Gene GL50803_7537 (G.lamblia)
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
GL50803_7537.AA | Protein | None | 401 | None | Fasta, JSON |
GL50803_7537.kin_dom | Protein Kinase Domain | None | 229 | None | Fasta, JSON |
Protein domains of GL50803_7537.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | GL50803_7537.AA | CK1 | 10-266 | 63 | 1.8e-179 | 602.49 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 10-266 Range on HMM: 1-271/271 Sequence Identity: 63% (171 aa) YQLHYRIGRGAFGELYRGVNLATGED--VAIKLEPIDAKPPQLLYESKLYKILVG------GVGIPYIYHYAPE--GEYNVLVMDLLGPSLEDLFTACNR |.. .|| |.||..| | |. .|| ||||||....| |||.||.|.|||| | ..||| .|....| |.||..||||||||||||| ||| YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR HFSLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGL-GRRKTTVYIIDFGLAKRY--MVGNTHIPYREHKSLTGTARYCSINTHLGLEQSRRDDLE .||||||||.|||||.|.|..| |||.||||||||||.|. |.....|||||||||||| . ..||||||.|.||||||| |||||||.|||||||.| KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME ALAYVFLYFLRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRG-QPTEFAAYLHYTRALRFDDRPDYA .|.||..||||| |||||||||||.||||||.|||.| |.| | .| | ||| || |.| |.|...|||. SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | GL50803_7537.AA | CK1-Unclassified | 10-240 | 61 | 2.6e-175 | 521.84 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 10-240 Range on HMM: 1-244/244 Sequence Identity: 61% (149 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYESKLYKILVGGV-------GIPYIYHYAPE--GEYNVLVMDLLGPSLEDLFTACNRH |.. .|| |.||| | ..|. |.| |||||| ..| |||.|| |....| .| ||| .|... | |.||..||||||||||||| ||| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK FSLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIG-LGRRKTTVYIIDFGLAKRYM---VGNTHIPYREHKSLTGTARYCSINTHLGLEQSRRDDLE ||||||||.|||||.|.|.|| |||.||||||||||.| ||.....||||||||.||| ..|||||| |.||||||| |||.|||.||||||||| FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE ALAYVFLYFLRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLT .|.||..|||.| ||||..|||.| .|||||.|.|.| |.|.| SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | GL50803_7537.AA | CK1-D | 10-268 | 65 | 5.70000000001e-156 | 524.46 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-261/261 Sequence Identity: 65% (172 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYESKLYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDLFTACNRHFSLKTVLML | . .|| |.||..| | |..|.|.||||||.| .| ||| .|||.||.. ||.||| | . ||.|||.||||||||||||| |.|.||||||||| YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML ADQMITRVEFLHLKNFLHRDIKPDNFLIGLGRRKTTVYIIDFGLAKRYMVGN--THIPYREHKSLTGTARYCSINTHLGLEQSRRDDLEALAYVFLYFLR |||||.|.|..| .||.||||||||||.|||.| .|||||||||||| . ||||||.|.||||||| |||||.|.|||||||||.| ||..|| | ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR GFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRGQPTEFAAYLHYTRALRFDDRPDYAYL | |||||||| |||||||.| |||.| .|. | .| | ||. |. |.| |.|||.|||.|| GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | GL50803_7537.AA | CK1-A | 10-268 | 62 | 7.1e-148 | 497.56 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-261/261 Sequence Identity: 62% (163 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYESKLYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDLFTACNRHFSLKTVLML |.| .|| |.||..| |.|. ||.||||.| .|. |||.||.|.|.|| |.|||| . .| | .|||.||||||||||||| |.|.|..|||||| YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML ADQMITRVEFLHLKNFLHRDIKPDNFLIGLGRRKTTVYIIDFGLAKRY--MVGNTHIPYREHKSLTGTARYCSINTHLGLEQSRRDDLEALAYVFLYFLR |||||.|.|..| |||.||||||||||.|.|| ...|||||||.| .|||||| | ||||||| ||| |||.|||||||.|...||..|| | ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR GFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRGQPTEFAAYLHYTRALRFDDRPDYAYL | |||||.||.||.||||||.|||.| ||| | .| |.||. |. |.|.|||.. ||| || GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | GL50803_7537.AA | CK1-G | 10-268 | 55 | 9.1e-143 | 480.6 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-266/266 Sequence Identity: 55% (148 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYESKLYKILVGGV-GIPYIYHYAPEGEYNVLVMDLLGPSLEDLFTACNRHFSLKTVLM |. .