Gene GL50803_8218 (G.lamblia)

GL50803_8218

Species: G.lamblia
Alias: GL50803_8218, GK203
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8218.AA Protein None 972 None Fasta, JSON
GL50803_8218.kin_dom Protein Kinase Domain None 273 None Fasta, JSON

Protein domain

Protein domains of GL50803_8218.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_8218.AA S_TKc 11-283 21 1e-31 112.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-283
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSLLEHEIMVNRALVHPNIMRYQYILNDKENCRYYLLMSYFSK--SDLGYQLVKRKE--
|..| |.|||. .. |......|| . |.|..            .. || . .   |||| .. ..  |    ..|. | | .    ||   ..||.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

THARFKEATIWTLMAQLYDVLLYLHSVDKRHSTDISIALLRDFRPSNFFLSSRGIIQIKSLQHLKLLEFGSVEAEPFASKLPPLLV--PYLAPDVLQGNY
.. .| | ... .|.|. . | |.||    |         ||  |.| .|..          |.|.  ||.            . .   |.|| ||    
LRFPFPE-HARFYMYQICCALEYCHSHGIIH---------RDLKPENILLDE----------HIKICDFGLARQL------TTFCGTPWYMAPEVL---G

YSA-SSDIWSLGCLLYELCTFQAFVTGRTPNDVLQALAGARHPIVLDHYSQSLSHVLSLMLQPNSRDRITLKQLGS-------FPQL
|.  ..|.||.||.|||... .      ... ... .            |... . .. .|| . ..|.|  ..          | .
YGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_8218.AA Pkinase 193-283 20 1.6e-18 66.59 Pfam 176-293 (293) Show / Hide 
Range on Protein: 193-283
Range on HMM: 176-293/293
Sequence Identity: 20% (24 aa)

PYLAPDVLQ-GNYYSASSDIWSLGCLLYELCTFQAFVTGR----TPNDVLQALAGARHPIVLDHYS-----------------------QSLSHVLSLML
.|.|| |.. |.||. ..|.||.||.|||... .    |.    . .| .| ..  ..|..  ...                       ... .... .|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QPNSRDRITLKQLGSFPQL
...  .|.| .|.   | .
CKDPKKRPTAEQILQHPWF
Kinase GL50803_8218.AA NEK 194-283 31 3.3e-17 57.48 In-house 190-286 (286) Show / Hide 
Range on Protein: 194-283
Range on HMM: 190-286/286
Sequence Identity: 31% (31 aa)

YLAPDVLQGNYYSASSDIWSLGCLLYELCTFQA--FVTGR--TPNDVLQALAGA-RHPIVLDH--YSQSLSHVLSLMLQPNSRDRITLKQLGSFPQL
|..| |.|.  |.  ||||||||.|||.||..      .     .            | . .|  ||| |. ..|.|||..  .| . .|. ..|..
YMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_8218.AA NEK2 11-158 29 1e-16 52.73 In-house 1-160 (319) Show / Hide 
Range on Protein: 11-158
Range on HMM: 1-160/319
Sequence Identity: 29% (47 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSLLEHEIMVNRALVHPNIMRYQYILNDKENCRYYLLMSYFSKSDLGYQLVKR-KETHA
|. |  .|.||  ...   . ..|  |. ||.||   .. |  .|  |. . | | |||| ||   . |..| . |. | | .  ||. |..|. .  . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLS-QMIKKCRKERQ

RFKEATIWTLMAQLYDVLLYLHS------------VDKRHSTDISIALLRDFRPSNFFLSS
.. |  ||  |.||   |   |               |  .    . | ||  | | ||..
YMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDY
Kinase GL50803_8218.AA Pkinase 11-132 26 6.4e-14 50.31 Pfam 1-126 (293) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-126/293
Sequence Identity: 26% (35 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSLLEH--EIMVNRALVHPNIMRYQYILNDKENCRYYLLMSYFSKS----DLGYQLVKR
|....|.|.|| .. |....  ||   |.|....|. .|...  . .  || . . | |||| |. ..  |  . ..|. | |  .     ||   ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLF-DYIST

