Gene GL50803_7514 (G.lamblia)

GL50803_7514

Species: G.lamblia
Alias: GL50803_7514, GK208
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_7514.AA Protein None 679 None Fasta, JSON
GL50803_7514.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of GL50803_7514.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_7514.AA STE 52-278 20 3.3e-24 82.47 In-house 69-359 (359) Show / Hide 
Range on Protein: 52-278
Range on HMM: 69-359/359
Sequence Identity: 20% (63 aa)

PRERRAIEADVSNIMDLV--HPHVASVVDFLDDKD-----RETYYIISETGSFTTAGDLVR------FSRNNN----SFIPEETIWCIAAHILLG-LSYC
. |.  |. ...  ...   ||..    .   ...     ... .|. |  .  .. |...      .. |.|    ...||. | .|.  || | |.| 
HEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYL

HLLCKPDPGSPSGILHRNIRPSSIIVVGEREYKLALFGVCHFRGNVVA--------------------SQGTLSLYMAPEVVFH------NAYSEKSDVW
| .          | || | |. | .      ||. ||||    . .|                      ||   .|||||.        . |..|.|.|
HSHH---------IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIW

ELGIVLYELCAKQRPFSGYD--RQQIKDAIMNACIQ----------SLPIY----------------------YSDELSAFICAMLKPDPSARSSVSTLL
 ||... |..  . |.. .   |     ...... |            |                        .|.|.  ||   |. ||. | ..| ||
SLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL

N--HPKL
.  || .
KSEHPFI
Kinase GL50803_7514.AA NEK2 189-278 34 1.3e-22 72.86 In-house 230-319 (319) Show / Hide 
Range on Protein: 189-278
Range on HMM: 230-319/319
Sequence Identity: 34% (31 aa)

YMAPEVVFHNAYSEKSDVWELGIVLYELCAKQRPFSGYDRQQIKDAIMNACIQSLPIYYSDELSAFICAMLKPDPSARSSVSTLLNHPKL
|| ||..    |.||||.| .| ..||.||   || .   .|    | .   . .| .||..|.. |  |.. |.. | |.  .| || .
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_7514.AA NEK 189-278 35 1.7e-22 76.33 In-house 190-286 (286) Show / Hide 
Range on Protein: 189-278
Range on HMM: 190-286/286
Sequence Identity: 35% (34 aa)

YMAPEVVFHNAYSEKSDVWELGIVLYELCAK--QRPFSGY--DRQQIKDAIMNA-CIQSLPIY--YSDELSAFICAMLKPDPSARSSVSTLLNHPKL
||.|||. .  |..|||.| || ||||.|.    .|| .   .  .    ||.    . .| .  ||..|. .|  ||..||. | |.. .|..| .
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_7514.AA Ciliate-E2-Unclassified 65-278 21 2.9e-22 74.02 In-house 70-352 (352) Show / Hide 
Range on Protein: 65-278
Range on HMM: 70-352/352
Sequence Identity: 21% (64 aa)

IMD---LVHPHVASVVDFLDDKDRETYYIISETGSFTTAGDLVRFSRNNNS----------------FIPEETIW-----CIAAHILLGLSYCHLLCKPD
||.   | |||   |..|  ..|... ||. |   .   |||  . .....                 ..|. .       ..|.||.||.|.|      
IMQQILLNHPHPFIVKMFYCFQDKQNIYIVME---YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH-----

PGSPSG-ILHRNIRPSSIIV-VGER--EYKLALFGVCHFRGNVVASQGTLS-------------------LYM----APEVVFHNAYS----EKSDVWEL
    .. |.||.| |. |..  . .  . |.. || . . .. . .. | .                    ||    ||||   . |.    .|.|.| |
----KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSL

GIVLYELCAKQRPFSGYDRQQ----------------IKDAIMNACIQ-----------SLPIYYSDELSAFICAMLKPDPSARSSVSTLLNHPKL
|..|||..  ..||..... |                ... |..  ||            ..  . | .. ... ||| .|. | . . .|||| .
GVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_7514.AA Ciliate-E2 64-278 19 7.1e-19 61.41 In-house 84-365 (365) Show / Hide 
Range on Protein: 64-278
Range on HMM: 84-365/365
Sequence Identity: 19% (60 aa)

NIMDLV-HPHVASVVDFLDDKDRETYYIISETGSFTTAGDLVRFSR------------------NNNSFIPEETIW-------CIAAHILLGLSYCHLLC
||. .. ||..   ...  .||....|.. |   .   |||  . .                  .  ..| .. .         ..| |.|.| |.|   
NILEQLNHPNIIKMYECFQEKDDNNIYLVME---YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK-

KPDPGSPSG-ILHRNIRPSSIIVVGEREYKLALFGVCHFRGNV-------VASQ---------GTLS------------------LYMAPEVVF------
        . |.||.| |. |..      |.. || . .  .        . ..         .| .                   |||||..       
--------NNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDN

---HNAYSEKSDVWELGIVLYELCAKQRPFSGYDRQQIKDAIMNACIQS-------------LPIYYSDELSAFICA----MLKPDPSARSS-VSTLLNH
   .. |..|.|.| ||..|||.. ...||     ||||.   .   .               . . |.|   .|      ||. ||. | .  . .|||
QQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNH

PKL
| .
PWF
Kinase GL50803_7514.AA TKL 137-276 17 5.8e-18 61.28 In-house 156-364 (364) Show / Hide 
Range on Protein: 137-276
Range on HMM: 156-364/364
Sequence Identity: 17% (38 aa)

CKPDPGSPSGILHRNIRPSSIIVVGERE--------------YKLALFGVCHF----------------------RGNVVASQGTLSLYMAPEVVFHN--
|.     . .|.||.. .. | |    .               |.. || . |                      ...   .|.    .|||||   .  
CT-----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMN

--------------AYSEKSDVWELGIVLYELCAKQRPFSGYDRQQIK------DAIMNACIQSLP----------------IYYSDELSAFICAMLKPD
               ||||.||.  ||||.|... .||...|.  ...      . .| .|  .|.                 .  ....  .    ..|
YTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHD

PSARSSVSTLLNHP
|..| | ...| . 
PEKRPSFQEILKRL
Kinase GL50803_7514.AA Pkinase 189-278 28 6.9e-18 64.34 Pfam 177-293 (293) Show / Hide 
Range on Protein: 189-278
Range on HMM: 177-293/293
Sequence Identity: 28% (33 aa)

YMAPEVVF-HNAYSEKSDVWELGIVLYELCAKQRPFSGY------DRQQIKDAIMN-----ACIQSLPIYYS---------------DELSAFICAMLKP
||||||.  .. |. |.|.| .|..|||.. .. ||.|       | .|. . ||       . .. .|.|.               .|.  ||. .|..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPSARSSVSTLLNHPKL
||. | .   .|.|| .
DPKKRPTAEQILQHPWF
Kinase GL50803_7514.AA NEK1 189-278 35 2.3e-17 56.95 In-house 187-276 (276) Show / Hide 
Range on Protein: 189-278
Range on HMM: 187-276/276
Sequence Identity: 35% (32 aa)

YMAPEVVFHNAYSEKSDVWELGIVLYELCAKQRPFSGYDRQQIKDAIMNACIQSLPIYYSDELSAFICAMLKPDPSARSSVSTLLNHPKL
|  ||      |  |||.| || ||||||.  .|| .   ..    |  ...  .|  || ||.  .  |.| .|. | || ..|  | .
YLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_7514.AA ULK 188-278 26 5.2e-16 52.46 In-house 216-329 (329) Show / Hide 
Range on Protein: 188-278
Range on HMM: 216-329/329
Sequence Identity: 26% (30 aa)

LYMAPEVVF----HNAYS-EKSDVWELGIVLYELCAKQRPFSGYDRQQIKDAIMNAC----------IQSLPIY---------YSDELSAFICAMLKPDP
|||||...     .  |.  |.|.| ||...||.   . ||...  .. .. |..            |.. |.           |.|.  .|  ||. |.
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE

SARSSVSTLLNHPKL
. | |   |.||| .
KDRISWEELFNHPWF
S_TKc GL50803_7514.AA S_TKc 14-278 22 6.3e-16 56.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-278
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

YATVRVLWRDHRGTVSVVAHADTRTEFLCQEILYTRFSPRERRAIEADVSNIMDLVHPHVASVVDFLDDKDRETYYIISETGSFTTA--GDLVRFSRNNN
|  .|.. .   |.|  . | .|  .. . .|          . |.  ..  .   ||..    |. .|   . .|.. |   .     ||| .. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVME---YCDGDLGDLFDYIKKRG

SF-----IPEETIWCIAAHILLGLSYCHLLCKPDPGSPSGILHRNIRPSSIIVVGEREYKLALFGVCHFRGNVVASQGTLSLYMAPEVVFHNAYSE-KSD
.      .|| ....... |...| ||| .          |.|| . |. | .    . |.. ||.. .        ||.  ||||||.    |.  |.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTP-WYMAPEVL---GYGKCKCD

VWELGIVLYELCAKQRPFSGYDRQQIKDAIMNACIQSLPIYYSDELSAFICAMLKPDPSARSSVSTLLN-------HPKL
.| .|..|||... . ||.  . |.. . |.           |.|.  ||. .|. ||. | ..  .|.       || .
WWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_7514.AA TKL-Unique 145-232 26 4e-15 49.94 In-house 129-243 (290) Show / Hide 
Range on Protein: 145-232
Range on HMM: 129-243/290
Sequence Identity: 26% (31 aa)

