Gene GL50803_6199 (G.lamblia)

GL50803_6199

Species: G.lamblia
Alias: GK076, GL50803_6199
External Links: GiardiaDB ,
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: CDC15

Sequence

Name Sequence Type Origin Length Description Download
GL50803_6199.AA Protein None 1708 None Fasta, JSON
GL50803_6199.kin_dom Protein Kinase Domain None 245 None Fasta, JSON

Protein domain

Protein domains of GL50803_6199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_6199.AA Ciliate-E2 67-266 18 3.2e-23 76.54 In-house 92-365 (365) Show / Hide 
Range on Protein: 67-266
Range on HMM: 92-365/365
Sequence Identity: 18% (56 aa)

PNLVKYIEAFA--DKEYFYVVMEFVPN-SLDQIIAHQRS------------TEHLAALYVTQIVK---------------GLIFIHYNG-YTHKRITPEH
||..|..|.|   |....| |||..   .| ..| ...             ||  .. . .||..               .| ..| ..   |  | || 
PNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

ILITNDGFVKISDFVLQNAYFADGDKDVRD---------------------------------------MAPEEILLLG---------RTTAVDIWNLGL
||.     .||.||   .. ..| | . |                                        |||| .   .          ....||| || 
ILF-----IKIIDF--GLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

LLFNCLAREHFFKNMADQEIIRLFQSTNAQNTINE-LVTFRLAECN-------------LNVSQACKEFILA----CLSIDYTFRPS-AQSLLQASFL
.|. .|  .. |                 |. | .  . |. .|..             ...|| || .|      .|  |   |.. .. .|.  ..
ILYEMLFGKPPF-----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_6199.AA STE 23-149 22 1e-18 62.84 In-house 15-191 (359) Show / Hide 
Range on Protein: 23-149
Range on HMM: 15-191/359
Sequence Identity: 22% (41 aa)

TYKALCNI---------------DGIVPAIKIYRLSDVSKSSVD------------FDQ----KEIDTAARSLL-QPNLVKYIEAFADK-------EYFY
.|||...                 | . |||. .|.. .... .             ..    |||..  ..    || |||. .. ..       .. .
VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW

VVMEFVP-NSLDQIIAHQRST---------------EHLAALYVTQIVKG-LIFIHYNGYTHKRITPEHILITNDGFVKISDF
..||...  |||.|| |  ..               |.. | .. ||.|| | ..| ... |  | | .||.     ||..||
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDF
Kinase GL50803_6199.AA CAMK 67-149 20 7e-18 53.53 In-house 98-240 (425) Show / Hide 
Range on Protein: 67-149
Range on HMM: 98-240/425
Sequence Identity: 20% (29 aa)

PNLVKYIEAFAD-------------------KEYFYVVM---EFVPNS------LDQIIAH---------------QRSTEHLAALYVTQIVKGLIFIHY
||..| .|.. |                   ....| ||   |....       .| |..|                | ||. |. |. ||. .. ..| 
PNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

NGYTHKRITPEHILITND-----------------GFVKISDF
..  |  . || ||....                 . .||.||
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
S_TKc GL50803_6199.AA S_TKc 1-266 21 9e-18 66.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-266
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

MKRDKLLLNGKYSINVKTNGERTYKALCNIDGIVPAIKIYRLSDVSKSSVDFDQKEIDTAARSLLQPNLVKYIEAFADKEYFYVVMEFVPN---SLDQII
 .  ...  | ..          ||.  . .| . |||| .         .  ..||.   .    ||.||....| | ...|.|||....   .| ..|
YEILRKIGKGAFGK--------VYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

AHQRS-------TEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFVKISDFVLQNAYFADGDKDVRD-------MAPEEILLLGRTT-AVDI
 ....       .|  |. |. ||...| ..| .|  |  . || ||...   .||.|| |   .        .        |||| .   | .. ..|.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDW

WNLGLLLFNCLAREHFFKNMADQEIIRLFQSTNAQNTINELVTFRLAECNLNVSQACKEFILACLSIDYTFRPSAQSLLQ-------ASFL
| .| .|. .|...  |    .|.....                         |. .|.||  ||  | . ||.|  .||         ..
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_6199.AA Ciliate-E2-Unclassified 64-266 20 5e-17 55.63 In-house 70-352 (352) Show / Hide 
Range on Protein: 64-266
Range on HMM: 70-352/352
Sequence Identity: 20% (60 aa)

LLQ--------PNLVKYIEAFADKEYFYVVMEFVPN-SLDQIIAH------------------QRSTEHLAA-----LYVTQIVKGLIFIHYNG-YTHKR
..|        |..||....| ||...| |||.... .| |.| .                  .. ||  |.      |  ||..|| ..|...   |  
IMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRD

ITPEHILITNDG---FVKISDFVL-----QNAYFADGDK-----------------DVRDM----APEEILLLGRT----TAVDIWNLGLLLFNCLAREH
|.|| ||..|.|    .||.|| .     || ..  ..                    . |    ||| .   .       ..||| || .|. .|  ..
IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY

FFK--NMAD-----QEIIRLFQSTN-----AQNTINELVTFRLAECN----LNVSQACKEFIL----ACLSIDYTFRPSAQSLLQASFL
 |.  |  .     ...| .    |      .. |..  ..   . .     ..|. .|.||      .|  .   |.... .|.  ..
PFYDNNCEQHQQLITQWI-N----NAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_6199.AA CMGC 67-149 18 4.2e-14 41.82 In-house 98-248 (513) Show / Hide 
Range on Protein: 67-149
Range on HMM: 98-248/513
Sequence Identity: 18% (28 aa)

PNLVKYIEAFADKE-----------------YFYVVMEFVPNSLDQIIAHQR----------STEHL------------AALYV------TQIVKGLI--
.|.|| .. | .|.                 ..| |.|.....| |.| ...           .|                 ..       || .||   
NNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

FIHYNG--YTHKRITPEHILITND--------------------GFVKISDF
..| ..    |  . || |||...                    | .|| ||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase GL50803_6199.AA Pkinase 67-149 34 4.2e-13 47.43 Pfam 60-156 (293) Show / Hide 
Range on Protein: 67-149
Range on HMM: 60-156/293
Sequence Identity: 34% (33 aa)

PNLVKYIEAFADKEYFYVVMEFVPN-----SLDQIIA---HQRS--TEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFV----KISDF
|| |.....| || . |.|||....     .|  .|    | .   .|. .  |..||..|| ..| .|  |  . || ||| |.| .    ||.||
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase GL50803_6199.AA STE20 24-149 27 2.1e-12 41.92 In-house 16-161 (288) Show / Hide 
Range on Protein: 24-149
Range on HMM: 16-161/288
Sequence Identity: 27% (41 aa)

YKALCNIDGIV----PAIKIYRLSDVSK--SSVDFDQKEIDTAARSLLQPNLVKYIEAFADK----EYFYVVMEFVPN-SLDQIIA--------HQRS--
||| ..  | .     |||.  |.. .    ...  ||||.  ...   || |||....  .    .  ..|||.    || .|.         |.    
YKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHK-GHP

-TEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFVKISDF
 .|   |    ....|| ..| |.. |  |   .||.| || ||..||
MNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADF
Kinase GL50803_6199.AA STE 166-266 22 5.4e-11 35.19 In-house 229-359 (359) Show / Hide 
Range on Protein: 166-266
Range on HMM: 229-359/359
Sequence Identity: 22% (32 aa)

MAPEEILL------LGRTTAVDIWNLGLLL------FNCLAREHFFKNMADQEIIRLFQSTNAQNTINELVTFRLAECNLN-------------------
|||| |.        | .| .||| ||...         .. .| ...|    .    |.   |        | .  | .|                   
MAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ---Q--------FEQL-CIVNGPPPPLPDHLSQNEMISYG

---------VSQACKEFILACLSIDYTFRPSAQSLLQ--ASFL
         .|. .|.||  || .|.  ||.|. ||.   .|.
GSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_6199.AA STE11-Unclassified 67-149 28 5.1e-10 31.77 In-house 65-151 (308) Show / Hide 
Range on Protein: 67-149
Range on HMM: 65-151/308
Sequence Identity: 28% (25 aa)

PNLVKYIEAF--ADKEYFYVVMEFVPN-SLDQIIAHQRS-TEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFVKISDF
.| |.|. .    ..   ...|| .|. |... . ...   | ... |..|| .||.. |..| .|. | .. |||  || .|..||
KNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDF
Kinase GL50803_6199.AA STE11 67-149 28 1.4e-09 31.14 In-house 70-161 (303) Show / Hide 
Range on Protein: 67-149
Range on HMM: 70-161/303
Sequence Identity: 28% (26 aa)

PNLVKYIEAFA---DKEYFYVVMEFVPN-SLDQIIAHQRST----EHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGF-VKISDF
.|.|.|. .     ....... ||..|. || ... | . .    |..   |..|| .|| . |..|  |. | .. ||.  ||  .|..||
KNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADF
Kinase GL50803_6199.AA STE11-Unclassified 235-266 46 1.9e-09 29.74 In-house 277-308 (308) Show / Hide 
Range on Protein: 235-266
Range on HMM: 277-308/308
Sequence Identity: 46% (15 aa)

VSQACKEFILACLSIDYTFRPSAQSLLQASFL
.||.||.|. .|. ||.  ||.|. ||| .|.
ISQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase GL50803_6199.AA Pkinase 166-266 23 2.4e-09 34.13 Pfam 178-293 (293) Show / Hide 
Range on Protein: 166-266
Range on HMM: 178-293/293
Sequence Identity: 23% (27 aa)

MAPEEIL-LLGRTTAVDIWNLGLLLFNCLAREHFFKNM------ADQEIIRLFQSTNAQNTINELVTFR---------LAECNLNVSQACKEFILACLSI
|||| |.   . ...||.| .|..|.  | ..  |..        ....|..  ..     . .. . .         . .   |.|..||.||  ||  
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCK

DYTFRPSAQSLLQASFL
| . ||.|. .||  ..
DPKKRPTAEQILQHPWF
Kinase GL50803_6199.AA PAKA 66-149 30 2.5e-09 29.05 In-house 57-147 (260) Show / Hide 
Range on Protein: 66-149
Range on HMM: 57-147/260
Sequence Identity: 30% (28 aa)

QPNLVKYIEAFADKEYFYVVMEFVPN-SLDQIIAHQRS------TEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFVKISDF
..|.|.||...  ..  .||||.    .|  .| . ..      .|  .|  . .. .|| ||| .. .|  |    ||.  || ||| ||
HKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDF
Kinase GL50803_6199.AA STE11 236-266 38 2.8e-08 26.34 In-house 273-303 (303) Show / Hide 
Range on Protein: 236-266
Range on HMM: 273-303/303
Sequence Identity: 38% (12 aa)

SQACKEFILACLSIDYTFRPSAQSLLQASFL
|..|..|.. |. .|.  ||.|. ||| .|.
SEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_6199.AA ASK 62-149 32 3.2e-08 23.26 In-house 46-139 (254) Show / Hide 
Range on Protein: 62-149
Range on HMM: 46-139/254
Sequence Identity: 32% (31 aa)

RSLLQPNLVKYIEAFADKEYFYVVMEFVP-NSLDQIIAHQ----RSTEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILI-TNDGFVKISDF
. |   |.|.|. .... .|| . || ||  || ...  .    .  |.  . |  ||..|| ..| |   |. |  . .|. |  | ||||||
KQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDF
Kinase GL50803_6199.AA ASK 234-266 51 3.5e-08 23.13 In-house 222-254 (254) Show / Hide 
Range on Protein: 234-266
Range on HMM: 222-254/254
Sequence Identity: 51% (17 aa)

NVSQACKEFILACLSIDYTFRPSAQSLLQASFL
..|..||.||| |  .| . |.||| |||  ||
ELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase GL50803_6199.AA PAKA 234-266 42 3.2e-07 21.54 In-house 228-260 (260) Show / Hide 
Range on Protein: 234-266
Range on HMM: 228-260/260
Sequence Identity: 42% (14 aa)

NVSQACKEFILACLSIDYTFRPSAQSLLQASFL
..||  ..|  .|| .|   |.|||.||.  ||
KWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase GL50803_6199.AA STE20 234-266 33 5e-06 18.38 In-house 256-288 (288) Show / Hide 
Range on Protein: 234-266
Range on HMM: 256-288/288
Sequence Identity: 33% (11 aa)

NVSQACKEFILACLSIDYTFRPSAQSLLQASFL
. |.  ..|.  || .|. .||.|. ||. .|.
KWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
TyrKc GL50803_6199.AA TyrKc 1-266 16 6e-06 -126.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-266
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

MKRDKLL--------LNGKYSINVKTNGERTYKALCNIDGIVPAIKIYRLSDVSKSSVDFDQKEIDTAARSLLQP-----NLVKYIEAFADK-------E
 . .| |          |...                   |  |.|  . .          ....   || . .      |.|. . .  ..       |
ITLGKKLGEGAFGEVYKGTWK-------------------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIE

YFYVVMEFVPN-SLDQII-AHQR-STEHLAALYVTQIVKGLIFIHYNGYTHKRITPEHILITNDGFVKISDF----VLQNA--------YFAD----GDK
  ..|||..|. .|.. . .|..  .      . .|| .|  ..| ... |  .    .|..... ||||||     . .         |       | |
PLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

D---VRDMAPEEILLLGRTTAVDIWNLGLLLFNCLAREHFFKN------MADQEIIRLFQSTNAQNTINELVTFRLAECNLN--------VSQACKEFIL
.   .| |||| |     ||. |.|  | ...  . .            | .||.|..            . . .  ..  |         ...  . ..
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY------------VKQGYRMPQPPNDYPMSFVCCPDEMYQIMK

ACLSIDYTFRPSAQSLLQASFL
 |   |   ||. . .   ...
QCWHEDPEDRPTFSEI--HECF
Kinase GL50803_6199.AA CAMK 166-266 16 1.9e-05 12.71 In-house 286-425 (425) Show / Hide 
Range on Protein: 166-266
Range on HMM: 286-425/425
Sequence Identity: 16% (23 aa)

MA-PEEIL--------------LLGRTTAVDIWNLGLLLFNCLAREHFFKNMADQEIIR------LFQSTNAQNTINEL--VTFRLAE------------
|| || ..                . . ..|.| .| .|. .|  .  |    |.||.         . .  . .  .     . . .            
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDD

-----CNLNVSQACKEFILACLSIDYTFRPSAQSLLQASFL
      . .||| || .|  .|  | . |....  |.  ..
ISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_6199.AA CMGC 230-266 16 0.001367 6.64 In-house 477-513 (513) Show / Hide 
Range on Protein: 230-266
Range on HMM: 477-513/513
Sequence Identity: 16% (6 aa)

ECNLNVSQACKEFILACLSIDYTFRPSAQSLLQASFL
..... .. . ...  .| .| . |..|.  ||  ..
FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_6199.AA STE11-Unclassified 166-186 45 0.187174 0.99 In-house 202-225 (308) Show / Hide 
Range on Protein: 166-186
Range on HMM: 202-225/308
Sequence Identity: 45% (11 aa)

MAPEEIL---LLGRTTAVDIWNLG
|||| |      | ....||| ||
MAPEVIKNSTQTGHCRKSDIWSLG