KETHARF--KEATIWTLMAQLYDVLLYLHS
 . | .|   | ..   | |.   | |.||
-WRHGCFYFSEWECKFYMYQILRGLEYCHS
Kinase GL50803_8218.AA NEK1 209-271 46 4.5e-13 41.86 In-house 202-264 (276) Show / Hide 
Range on Protein: 209-271
Range on HMM: 202-264/276
Sequence Identity: 46% (30 aa)

SDIWSLGCLLYELCTFQ-AFVTGRTPNDVLQALAGARHPIVLDHYSQSLSHVLSLMLQPNSRDR
|||||||| ||||||   .|  .  .| ||  . |  .||.  |||. |.  .| |.. | |.|
SDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPP-HYSYELQSLVSQMFKRNPRHR
Kinase GL50803_8218.AA ULK 194-283 26 5.7e-13 41.69 In-house 217-329 (329) Show / Hide 
Range on Protein: 194-283
Range on HMM: 217-329/329
Sequence Identity: 26% (30 aa)

YLAPDVLQGN-----YYSASSDIWSLGCLLYELCT-FQAFVTGRTPNDV---LQALAGA---------RHPIVLD------HYSQSLSHVLSLMLQPNSR
| || .|||.     ||.. .|||||||..||. .    |..     ..   .| |             .|.  .      . |. .   .. ||| . .
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

DRITLKQLGSFPQL
|||.  .| . | .
DRISWEELFNHPWF
Kinase GL50803_8218.AA STE 194-283 18 1.1e-12 41.21 In-house 228-359 (359) Show / Hide 
Range on Protein: 194-283
Range on HMM: 228-359/359
Sequence Identity: 18% (25 aa)

YLAPDVLQG------NYYSASSDIWSLGCLLYELCTFQAFVTGRTPNDVLQALA--G-------------ARHPIVLD-------------------HYS
. || |.|.      . |....|||||||.. |..| .      .|  .. . .  .               .|   |                   ..|
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWS

QSLSHVLSLMLQPNSRDRITLKQLGS--FPQL
... . ... || . ..| | .|| .   | .
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_8218.AA CAMK-Unique 11-132 18 8.2e-12 35.07 In-house 1-175 (363) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-175/363
Sequence Identity: 18% (32 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSL------------------LEHEIMVNRALVHPNIMRYQYI----LNDKEN------
| ..  .|.|... .| ..| |||   ||| .   .  .. . .                  |. |. . . . |||| .  ..      |...      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

-------CRYYLLMSYFSKSDLGYQLVKR----------------KETHARFKE--ATIWTLMAQLYDVLLYLHS
        ..|..|.|  . ||   ..|.                |    .| |  . . ..|..|  .. |.||
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHS
Kinase GL50803_8218.AA NEK 11-132 23 1e-11 37.95 In-house 1-132 (286) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-132/286
Sequence Identity: 23% (31 aa)

YQLLSKLGKGSRSTIYLAQDNETGNY-----LACKELCYRDWDSSELSLLE-HEIMVNRALVHPNIMRYQYILNDKENCRYYLLMSYFS-KSDLGYQ---
|... |.|.|| .. |.... ..|.      .. |.  .   .. |   .  .|. . . | |||| .|     ...| . .  | |   . ||  .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LVKRKETHARFKEATIWTLMAQLYDVLLYLHS
. |.|. .  | | .||  ..|.   | |.|.
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHD
Kinase GL50803_8218.AA ULK 194-283 25 2.6e-11 36.45 In-house 213-324 (324) Show / Hide 
Range on Protein: 194-283
Range on HMM: 213-324/324
Sequence Identity: 25% (28 aa)

YLAPDVLQGN-----YYSASSDIWSLGCLLYELCT-FQAFVTG-RTPN----DVLQ-----ALAGARHPIVLD------HYSQSLSHVLSLMLQPNSRDR
| || .|||.     ||.. .|||||||..||. .    |..  .. .    . ..      .     ||  .      . |. .   .. ||| . .||
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR

ITLKQLGSFPQL
|.  .. . | .
ISWEEIFNHPWF
Kinase GL50803_8218.AA NEK2 194-223 50 2.6e-11 34.21 In-house 230-259 (319) Show / Hide 
Range on Protein: 194-223
Range on HMM: 230-259/319
Sequence Identity: 50% (15 aa)

YLAPDVLQGNYYSASSDIWSLGCLLYELCT
|  | ...|  |.  |||||.|||.||.|.
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCA
Kinase GL50803_8218.AA Ciliate-E2-Unclassified 194-283 23 3.8e-11 34.94 In-house 232-352 (352) Show / Hide 
Range on Protein: 194-283
Range on HMM: 232-352/352
Sequence Identity: 23% (29 aa)

YLAPDVLQG-NYYS---ASSDIWSLGCLLYELCTFQAFVTGRTPND----------------VLQALAGARHPIVL-------DHYSQSLSHVLS----L
|.|| |||| ||.     ..||||||..|||... .    ... ..                ..|        .         .| |..  . ..     
YTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

MLQPNSRDRITLKQLGSFPQL
||. |   |||..|.   | .
MLKKNPNKRITFEQILNHPWF
Kinase GL50803_8218.AA STE 11-73 20 6.1e-11 34.99 In-house 1-95 (359) Show / Hide 
Range on Protein: 11-73
Range on HMM: 1-95/359
Sequence Identity: 20% (19 aa)

YQLLSKLGKGSRSTIYLAQDNE---------------TGNYLACKELCYRDWDS---------------SELSLLEHEIMVNRALV--HPNIMRY
.....|.|||.  | |.| ...               ||.. | |.. ... ..               .|.  ...|| . . .   |||| .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKY
Kinase GL50803_8218.AA Ciliate-E2 193-283 21 1.5e-10 32.44 In-house 252-365 (365) Show / Hide 
Range on Protein: 193-283
Range on HMM: 252-365/365
Sequence Identity: 21% (26 aa)

PYLAPDVLQ---------GNYYSASSDIWSLGCLLYELCTFQA-FVTGRTPNDVLQALAGARHPIV-----------------LDHYSQSLSHVLSL---
.|.|| .|.         ...|. ..||||||..|||... .  |         .|        .                   .. ||.  . ..    
GYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK

-MLQPNSRDRIT-LKQLGSFPQL
 ||| .   |||  .|.   | .
RMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_8218.AA Ciliate-E2 11-132 18 1.6e-09 28.81 In-house 1-178 (365) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-178/365
Sequence Identity: 18% (34 aa)

YQLLSKLGKGSRSTIYLAQDNETGN-----------------------YLACKELCYRDWDSSELSLLEHEIMVNRALV----------------HPNIM
| .. |.|.|. ...|.... ....                       . | | .  .     ..  .. || ..| .                 ||||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKN-----QIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII

RYQYILNDKENCRYYLLMSYFSKSDLGY--QLVKRKETHA-----RFKEATIWTLMAQLYD---------------VLLYLHS
.. .   .| .  .|| | |..  || .  .  | |..|      .|.|  | ..|.|. .                | ||||
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS
Kinase GL50803_8218.AA ULK 11-83 26 7e-09 27.71 In-house 1-92 (324) Show / Hide 
Range on Protein: 11-83
Range on HMM: 1-92/324
Sequence Identity: 26% (24 aa)

YQLLSKLGKGSRS-TIYLAQDNET---GNYLACKELC--YRDWDSSE------LSLLEHEIMVNRALV---HPN--IMRYQYILNDK--ENC
|.|  .|||||   . | . ...|   . | |||     .   ...|      . ||. || . . |    |||  | ..  .....   |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNI
Kinase GL50803_8218.AA CAMK 193-219 33 9.4e-09 23.58 In-house 284-325 (425) Show / Hide 
Range on Protein: 193-219
Range on HMM: 284-325/425
Sequence Identity: 33% (14 aa)

PYLA-PDVLQG--------------NYYSASSDIWSLGCLLY
.| | | ||.|               ||. ..|.||.|..||
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_8218.AA Ciliate-E2-Unclassified 11-132 19 2e-08 25.35 In-house 1-161 (352) Show / Hide 
Range on Protein: 11-132
Range on HMM: 1-161/352
Sequence Identity: 19% (31 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELC-YRDWD-------SSELSLLEHEIMVN----------------RALVHPNIMRYQYILNDK------
| .. ..|.|. ...|..|..... | | |... ... .         |... ..|.. .                . . ||.|... |. .||      
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

-ENCRYYLLMSYFSKSDL----GYQLVKRKETHARFKEATIW-----TLMAQLYDVLLYLHS
 | |..  |. | .|.      |  |......  .| |  .      ...||. . | |||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH
Kinase GL50803_8218.AA ULK 11-83 23 6.8e-08 23.74 In-house 1-95 (329) Show / Hide 
Range on Protein: 11-83
Range on HMM: 1-95/329
Sequence Identity: 23% (22 aa)

YQLLSKLGKGSRSTIYLAQDNET----GNYLACKELCYRDWDSSELS--------LLEHEIMVNRALV--------HPNIMRYQYILNDK--ENC
|.|  .|||||  . | . ...|    . . ||| ..    . ..          ||. || . . |         |||| ..  .....   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNI
Kinase GL50803_8218.AA CAMK 16-132 14 1.4e-07 19.76 In-house 1-197 (425) Show / Hide 
Range on Protein: 16-132
Range on HMM: 1-197/425
Sequence Identity: 14% (29 aa)

KLGKGSRSTIYLAQDNETG------------NYLACKELCYR-------------------------DW-DSSELSLLEHEIMVNRALV-------HPNI
.||.|| .. .|... .|.               |.| .  .                         .| . . .  ...|| . . |        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

MRYQYILND-----------KENC-------RYYLLM---SYFSKSDL---GYQLVKRKET------------HARFKEATIWTLMAQLYDVLLYLHS
 .   .  |             ..       ..|. |    | |  .|    .. .....             . ||.|.   ... |. . . |.||
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS
Kinase GL50803_8218.AA TyrKc 11-281 17 8.6e-07 -112.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-281
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSLLEHEIMVNRAL--VHPNIMRYQYILNDK-EN----CRYYLLMSYFSKSDLGYQLVK
 .|. ||| |   ..|... .      | | |         .  . .|. . . |   |||| |   .  .. .|      ....| | .. ||   | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKETHARFKEATIWTLMAQLYDVLLYLHSVDKRHSTDISIALL-RDFRPSNFFLSSRGIIQIKSLQHLKLLEFG---SVEAE--------PFASK---LP
....   .. ..    . |  .   ||||            .  ||    |  .....        . |   ||    .. .           .|     
HRPK---LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

PLLVPY--LAPDVLQGNYYSASSDIWSLGCLLYELCTF-QAFVTG-----RTPNDVLQALAGA-RHPIVLD-------HYSQSLSHVLSLMLQPNSRDRI
  ..|.  .|| ... . ..  ||.|| | ...|..|. |    |      .. .|.. .    | |.  .       . .. .  . .   . .  || 
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TLKQLGSFP
| ... .. 
TFSEIHECF
Kinase GL50803_8218.AA CAMK-Unique 193-221 25 1.8e-05 13.8 In-house 240-286 (363) Show / Hide 
Range on Protein: 193-221
Range on HMM: 240-286/363
Sequence Identity: 25% (12 aa)

PYLAP--------------DVLQGNYYSASS----DIWSLGCLLYEL
.|.||               |. .  |.  .    |||||| ..|..
CYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYM
Kinase GL50803_8218.AA NEK1 11-74 25 0.019704 4.45 In-house 1-64 (276) Show / Hide 
Range on Protein: 11-74
Range on HMM: 1-64/276
Sequence Identity: 25% (16 aa)

YQLLSKLGKGSRSTIYLAQDNETGNYLACKELCYRDWDSSELSLLEHEIMVNRALVHPNIMRYQ
|  ....|.||    .|... | |  .. ||       ..| .    |  . . . |||| .|.
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYK
Kinase GL50803_8218.AA CAMK 250-276 22 0.073374 0.97 In-house 384-418 (425) Show / Hide 
Range on Protein: 250-276
Range on HMM: 384-418/425
Sequence Identity: 22% (8 aa)

DHYSQS--------LSHVLSLMLQPNSRDRITLKQ
|. |..          . .. |||..  .|.|..|
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQