAG-------ARPFHT--MDIWSLGATLFELCMRRPYVTGWTRQQVL--ELSLAPPNITVELTTNPANTKFKY------SRKLSDFITD--
|| | ||| | |       ..  ..   |||||| .|.|... .|       || .  .... .|. . . |. .    .|.      | .  |.|    
TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFG

--LLNPRPERRPS-TDDLIARPPI
  .|.  || |..  ....  | .
KRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_5554.AA NEK 258-290 34 3.4e-09 28.94 In-house 252-286 (286) Show / Hide 
Range on Protein: 258-290
Range on HMM: 252-286/286
Sequence Identity: 34% (12 aa)

K--YSRKLSDFITDLLNPRPERRPSTDDLIARPPI
.  ||..|...|. .|.. || |||.......| |
HRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_5554.AA CDK7 192-225 54 1.1e-07 16.09 In-house 168-202 (288) Show / Hide 
Range on Protein: 192-225
Range on HMM: 168-202/288
Sequence Identity: 54% (19 aa)

YNAPELLAGARPFHT-MDIWSLGATLFELCMRRPY
| ||||| ||| . |  |.|| |  . ||  | ||
YRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPY
Kinase GL50803_5554.AA STE-Unique 189-290 25 1.2e-07 22.58 In-house 511-616 (616) Show / Hide 
Range on Protein: 189-290
Range on HMM: 511-616/616
Sequence Identity: 25% (28 aa)

TPCYNAPELLAGA----RPFHT-MDIWSLGATLFELCMRRPYVTGWTRQQVLEL--SLAPPNITVEL---TTNPANTKFKYSRKLSDFITDLLNPRPERR
||||..|| . ..     |. |  ||||||...|..|   |    |. .....   ... .. .  .   . |..    |..  . .||  .|.. |  |
TPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPP---WHQRYHMQAYIEMCIHIHCQPPQCPIENIPP---KCQPEQQQFIEKCLERNPHHR

PSTDDLIARPPI
||. .|   .  
PSAHQLLHHFWL
Kinase GL50803_5554.AA TKL 189-288 17 1.6e-07 23.18 In-house 236-364 (364) Show / Hide 
Range on Protein: 189-288
Range on HMM: 236-364/364
Sequence Identity: 17% (23 aa)

TPCYNAPELLAGA----------------RPFHTMDIWSLGATLFELCMRR-PYVTGWTRQQVLE-------LSLAPPNITVELTTNPAN-----TKFKY
||.. |||.| |.                  .  .|..| |  |.|.. |. ||   . .....           .  .   .. . . |          
TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDC

SRKLSDFITDLLNPRPERRPSTDDLIARP
 . ... ..|  .. || ||| .... | 
PPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_5554.AA Pkinase 189-290 23 2.3e-07 27.13 Pfam 174-293 (293) Show / Hide 
Range on Protein: 189-290
Range on HMM: 174-293/293
Sequence Identity: 23% (29 aa)

TPCYNAPELLA-GARPFHTMDIWSLGATLFELCMRRPYVTGW------TRQQVLELSLAPPNITVELTTNP--ANTKFKY----------SRKLSDFITD
|| | |||..  |    .  |.||.| .|.|.. .||   |       . .|.... . ||.   . ....    . |..          |. . |||..
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKW

LLNPRPERRPSTDDLIARPPI
.|.. |..||. ...   | .
CLCKDPKKRPTAEQILQHPWF
Kinase GL50803_5554.AA STE 189-290 21 7.2e-07 20.42 In-house 226-359 (359) Show / Hide 
Range on Protein: 189-290
Range on HMM: 226-359/359
Sequence Identity: 21% (30 aa)

TPCYNAPELLAGARPF------HTMDIWSLGATLFELCMRRPYVTGWTRQQVLELSL-----------------APPNITVELT-----------TNPAN
|| . ||| . . .           |||||| |. |..  .|     .  ... . .                  || .  .|            | .  
TP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGT-T--

TKFKYSRKLSDFITDLLNPRPERRPSTDDLIA--RPPI
 . |.| .. |||   |.  |. ||....|.    | |
YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_5554.AA Ciliate-E2-Unclassified 189-290 21 2e-06 18.15 In-house 225-352 (352) Show / Hide 
Range on Protein: 189-290
Range on HMM: 225-352/352
Sequence Identity: 21% (27 aa)

TPCYN----APELLAGARPFHT----MDIWSLGATLFELCMRRPYVTGWTRQQ--VLEL-------SLAPPNITVELTTNPANTKF-----KYSRKLSDF
||.|     |||.| |  . |.     ||||||  |.|... ..   . .. |  .|.         .   ..  .  ..  . ..     . | .  ||
TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDF

IT----DLLNPRPERRPSTDDLIARPPI
|.     .|. .|. |.. ....  | .
INDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_5554.AA NEK2 259-290 34 2e-06 17.76 In-house 288-319 (319) Show / Hide 
Range on Protein: 259-290
Range on HMM: 288-319/319
Sequence Identity: 34% (11 aa)

YSRKLSDFITDLLNPRPERRPSTDDLIARPPI
||| |.. |.  .|  .. |||.. ... | |
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_5554.AA NEK4 258-290 33 8e-06 17.17 In-house 225-257 (257) Show / Hide 
Range on Protein: 258-290
Range on HMM: 225-257/257
Sequence Identity: 33% (11 aa)

KYSRKLSDFITDLLNPRPERRPSTDDLIARPPI
.||  | . .  .|. .|..|||  |..  | |
NYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_5554.AA NEK1 259-290 31 8e-06 16.31 In-house 245-276 (276) Show / Hide 
Range on Protein: 259-290
Range on HMM: 245-276/276
Sequence Identity: 31% (10 aa)

YSRKLSDFITDLLNPRPERRPSTDDLIARPPI
||..|.  .. ...  |. |||. ..  || |
YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_5554.AA NEK2 189-220 40 0.004548 6.04 In-house 227-258 (319) Show / Hide 
Range on Protein: 189-220
Range on HMM: 227-258/319
Sequence Identity: 40% (13 aa)

TPCYNAPELLAGARPFHTMDIWSLGATLFELC
|| |  ||.. |       ||||.|  ..|.|
TPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMC
Kinase GL50803_5554.AA NEK1 208-220 76 0.00803 5.82 In-house 203-215 (276) Show / Hide 
Range on Protein: 208-220
Range on HMM: 203-215/276
Sequence Identity: 76% (10 aa)

DIWSLGATLFELC
||||||  | |||
DIWSLGCVLYELC
Kinase GL50803_5554.AA NEK 208-221 64 0.009828 5.92 In-house 206-219 (286) Show / Hide 
Range on Protein: 208-221
Range on HMM: 206-219/286
Sequence Identity: 64% (9 aa)

DIWSLGATLFELCM
||||||  |.|.|.
DIWSLGCVLYEMCT
Kinase GL50803_5554.AA NEK4 189-219 46 0.089223 2.38 In-house 165-195 (257) Show / Hide 
Range on Protein: 189-219
Range on HMM: 165-195/257
Sequence Identity: 46% (15 aa)

TPCYNAPELLAGARPF-HTMDIWSLGATLFEL
|| |  ||.  | ||. .  ||||||  ..|.
TPYYMSPECF-GNRPYDYKSDIWSLGCCVYEM
Kinase GL50803_5554.AA NEK 154-168 53 0.381118 0.26 In-house 272-286 (286) Show / Hide 
Range on Protein: 154-168
Range on HMM: 272-286/286
Sequence Identity: 53% (8 aa)

DLRPSCIYISEMGFV
..||||  | || |.
EQRPSCNQILEMPFI