|| | ||||. | |. ..| ||||.||. . ||| | . |||| | . |||..| . ..| ||..||||||||||||| |.|.||.|||.| YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM LADQMITRVEFLHLKNFLHRDIKPDNFLIGL--GRRKTTVYIIDFGLAKRYMVGNT--HIPYREHKSLTGTARYCSINTHLGLEQSRRDDLEALAYVFLY .| |||.|.| .| .. . ||.|||||||| ... ...|||||.|| |. .| |||||||||||||||| ||||||| |||||||.||| .|.| VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY FLRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRG--QPTEFAAYLHYTRALRFDDRPDYAYL |||| |||||||| . ...|.|| ..| . .|| | . | .|| || | | | |.. ||| || FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | GL50803_7537.AA | CK1 | 10-268 | 36 | 6.2e-123 | 414.72 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-339/339 Sequence Identity: 36% (124 aa) YQLHYRIGRGAFG-ELYRG-----VNLATG-----EDVAIKLEPIDAK--PPQLLYESKLYKILVGG-------------------VGIPYIYHYAPEGE ... || |.|| . |.. ... .. |..|.|.||.... .|||..|...||.| || ...| .|.|. |.. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --YNVLVMDLLGPSLEDLFT---ACNRHFSLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGL------GRRKT--------TVYIIDFGLAK-RY ||..||.||||.||||. |||.||.||.||.|.||. ..|..| ..|.|||||||||..|. |.. . .||.||||.|. .| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY MVGNT-------------HIPYRE---HKSLTG-TARYCSINTHLGLEQSRRDDLEALAYVFLYFLRGF--LPWQGLKANTK-------RQKYEKILEKK . . |.|.|| .|...| ||||||||.||| ||.|||||....|.....|.| ||||..|...| ..|||.| ||| RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK LSSPIESLTRGQ-----PTEFAAYLHYTRALRFDDRPDYAYL .| |.. | . | || .. | |.|...|||||... MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | GL50803_7537.AA | TTBKL | 10-272 | 27 | 4.8e-49 | 163.76 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 10-272 Range on HMM: 1-288/288 Sequence Identity: 27% (81 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDA-K--PPQLLYESKLYKILV--GGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDLF-TACNRH-FS .. ||.|.||. |..... . .|.|.. |. . . . | .. . | | .| .. . .. || .|| |.||.| || . .|.. || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGLG----RRKTTVYIIDFGLAKRYM--VGNT----------HIPYRE---HKSLTGTARYCSINT |.. .. | . . .| . |.|||.|| |. .|. .| .||.||||.|..|. |.. . . |. . .. || ||||.| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HLGLEQSRRDDLEALAYVFLYFLRGFLPWQGLK-AN-TKRQKYEKILEKKLSSPI-ESLTRGQPTEFAAYLHYTRALRFDDRPDYAYLRKIF |...||.| ||| .. |.. ... | |||.... . . | ....|. . . . .. | ||. . |.||. ||||| .....| HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRD---HDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | GL50803_7537.AA | Worm6 | 10-268 | 28 | 9.3e-48 | 164.98 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-279/279 Sequence Identity: 28% (80 aa) YQLHYRIGRGAFGELYRGVNLATGE--DVAIKLEP--IDAKPPQLLYESKLYKIL--VGGVGIPYIYHYAPEGE--YNVLVMDLLGPSLEDLFTAC-NRH ... || |.|| | . ... .|.|.| .| ..| | | . .. . . | .. .. .| .|| |.|..|.|| .. .|. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGL-----GRRKTTVYIIDFGLAK--RYMVGNT-HIPYR-EHKSLTGTARYCSINTHLGLEQSR ||. | | .| |.. ..| || |.|||.|| || || . |.|..|||... .|. .. .. | .. || ||.... | | ||.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLEALAYVFLYFLRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRG-QPT-EFAAYLHYTRALRFDDRPDYAYL .||.| |. . ...| |||...|. .|. | .....|.... | |. || . . | ... |||||... KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | GL50803_7537.AA | TTBK | 10-268 | 33 | 1.3e-44 | 154.54 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 10-268 Range on HMM: 1-257/257 Sequence Identity: 33% (89 aa) YQLHYRIGRGAFGELYRGVNLATG-EDVAIKLEPIDAKPPQLLYESKLYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDL-FTACNRHFSLKTVL . .|| |.||| | . .. . | ||||.| ... | | | | | . . . ..| .||.|.| .| || . ||| | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL MLADQMITRVEFLHLKNFLHRDIKPDNFLIGLGRRKT-TVYIIDFGLAKRYMVGNTHI-PYREHKSLTGTARYCSINTHLGLEQSRRDDLEALAYVFLYF | |.. .| | |||||||| || .|. .. .|..||||| .|. . . | || ||.|| ||| |. | |.||| | |. | RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF LRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRGQPTEFAAYLHYTRALRFDDRPDYAYL . | ||| .| ... | | | | || ... . | . |||||. . VQGQLPWRKIKDK------DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | GL50803_7537.AA | Pkinase | 10-239 | 20 | 7.5e-38 | 134.91 | Pfam | 1-242 (293) | Show / Hide |