SG--ILHRNIRPSSIIVVGE-----REYKLALFGVCHFRGNVVASQGTLS--------------LYMAPEVVFH--NAYSEKSDVWELGIVLYELCAKQR
..  |.||....|.. |. .        |.. || . |. .   ...|..              ..|||||     . |||||||.  ||||.|.   ..
CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSK--INKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI

------PFSGYDRQQIK
      |..|.|..|..
TKTYKKPYQGMDQEQWC
Kinase GL50803_7514.AA NEK11 189-278 36 8e-15 50.44 In-house 170-259 (259) Show / Hide 
Range on Protein: 189-278
Range on HMM: 170-259/259
Sequence Identity: 36% (33 aa)

YMAPEVVFHNAYSEKSDVWELGIVLYELCAKQRPFSGYDRQQIKDAIMNACIQSLPIYYSDELSAFICAMLKPDPSARSSVSTLLNHPKL
||.|| . |  |  |||.| |  .|||.|  .  | | .   |   |.     |||  |  || . .  ||  .|| | |   .|  | .
YMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase GL50803_7514.AA Pkinase_Tyr 190-217 39 3.2e-07 25.06 Pfam 181-208 (270) Show / Hide 
Range on Protein: 190-217
Range on HMM: 181-208/270
Sequence Identity: 39% (11 aa)

MAPEVVFHNAYSEKSDVWELGIVLYELC
||||. ... ...|||||  |....|..
MAPECINYGKFTTKSDVWSFGVLMWEIF
TyrKc GL50803_7514.AA TyrKc 39-278 16 4.3e-07 -107.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-278
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

EFLCQEI-----------------------LYTRFSPRERRAIEADVSNIMDL--VHPHVASVVDFLDDKDR-----ETYYIISETGSFTTAGDLVRFSR
  | ...                        ..      |...    .  . |   ||..   .    .. |     | ..|. |   .   |||  . |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME---YMPHGDLKDYLR

NNNSFIPEETIWCIAAHILLGLSYCHLLCKPDPGSPSGILHRNIRPSSIIVVGEREYKLALFGVC--HFRG-------NVVAS----QGT--LSL-YMAP
..   .. ..   ..  |  | .| |           .. || .    . |  ..  | . || .  .  .        .  .    .|   | .  |||
KHRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EVVFHNAYSEKSDVWELGIVLYELCAK-QRPFSG-----YDRQQIKDAIMNACIQSLPIY--------YSDELSAFICAMLKPDPSARSSVSTLLNHPKL
|. ... ...|||||  |....|..   | | .|      . |..   ...      | .         .||.   .    . ||. | . |..  | ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase GL50803_7514.AA NEK 101-134 27 3.4e-05 14.67 In-house 92-131 (286) Show / Hide 
Range on Protein: 101-134
Range on HMM: 92-131/286
Sequence Identity: 27% (11 aa)

GDLVRF---SRNNNS---FIPEETIWCIAAHILLGLSYCH
||| ..     ..     ...||.|| . ....|.| |.|
GDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMH
Kinase GL50803_7514.AA Pkinase 114-150 30 0.023044 9.44 Pfam 103-132 (293) Show / Hide 
Range on Protein: 114-150
Range on HMM: 103-132/293
Sequence Identity: 30% (12 aa)

I--PEETIWCIAAHILLGLSYCHLLCKPDPGSPSGILHR
.  .|... ...  || || |||           ||.||
FYFSEWECKFYMYQILRGLEYCHSM---------GIIHR
Kinase GL50803_7514.AA NEK2 108-154 27 0.235309 0.18 In-house 95-153 (319) Show / Hide 
Range on Protein: 108-154
Range on HMM: 95-153/319
Sequence Identity: 27% (16 aa)

RNNNSFIPEETIWCIAAHILLGLSYCHL----------LCKPDPGSPS--GILHRNIRP
|.   ...|| || | . ... |  ||             .  | ..    |||| | |
RKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKP
Ank GL50803_7514.AA Ank 443-466 29 2.863723 5.23 Pfam 1-24 (33) Show / Hide 
Range on Protein: 443-466
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

EGKTILMGAAESGFSYVVEQFISQ
.| | |. |...|   ||. ....
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_7514.AA Ank 474-495 31 0.000286 19.66 Pfam 1-22 (33) Show / Hide 
Range on Protein: 474-495
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

QGRTALMYAVLGGSLKCVRLLV
 |.|.|..|.. |....|..|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_7514.AA Ank 505-537 21 0.398321 8.32 Pfam 1-33 (33) Show / Hide 
Range on Protein: 505-537
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

QGKTALAYAIANKDIELIRVLRDAEWNVVIHGN
 | |.| .|. . ..| .. | ..  .| .. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD