Gene GL50803_7103 (G.lamblia)

GL50803_7103

Species: G.lamblia
Alias: GK176, GL50803_7103
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_7103.AA Protein None 500 None Fasta, JSON
GL50803_7103.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of GL50803_7103.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_7103.AA NEK 11-130 24 8.1e-10 31.16 In-house 1-131 (286) Show / Hide 
Range on Protein: 11-130
Range on HMM: 1-131/286
Sequence Identity: 24% (33 aa)

YKPERLLGQTPRSSVYLVRR-SDGAV-----VALKEIDLSVCGSTARAVVE-NLESLSNKLSHQNLVSCHNYTVNEETGYAYVELDYCP-GGSLADLFKK
|.  . .||   ..||.||| ||| .     ...|.|... . .  .     |   .  .| |.| |. ..  . |. .. . . .||  || |....|.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

QRRLIQQM----PIS--QIWLIAAHLLSALSYLH
   . .|     ...  ||| . .....|| |.|
---IKKQKQKGKYFEEEQIWDWFIQMCLALKYMH
Kinase GL50803_7103.AA STE 24-130 19 3.1e-09 28.89 In-house 14-169 (359) Show / Hide 
Range on Protein: 24-130
Range on HMM: 14-169/359
Sequence Identity: 19% (30 aa)

SVYLVRRSD----------------GAVVALKEIDLSVCGS---------------TARAVVENLESLSNKLS--HQNLVSCHNYTVNE-----ETGYAY
.||. .. .                | ..| |...|. | .               . .  ...  .. .|..  |.| | .. . ..|     . .. .
TVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW

VELDYCPGGSLADLFK-KQRRLI---------QQMPISQIWLIAAHLLSA-LSYLH
. . |..|||| |. | |  ..          . .| |||  |.  .| . |.|||
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH
Kinase GL50803_7103.AA S_TKc 11-246 16 1.1e-08 -49.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-246
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

YKPERLLGQTPRSSVYLVRRSD-GAVVALKEIDLSVCGSTARAVVENLESLSNKLSHQNLVSCHNYTVNEETGYAYVELDYCPG--GSLADLFKKQRR--
|.  |..|.   ..||..|  . | .||.|.|.        . .   .. |..   | |.| .. . ..   .. |. ..||.|  |.| |. ||..|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

LIQQMPISQIWLIAAHLLSALSYLH--------------------------FSYKHGGEVRCVTHGFITPESILLGPAGNAYLNIFSTDRITA-R-----
| ...|  ... ... ...|| |.|                          .. .      |.|  .. || .                  .  .     
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL--TTFCGTPWYMAPEVL----------------GYGKCKCDWWS

----LVEPVEQEIPLAERCQKDIRDLGTIFAKMAGLAPQDIQTSELFSSEPGLRCFLMACCGLGDVQCSSAAELLL----------F
    | | .  . |          .. ..| |.               |....  |.. |.     .  .| |.|           |
CGCILYEMLCGYPPFP--------QMQMMFKKIG--------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_7103.AA Ciliate-E2-Unclassified 11-130 16 1e-06 19.07 In-house 1-160 (352) Show / Hide 
Range on Protein: 11-130
Range on HMM: 1-160/352
Sequence Identity: 16% (27 aa)

YKPERLLGQTPRSSVYLVRRSDGAVV-----ALKEIDLSVCGSTARAVVENLE---SLSNK---------------LSHQNLVSCHNYTVNEETGYAYVE
||  . .||   ..||......   .     . | .. ...        ...|     ..|               |.|....  . . . . . . |  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LDYCPGGSLADLFKKQ-----------RRLIQQMPI--SQIW-----LIAAHLLSALSYLH
..||.||.| .  ||.           ... |.  .   |.       ..|..|..|.|||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH
Kinase GL50803_7103.AA MELK 33-130 27 2e-06 17.32 In-house 24-114 (254) Show / Hide 
Range on Protein: 33-130
Range on HMM: 24-114/254
Sequence Identity: 27% (27 aa)

GAVVALKEIDLSVCGSTARAVVENLESLSNKLSHQNLVSCHNYTVNEETGYAYVELDYCPGGSLADLFKKQRRLIQQMPISQIWLIAAHLLSALSYLH
.  ||.| .|    |.    |  ....| | |.||..  |. | . |     .. ..||||| . |   .| || .    ..   .   ..||..|.|
NQMVAIKIMDKNQLGHDLPRVKTEMDALKN-LRHQHI--CQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEE----EETRHFFRQIVSAIAYVH
Kinase GL50803_7103.AA TK 11-130 9 6e-06 15.21 In-house 1-251 (486) Show / Hide 
Range on Protein: 11-130
Range on HMM: 1-251/486
Sequence Identity: 9% (25 aa)

YKPERLLGQTPRS---SVYLVRRSDGA--------------------------VVALKEIDLSVCGSTAR----------------AVVENLESLSN-KL
 . .. ||.        ||. .  ..                            || | . .    | ..                . .| .. ... ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHQNLVSCHNYTVNEET----------GYAYVELDYCPGGS----LADLFKKQRRLIQQ-----------------------------------------
 |.|.|... . . .|.          .  .. . |.|.|.    | |  .| |.  |.                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MPISQIWLIAAHLLSALSYLH
                               ..  |   ... . ....|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Kinase GL50803_7103.AA Ciliate-E2 54-130 16 8e-06 15.89 In-house 63-177 (365) Show / Hide 
Range on Protein: 54-130
Range on HMM: 63-177/365
Sequence Identity: 16% (19 aa)

VENLESLSN----------------KLSHQNLVSCHNYTVNEETGYAYVELDYCPGGSLADLFKKQRRLI-------QQMPISQIWLIAAHLLS------
... ... .                .|.| |.. .. .  .. . . |  ..|| ||.| |. |...          ... . .|  | ...|.      
IKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA

---------ALSYLH
         || |||
EFYIACIILALEYLH
Kinase GL50803_7103.AA GCN2 59-130 22 1.5e-05 14.91 In-house 255-325 (511) Show / Hide 
Range on Protein: 59-130
Range on HMM: 255-325/511
Sequence Identity: 22% (17 aa)

SLSNKLSHQNLV--SCHNYTVNEETGYAYVELDYCPGGSLADLFKKQRRLIQQMPISQIWLIAAHLLSALSYLH
. .. ..|.|.|  .|.|.   .|. | |  ..||.|..|... . .   ..     ..| ... .|..|.|.|
DKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIH
Kinase GL50803_7103.AA Pkinase 11-130 19 1.7e-05 20.55 Pfam 1-125 (293) Show / Hide 
Range on Protein: 11-130
Range on HMM: 1-125/293
Sequence Identity: 19% (25 aa)

YKPERLLGQTPRSSVYLVRRSDGAV-VALKEIDLSVCGSTARAVVEN--LESLSNKLSHQNLVSCHNYTVNEETGYAYVELDYCPGG----SLADLFK--
|. .| .|.   ..||. .. .    ||.|.|...   |  .    .    .. ..|.| | | .. .  .   .. |. ..||.||    .|.|. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

KQRRLIQQMPISQIWLIAAHLLSALSYLH
......  ..  ..  ..  .|..| |.|
RHGCFY--FSEWECKFYMYQILRGLEYCH
Kinase GL50803_7103.AA CAMK 16-130 13 2e-05 12.68 In-house 1-196 (425) Show / Hide 
Range on Protein: 16-130
Range on HMM: 1-196/425
Sequence Identity: 13% (29 aa)

LLGQTPRSSVYLVRRS-DG------------AVVALKEIDL------------------------------SVCGSTARAVVENLESLSNK---LSHQNL
 ||.   . |.|...  ..              || | ||                                .     |  .| . .|...   |.| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSCHNYTV------------NEETG------YAYVEL---DYCPGG----SLADLFKKQ-----------------------RRLIQQMPISQIWLIAAH
.... .              . ...      . |  .   .||.||     | |  ...                       ||...|            
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQ------------

LLSALSYLH
..||. |.|
ICSAVHYCH
Kinase GL50803_7103.AA NEK2 63-130 32 4.3e-05 12.95 In-house 54-121 (319) Show / Hide 
Range on Protein: 63-130
Range on HMM: 54-121/319
Sequence Identity: 32% (22 aa)

KLSHQNLVSCHNYTVNEETGYAYVELDYCPGGSLADLFKKQRRLIQQMPISQIWLIAAHLLSALSYLH
.| |.| |   .  .....   |.   || || |. . || |   | |. . || | . |..||   |
QLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECH
Kinase GL50803_7103.AA WEE 90-130 27 5.7e-05 12.7 In-house 86-128 (297) Show / Hide 
Range on Protein: 90-130
Range on HMM: 86-128/297
Sequence Identity: 27% (12 aa)

YCPGGS--LADLFKKQRRLIQQMPISQIWLIAAHLLSALSYLH
|| |||  |.....   .  . .| ..|| |  ... .|...|
YCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIH
Ank GL50803_7103.AA Ank 383-410 39 3.4e-05 22.98 Pfam 1-28 (33) Show / Hide 
Range on Protein: 383-410
Range on HMM: 1-28/33
Sequence Identity: 39% (11 aa)

NGWTALMAAAQQGSEECVKLLVPHEACI
.|.|.|. |.. |..|.||.|. | |..
DGFTPLHLACRCGHTEVVKMLLQHGADV
Ank GL50803_7103.AA Ank 353-382 30 0.000213 20.12 Pfam 1-33 (33) Show / Hide 
Range on Protein: 353-382
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

VGCTALMFAAAYDYIECARLLLD---EVCMQDA
 |.|.|. |. ....|....||.   .|..|| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_7103.AA Ank 414-437 41 1.3e-05 24.49 Pfam 1-24 (33) Show / Hide 
Range on Protein: 414-437
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

NGFTALMAAAANGRLSCVHLLLEH
.|||.|. |. .|....| .||.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_7103.AA Ank 445-465 38 0.00238 16.34 Pfam 1-21 (33) Show / Hide 
Range on Protein: 445-465
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGRTALMWGAFTGHLDCAKAL
||.|.|.. .. ||....| |
DGFTPLHLACRCGHTEVVKML