Range on Protein: 10-239 Range on HMM: 1-242/293 Sequence Identity: 20% (52 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLY------ESKLYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGPSLEDLFTAC------ |... .||.|.||. |.... ||. ||.| . . . .. .. | .. | | . ... . .... .||.... |. .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLY-VMDLFDYISTW -NRHF--SLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIG-LGRRKTTVYIIDFGLAKRYMVGNTHIPYREHKSLTGTARYCSINTHL-GLEQSRR .. | | ... . . |.. .|..| ....|||.||.|.|| | ...| |.|||||| . . ... ....|| .|.. .. | . ... RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK DDLEALAYVFLYFLRGFLPWQGL----KANTKRQKYEKILEKKLSSPIESL | .. .. ..| | .|..| . ....|....|....|..... . VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWW |
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Kinase | GL50803_7537.AA | VRK | 81-220 | 35 | 1.4e-26 | 82.45 | In-house | 106-250 (284) | Show / Hide |
Range on Protein: 81-220 Range on HMM: 106-250/284 Sequence Identity: 35% (52 aa) LVMDLLGPSLEDLFT-ACNRHFSLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGLGRRKTTVYIIDFGLAKRYMVGNTHIPYREHKSLT--GTAR .||. .| .|. . ... || |||| || .|. |.|| .. | ||| | | |. . .|| .|.||| || . | .| | . || MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCHNGTCE YCSINTHLGLEQSRRDDLEALAYVFLYFLRGFLPWQGLKA--NTK . |. |.| ||| ||| |.| .. | |.||| .. ... FTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPE |
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Kinase | GL50803_7537.AA | S_TKc | 10-277 | 19 | 2.6e-15 | 47.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-277 Range on HMM: 1-231/231 Sequence Identity: 19% (54 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYESKLYKILVGGVGIPYIYHYAPEGEYNVLVMDLLGP---SLEDLFTACNRH-----F |... ||.||||. |.... ||. |||| . ... | .. | . | .| . . .. .||.... .| |. ..|| | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SLKTVLMLADQMITRVEFLHLKNFLHRDIKPDNFLIGLGRRKTTVYIIDFGLAKRYMVGNTHIPYREHKSLTGTARYCSINTHLGLEQSR-RDDLEALAY . .. .. |.. .|..| ....|||.||.| |. .. |.|||||... ... || |.. .. . | .. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC VFLYFLRGFLPWQGLKANTKRQKYEKILEKKLSSPIESLTRGQPTEFAAYLHYTRALRFDDRPDYAYLRK----IFRELFV .. .| | |.. . . ..||. . |. . ..|| . . | .. ILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | GL50803_7537.AA | TyrKc | 10-272 | 18 | 7e-07 | -111.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-272 Range on HMM: 1-280/280 Sequence Identity: 18% (59 aa) YQLHYRIGRGAFGELYRGVNLATGEDVAIKLEPIDAKPPQLLYE--SKLYKI---------LVGGVGIP-----------YIYHYAPEGEYNVLVMDLLG .| .|.||||| |.|. ..||.| || . ... . . |. |.| . . . |.| | . . . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP PSLEDLFTACNRHFSLKTVLMLADQMITR-VEFLHLKNFLHRDIKPDNFLIGLGRRKTTVYIIDFGLAKRYMVG------NTHIPYREHKSLT--GTARY ...|. | . | . |.|| ||. |||. | |.| .. || | ||||.. . . .|||. | K------------LCMKDLLSFC-WQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW CSINTHLGLEQSRRDDLEALAY-------------VFLY--FLRGFLPWQGLKA--NTKRQKYEKILEKKLSSPIESLTRG-----QPTEFAAYLHYTRA ... |.. | | .. | .| |. | . .. .|.. . . . .. |.| . MAP--------------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWH LRFDDRPDYAYLRKIF .||| . ....| EDPEDRPTFSEIHECF |
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Kinase | GL50803_7537.AA | VRK | 10-42 | 26 | 0.059682 | 2.54 | In-house | 1-38 (284) | Show / Hide |
Range on Protein: 10-42 Range on HMM: 1-38/284 Sequence Identity: 26% (10 aa) YQLHYRIGRGAFGELYRG---VNLAT--GEDVAIKLEP . | ||.| ||..| .. .. . . .|.|| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP |