Gene GL50803_6140 (G.lamblia)

GL50803_6140

Species: G.lamblia
Alias: GK160, GL50803_6140
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_6140.AA Protein None 638 None Fasta, JSON
GL50803_6140.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of GL50803_6140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_6140.AA Ciliate-E2-Unclassified 69-218 22 2.1e-13 42.91 In-house 75-269 (352) Show / Hide 
Range on Protein: 69-218
Range on HMM: 75-269/352
Sequence Identity: 22% (45 aa)

LARIHHPNIVHSEFPIEHDGYLYVQMDRYCT--SLETMIR-------------TSRLRRLQFSKSQIL-----TIVTQVSAALAYLHSAHKDRESLSAIV
|  . ||.||. ..  . . ..|  |. ||   .|. .|.              ....| .|.  |..     ..  |.  .| |||. ..       |.
LLNHPHPFIVKMFYCFQDKQNIYIVME-YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN-------II

HGRVQPANILVNEDGR--QFALSNAGVHR-------------------SRQKFSNTV--------YTAPEILLDADLT----PAADMWSLGVILYELATK
|   .| |||....|.  .  ..  |  .                   ..|... ..        |||||.|           ..|.|||||||||. . 
HRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG

NRP
..|
YYP
Kinase GL50803_6140.AA TKL 118-220 15 8e-13 42.51 In-house 132-290 (364) Show / Hide 
Range on Protein: 118-220
Range on HMM: 132-290/364
Sequence Identity: 15% (26 aa)

SQILTIVTQVSAALAYLHS----AHKDRESLSA--IVHGRVQPANILVNEDGR-------------QFALSNAGVHRSRQ--------------------
.|.. .. ... ...||||    ...         |.|    ..||||.|...                ..  |  |. .                    
HQRCRWALDIARGMNYLHSMNPKWCT------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQN

---KFSNTV----YTAPEILLDA----------------DLTPAADMWSLGVILYELATKNRPEF
   . .. .    . |||.| ..                . ....|..| |..|.|..|  ||..
NRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
S_TKc GL50803_6140.AA S_TKc 21-276 21 4.5e-12 0.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-276
Range on HMM: 1-231/231
Sequence Identity: 21% (59 aa)

DALGPVLYQGVGASIYAHITRP------GKVIKEVSIYGLQEAKLKALRMSFQDLARIHHPNIVHSEFPIEHDGYLYVQMDRYCT---SLETMIRTSRLR
  .. .. .|  .. |  . .        |.||   .  ..| ..             ||||||.    ... ..||. |.   .   .| ..|.  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

RLQ--FSKSQILTIVTQVSAALAYLHSAHKDRESLSAIVHGRVQPANILVNEDGRQ-----FALSNAGVHRSRQKFSNTVYTAPEILLDADLTP-AADMW
.|.  |.  ..  .. |.  ||.|.|| .        |.|  . |.|||..|   .     | |.       .       | |||.|     .. ..|.|
GLRFPFPE-HARFYMYQICCALEYCHSHG--------IIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGVILYELATKNRPEFISGCMLECGFAEGWVPDLSSVEDVLLNNIIRRLLIFDPISRMSSSELSS----ILQDSQS
|.|.||||...  .| |    | .     |         .  . ..||..| .||  |..  |.      | ..   
SCGCILYEMLC-GYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_6140.AA Ciliate-E2 69-218 20 9.7e-11 33.07 In-house 86-295 (365) Show / Hide 
Range on Protein: 69-218
Range on HMM: 86-295/365
Sequence Identity: 20% (47 aa)

LARIHHPNIVHSEFPIE--HDGYLYVQMDRYCTS--LETMIRTSRLRR-------LQFSKSQILTIVTQVSA---------------ALAYLHSAHKDRE
| .. ||||.      .   | ..|  |. ||    |.  |. ... |       ..|.  .|..| .|.                 || |||| .    
LEQLNHPNIIKMYECFQEKDDNNIYLVME-YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN----

SLSAIVHGRVQPANILVNEDGRQFALSNAGVHRSRQKF---------------------------------------SNTVYTAPEILLDAD--------
    |.|    | |||.        ..  |  .  ...                                        .  | |||||   .        
---NIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

-LTPAADMWSLGVILYELATKNRP
  . ..|.|||||||||. ....|
GYDYKCDIWSLGVILYEMLFGKPP
Kinase GL50803_6140.AA CMGC 73-218 18 2.1e-10 29.42 In-house 96-341 (513) Show / Hide 
Range on Protein: 73-218
Range on HMM: 96-341/513
Sequence Identity: 18% (48 aa)

HHPNIVHSEFPIEHDG-----------------YLYVQMDRYCTSLETMIRTSRL-----RRLQFSKSQ------------ILTIV------TQVSAALA
||.|||.    . |..                 .||  ..   ..|  .|.  .      |.. .|  .            |  ..       |.  .|.
HHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK

--YLHSAHKDRESLSAIVHGRVQPANILVNEDGRQ------------------------FALSNAGVHRSRQKFS---------------NTVYT-----
  |.||. .       |.|    |.|||.|....                         | |. .  ..|...|.               |  ||     
LKYCHSHWG------NIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVT

----APEILLDADL----------TPAADMWSLGVILYELATK-------NRP
    |||||| .            |.. ||||.| |..|. |.        .|
RWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP
Kinase GL50803_6140.AA RSKL 185-212 51 2.2e-10 19.78 In-house 344-371 (436) Show / Hide 
Range on Protein: 185-212
Range on HMM: 344-371/436
Sequence Identity: 51% (15 aa)

YTAPEI-LLDADLTPAADMWSLGVILYEL
|.|||       ||.| | ||.|..||||
YCAPEVGQI-WELTEACDWWSYGAVLYEL
Kinase GL50803_6140.AA TK 100-214 13 5.5e-10 28.87 In-house 145-389 (486) Show / Hide 
Range on Protein: 100-214
Range on HMM: 145-389/486
Sequence Identity: 13% (35 aa)

SLETMIRTSRLRRLQ------------------------------------------------------------------------FSKSQILTIVTQV
|| .  |..| .. .                                                                        ..  | | .  |.
SLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQI

SAALAYLHSA---HKDRESLSAI---VHGRVQPANILVNEDGR----------QFALSNAGVH------RSRQKFSNTVY--------------------
.....||||             |   ||. .   |.||.|...          .  ..  |        ..|   |.. |                    
ACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPW

----------------TAPEILLDAD---------LTPAADMWSLGVILYELAT
                .||| |.|            |.. |.||.|| ..|. |
QDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase GL50803_6140.AA AGC 185-214 46 1.1e-09 19.67 In-house 273-300 (395) Show / Hide 
Range on Protein: 185-214
Range on HMM: 273-300/395
Sequence Identity: 46% (15 aa)

YTAPEILLDADLTPAADMWS--LGVILYELAT
| |||||     ..|.| ||  ||...||. |
YMAPEIL----YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_6140.AA MARK 185-218 45 4.8e-09 25.88 In-house 171-205 (262) Show / Hide 
Range on Protein: 185-218
Range on HMM: 171-205/262
Sequence Identity: 45% (16 aa)

YTAPEILLDADLT-PAADMWSLGVILYELATKNRP
| ||||.|  . . |..|.|||||.|| . . . |
YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFP
Kinase GL50803_6140.AA Pkinase 185-216 42 1.5e-08 31.36 Pfam 177-209 (293) Show / Hide 
Range on Protein: 185-216
Range on HMM: 177-209/293
Sequence Identity: 42% (14 aa)

YTAPEILL-DADLTPAADMWSLGVILYELATKN
| |||... . . .|..||||.|.||||.....
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase GL50803_6140.AA CAMK 185-210 36 2e-08 22.51 In-house 285-325 (425) Show / Hide 
Range on Protein: 185-210
Range on HMM: 285-325/425
Sequence Identity: 36% (15 aa)

YTA-PEILLD--------------ADLTPAADMWSLGVILY
| | ||.|.                  .|..||||.|||||
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
TyrKc GL50803_6140.AA TyrKc 46-271 17 2e-06 -119.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-271
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

IKEVSIYG---------------------LQEAKLKALRMSFQDLARI--HHPNIVHSEFPIEHD-------GYLYVQMDRYCT--SLETMIRTSRLRRL
|.   . |                       .| .....   . . ..  ||||||     . ..       . |.. |  |.   .|   .| .| .  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME-YMPHGDLKDYLRKHRPK--

QFSKSQILTIVTQVSAALAYLHSAHKDRESLSAIVHGRVQPANILVNEDGRQ----FALSNAGVHR-------SRQKF-----SNTV----YTAPEILLD
 .. .. | . .|...  .||||          ..|      |.||.|...     | || .. .        .  .      ..|.     .||| . .
-LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

ADLTPAADMWSLGVILYELATKNRPEF-------ISGCMLECGFAEGWVPDLSSV---------EDVLLNNIIRRLLIFDPISRMSSSELSSIL
   |.. | || || ..|. |   .         .|   .     .|  ..              | . . |...   .|| .| . ||. ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_6140.AA SCY1 56-163 18 5e-06 16.86 In-house 35-162 (337) Show / Hide 
Range on Protein: 56-163
Range on HMM: 35-162/337
Sequence Identity: 18% (26 aa)

EAKLKALRMSFQDLARIHHPNIVHSEFPIEHDGY--LYVQMDRYCTSLETMIRTSRLRRLQFSK--------------------------SQILTIVTQV
| .  .|. ... |.|. ||||.  . |.| ...  .|.   . ...||.  .... ... ...                          . .   . |.
EEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYA-TEEIFQPLENVLKKWDNKKSCQTQKTQDVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQI

SAALAYLH-SAHKDRESLSAIVHGRVQPANILVNEDG
. || .|| ..|        .||. ..|..|.||..|
LDALSFLHNDCH--------MVHNNICPESIFVNKNG
Kinase GL50803_6140.AA SCY1 185-218 23 4.3e-05 13.67 In-house 226-272 (337) Show / Hide 
Range on Protein: 185-218
Range on HMM: 226-272/337
Sequence Identity: 23% (11 aa)

YTAPEILLD-------------ADLTPAADMWSLGVILYELATKNRP
..|||...                .|.|.||.|||.  ... .. .|
WLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKP
Kinase GL50803_6140.AA Pkinase 69-163 27 8.7e-05 18.0 Pfam 54-145 (293) Show / Hide 
Range on Protein: 69-163
Range on HMM: 54-145/293
Sequence Identity: 27% (27 aa)

LARIHHPNIVHSEFPIEHDGYLYVQMDRY-CT----SLETMIRTSRLRRLQFSKSQILTIVTQVSAALAYLHSAHKDRESLSAIVHGRVQPANILVNEDG
..|..|||||      | ....|. |.   ..    .| ..|.|.| ... ||  ..  ...|.  .|.|.||          |.|  . |.|||....|
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNG
Ank GL50803_6140.AA Ank 317-349 45 4.2e-07 29.87 Pfam 1-33 (33) Show / Hide 
Range on Protein: 317-349
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DGLTTLMCAARSGNVDVIKQLIDTGEGVRAQDA
|| | |..|.|.|...|.| |.. |  | ||| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_6140.AA Ank 350-376 29 1.248873 6.53 Pfam 1-25 (33) Show / Hide 
Range on Protein: 350-376
Range on HMM: 1-25/33
Sequence Identity: 29% (8 aa)

AGLTALMHATVKKQYDAIKVLVAFEHG
 | |.|. |  . ... .| |.   ||
DGFTPLHLACRCGHTEVVKMLLQ--HG
Ank GL50803_6140.AA Ank 381-401 23 0.018713 13.11 Pfam 1-21 (33) Show / Hide 
Range on Protein: 381-401
Range on HMM: 1-21/33
Sequence Identity: 23% (5 aa)

GGQTALMHAAQMNDPQAIHLL
 |.|.|. |....... . .|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_6140.AA Ank 422-445 37 3.468158 4.93 Pfam 1-24 (33) Show / Hide 
Range on Protein: 422-445
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

KSRTALMGAAAQGFTRAVEALLQY
  .|.|. |.  | |. |. |||.
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_6140.AA Ank 453-473 33 0.014221 13.54 Pfam 1-21 (33) Show / Hide 
Range on Protein: 453-473
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

LHQTALMYAASQNHLEAVQLL
  .|.|..|.. .|.| |..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_6140.AA Ank 514-537 29 0.000592 18.52 Pfam 1-24 (33) Show / Hide 
Range on Protein: 514-537
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

MGYSALMIAANEGQFDIVQLLVEH
.|...|..|.  |. ..|..|..|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_6140.AA Ank 484-513 30 0.014589 13.5 Pfam 1-33 (33) Show / Hide 
Range on Protein: 484-513
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

MSQTALILAVQRGNVNVVPFLLC---EVGMKNN
. .|.| ||...|...|| .||    .| ....
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_6140.AA Ank 545-566 27 0.066241 11.13 Pfam 1-22 (33) Show / Hide 
Range on Protein: 545-566
Range on HMM: 1-22/33
Sequence Identity: 27% (6 aa)

TQSTALISAAYNNHSQIVELLI
   |.|  |....| ..|..|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_6140.AA Ank 576-599 37 3.2e-05 23.07 Pfam 1-24 (33) Show / Hide 
Range on Protein: 576-599
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

HGLTALMEAAKHGYIDVVRILVDH
.| |.|. |...|...||. |..|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_6140.AA Ank 607-627 33 14.302946 2.71 Pfam 1-21 (33) Show / Hide 
Range on Protein: 607-627
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

LGRTARTMALKFGHSEIADFL
 |.|.  .| . || |.. .|
DGFTPLHLACRCGHTEVVKML