Gene GL50803_7356 (G.lamblia)

GL50803_7356

Species: G.lamblia
Alias: GK268, GL50803_7356
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_7356.AA Protein None 537 None Fasta, JSON
GL50803_7356.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_7356.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_7356.AA S_TKc 14-283 14 1.6e-10 -22.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-283
Range on HMM: 1-231/231
Sequence Identity: 14% (44 aa)

NAIDQHLSSFKYLSLYTLKGTD-------KFMAEEIDAEIQGEGERATLDMLYAEYASAQLLAHSNIIRYHGLFVHAYYVYNVTQFCATPLSAVKFYNKD
  | ... .  . . |  . ..       | .                 .... | .  .   | ||..... |..  ..| |. .| . |  .. | |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

CG-------LSVSDVLKFTAQTALALAYLHSPYKV-----------GPQHI-------STFCLPRVHGWMSLDSVVIDAASSRYVVMDLVPTLRRLRVKS
.|       ..  .. ....|...||.|.||   .              ||       ...                                       
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------------------------------------

KRTPMSRRYFSPEKLLRGDDSPGFPQDDAWSLGIILYECITNQKFNCPDKEHYATEEQWTEFMGKHIDLIQDVWLRNLVMQLLAFNPAERLTVEELLM--
.    .. | .|| |     . |..  | ||.|.||||... .   .       ....  . .|       .  ........| ..|..|.|. |.|   
TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----DPRI
     .| .
WDIKCHPWF
Kinase GL50803_7356.AA Ciliate-E2 209-283 20 1.9e-07 21.58 In-house 278-365 (365) Show / Hide 
Range on Protein: 209-283
Range on HMM: 278-365/365
Sequence Identity: 20% (20 aa)

DAWSLGIILYECITNQK-FNCPDKEHYATEEQWTE----FMGKH-------------IDLIQDVWLRNLVMQ----LLAFNPAERLT-VEELLMDPRI
| ||||.||||.....  |          ..|  .    |  ..             . .  .    .|  .    .|  .| .|.|  |..|  | .
DIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_7356.AA CASK 257-283 33 2.2e-07 19.69 In-house 304-330 (330) Show / Hide 
Range on Protein: 257-283
Range on HMM: 304-330/330
Sequence Identity: 33% (9 aa)

RNLVMQLLAFNPAERLTVEELLMDPRI
..||.. |. .|..|... | |  | |
KDLVRRMLMADPHHRISIYEALNHPWI
Kinase GL50803_7356.AA MARK 256-283 46 3e-06 16.41 In-house 235-262 (262) Show / Hide 
Range on Protein: 256-283
Range on HMM: 235-262/262
Sequence Identity: 46% (13 aa)

LRNLVMQLLAFNPAERLTVEELLMDPRI
.|||. .|| .|| || |.||....| .
CRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase GL50803_7356.AA Ciliate-E2-Unclassified 209-283 21 8e-06 16.23 In-house 252-352 (352) Show / Hide 
Range on Protein: 209-283
Range on HMM: 252-352/352
Sequence Identity: 21% (22 aa)

DAWSLGIILYECITNQK-FNCPD-KEHYATEEQWTEF----MGKHIDLIQDVWL-----------------RNLVM----QLLAFNPAERLTVEELLMDP
| ||||.||||.....  |.... ..|. ...||. .    .  . . .|  .                   ...     ..|  || .|.| |..|  |
DIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHP

RI
 .
WF
Pkinase GL50803_7356.AA Pkinase 60-130 20 1.3e-05 20.91 Pfam 49-126 (293) Show / Hide 
Range on Protein: 60-130
Range on HMM: 49-126/293
Sequence Identity: 20% (17 aa)

AEYASAQLLAHSNIIRYHGLFVHAYYVYNVTQFCAT-----PLS----AVKFYNKDCGL--SVSDVLKFTAQTALALAYLHS
.| .  . | | ||.|... |    ..| |. .|        |.    .     .....  |  .. ..  |.. .|.|.||
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase GL50803_7356.AA ERK7 258-283 46 1.7e-05 14.37 In-house 267-292 (292) Show / Hide 
Range on Protein: 258-283
Range on HMM: 267-292/292
Sequence Identity: 46% (12 aa)

NLVMQLLAFNPAERLTVEELLMDPRI
.|. .||.||| .|||.|. |  | .
DLLKRLLVFNPKKRLTAEQALQHPYV
Kinase GL50803_7356.AA ERK3 259-283 40 3e-05 12.4 In-house 276-300 (300) Show / Hide 
Range on Protein: 259-283
Range on HMM: 276-300/300
Sequence Identity: 40% (10 aa)

LVMQLLAFNPAERLTVEELLMDPRI
.  |.| |.| .||| |. |  | .
FLEQMLTFDPMDRLTAEMALQHPYM
Kinase GL50803_7356.AA MAPK-Unclassified 257-283 33 3.2e-05 14.25 In-house 549-575 (575) Show / Hide 
Range on Protein: 257-283
Range on HMM: 549-575/575
Sequence Identity: 33% (9 aa)

RNLVMQLLAFNPAERLTVEELLMDPRI
...| ..|.|||  | | ...|  | .
IDFVQKMLQFNPWKRITADQALEHPYF
Kinase GL50803_7356.AA MAPKAPK 258-283 46 3.2e-05 13.42 In-house 243-268 (268) Show / Hide 
Range on Protein: 258-283
Range on HMM: 243-268/268
Sequence Identity: 46% (12 aa)

NLVMQLLAFNPAERLTVEELLMDPRI
.|. .||  .|.||||.||..  | |
DLIRKLLRTDPTERLTIEEFMNHPWI
Kinase GL50803_7356.AA CMGC 256-283 28 5.7e-05 11.26 In-house 486-513 (513) Show / Hide 
Range on Protein: 256-283
Range on HMM: 486-513/513
Sequence Identity: 28% (8 aa)

LRNLVMQLLAFNPAERLTVEELLMDPRI
...|....| ..|..|.|.|. |  | .
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_7356.AA TBCK 189-219 28 0.000105 12.65 In-house 148-196 (346) Show / Hide 
Range on Protein: 189-219
Range on HMM: 148-196/346
Sequence Identity: 28% (14 aa)

RYFSPEKLLRGDDSP------------------GFPQDDAWSLGIILYE
|| .|| .|.| ...                  . |. | ||||.|. |
RYMAPERILQGEMKTTDHMPPTNPLPPKTTNLSSNPKSDVWSLGCIMLE
Kinase GL50803_7356.AA Pkinase 187-283 16 0.001222 13.95 Pfam 174-293 (293) Show / Hide 
Range on Protein: 187-283
Range on HMM: 174-293/293
Sequence Identity: 16% (23 aa)

SRRYFSPEKLLRGDDSPGFPQDDAWSLGIILYECITNQKFNCPDKEHYATEEQWTEFMGK----------HIDLIQD-----------------------
...| .|| ..  ....  |  | ||.|.|||| .. .                . | |.           |..| .                       
TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGR----------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF

--------VWLRNLVMQLLAFNPAERLTVEELLMDPRI
         ... ..  .|...|..|.| |..| .| .
HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_7356.AA TBCK 255-283 27 0.005263 6.47 In-house 318-346 (346) Show / Hide 
Range on Protein: 255-283
Range on HMM: 318-346/346
Sequence Identity: 27% (8 aa)

WLRNLVMQLLAFNPAERLTVEELLMDPRI
||...  . | ..| .| . .||. .| .
WLIQIIRKCLQMCPMKRPSPTELMEHPMF
Kinase GL50803_7356.AA CMGC 70-130 13 0.049563 1.42 In-house 97-200 (513) Show / Hide 
Range on Protein: 70-130
Range on HMM: 97-200/513
Sequence Identity: 13% (14 aa)

HSNIIRYHGLFVHAY-----------------YVYNVTQFCATPLSAVKFYNKD--------------------------CGLSVSDVLKFTAQTALALA
| ||.. .  |.|                   ..| |. .. . |  .   |..                          . ... ..  .. |   .|.
HNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLK

--YLHS
  |.||
LKYCHS
Kinase GL50803_7356.AA MARK 209-218 70 0.063541 2.27 In-house 188-197 (262) Show / Hide 
Range on Protein: 209-218
Range on HMM: 188-197/262
Sequence Identity: 70% (7 aa)

DAWSLGIILY
| ||||..||
DIWSLGVVLY
Zf-C3HC4 GL50803_7356.AA zf-C3HC4 487-525 22 1.6e-07 22.79 Pfam 1-48 (48) Show / Hide 
Range on Protein: 487-525
Range on HMM: 1-48/48
Sequence Identity: 22% (11 aa)

CSVCLGSLSNIV---FYRCNHI----ACCNVCLEHILN--STRTCPIC
| .|.. ... .   .  |.|      .|  |.....|   ...||||
CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCIKRWWNHSGNTQCPIC
RING GL50803_7356.AA RING 487-525 30 0.000138 21.77 SMART 1-23 (23) Show / Hide 
Range on Protein: 487-525
Range on HMM: 1-23/23
Sequence Identity: 30% (12 aa)

CSVCLGSLSNIVFYRCNHIACCNVCLEHILNSTRTCPIC
|..||     .|.  |.|   |  |.         ||||
CPICLE----PVVLPCGH--FCY-CI---------CPIC